If cell diversity and developmental biology are your thing, my talk will extremely be your jam. Come for the whole-mount spatial transcriptomics and 14Tb light-sheet videos, stay for the humble RNA in situs. Everyone loves in situs 🧪🐟🧅

From fate to form: the journey to whole-embryo spatial transcriptomics! congratulations @yinanwan.bsky.social , so well deserved!!!

very cool method to detect positive selection on regulatory sequences!

🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals. For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq. www.biorxiv.org/content/10.1...

Using a newly developed AI model, the research group @schierlab.bsky.social @biozentrum.unibas.ch @unibasel.ch has discovered in #zebrafish that certain sections of #mRNA control the extent of protein synthesis during early embryonic development. ow.ly/4zyU50V7v1c @cellpress.bsky.social

The Genomic Code: the genome instantiates a generative model of the organism https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00008-3

Please spread the word: we have @snf-ch.bsky.social -funded #Postdoc and #PhD positions in our lab, to investigate the gene regulatory dynamics during vertebrate skeletogenesis in a comparative setting (see doi.org/10.1101/2024... doi.org/10.1101/2024... ) apply by 31.12.24, start date by 1.2.25!

Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)