Thank you very much @mitoworld.bsky.social for highlighting our work and the upcoming trial! We plan to start recruiting individuals with MT-ATP6 variants later this year.

A patient‑derived iPSC screen by Prigione identified sildenafil as a potential therapy for #LeighSyndrome, a devastating #mitochondrialdisease. @cp-cell.bsky.social Now recruiting for clinical trials! mitoworld.org/using-ips-ce... #UMDF #mitoscientists #mitochondria #SynLeigh @ema.europa.eu

In this new review Wittich et al., including @aleprigio.bsky.social, discuss human stem cell–derived #organoids as increasingly powerful 3D models for #drugdiscovery, improving disease modeling & drug screening by better capturing human tissue structure & function. 🧪 #NAMs #biotech

Fantastic work from @andrearossilab.bsky.social Rossi lab on the development of @cleanfinder.bsky.social for nuclear and mitochondrial genome editing application. Greatful that my lab have contributed!

In the midst of bad news in the word, it was amazing and humbling to see our recent discovery of sildenafil in Leigh syndrome in @cp-cell.bsky.social highlighted among five inspiring uplifting stories in @nature.com www.nature.com/articles/d41...

Our spotlight article is out in Cell Metabolism highlighting the exciting publication by Du et al in Cell showing the effectiveness of mitochondrial transplantation @cellpress.bsky.social authors.elsevier.com/a/1n2ge5WXUl...

Thanks Leo for sharing! 🙏

Super excited to share our latest work! In collaboration with Antonio del Sol, we show that brain organoids coupled with deep learning screening allow uncovering new repurposable drugs for the incurable mitochondrial disease Leigh syndrome. www.nature.com/articles/s41...

Brain organoids used to screen drug candidates for genetic mitochondrial disease Leigh Syndrome identifies utility of sildenafil (Viagra) 📷 Annika Zink, Dao-Fu Dai, Annika Wittich et al @aleprigio.bsky.social @hhu.de in @cp-cell.bsky.social ➡️ bpod.org.uk/archive/2026... + @rooph.bsky.social

Really impressive study showing an actual successful end-to-end rare disease example how to use IPSC + repurposable drug screening followed up by increasing complex diseases models (and functional analyses) to find a drug that is successfully tested in patients. Congratulations 💪

www.sciencedirect.com/science/arti... Check this tour de force by @aleprigio.bsky.social and collegues Brilliant paper. Showing the true potential of hiPSC-based disease modeling studies to tackle real-world therapies

#NotTheCover We proposed this image for our paper out now in CELL @cellpress.bsky.social It depicts sildenafil treatment like a wave displacing the visual noise associated with mitochondrial dysfunction. Fantastic work from Emma Vidal at DrawImpacts!

Insightful commentary in @science.org on our paper out now in @cellpress.bsky.social. Thank you very much to Catherine Offord for writing this piece and to @vgamalab.bsky.social for the supportive words! www.science.org/content/arti...

Our collaborative work is out now in CELL @cellpress.bsky.social We sugggest sildenafil as a repurposable drug for mitochondrial disease. A clinical trial is planned to start later this year. Thanks to collaborators, funders, and patient organizations! www.sciencedirect.com/science/arti...

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy @cellcellpress.bsky.social @aleprigio.bsky.social www.cell.com/cell/fulltex...

🌍 Applications are open! The IBRO Exchange Fellowships give early career #neuroscientists to conduct lab visits with several expenses covered during the exchange. 🗓 Apply by 15 Apr: https://ibro.org/grant/exchange-fellowships/#neuroscientists #grant #IBROinAsiaPacific #IBROinUSCanada #IBROinAfrica #IBROinLatAm

NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought www.nature.com/articles/s41...

Interested in energy-based thinking around health? Interested in mitochondria and body-mind processes? Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th. Poster abstract submission open. www.picardlab.org/misbie

🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study + past & current team @labspagnoli.bsky.social + collaborators #VigilanteLab @kingslsm.bsky.social ➡️ doi.org/10.1126/scia... short 🧵 below & more acknowledgments ⤵️

A new #DMMPerspective from Wenqing Xu & @aleprigio.bsky.social explores increasing evidence of #neurodevelopmental aspects in #HuntingtonsDisease & early interventions that might lead to prevention or delay of the disease pathology journals.biologists.com/dmm/article/...

Thanks for the highlight @dmmjournal.bsky.social

Out now in @natmetabolism.nature.com 🚨 This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing as well as in metabolic, neuroinflammatory and neurodegenerative diseases contributes to cognitive decline.

An atlas of mitochondrial ATP synthase activity across the lifespan #mitochondria www.sciencedirect.com/science/arti...

Our latest perspective is out in Dis Model Mech (@biologist.bsky.social)! We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy. doi.org/10.1242/dmm....

Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases go.nature.com/4fYoEwG

Two papers in today's issue of @nature.com ‬: 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.

Our latest review is out in STEM CELLS! We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders. academic.oup.com/stmcls/advan...

🎙️ Focus Speakers – Alessandro Prigione 👀 Curious to know who will be speaking at #euromit2026 ? ✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress. #euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers @ua-recherche.bsky.social

Looking forward to Euromit 2026!!

mtDNA editing!

Exciting news! Our most important work is out as preprint! We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use. Next step is the clinical trial starting early next year! www.medrxiv.org/content/10.1...

Nature research paper: Spatial transcriptomics reveals human cortical layer and area specification https://go.nature.com/3GUX8Tm

Molecular machineries shaping the mitochondrial inner membrane www.nature.com/articles/s41...

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬 📅 registration closes MAY 30th, so don’t wait to snag your spot! Stay tuned - more updates about the topics and speakers coming soon! 🎙️

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...

Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids

After decades of research on stem cells and their reprogramming, we're now seeing extensive clinical trial assessment, some with very encouraging results. This is a new @science.org outstanding review of the biology and ongoing research efforts www.science.org/doi/10.1126/...

Great study by @nataliabaumann.bsky.social @djabaudon.bsky.social & collaborators, showing how regional differences in progenitor metabolism shape brain growth during development @cp-cell.bsky.social www.cell.com/cell/abstrac...

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open. Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland! meetings.embo.org/event/25-mit...

Honored to be part of this landmark forum article @cp-cellstemcell.bsky.social outlining a roadmap for genomic safety in human pluripotent stem cell therapies. Thankful to Ivana Barbaric for leadership and to all coauthors for great efforts. kwnsfk27.r.eu-west-1.awstrack.me/L0/https://a...

"we have been watching with growing concern policy changes in the US...The scale of disruption to science is unprecedented...We are concerned with policies that threaten censorship & removal of public data...To our colleagues in the US, we stand with you" journals.biologists.com/jcs/article/...

Wonderful to see this out!Thanks to all clinicians for sharing their data. By looking at the natural history of Leigh syndrome patients with mitochondrial mutations MT-ATP6 and MT-ATP8 we can learn key aspects to monitor for future clinical trials. www.neurology.org/doi/10.1212/...

🌍Euromit 2026 is coming to Angers!🌍 ✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨ 📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬

REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch... Please re-post!

Ahead of #RareDiseaseDay, please join us to educate and increase awareness about rare mitochondrial diseases Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected Please share to advance rare www.thelilyfoundation.org.uk/affected-by-...

Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social Thanks to everyone involved! www.cell.com/cell-metabol...