Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies https://www.biorxiv.org/content/10.64898/2025.12.29.696944v1

Mutational analyses reveal PLP-independent functions at PipY, the cyanobacterial paradigm for pyridoxal-phosphate binding proteins https://www.biorxiv.org/content/10.64898/2025.12.29.696868v1

A generalized test of genotype-phenotype causality in population-sampled nuclear families https://www.biorxiv.org/content/10.64898/2025.12.29.696865v1

Integrative multiomic analysis on single-nucleotide variants identifies candidate genes for human craniofacial malformation https://www.biorxiv.org/content/10.64898/2025.12.29.696805v1

Improved Bayesian inference of hybrids using genome sequences https://www.biorxiv.org/content/10.64898/2025.12.26.696621v1

DNA replication errors drive genome-wide small inverted triplication dynamics https://www.biorxiv.org/content/10.64898/2025.12.26.696596v1

Surprising regulatory plasticity for the conserved HOG pathway in diverse Saccharomyces cerevisiae strains https://www.biorxiv.org/content/10.64898/2025.12.28.696518v1

Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons https://www.biorxiv.org/content/10.64898/2025.12.26.696633v1

Evidence for an ancient master sex determination gene in Hymenoptera https://www.biorxiv.org/content/10.64898/2025.12.24.696408v1

DOCK7 regulates WNT signaling and NMJ clustering in normal and DMD muscle https://www.biorxiv.org/content/10.64898/2025.12.23.696254v1

The aging transcriptome: a condition-dependent response to a deteriorating soma https://www.biorxiv.org/content/10.64898/2025.12.22.696078v1

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1

A shared genetic regulator of metabolism and addiction-related behavior in mice and humans https://www.biorxiv.org/content/10.64898/2025.12.23.696269v1

Globodera pallida virulence on major potato resistance has a common genetic basis across Western Europe https://www.biorxiv.org/content/10.64898/2025.12.22.695896v1

Charting the cognitive development of children using adult 'polygenic g scores' https://www.biorxiv.org/content/10.64898/2025.12.19.695378v1

Histological and Metagenomic Analysis of Microbial Communities in Archaeological Human Bones https://www.biorxiv.org/content/10.64898/2025.12.21.695837v1

Longitudinal modelling reveals widespread non-additive genetic effects underlying developmental plasticity https://www.biorxiv.org/content/10.64898/2025.12.19.695443v1

Barriers to Antimicrobial Resistance Gene Exchange in Methicillin Resistant Staphylococcus aureus Cluster into Transfer Islands https://www.biorxiv.org/content/10.64898/2025.12.19.694131v1

Chromosome length is not the sole determinant of sexually dimorphic crossover rates during mammalian meiosis: Insights from genetically diverse mouse strains https://www.biorxiv.org/content/10.64898/2025.12.19.695521v1

Genetic Linkage Studies in F2 Cowpea (Vigna Unguiculata (L.) Walp) Mapping Populations Using Qualitative Morphological and SNP Markers https://www.biorxiv.org/content/10.64898/2025.12.19.695351v1

COPS5 is Essential for Sertoli Cell Function and Male Fertility in Mice https://www.biorxiv.org/content/10.64898/2025.12.19.695357v1

The Paraphyletic Origins of Genetic Resistance to Cabbage Stem Flea Beetle in Brassica oleracea https://www.biorxiv.org/content/10.64898/2025.12.18.695260v1

Adipocyte-related genes analysis contributes to the prognosis of atrial fibrillation https://www.biorxiv.org/content/10.64898/2025.12.18.695292v1

Evaluation of annual ryegrass genotypes for forage yield and blast resistance https://www.biorxiv.org/content/10.64898/2025.12.18.695135v1

A pain-reducing Kv6.4 variant spares other Kv6 channels, offering a target for uterine pain https://www.biorxiv.org/content/10.64898/2025.12.18.692915v1

Insertion of rare autism variants in synaptic genes induce novel behavioral phenotypes in C. elegans https://www.biorxiv.org/content/10.64898/2025.12.19.695228v1

High false sign rates in transcriptome-wide association studies https://www.biorxiv.org/content/10.64898/2025.12.19.695550v1

Crosstalk between and developmental dynamics of C. elegans Argonaute proteins https://www.biorxiv.org/content/10.64898/2025.12.17.694999v1

Structural semantic evolutionary distance (SSED) unifies the selection of cancer driver genes across macroevolution and tumorigenesis. https://www.biorxiv.org/content/10.64898/2025.12.17.694808v1

Calorie restriction leads to degradation of mutant uromodulin and ameliorates inflammation and fibrosis in UMOD-related kidney disease https://www.biorxiv.org/content/10.64898/2025.12.16.694693v1

Mesodermal-specific MECP2 expression in Drosophila induces visceral and skeletal muscle defects rescued by butyrate supplementation https://www.biorxiv.org/content/10.64898/2025.12.16.694631v1

Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway https://www.biorxiv.org/content/10.64898/2025.12.16.694484v1

A target product profile for a rapid diagnostic test to monitor mosquito gene drive presence and frequency https://www.biorxiv.org/content/10.64898/2025.12.16.694691v1

LDLR variant classification through activity-normalized prime editing screening https://www.biorxiv.org/content/10.64898/2025.12.16.694467v1

Methylphenidate exposure alters brain gene expression and induces transgenerational DNA methylation changes in Poecilia reticulata guppies https://www.biorxiv.org/content/10.64898/2025.12.16.694564v1

QTL Identification for Morphological and Phytochemical Traits in 45 F2 Cowpea (Vigna Unguiculata (L.) Walp) Mapping Populations https://www.biorxiv.org/content/10.64898/2025.12.16.694557v1

A Single Genomic Region Controls Primocane Fruiting in Tetraploid Blackberry https://www.biorxiv.org/content/10.64898/2025.12.15.694498v1

Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice https://www.biorxiv.org/content/10.64898/2025.12.15.694380v1

Prior exposure to hypoxia alters DNA methylation patterns in the eastern oyster https://www.biorxiv.org/content/10.64898/2025.12.15.694390v1

Ancient genomes from the siege and destruction of Middle Bronze Age Roca Vecchia (Apulia, Italy) shed light on Aegean contacts and conflicts https://www.biorxiv.org/content/10.64898/2025.12.15.694319v1

A Human Genetics Framework for De-risking Gene Editing Targets for Hematopoietic Cell and Gene Therapy https://www.biorxiv.org/content/10.64898/2025.12.15.694499v1

Multiparametric Assessment of TNNI3 Variant Phenotypes in Human iPSC-Cardiomyocytes Correlates with Disease Severity in Patients https://www.biorxiv.org/content/10.64898/2025.12.13.691658v1

Microsatellite Analysis of Genetic Differentiation Among Populations of the Malaria Vector, Anopheles funestus, across Mainland Tanzania Reveals Contrasted Patterns of Geographic Isolation and Gene Flow https://www.biorxiv.org/content/10.64898/2025.12.14.694266v1

Alzheimer disease risk variant rs11218343 determines functional expression of SORL1 in microglia https://www.biorxiv.org/content/10.64898/2025.12.15.694337v1

The shifting dynamics of ancestry and culture at a post-Roman crossroads https://www.biorxiv.org/content/10.64898/2025.12.12.693924v1

Mitochondrial DNA Imputation Accuracy and Its Application in a Southern African Mitochondrial Genome-wide Association Study https://www.biorxiv.org/content/10.64898/2025.12.11.693816v1

Retention of a single Cenp-C gene in different syntenic locations in the montium group of Drosophila species https://www.biorxiv.org/content/10.64898/2025.12.11.693522v1

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains https://www.biorxiv.org/content/10.64898/2025.12.12.693865v1

Going Against the Grain: Investigating the C4 Wheat Hypothesis with Spatial Transcriptomics https://www.biorxiv.org/content/10.64898/2025.12.11.691720v1

A high-throughput methods SNIPR-Nm reveals small RNA methylation ratio https://www.biorxiv.org/content/10.64898/2025.12.11.693694v1