This seems likely true from some research we have ongoing as well. One persistent problem the NHS has is it's held to a punishing standard of "efficiency" where it's always running at close to capacity, but any operations researcher will tell you run at 80% or so. www.bbc.co.uk/news/article...

Are you using any of our factor models, such as MOFA? 🛵 You might’ve found it challenging to tailor them to your specific use cases - not anymore! Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n

Staff at Dundee University are taking action again next week to defend jobs and resist compulsory redundancies. A year after the university’s financial crisis, uncertainty still hangs over hundreds of staff. Solidarity with Dundee UCU members fighting for fairness and job security. ✊

Chris' lab does very cool work, can recommend highly.

Important to note that this is 3'-end sequencing, not full transcript sequening, so no use to anyone interested in transcript-structure, splicing, unannotated genes, or non-polyA transcripts. But still, whole genome gene-expression, from cell pellet samples in 3 days for $50 is pretty amazing.

Next week LinkedIn will use your personal data for AI training by automatically enabling permissions. To manually turn off go to: Settings ➡️ Data Privacy ➡️ under “How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off

this is so fucking bad. men get breast cancer. cis men get breast cancer. cis men who don't have Kleinfelter's can also get breast cancer. bodies are complicated, that's the thing. stuff is *complicated*.

After 13 years of analyzing sequencing data, I am an "expert" in doing it. I gained those experiences not because I am smarter, but simply because I made more mistakes, and encountered more problems.

Often forgotten, ignored, or overlooked detail of peer review practices:

Graeber outlined 5 types of BS job: Flunkies, Goons, Box-tickers, duct-tapers and Taskmasters. Ask yourself: Which of these could be automated?

thread of skulls, which apart from being a useful guide to Nazi/not Nazi skulls has an interesting cultural angle.

New blog post alert! A personal retrospective on reaching a decade of development for @multiqc.info 😊

I think I just found my first AI generated preprint on bioRxiv. Unclear methodology, invalid citations, and dead links. Are these supposed to get reported somewhere?

This remains the funniest way to hear about an internet outage, though.

I regularly get derailed when someone tries to benchmark clustering methods, trying the find the "best" one or the one that agrees with "ground truth". Which clustering of the below animals is the best or the true one? By row, or by column?

Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

RIP John Gurdon

RIP. He changed Dev Bio in so many ways.

This year's Crick @crick.ac.uk PhD programme is open for applications - £27,715 tax-free student stipend per year for 4 years - Tuition fees paid - Student visa fee & health surcharges covered Deadline 5 Nov We have a project available. For all the details visit: www.crick.ac.uk/careers-stud...

These are hilarious.

Today is the 89th anniversary of The Battle of Cable Street when the people of the East End of London halted the march of Oswald Mosley’s Blackshirts through Stepney.

Fantastic essay on "the essay" by Zadie Smith www.newyorker.com/magazine/202...

People are panning this article because current AI systems aren’t sentient - and those people are right, they’re not. BUT.

I cannot recommend the Georgina Ferry's biography of Dorothy Crowfoot Hodgkin enough. A fascinating and engaging account of an amazing life. But someone I knew much about before, but an instant new scientific hero. uk.bookshop.org/p/books/doro...

I wish more people got this. Science is inefficient. I'd say probably say inherently inefficient. I know we all want to hurry up and make the world a better place with those tax dollars, but I believe the harder we try to rush things, the less effective we will be in the long run.

"Science is not broken, and it most certainly is not dying. It is an inefficient human activity....When we catastrophize, we feed a disillusionment which political actors can weaponize to get rid of scientific evidence they find inconvenient." #AcademicSky 🧪

This dataset gives you data on student earnings 5 years after graduation. Shows that bioscientists make less than historians, geographers, or even politics. Something to think on when people are saying that kids should do real STEM subjects, and not silly humanities. www.thetimes.com/article/63c3...

Hah. This is perfect.

I believe that studies also show associations with the male parent taking Tylenol during pregnancy so there's negative controls too.

This is truly an incredible breakthrough IMO. Really exemplifies what you get when deep domain expertise (popgen/evolution/disease genetics in this case) fuses with cleverly crafted ML. What u get r sleek, well thought out architectures that absolutely destroy the behemoths. Wow!! 1/

Great day to post a ballot (when isn't it?!) The announcement of more potential restructures during the ballot period shows just how shameless Uni of Sheffield management is! It's so important everyone votes in our local dispute to save jobs @sheffielducu.bsky.social

University of Sheffield @ucu.org.uk members, have you voted? If you haven't, please do so immediately as the deadline is soon. Trade union solidarity is one the most important tools we've got left in our much troubled world. Don't waste it. @sheffielducu.bsky.social @ucuhallam.bsky.social

An actual quote from the Secretary of State for Business and Trade Too often people go to university to ‘explore research and knowledge’ Look forward to Wes S saying 'too often people go to hospital to have operations' or Heidi Alexander saying 'too often people go to the station to catch a train'

Only single cell sequencing of the all these post docs will reveal why

It's that time of the year again... Soon the applications for 12 PhD positions at @sangerinstitute.bsky.social will open. Interested in genomics and thinking about doing a PhD? Join us at Sanger. www.sanger.ac.uk/about/study/...

Russell gave Mosley the benefit of the doubt, and STILL found him unworthy of further discourse.

Bertrand Russell, at 89 years old, to Sir Oswald Mosley, a man most famous for founding, in 1932, the British Union of Fascists. I'm all for civil discourse. But everyone can and should draw a line at who they will talk to. Notice that Russell did not demean himself with incivility, either.

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

This is now the third year that I'm reminded how greatful I am to @jkpritch.bsky.social when I'm preparing my human genetics lectures, for An Owner's Guide to the Human Genome (web.stanford.edu/group/pritch...). It really is the textbook we are all missing. Its crazy no real alternative exists.

Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...

"There is a separation of white people and colored people in the United States. That separation is not a disease of colored people. It is a disease of white people. I do not intend to be quiet about it." - Albert Einstein, 1946

minimap2.com is potentially a phishing site. Please don't use anything from that website. github.com/lh3/minimap2...

The average Pixar movie costs about $200m to make these days, and makes about $1bn. If only 6% of the people that usually see a pixar movie see this, they have doubled their money. 15% and it is as profitable as Pixar. If you drive the cost down far enough, you can still make money out of crap.

NEW What Banksy's RCJ mural maybe gets wrong Judges are not to blame for protest laws promoted by the executive and passed by parliament and implemented by the police and prosecuted by the Crown By me Substack: emptycity.substack.com/p/what-banks... Own blog: davidallengreen.com/2025/09/what...

I often find the moral maze difficult to listen to and very irritating. However, I do think that at its best it is a useful way for me to understand the thinking of those I disagree with, and hearing those arguments allows me to hone my own responses to such things.

I find it interesting with the news about Florida that the UK has no babies mandates, and infect had only ever had one (or smallpox). Of course our vaccinations rates are high (or at least we're, historically) even in the absence of a mandate.

Excited to say we’re hiring 😊. We’re looking for a post-doc in ancient pathogen genomics to join our friendly supportive team in London at @ugiatucl.bsky.social. Start date January 2026. www.ucl.ac.uk/work-at-ucl/...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

“I don’t want asylum seekers to live on my street” is genuinely a wild thing to say as a notionally progressive politician