We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. aacrjournals.org/cancerdiscov...

Excited to see our review out in @cp-trendsendomet.bsky.social! Great team effort and lots of fun to dive into how #islets form and how we can use this knowledge for #diabetes therapy. @mireiamoli.bsky.social @ckarampelias.bsky.social @heikolickert.bsky.social www.sciencedirect.com/science/arti...

Next, @ingridtsang.bsky.social chronicles a day in the life of a Reviews Editor (including must-have snacks!) thenode.biologists.com/a-day-in-the...

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

💥 Great fun writing this #review with @alejotorrescano.bsky.social – reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity - Just out online ➡️ rdcu.be/fiw3c @wellcometrust.bsky.social @kingscollegelondon.bsky.social @kingslsm.bsky.social

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵

It's difficult to succinctly summarize a entire germ layer, but Aaron Zorn, Scott Rankin and I tried recently! Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now. shorturl.at/kHf9Y

New Pre-Print Alert! Evolving initial conditions: an alternative developmental route to morphological diversity with Shannon Taylor and @jamesehammond.bsky.social www.biorxiv.org/content/10.6...

I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍

Had so much fun at @bsdb.bsky.social a few weeks go and am very excited about all the upcoming stories I saw. Check out the #preprint list I've collated from the meeting, now on @prelights.bsky.social👇 prelights.biologists.com/prelists/bsd... And please do let me know if there are any I missed 👀

🚨The abstract submission deadline is this Friday 17 April 2026.

A question I get asked all the time by @dev-journal.bsky.social authors "Why does it cost so much to publish a paper?" We break down the finances and explain where the money goes Spoiler: quality publishing takes a village (people + infrastructure) journals.biologists.com/dev/article/...

Working on the 2027 Pancreatic Diseases GRC (www.grc.org/pancreatic-d...) and I am just so excited about the developing programme.... and it's May 9-14, Renaissance Tuscany Il Ciocco, Italy. Have a look and remember to mark your calendars.

Tomorrow is the day… Swim22 starts… yay!!! 🎉 🏊‍♀️ 🔬 🧫 We are back in the pool for @diabetesuk.bsky.social to support people living with diabetes and research towards better treatments and a cure, please donate! swim22.diabetes.org.uk/teams/stem-c...

YEN 2026 registration is now live! Join us for the 2026 YEN conference on the 15th of June at the Francis Crick Institute, London, UK. Sign up now to attend and submit your poster/abstract: forms.gle/2HQEmZgEi4hP... Abstract submission deadline is 15 May. Stay tuned for more information!

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Fully funded PhD post, UK/Home student, starting 01/06/26. Interested in working at the interface of dev bio, biophysics and cell biology? Great collaboration with Amy Beedle and @leonerossetti.bsky.social Informal enquiries welcome. Deadline 15/03 #neuralcrest www.kcl.ac.uk/study-legacy...

We summarised the many roles of material phase transitions in development (and they are not just mechanical 🤔)

Pinna-pointing the roles of Eya1 and Tbx1 in outer ear development This Research Highlight showcases work from Juan Fons, Abigail Tucker and colleagues: journals.biologists.com/dev/article/...

How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔 We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns. buff.ly/w56OUJT

I’m a guest editor for a JoVE Methods Collection on Unrevealing Human Skin Lineages, Microenvironments, and Adaptations with Single-Cell & Spatial Transcriptomics We invite abstracts on human skin biology. 👉 Submit : lnkd.in/eAcnxvih #JoVE #SkinScience #HumanSkin #Omics #ESDR

Our new paper: Entropy Sorting Feature Selection (ESFS) A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction A thread www.biorxiv.org/content/10.6...

👀 Check out @the-node.bsky.social where @alejotorrescano.bsky.social (first author) share #behindthepaper stories about our recent paper ⤵️ Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” thenode.biologists.com/behind-the-p...

Congratulations to Rashmi and Karolina and also to the technology development studio of the MPI-CBG without whom the screen would not have been possible. If you are interested in high-content screening in organoid models, you may want to take a look.

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...

Congratulations to Byung Ho from the @anne-grapin.bsky.social lab @mpi-cbg.de and the rest of the team to this fantastic publication: www.nature.com/articles/s41...

Our work is finally published in @science.org Advances! 🎉 My very first paper, and what a journey it's been 🙂‍↕️ Huge thanks to the whole team, and especially to @pjsaez.bsky.social for believing in me. It turned out way better than I could've ever dreamt ✨ 📄 science.org/doi/10.1126/sciadv.ads2734

New year, new beginnings! Join us for all things animal & plant devbio at the 2026 @bsdb.bsky.social meeting in Warwick! Abstract submission closing NEXT FRIDAY 16th JAN - join us!

Here's the news piece from the IoPPN about our paper today! A wonderful way to end the year. www.kcl.ac.uk/news/structu...

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...

Check this beautiful work from the lab, led by the great #GeorginaGoss! It was a joy to be involved!

Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours" link.springer.com/article/10.1... #DevBio 🧪

Reminder to apply - talk applications accepted continuously, there is no deadline. We will be seeking speakers throughout all of next year, so if you have a story on metabolism in development you're excited to share, here's the perfect place:

I’m thrilled to introduce you to the NeuMap! our latest work [email protected]. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...

🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then! www.science.org/doi/10.1126/...

Research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬 www.kcl.ac.uk/news/researc... Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791

🚨 here it is the #DashBoard accompanying our new paper (see 🧵 below) ➡️ spatial-pancreatic-maps.sites.er.kcl.ac.uk 😃 have fun exploring the dataset & #spatial #maps 🗺️ 👏 👏 Kudo to Sami (#Siwanarta Ma) MScs Bioinformatics for building the #DashBoard !!

Thrilled to see the work of my postdoc in the @labspagnoli.bsky.social finally published! Many thanks to all the co-authors for all the help!

Pathogenic Keratinocyte States and Fibroblast Niches Define the Tissue Microenvironment in Severe Hidradenitis Suppurativa #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.1101/2025.11.11.682326v1

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...

New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky

Happy to share a new tool from the @heikolickert.bsky.social lab! We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells. doi.org/10.1016/j.sc... Thanks to all the co-authors that helped in the present and the past!

I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting! Registration and abstract submission is now open - join us! bsdb.org/meetings/ March 23-26, 2026 - UK

Out @natcomms.nature.com: our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀 Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!). Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social rdcu.be/eIJm5

Hot off the press! Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 www.nature.com/articles/s41...

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇