NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought www.nature.com/articles/s41...

Interested in energy-based thinking around health? Interested in mitochondria and body-mind processes? Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th. Poster abstract submission open. www.picardlab.org/misbie

🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study + past & current team @labspagnoli.bsky.social + collaborators #VigilanteLab @kingslsm.bsky.social ➡️ doi.org/10.1126/scia... short 🧵 below & more acknowledgments ⤵️

A new #DMMPerspective from Wenqing Xu & @aleprigio.bsky.social explores increasing evidence of #neurodevelopmental aspects in #HuntingtonsDisease & early interventions that might lead to prevention or delay of the disease pathology journals.biologists.com/dmm/article/...

Thanks for the highlight @dmmjournal.bsky.social

Out now in @natmetabolism.nature.com 🚨 This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing as well as in metabolic, neuroinflammatory and neurodegenerative diseases contributes to cognitive decline.

An atlas of mitochondrial ATP synthase activity across the lifespan #mitochondria www.sciencedirect.com/science/arti...

Our latest perspective is out in Dis Model Mech (@biologist.bsky.social)! We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy. doi.org/10.1242/dmm....

Israel has committed genocide in Gaza, UN commission of inquiry says www.bbc.com/news/article...

Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases go.nature.com/4fYoEwG

Two papers in today's issue of @nature.com ‬: 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.

Our latest review is out in STEM CELLS! We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders. academic.oup.com/stmcls/advan...

🎙️ Focus Speakers – Alessandro Prigione 👀 Curious to know who will be speaking at #euromit2026 ? ✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress. #euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers @ua-recherche.bsky.social

Looking forward to Euromit 2026!!

mtDNA editing!

Exciting news! Our most important work is out as preprint! We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use. Next step is the clinical trial starting early next year! www.medrxiv.org/content/10.1...

Nature research paper: Spatial transcriptomics reveals human cortical layer and area specification https://go.nature.com/3GUX8Tm

Molecular machineries shaping the mitochondrial inner membrane www.nature.com/articles/s41...

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬 📅 registration closes MAY 30th, so don’t wait to snag your spot! Stay tuned - more updates about the topics and speakers coming soon! 🎙️

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...

Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids

After decades of research on stem cells and their reprogramming, we're now seeing extensive clinical trial assessment, some with very encouraging results. This is a new @science.org outstanding review of the biology and ongoing research efforts www.science.org/doi/10.1126/...

Great study by @nataliabaumann.bsky.social @djabaudon.bsky.social & collaborators, showing how regional differences in progenitor metabolism shape brain growth during development @cp-cell.bsky.social www.cell.com/cell/abstrac...

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open. Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland! meetings.embo.org/event/25-mit...

Honored to be part of this landmark forum article @cp-cellstemcell.bsky.social outlining a roadmap for genomic safety in human pluripotent stem cell therapies. Thankful to Ivana Barbaric for leadership and to all coauthors for great efforts. kwnsfk27.r.eu-west-1.awstrack.me/L0/https://a...

"we have been watching with growing concern policy changes in the US...The scale of disruption to science is unprecedented...We are concerned with policies that threaten censorship & removal of public data...To our colleagues in the US, we stand with you" journals.biologists.com/jcs/article/...

Wonderful to see this out!Thanks to all clinicians for sharing their data. By looking at the natural history of Leigh syndrome patients with mitochondrial mutations MT-ATP6 and MT-ATP8 we can learn key aspects to monitor for future clinical trials. www.neurology.org/doi/10.1212/...

🌍Euromit 2026 is coming to Angers!🌍 ✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨ 📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬

REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch... Please re-post!

Ahead of #RareDiseaseDay, please join us to educate and increase awareness about rare mitochondrial diseases Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected Please share to advance rare www.thelilyfoundation.org.uk/affected-by-...

Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social Thanks to everyone involved! www.cell.com/cell-metabol...

I'm co-organizing a Cell Symposia on Metabolites in Organellar Communication with @robzonculab.bsky.social, Kivanc Birsoy, and Allyson Evans (@cp-cellmetabolism.bsky.social). It will be in Sitges May 11-13. Submit an abstract by Feb 14. Hope to see you in Spain! cell-symposia.com/metabolites-...

SY-Stem 2025 Symposium: Registration deadline on February 15th! SY-Stem - a symposium focusing on the next generation of stem cell researchers - is organized by IMBA and @impvienna.bsky.social. Register online: bit.ly/4jekaDg Check out the program: bit.ly/4jDioM6

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

The U.S. has had probably the best university system in the world since the late 1940s; government investments (state and federal) drove that success. That may have changed overnight. 🧵🧪

New year, new version of mitoXplorer 3.0 (mitoxplorer3.ibdm.univ-amu.fr) : mine your single-cell RNA-seq data from a mitochondrial perspective by creating cell-type specific pseudo-bulks or by looking at mitochondrial variability on single-cell level. Check it out at doi: doi.org/10.1101/2024...

Very interesting opinion piece. The only thing I would disagree with is the line: "what can be done? The sad answer is not that much". People (in US and outside) need to fight this at all levels. Our world as we know it is on the line.

Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar. This thursday, usual time and place.

Delighted to share our latest review article summarizing the use of induced pluripotent stem cells (iPSCs) to model mitochondrial disorders with 2D and 3D organoid approaches. www.sciencedirect.com/science/arti...

1/ Pleased to share our review, published today @natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...

My regular reminder that there is an open call @pasteur.fr for junior group leader covering various axis (including topics related to development biology), open till Feb. 28th. Don't hesitate to DM me or reach out by email if you want to get more context. research.pasteur.fr/fr/call/call...

Düsseldorf stellt sich quer und Mitglieder der @hhu.bsky.social sind dabei! Wer ebenfalls Flagge für Demokratie zeigen möchte und dafür noch ein Plakatmotiv braucht, kann sich gerne bei uns (auch per PM) melden - wir teilen unseren #HeineGegenRechts mit euch!

Sad to see webpages of NIH diversity supplements taken down. I know this was suspected to happen, but it’s heartbreaking to see. www.nature.com/articles/d41... Eg., NIMH www.nimh.nih.gov/about/organi...

We are recruiting 2 postdocs to help us understand the mechanisms underlying HSV-1 latency. You will be part of a collaborative team & receive extensive mentorship to develop your own independent line of research. #stemcells #virology Please share 🙏 careers.humantechnopole.it/o/postdoc-ha...

"The science of extreme longevity continues as an immense joke." —The first man to “survive” past 110 actually died at 65. —Blue zones are a myth —Pervasive false claims about longevity and supercentenarians Gift link www.nytimes.com/2025/01/20/o...

Brains minimize energy consumption while maximizing computation. In humans, this trade-off is reconciled towards complex behaviors & hence relatively high energy use Review & synthesis with @sharnajamadar.bsky.social @annabhlr.bsky.social & Hamish Deery tinyurl.com/47c9n65w osf.io/preprints/os...