Help needed! Does anyone have experience extracting nuclei from flash frozen tissue? Especially helpful if it is fish skin or tail tissue! We are trying to get some precious melanoma samples processed for snRNAseq but are having issues with either nuclei number and/or quality

LEARN THE TRUTH NOW 🥵🐟

New preprint from the lab, led by Bradley Cutler. With the @james-gagnon.bsky.social lab we use zebrafish to show that fever is not a reduction in the perception of warmth. Immune signals instead increase the valence of warming stimuli while cooling turns aversive. www.biorxiv.org/content/10.6...

Open-rank search: 2 (!) PI positions in Pulmonary Biology at @cuanschutz.bsky.social 🌄 We are looking for new colleagues @cupediatrics.bsky.social, working in lung fibrosis, focusing on #devbio, stem cell, & regen.biology of the lung 🫁🫀. Please help spread the word! cu.taleo.net/careersectio...

(1/15) Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.

I'm very sad to share that my advisor and colleague Jim Keener has passed away. Jim's impact on mathematical biology, through his writing and prolific mentorship, is hard to overstate. I'll write more personal reflections soon, but given his influence on so many, I wanted to share the news.

Applications due tomorrow!

Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...

🐸Do salamanders need adaptive immunity to regenerate limbs and tails? 🐸 Nope! 🚨Check out back-to-back pre-prints from PhD student in our lab Chimezie (tinyurl.com/42wst3bh) and from our collaborators the Max Yun lab (tinyurl.com/b92rzwzr)

Please share widely! We will imminently be posting a technician position in our lab group since @rheasood.bsky.social is off to grad school 🙌! If you know of anyone excited about molecular biology, evolution, and functional genomics please have them reach out (schumer at stanford). Start date ~June

A very moving tribute to one of the founders of modern Stem Cell Biology: Gail Martin. Well worth a read. www.pnas.org/doi/10.1073/...

Excited to share a new review by @kocherlab.bsky.social and me: Nature-inspired neuroscience We discuss diverse sensory systems and behaviors across the animal kingdom and argue for their integration into neuroscience. New tools in diverse systems are making this possible ✨ tinyurl.com/y5y9du27

Did you know the Santa Cruz Developmental Biology Meeting has an entire session just for NEW PI Talks? And a New PI Keynote Talk? It does! These will be chosen from the abstracts. New PIs, sign up! @socdevbio.bsky.social @rashmi-priya.bsky.social @lowelab.bsky.social scdb2026.sites.ucsc.edu

In 1936, a U.S. Forest Service ranger was fishing high in the Utah mountains when he found something bizarre: Cutthroat trout with tiny - or missing - dorsal fins! 🧵

Once-Adventurous Salmon Can’t Believe She Ended Up Moving Back To Birthplace, Having A Bunch Of Kids https://theonion.com/once-adventurous-salmon-can-t-believe-she-ended-up-movi-1825827223/

Very happy to share this study from our group and colleagues now out in Science! We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function #Zebrafish #Gut

Students from the MBL's Embryology course cleared this turtle embryo last year using LifeCanvas Technologies Inc.'s SmartBatch+, labeled with acetylated tubulin to visualize the nervous system, and imaged with the #MegaSPIM light-sheet microscope. #microscopy

“Here we present ZMAP (Zebrafish Meta Atlas Project), a harmonized reference integrating 8 published whole-embryo zebrafish scRNA-seq datasets comprising 798,790 cells across 15 developmental time windows.” 🐟 🧪 New work from @danwagnerlab.bsky.social 🔗 to WebApp: wagnerlabucsf.github.io/zmap/

📢📢 My lab at @utah.edu is officially open and I'm RECRUITING — especially techs/specialists and postdocs! Our research focuses on the neurobiology of interoception and learning & memory using tools from systems/comp neuro. Please share! 🧠🏔️🏜️ Apply/more info: zimmerman-lab.org#positions

Signatures of sex ratio distortion in humans https://www.biorxiv.org/content/10.64898/2026.02.04.702084v1

It gives me comfort that my weird science obsessions protect me from the algo. Like, sorry honey, you're gonna have to sort a whole bunch posts about hagfish slime before you figure out what brand of sweatpants I prefer.

I’m recruiting new members to the Farrell Lab this summer. We will have space for 1 postdoc (since Abhinav is leaving to start his own lab at U Arizona!!) and 2 postbacs, since my current two will leave for PhD programs at the end of the summer. More details in thread:

Is this the greatest thread in the history of science blue sky?

She uses the bristled end of a deck brush on her back and hindquarters, using repeated place-and-pull motions. For more sensitive areas such as the belly flap, udder, and anal region, she switches to the stick end, using careful, repeated poke-and-lift movements. See video link: youtu.be/bAk4PFEuWKQ

Don't miss out. Apply to our 2026 Advanced Research Training Courses today!

Defending PhD student, looking over their thesis: “If I knew then what I know now, I could’ve done all of this in like 9 months.” A thread about my favorite pioneering cave explorers and why I don’t think AI will ever “solve” biology.

Over the past weeks I have been reading the earliest papers on zebrafish development, and came to realize that in the “canonized" version of zebrafish history we neglect some important people pre-Streisinger. I will try to correct here the record. Let’s start with Edward C. Roosen-Runge. (1/7)

Happy Coelacanth Day!

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

She let me know that they recently received guidance that, ONLY for the January EI deadline (1/27/2026) and the February ESI deadline (2/3/2026), PIs can submit MIRAs even if their previous application (R35, R01, R15, R21, and R37) is still considered under review.

I was today years old when I learned that there is a superb (freely available) documentary from 1961 on early zebrafish development by J.V. Durden. collection.nfb.ca/film/embryon... (1/2)

FYI - if you already have a pending MIRA application, you need the summary statement in hand by Jan 27th to hit this first FOA deadline.

Neuro grad students! Applications for the 6th annual - Rising Stars in Neuroscience - due Jan 9! Don’t miss this chance to present research, sharpen science communication skills and connect with peers & faculty. Plus you’ll get to experience stunning Utah! medicine.utah.edu/neurobiology...

We have a new preprint on bioRxiv from postdoc Delai Huang and colleagues. It's not about peacocks. www.biorxiv.org/content/10.6...

I'm hiring a postdoc through Utah Math. Deadline Dec 15. If you work in math/comp bio (SciML, stochastic modeling, single-cell data), please apply! Vibrant math bio community & unbeatable outdoors. Mention me in your cover letter & reach out with any questions. www.mathjobs.org/jobs/list/27...

***Important*** BIO will host a Virtual Office Hour (VOH) on Thurs, Dec 18th, 2025, 1 - 2 pm ET. In this VOH, we’ll be joined by leadership to outline updates to NSF’s review process & share news relevant to all areas of research funded by BIO. Register here: nsf.zoomgov.com/webinar/regi...

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...

SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

Part 6: For decades, the zebrafish has helped scientists unlock the mysteries of genetics, development, & disease. But the fish that power most discoveries have spent generations inside lab tanks. This video captures footage of zebrafish in their natural environment in Nepal. youtu.be/cCZhZpPALqw

I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A

An engineer wanted to make a quiet high-speed train. “The question then occurred to me — is there some living thing that manages sudden changes in air resistance as a part of daily life?” The answer: the kingfisher. See my story today for more tales of bioinspiration. Gift link: nyti.ms/4otNQyl

Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...

Cat flea, homage to Hooke. Micron in Moleskine. 🔬🖊️

💥OUR LAB IS HIRING!!💥 We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity. Application link: tinyurl.com/3tpvphpm #SciJob #JobAlert

1🧵 Excited to share my first PhD paper, published in @dev-journal.bsky.social What if fish gills —often overlook —hold secrets about development, patterning, and function? We uncovered how early patterning shapes adult gill architecture. journals.biologists.com/dev/article/... #DevBio #Zebrafish

Come be my colleague in the department of neuroscience at OSU. We are hiring for an open rank tenure track faculty position in several focus areas. neurojobs.sfn.org/job/39081/te...

Just keep thinking about fish

Now published @natecoevo.nature.com with @annika-nichols.bsky.social, our latest on the evolution of 𝘴𝘭𝘦𝘦𝘱 across 𝟲𝟬 𝘀𝗽𝗲𝗰𝗶𝗲𝘀 of cichlid fishes! doi.org/10.1038/s415... with members of the @schierlab.bsky.social and Salzburger labs, as well as the burgeoning Shafer lab @uoftcellsysbiol.bsky.social

Proposed cuts to the National Institutes of Health and the National Science Foundation “would cause immense and largely irreversible damage to the successful American scientific enterprise,” write Jerry Kaplan and Dana Carroll in an op-ed.

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...