Final version of our paper now published. elifesciences.org/articles/109... Take homes: CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n

Doing happy mini preps today. Wait until they find out what solutions im about to put in them.

Once again I'm more than happy to accept invitations to talk in Edinburgh and the North of England in July 2027. In fact, let's get a group together to tour all of these towns. Who's in? #TourdeTourdeFrance www.theguardian.com/sport/2026/j...

Is it LTNs? No wait! Bike Lanes, right? Of course it can't be due to TOO MANY FEKKIN CARS! Source: Devon Live search.app/XxSnu

What an absurd article. I'm all for preservation of and education about local cultures, but if you go to a world class Uni like York, don't be surprised if the student population is made up of a large number of people from outside Yorkshire. www.theguardian.com/education/20...

Here's an idea for 2026...

And time for a Japanese Negroni. Thanks, Maya!

Oh my giddy aunt this is amazing. I'm in awe of the avocado.

Check it, kids. @anzymiller.bsky.social has taken dTAG-mediated protein expression control to the next level.

Morning, kids.

Wow. Cells ratcheted up the Transposon Arms Race a notch further than we'd realised.

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

Did a journal club on this yesterday. Very insightful and clever treatment of gene expression: for a protein involved in noise suppression, p≤0.05 isn't the whole story. Stratification of p-values shows what you can get by thinking outside the "standard" methods. Nicely done!

Looking for a PhD? 3 days left to apply for a fully funded China Scholarship Council & University of Exeter studentship! Join the Living Systems Institute—where Maths, Physics, Bio and Biomed meet—and carry out cutting-edge interdisciplinary research. tinyurl.com/y3ufdnxf @exeter.ac.uk

Last chance to apply for one of the LSI PhD projects intake Sept 2026! Deadline tomorrow, 26.11.2025, noon. www.exeter.ac.uk/research/ins... @exeter.ac.uk @lsiexeter.bsky.social

The Zaphrod Beeblebrox of anemones.

Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...

@teamlabouruk.bsky.social please take note.

This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.

Language models cannot reliably distinguish belief from knowledge and fact #AI Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation. www.nature.com/articles/s42...

Really good! 👏🏻🤣

Are you looking for a PhD starting in September 2026/27? Then do not miss the fantastic opportunity to be part of the LSI PhD Community. New positions for the LSI PhD Programme are out now. www.exeter.ac.uk/research/ins... Deadline: 26.11.2025

about PAE #alphafold PAE viewer pae-viewer.uni-goettingen.de PAE Figure editor thecodingbiologist.com/tools/pae.html

🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics doi.org/10.1371/jour... Let's break down what we found! 👇

We did journal club today on this preprint - interesting parallels that CHD4 and its partners block aberrant TF binding in mESCs (this preprint), human cells (PMID:38281186), and fly testis (PMID:28522526). Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.

🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate? We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Planarian #NuRD Alert! "the NuRD complex may drive differentiation into somatic lineages in planarians" Yeah it does. #NuRDIsTheWormyWord #Chromatin #Transcription doi.org/10.3389/frag...

Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org

These images are separated by one day

On National Poetry Day, the greatest poem I have ever read

I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky Please share the ad below with anyone who may be interested.

Truth to ReformUK is like daylight to a vampire…… and It’s our job to let the light in. 🔦 yorkshirebylines.co.uk/society/inco...

If you want to know why we should care about protein expression dynamics have a read of the perspective piece I wrote for @dev-journal.bsky.social. While you're there check out my fellow Pathway to Independence fellows' interesting pieces! journals.biologists.com/dev/article/...

Handmade by the artist. Comes in gift box with numbered and signed card of authenticity. Available for preorder for short time only👇👇👇👇 coldwarsteve.bigcartel.com/product/patr...

NOT TO BE MISSED. My awesome colleague Rob Brewster may have COMPLETELY upended our understanding of how TFs work ... a must-read for anyone who cares in the slightest about gene regulation

Please share! PhD projects available through @gw4biomeddtp.bsky.social Please get in touch if you are interested in studying chromatin biology in stem cell models gw4biomed.ac.uk/architects-o... gw4biomed.ac.uk/risk-vs-prot... gw4biomed.ac.uk/rna-dependen... gw4biomed.ac.uk/investigatin...

What a job done by the @fnucleosome.bsky.social organisers. Awesome autumn lineup of speakers!

Check it out, Chromatin Kids! Chromatin remodeller does stuff to Transcription Factors! Functions where it is seldom seen! Both decreases and increases chromatin accessibility! How cool is that?

HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naive pluripotency https://www.biorxiv.org/content/10.1101/2025.08.25.671447v1

So nice to see a UK politician with a conscience for a change. @libdems.org.uk

Nice reminder that opposing genocide in Gaza is never antisemitic, but rather in full solidarity with huge swathes of the Israeli people.

Migrants didn't cut council funding. Migrants didn't cut NHS funding. Migrants didn't close youth centres. Migrants didn't sell off council houses. Migrants aren't filling our rivers with sewage. Farage and co. will tell you to point the finger at migrants. Don't fall for it.

Whatever patriotism is, it certainly isn’t encouraging hate of a fellow human because of their race, religion or heritage, while waving a flag. Pass it on.

Come on #Strava, there's no need for mockery.

This is the final map of origins of BDH Lab members, 2019-2025 in Cambridge. Not too bad, even if the UK is hard to make out. Already have a good starting set for a new map for the BDH Lab @lsiexeter.bsky.social edition!

The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat... My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.