Alex Schier
@schierlab.bsky.social
📤 2445
📥 71
📝 35
Schierlab. Biozentrum Basel. Development. Behavior. Zebrafish. Curious.
Might cerebellar disinhibition underlie Restless Legs Syndrome symptoms? Will Joo found that loss of the RLS-associated gene meis1b perturbs locomotion in zebrafish by disinhibiting cerebellar output.
www.sciencedirect.com/science/arti...
14 days ago
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reposted by
Alex Schier
Oded Mayseless
14 days ago
11/11 Big picture: the larval zebrafish olfactory bulb is organized spatially, transcriptionally, and functionally in ways that reflect behavioral preference. Paper:
www.biorxiv.org/content/10.6...
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reposted by
Alex Schier
Oded Mayseless
14 days ago
7/11 Luckily,
@yinanwan.bsky.social
and Jakob developed a powerful approach for multiplexed whole-mount gene-expression mapping. Sequentially imaging 68 genes in intact larval brains, defined anatomical and transcriptional boundaries of the olfactory bulb at cellular resolution.
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reposted by
Alex Schier
Oded Mayseless
14 days ago
1/11 Excited to share my postdoc work from
@schierlab.bsky.social
and Rainer Friedrich! 🐟👃 How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵
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reposted by
Alex Schier
bioRxiv Developmental Biology
about 1 month ago
Interpretable decoding of cell fate from a snapshot of combinatorial signaling
https://www.biorxiv.org/content/10.64898/2026.05.17.725652v1
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reposted by
Alex Schier
Biozentrum, University of Basel
about 2 months ago
🧪 A new study led by Dr. Janani Durairaj and Prof. Torsten Schwede shows that current AI models in drug discovery still face limitations. Learn more👇
@ninjani.bsky.social
@torstenschwede.bsky.social
@unibas.ch
@snsf.ch
@natureportfolio.nature.com
www.biozentrum.unibas.ch/news/detail/...
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AI models still reach limits in drug discovery
Developing new medicines is a slow and costly process. For some years now, artificial intelligence (AI) has been considered a promising tool to accelerate drug discovery by identifying drug candidates...
https://www.biozentrum.unibas.ch/news/detail/ai-models-still-reach-limits-in-drug-discovery
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reposted by
Alex Schier
Scott Horton
3 months ago
Jack Szostak "All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."
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I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.
Attacks on science and immigrants are destroying America.
https://open.substack.com/pub/ofthebrave/p/im-a-nobel-prize-winning-immigrant?utm_campaign=post-expanded-share&utm_medium=web
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reposted by
Alex Schier
Yinan Wan
3 months ago
With this “Behind the paper” story, I’d like to give special thanks to two remarkable contributors whose generosity made a big difference:
@jialinliu.bsky.social
for the scMultiomics data behind the multiomic atlas, and Guoqiang Yu’s group for sharing ITEC cell tracking, which enabled MERFISH-FATE.
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reposted by
Alex Schier
the Node
3 months ago
From fate to form: the journey to whole-embryo spatial transcriptomics In this 'Behind the paper' feature,
@yinanwan.bsky.social
shares the inside story of an ambitious journey with
@schierlab.bsky.social
& co.
thenode.biologists.com/from-fate-to...
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From fate to form: the journey to whole-embryo spatial transcriptomics - the Node
Where molecules meet form I have long been interested in understanding how development emerges at the intersection of molecular and spatial organization.
https://thenode.biologists.com/from-fate-to-form-the-journey-to-whole-embryo-spatial-transcriptomics/research/
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reposted by
Alex Schier
Sally Lowell
3 months ago
"We want to see the academic publishing industry change in a way that benefits science, not just profits"
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reposted by
Alex Schier
James Briscoe
3 months ago
A question I get asked all the time by
@dev-journal.bsky.social
authors "Why does it cost so much to publish a paper?" We break down the finances and explain where the money goes Spoiler: quality publishing takes a village (people + infrastructure)
journals.biologists.com/dev/article/...
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‘Why is publishing so expensive?’
For many of us who work in scientific publishing, the title of this Editorial is a question we hear all the time when we're out talking to academics. And it's a perfectly reasonable one. After all, re...
https://journals.biologists.com/dev/article/153/6/dev205641/371201/Why-is-publishing-so-expensive
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reposted by
Alex Schier
Biozentrum, University of Basel
3 months ago
Prof. Markus Rüegg and Dr. Judith Reinhard joined the Telebasel studio to talk about progress and the ongoing challenges of the gene therapy they’ve developed to treat LAMA2-related muscular dystrophy, a currently incurable and fatal muscle disease affecting children.
telebasel.ch/sendungen/pu...
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Basler Forschende entwickeln Gentherapie gegen… | Telebasel
Ungefähr jedes Jahr wird in der Schweiz ein Kind mit einer schweren Muskelschwäche geboren. LAMA2-Muskeldystrophie ist unheilbar. Nun haben Forschende am…
https://telebasel.ch/sendungen/punkt6-thema/235263
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Alex Schier
MadScientist
4 months ago
It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression
www.biorxiv.org/content/10.6...
+🧪
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https://www.biorxiv.org/content/10.64898/2026.03.12.711203v1
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reposted by
Alex Schier
Biozentrum, University of Basel
4 months ago
Embryogenesis in 4D: a developmental atlas for genes and cells 🧪
@schierlab.bsky.social
developed a new method (#weMERFISH) that visualizes the activity of hundreds of genes across the entire zebrafish embryo with subcellular resolution.
lnkd.in/eHY5gXDx
@erc.europa.eu
@snsf.ch
@unibas.ch
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reposted by
Alex Schier
University of Basel
4 months ago
How does a tiny cluster of cells become an embryo? Researchers
@biozentrum.unibas.ch
mapped gene activity across the entire zebrafish embryo, creating a 4D atlas that links gene expression to cell movement & development.
www.unibas.ch/en/News-Even...
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Embryogenesis in 4D: a developmental atlas for genes and cells
Researchers at the University of Basel create a 4D atlas revealing how thousands of genes shape embryonic development in the zebrafish embryo.
https://www.unibas.ch/en/News-Events/News/Uni-Research/Embryogenesis-in-4D--a-developmental-atlas-for-genes-and-cells.html
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reposted by
Alex Schier
Yinan Wan
4 months ago
Very grateful to everyone who made this work possible. I feel incredibly lucky to have worked with such an amazing team. Special thanks to: Jakob El Kholtei, KJ Jenie,
@mcolomerr.bsky.social
, and of course our wonderful collaborator Bogdan Bintu and my mentor
@schierlab.bsky.social
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Very happy to see this out. 👏
@yinanwan.bsky.social
Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science
www.science.org/eprint/5MHTM...
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Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...
https://www.science.org/eprint/5MHTMR4RZ75TTPBZSW4J/full?activationRedirect=/doi/full/10.1126/science.adt3439
4 months ago
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reposted by
Alex Schier
Stand Up for Science!
4 months ago
TODAY IS THE DAY. NATIONWIDE rallies in your local city are kicking off today to SAVE SCIENCE, PROTECT HEALTH, and DEFEND DEMOCRACY. Visit
standupforscience.net/march7
to find your local rally! GET OUT THERE SCIENCE ACTIVISTS!!!
#March7
#standupforscience
#science
#rally
#savescience
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Stand Up for Science: March 7th, 2026 — STAND UP FOR SCIENCE
https://www.standupforscience.net/march7
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reposted by
Alex Schier
Biozentrum, University of Basel
4 months ago
The Summer Call for our prestigious, fully funded
#PhDFellowships
is now open to talented early-career scientists worldwide. 🔬 Rotation-based program 🌍 International community 🗓 Apply by May 8, 2026 Apply now and join a leading life sciences institute!
www.biozentrum.unibas.ch/phd/internat...
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Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
https://www.biozentrum.unibas.ch/phd/international-phd-program/phd-fellowships-2026
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reposted by
Alex Schier
Pauli Group (posts by Andi Pauli)
4 months ago
One more week to finalize your applications for the 2026 MBL zebrafish course at Woods Hole! Application deadline extended to March 9. Please repost and forward to anyone interested in learning 'everything zebrafish'!
www.mbl.edu/education/ad...
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Deadline March 1. Join the new Dietschy Facility for Tissue Science.
www.biozentrum.unibas.ch/open-positio...
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Research Specialist in Microscopy and Spatial Transcriptomics (80-100%)
https://www.biozentrum.unibas.ch/open-positions/detail/research-specialist-in-microscopy-and-spatial-transcriptomics-80-100
4 months ago
1
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Deadline March 1. Join the new Dietschy Facility for Tissue Science.
www.biozentrum.unibas.ch/open-positio...
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Research Specialist in Computational Neuroscience and Data Analysis (80-100%)
https://www.biozentrum.unibas.ch/open-positions/detail/research-specialist-in-computational-neuroscience-and-data-analysis-80-100
4 months ago
0
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Deadline March 1. Join the new Dietschy Facility for Tissue Science.
www.biozentrum.unibas.ch/open-positio...
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Research Specialist in Image Analysis (80-100%)
https://www.biozentrum.unibas.ch/open-positions/detail/research-specialist-in-image-analysis-80-100
4 months ago
0
9
6
reposted by
Alex Schier
Pauli Group (posts by Andi Pauli)
5 months ago
Switching fields or wanting to become an expert in
#zebrafish
research? The
@mblscience.bsky.social
2026 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field! Application deadline: March 2 Please spread the word!
www.mbl.edu/education/ad...
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reposted by
Alex Schier
Peter Fabian
5 months ago
Thinking about EZM2026 in Vienna? 🐟 Travel grants are now open for students & ECRs. 7–11 July 2026 | Deadline: March 15 Hope to see many of you there!
@ezsociety.bsky.social
#zebrafish
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11
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reposted by
Alex Schier
Louis-Jeantet Foundation
6 months ago
FIONA DOETSCH
@doetschlab.bsky.social
@biozentrum.unibas.ch
@unibas.ch
is awarded the 2026 Louis-Jeantet Prize for Medicine for discovering the identity of neural stem cells in the adult mammalian brain and for demonstrating that they enable mammals to adapt to specific physiological states.
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reposted by
Alex Schier
Dr Emma Hodcroft
7 months ago
Best Christmas Card of 2025 award goes out to the
@biozentrum.unibas.ch
for this incredible building-themed-advent-calendar! Opening a window each day has been fantastic! ❄️☃️😁
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We will miss you Madalena and follow your exciting research at
[email protected]
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7 months ago
0
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reposted by
Alex Schier
Madalena M. Reimão Pinto
7 months ago
This past month marked the end of an era at the
@schierlab.bsky.social
@biozentrum.unibas.ch
. It was a meaningful, intense, often challenging, but also incredibly rewarding chapter of my scientific journey. Thank you all in the Schier Lab for the unconditional support and the Schierleading!
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Alex Schier
Biozentrum, University of Basel
7 months ago
🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging.
@unibas.ch
@snsf.ch
👉
www.biozentrum.unibas.ch/news/detail/...
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Shapeshifting gates guard the cell nucleus
An international study led by the University of Basel has discovered that nuclear pore complexes – tiny gateways in the nuclear membrane – are not rigid or gel-like as once thought. Their interiors ar...
https://www.biozentrum.unibas.ch/news/detail/shapeshifting-gates-guard-the-cell-nucleus
2
11
5
reposted by
Alex Schier
Pauli Group (posts by Andi Pauli)
7 months ago
... and we would love to see you ALL - working with ANY fish model - join us in Vienna for
www.ezm2026.org
, the biggest fish meeting in 2026! We plan to have a special session 'beyond zebrafish' and would love to include talks representing other fish systems across all sessions. Pls spread the word!
add a skeleton here at some point
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12
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reposted by
Alex Schier
Biozentrum, University of Basel
9 months ago
Apply for our Master of Science in Physics of Life – training in cutting-edge research at the interface of physics, mathematics, engineering and life sciences. Scholarships available. Application deadline: 30 November. More:
www.biozentrum.unibas.ch/education/de...
@biozentrum.unibas.ch
@unibas.ch
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reposted by
Alex Schier
Carolyn Bertozzi
9 months ago
👏 👏 👏
orgchart.mit.edu/letters/rega...
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Regarding the Compact | MIT Organization Chart
The U.S. Department of Education recently sent MIT and eight other institutions a proposed “Compact for Academic Excellence in Higher Education," along with a letter asking that MIT review the document.
https://orgchart.mit.edu/letters/regarding-compact
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reposted by
Alex Schier
Biozentrum, University of Basel
9 months ago
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum
#University
#Basel
#Professor
#Structural
#Biology
#Biophysics
#Biological
#Imaging
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reposted by
Alex Schier
Biozentrum, University of Basel
10 months ago
We’re proud of our global research community at the Biozentrum
@unibas.ch
! Our scientists from 40+ countries bring their passion & diverse cultures to every discovery. 🔬Join us:
www.youtube.com/watch?v=p_Cg...
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Working at the Biozentrum Basel | World-Class Science & Life in Switzerland
YouTube video by BiozentrumBasel
https://www.youtube.com/watch?v=p_CgNizzUcM
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reposted by
Alex Schier
Katie Kindt
11 months ago
The Zebrafish Neurobiology meeting will be held this fall- Nov 19-22 at Cold Spring Harbor Laboratory. Abstracts are due Sept 5th.
#cshlzebrafish
Please join us in person or attend virtually with access to posters and oral sessions via zoom.
meetings.cshl.edu/meetings.asp...
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Zebrafish Neurobiology
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
https://meetings.cshl.edu/meetings.aspx?meet=ZEBRA
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reposted by
Alex Schier
University of Basel
10 months ago
Seven researchers from the University of Basel receive ERC Starting Grants – an exceptional result for the University of Basel. Over the next five years, they will each receive between EUR 1.5 million and EUR 2.3 million in funding.
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Seven researchers from the University of Basel receive ERC Starting Grants
In the competition for highly sought-after research funding from the European Research Council, seven researchers from the University of Basel convinced the jury with their project ideas. Over the nex...
https://www.unibas.ch/en/News-Events/News/Uni-People/ERC-Starting-Grants-2025-University-Basel-Beltra-Borsa-Brueckner-Rumpf-Weiss-Sznurkowska-Smolenski-Weiss.html
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15
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reposted by
Alex Schier
Biozentrum, University of Basel
10 months ago
Save-the-date Career Event
@unibas.ch
– October 22, 2025 Join us for an inspiring two-part event: Interview with Thomas Schinecker, CEO of Roche; Panel with leaders from Roche and McKinsey & Company; Apéro & Networking. More information:
www.biozentrum.unibas.ch/events/confe...
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reposted by
Alex Schier
Maxwell Shafer
10 months ago
Now published
@natecoevo.nature.com
with
@annika-nichols.bsky.social
, our latest on the evolution of 𝘴𝘭𝘦𝘦𝘱 across 𝟲𝟬 𝘀𝗽𝗲𝗰𝗶𝗲𝘀 of cichlid fishes!
doi.org/10.1038/s415...
with members of the
@schierlab.bsky.social
and Salzburger labs, as well as the burgeoning Shafer lab
@uoftcellsysbiol.bsky.social
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Alex Schier
Ben Engel
10 months ago
BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the
@biozentrum.unibas.ch
@unibas.ch
, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍
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Alex Schier
Biozentrum, University of Basel
10 months ago
🧪 The University of Basel is setting up a new endowed professorship in
#ClimateBiophysics
at the
@biozentrum.unibas.ch
, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research
@unibas.ch
.
www.biozentrum.unibas.ch/news/detail/...
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New endowed professorship strengthens climate research at the University of Basel
The University of Basel is setting up a new endowed professorship at the Biozentrum to make fundamental discoveries at the interface between biophysics and climate-relevant environmental biology. This...
https://www.biozentrum.unibas.ch/news/detail/new-endowed-professorship-strengthens-climate-research-at-the-university-of-basel
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reposted by
Alex Schier
Biozentrum, University of Basel
10 months ago
Assistant Project Coordinator – Biozentrum PhD Fellowships – PhD Student Office (80% - 100%)
www.biozentrum.unibas.ch/open-positio...
#Biozentrum
#Basel
#joboffer
#hiring
#job
#recruiting
#careers
#Assistant
#ProjectCoordinator
0
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reposted by
Alex Schier
Biozentrum, University of Basel
11 months ago
NCCR AntiResist, “New approaches to combat antibiotic-resistant bacteria”, is recruiting a Scientific Officer (80-100%)
lnkd.in/eEU7CBTb
@biozentrum
@unibas.ch
#Biozentrum
#Basel
#research
#science
#joboffer
#hiring
#job
#recruiting
#careers
#Scientific
#Officer
#NCCR
#AntiResist
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Everything (and more) you wanted to know about Nodal Signaling. A Paradigm for TGFβ Signaling in Embryonic Development | Annual Reviews -
www.annualreviews.org/content/jour...
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Nodal Signaling: A Paradigm for TGFβ Signaling in Embryonic Development | Annual Reviews
Nodal signaling molecules are TGFβ family ligands that arose early during bilaterian evolution and are crucial for several key steps in embryonic development. They regulate the specification of mesode...
https://www.annualreviews.org/content/journals/10.1146/annurev-cellbio-112122-030209?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
11 months ago
0
15
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reposted by
Alex Schier
Biozentrum, University of Basel
11 months ago
Apply now for the prestigious and independent
#BiozentrumPhDFellowships
. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025.
bit.ly/4caiqqX
@biozentrum.unibas.ch
@unibas.ch
#fellowship
#PhD#Switzerland
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Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
https://bit.ly/4caiqqX
0
15
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reposted by
Alex Schier
Eileen Furlong
11 months ago
To all post-docs: The Genome Biology dept @embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/job/Group-Leader---Genome-Biology-Unit_JR2069
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There are only so many science jobs abroad to absorb U.S. scientists. What’s coming is more than a brain drain — it’s a brain drought, as new talent stops entering US science altogether.
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11 months ago
0
4
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reposted by
Alex Schier
If you are in the Boston area on July 23, join me, Doug Melton, Kara McKinley, Barbara Treutlein, Hans Clevers, and Ivan Martin for a discussion on stem cells and organoids in biology and medicine. Register here:
swissnex.org/boston/event...
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Biological Engineering: A Conversation on the Future of Medicine - Swissnex in Boston and New York
Connecting Switzerland, North America and the world in science, education, innovation and art.
https://swissnex.org/boston/event/biological-engineering-a-conversation-on-the-future-of-medicine/
12 months ago
0
13
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If you are in the Boston area on July 23, join me, Doug Melton, Kara McKinley, Barbara Treutlein, Hans Clevers, and Ivan Martin for a discussion on stem cells and organoids in biology and medicine. Register here:
swissnex.org/boston/event...
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Biological Engineering: A Conversation on the Future of Medicine - Swissnex in Boston and New York
Connecting Switzerland, North America and the world in science, education, innovation and art.
https://swissnex.org/boston/event/biological-engineering-a-conversation-on-the-future-of-medicine/
12 months ago
0
13
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From July 4, 2015 to July 4 now. "Once democratic expectations are lowered, rebuilding them becomes exponentially harder. The best remedy is dishabituation – to see things in light of our best historical practices, our largest ideals, and our highest aspirations".
www.science.org/doi/10.1126/...
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Will we habituate to the decline of democracy?
The recent attack on science in the US is not only undermining knowledge; it is also undermining democracy. In a healthy democracy, public policy is guided by evidence, and truth is the shared foundat...
https://www.science.org/doi/10.1126/sciadv.adz8654
12 months ago
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4
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