In a recent perspective, @fda.gov leadership notes that "[t]he utility of NAMs extends well beyond safety assessment. Accumulating evidence shows they can improve the efficiency and predictive value of drug development itself." #NAMs #drugdevelopment #preclinical 🧪

🚨👉 Ask your Representative to co-sponsor the PRIMATE Act: support.peta.org/page/96444/a... For more information on monkey importation and its consequences, see the posts below 👇 6/9

Late last week, Reps. Greg Steube and @titus.house.gov introduced the Preventing Risky Importation of Monkeys to Avoid Toxic Exposures Act, or PRIMATE Act (H.R. 8471). More than 20,000 primates are imported into the U.S. every year for experimentation and testing. 🧵 #PRIMATEAct

Last week, on behalf of SAO & colleagues, I submitted written public testimony to the LHHS Subcommittee, which appropriates funding for #NIH. We asked that NIH be given sufficient funding & clear direction to take the steps listed in the graphic. #SciPol

🧠 @ucsanfrancisco.bsky.social researchers used #STICR (single-cell RNA-sequencing-compatible tracer for identifying clonal relationships), a recently developed tool for clonal cell lineage tracing, on human tissue samples to map cortical development. #neuroskyence #CellBio #RNAseq 🧬

The #WW4AIL day 4️⃣ topic is #cognition 🧠 As evidence of the rich emotional lives & cognitive abilities of animals grows, it becomes even more ludicrous for some to dismiss that laboratory experiments induce fear, distress, & pain in the animals subjected to them. www.linkedin.com/pulse/world-...

At the @hubrechtinstitute.bsky.social, @thecleverslab.bsky.social developed a primary human adult alveolar #organoid model that allows for long-term expansion of alveolar progenitor and differentiated cell types, to study how inflammation affects alveolar regeneration. 🫁

The next COLAAB member in our spotlight series is: 🌟 Ross Dobie! 🌟 Ross Dobie, PhD, is Head of Science at the Centre for Human Specific Research 👉 humanspecificresearch.org Based in Edinburgh, Scotland, Ross has been a member of the COLAAB Evidence Working Group since 2025.

On the 3rd day of #WW4AIL, SAO is discussing standard laboratory housing conditions, how they prevent animals from expressing natural behaviors & confound experimental results. www.linkedin.com/pulse/world-... #WWAIL #Reproducibility #AnimalResearch #AnimalWelfare

"[M]onkeys with documented infections, injuries, and recurring illness can still be cleared for studies if they meet basic criteria like age and weight ... That’s not a definition of health. It’s a definition of usability..." @statnews.com www.statnews.com/pharmalot/20...

It's Day 2 of #WW4AIL! 🐁 Today, SAO is exploring the unmanaged & mismanaged pain of animals in laboratories, including the consequences of poor reporting. This issue affects animal welfare (obviously), but also reproducibility & quality. www.linkedin.com/pulse/world-... #WWAIL #AnimalWelfare

In a recent case & commentary, Drs. David Feinstein & John Pawlowki of @harvardmed.bsky.social argue that medical curricula should incorporate input from a diverse range of stakeholders, including perspectives on animal rights. #MedEd #MedSky #SurgEd #SurgSky

The COLAAB's @mikalahsinger.bsky.social is traveling to ️☀️ Chula Vista, CA next month for the 📚 @scholarlypub.bsky.social Annual Meeting. She’ll network & present a poster w/ recommendations for editors to help mitigate animal methods bias & ensure fair review of submissions without animal use. 👇

It's #WW4AIL! 🐁 Non-animal methods are steadily replacing the use of animals in experiments, but millions+ are still used every year. Many experience pain & distress, & most ultimately die. This week, SAO will be discussing key issues affecting animals in labs. ⬇️ www.linkedin.com/pulse/world-...

📢 BIG ANNOUNCEMENT! 🥁... Research Modernization NOW, our #SciencePolicy roadmap, has become a living online resource! 📚 Dive into a resource packed with everything you need to know about animal experimentation and why we must transition to human-relevant, non-animal methods. 🧵

What if biobanking were treated as shared #PublicHealth infrastructure? In a new perspective, Melissa V. Olson describes how they do it at The Johns Hopkins BioBank, a @pathologists.bsky.social accredited program that's part of the @jhu.edu Genetic Resources Core Facility.

Published Friday in The Scientist, my colleagues, Dr. Lisa Jones-Engel & @katherineroe.bsky.social, push back on claims that animal advocates are distorting or somehow misleading the public & policymakers by drawing attention to oversight records. www.the-scientist.com/animal-resea...

Large‑scale, human‑only neuroscience reveals the "neural fingerprint" of #psychedelics, mapping how these substances may disrupt rigid patterns of thought & promote flexibility by reshaping brain connectivity. 💡🧠 #neuroskyence By @meryldl.bsky.social: www.nationalgeographic.com/health/artic...

At #CUDenver, the Magin lab is engineering a new partly donor-derived, partly synthetic model for studying lung diseases. 🫁 "We’re not just conducting research ... We’re combining engineering, medicine, and industry to find treatments that work." - @chelsea-magin.bsky.social #pulmsky

RPI scientists highlight the growing importance of human bone #organoids for studying #diabetes ‑associated skeletal disease. Animal experiments & 2D cellular models cannot capture human bone structure, disease heterogeneity, or clinical outcomes.

First up in our COLAAB member spotlight series: ✨ Catharine E. Krebs, PhD ✨ Catharine does research policy work at the US-based nonprofit @pcrm.org. She is a founding member of both of our working groups, where she enjoys working with collaborators across sectors, disciplines, & global regions.

For the Tomorrow’s Cure podcast, host @cathywurzer.bsky.social explores how 3D #bioprinting is advancing human skin research. Saranya Wyles, MD, PhD & Adam Feinberg, PhD discuss building living skin models from human cells and biologic materials to study aging, wound healing, and disease.

💡 @replanimalres.bsky.social has been doing impressive work unpacking assumptions that still shape debates about animal experimentation. Their recent blogs tackle under-discussed questions with thoughtfulness. These & others are worth a read! 🔗s below 👇 #bioethics #animalresearch

🔔 FYI for researchers: New #NIH funding opportunity! DPCPSI & ORWH have released a ROA on "Computational Modeling of Hormone Homeostasis," seeking innovative, early‑stage #insilico approaches to model hormone‑mediated biological processes and improve sex‑specific drug assessment. #NIHFunding

Really enjoyed our COLABB-wide meeting last week! Some of the best people to work with!

This 🆕 highly realistic, ethical, and accessible 3D-printed simulator could help replace the use of live rats in microneurosurgical training. From Amini et al. of @uni-magdeburg.de, in @jnajournal.bsky.social: doi.org/10.3171/2025... #MedEd #SurgEd #MedSky #SurgSky #Neurology #Neurosurgery

It’s #NationalPublicHealthWeek ❣️ We often talk about how animal-free biomedical science improves research and treatments, but that’s not the whole story. Here are 4️⃣ lesser‑discussed ways modernizing science and medicine can further strengthen #PublicHealth 🧵 #NPHW #HealthPolicy #SciPol

✨ THIS THURSDAY ✨ is the first of 3️⃣ panels covering key themes of #JaneGoodall 's legacy, "bringing together panelists spanning across different regions and generations, all doing inspiring and transformational work connected to Dr. Jane Goodall’s life message." #animalwelfare #cognition #sentience

"In 2006, a drug called TGN 1412 met every preclinical safety requirement. Clean in animal models. Clean in monkeys. Ninety minutes after six human volunteers received their first dose at a London hospital, they were fighting for their lives with their immune systems in overdrive." 🧵

John was brilliant and wise and kind and such a strong advocate for animals in laboratories. He will be missed 💔 obits.dallasnews.com/us/obituarie...

#CallForPapers! 📣 @commsbio.nature.com and @natcomms.nature.com are seeking primary research articles from authors who use stem cell-based #organoid models for studying #InfectiousDisease. Submit by December 21! www.nature.com/collections/... #assembloid #stemcell #IDsky #Virosky #Microsky

Love this new piece from @bittelmethis.bsky.social honoring rats. They deserve much more respect and care than they're allotted. Featuring @beebrookshire.bsky.social and rodentologist Bobby Corrigan More from the article & my thoughts in this 🧵 #RatsHaveRights 🐀 🩶

🆕 review! Anna Niarakis and Philippe Moingeon explore how #DigitalTwin technology can accelerate precision medicine for immune-related pathologies. They highlight recent advances and outline future directions for the field. #Immunosky

In this perspective, @jainlabtamu.bsky.social et al. discuss the importance of including temporal & spatial components when designing & developing vascular microphysiological models for applications in chronic disease, personalized medicine, drug testing, & tissue engineering. 🧪

The next generation of science starts here. Join a tuition-free, award-winning program exploring human-based research methods. Plus, receive hands-on training, career development, and a global community of scientists. 📍 June 15-18 ⏳ Apply by April 24 SummerImmersion.org

Last month, the Canadian Council on Animal Care released its Ethics Principles for Animal Use in Science, replacing 30+ years of guidance and setting expectations for experimentation, testing, and teaching in Canada. ccac.ca/Documents/St... A few notable (maybe hopeful 🤞) things 👇🧵 #bioethics

Is peer review bias slowing down the adoption of #MicrophysiologicalSystems? If you're attending the 2026 MPS World Summit in Washington, D.C. this May, let's connect! ✈ #AnimalMethodsBias #PeerReview #MPSWorldSummit #MPS #NAMs #organonchips

WSU engineers developed a 3D-printed dynamic heart model. Components in the myocardial walls enable it to mimic ventricular contraction & realistic mitral valve motion, supporting minimally invasive #SurgEd. advanced.onlinelibrary.wiley.com/doi/10.1002/... #CardioSky #SurgSky #MedEd #MedSky

Aldaver Inc. is showcasing next-generation surgical simulators that replace animal and human tissue with human-relevant synthetic models that provide realistic tactile feedback, are anatomically accurate, and customizable. #MedEd #MedSky Learn more: www.linkedin.com/posts/aldave...

🆕 🧠 🩹 @sahoolab.bsky.social of @sasn.rutgers.edu review how hiPSC-based models are changing what's possible for neural repair research & treatment. #Organoids, #assembloids, & #microengineering can do that too! 🔗 doi.org/10.1016/j.pn... #RegenerativeMedicine #Neuroskyence #Neuroengineering

Replacement changes what tools are available. Displacement changes how science is done. @nicodmueller.bsky.social's revisit of “Lane‑Petter’s Pipeline” provides the wider lens we need to modernize and humanize biomedical research. 🧵 #bioethics #paradigmchange #scipol #metasci #philsci

In response to criticism of the CDC's decision to end its in-house experiments on non-human primates, Drs. Lynn Taylor & Zach Burns, along w Etai Bally, penned a powerful letter outlining the many reasons the agency's choice was a good one. 🧵 #bioethics #IDsky

I'd really like to see this discussed more. The *whole point* of these protocols is to terrorize animals. And in ways that don't reflect how most humans develop this condition, or the other psych conditions that the "chronic unpredictable stress" paradigms attempt to model.

Great new resource for educators! 🧑‍🏫🧫🧬🧪 @scienceinnovation.ec.europa.eu #JRC & #Scientix partnered to create this module to teach high schoolers about laboratory practices using non-animal #invitro methods. www.scientix.eu/resources/kn... #STEM #STEMeducation #ITeachBio #NAMs #HiSciSky

The Winter 2025-2026 edition of SAO's newsletter will be hitting inboxes soon! No spam! Only 4 content-packed emails per year. For anyone following: #BiomedicalResearch #Bioethics #SciPol #MedEd #NAMs 🧪 Sign up on the bottom of our homepage at: ScienceAdvancement.org

Using @emulatebio.bsky.social’s organ-on-chip platform, researchers at @qmulsems.bsky.social created a human coronary artery organ-chip model of vascular inflammation. onlinelibrary.wiley.com/doi/10.1002/... #CardioSky #OrganChip #OrganOnChip #Bioengineering 🧪

To better understand how cirrhosis reshapes the liver and impacts its function, a UW team led by @kellystevens.bsky.social developed the LiverMap pipeline and used it to generate a high-resolution 3D reconstruction of the human liver. www.nih.gov/news-events/... #hepatology #gastrosky 🧪

🚨 New paper by myself and @tristankatz.bsky.social 🚨 "Harm-Benefit Analysis for Animal Experiments Is Not Utilitarian" It's commonly claimed that HBA – used in the licensing of animal studies – is utilitarian. We say this vastly oversells the framework. #animalexperimentation #animalresearch #3Rs

My friend and colleague @katibertrand.bsky.social's excellent piece on animal sentience was published in @panworks.bsky.social! 🪼🐟🐛🐜✨🧠✨🐝🪳🦗🐙

Last year, we urged NIH to take concrete steps to address #AnimalMethodsBias in grant review. Here's what we learned from the conversation 🧵 #SciencePolicy #SciPol #PeerReview #GrantReview #ResearchFunding #NAMs #NIH #CSR 🧪