The flu and pneumonia kill over 45,000 people a year. Moderna developed a new mRNA flu vaccine for people 50 and older--who are most at risk. Prasad, unilaterally, against the recommendation of experts within the agency, denied Moderna's appplication. www.statnews.com/2026/02/11/m...

“Diplotypes were assigned using the pb-StarPhase algorithm, which was considered the gold standard for this study” 😎

✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6: www.nature.com/articles/s41... #Pharmacogenomics @pharmvar.org @clinpgx.org

Please share this with your network: Postdoctoral position available in my group. www.linkedin.com/jobs/view/43...

Groundhog Day Meaning xkcd.com/3202/

This is a cover up of a murder, led by our own federal government.

“We cannot pursue our mission to improve the health and well-being of all Americans while DHS agents are murdering, assaulting, and terrorizing people who call this country home…We believe ICE and CBP are a greater threat to the health of our nation than the lapse of HHS services.”

Point blank. 10-shots. Execution. A US citizen, a VA ICU Nurse. Then lying. Blocking a real investigation.

The killing of Alex Pretti is a heartbreaking tragedy. It should also be a wake-up call to every American, regardless of party, that many of our core values as a nation are increasingly under assault.

I cannot imagine the devastation this family is experiencing today. This statement is powerful and must be read.

It’s currently operating totally outside of our constitutional rules. Habeas corpus , due process of law, equal protection, freedom of speech, 4th amendment protections against search and seizure, are all not being enforced in any common sense or meaningful way.

I would argue that the case for dismantling ICE has, at this point, virtually nothing to do with larger questions of immigration enforcement and reform, it's just clearly incompatible with a free and democratic society to maintain a secret police force with sweeping and arbitrary authority.

How long would you survive with no DNA? What the latest What If? video in collaboration with @minuteearth.bsky.social! www.youtube.com/watch?v=s3oL...

We just released a fairly substantial update to HiPhase that enables (beta) support for RNA (isoseq) datasets. There are some incidental improvements to WGS phasing as well! Full release notes here: github.com/PacificBiosc...

1,000 PacBio genomes in a prospectively designed clinical utility study. This was the biggest and most important study that made us go live in diagnostics. Long-read genomes as a genetic first tier test across many rare diseases! www.medrxiv.org/content/10.6...

Block instantly.

Finally found time to play expedition 33… what an absolutely phenomenal experience! (Just ended act 2 for those who have played)

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

I am hiring a staff bioinformatician for my new lab at the University of Utah! Please consider applying if you are on the hunt: employment.utah.edu/salt-lake-ci...

NEW: Data released by ICE shows that virtually the entire growth of detention in the last few months has been among people with no criminal record at all - no prior convictions (no matter how minor) and no pending criminal charges.

I feel like no matter how many times I build a tool with multi-threading, I will always build it sub-optimally the first time... (bonus: it's often the first *few* times 🫠)

A reminder - before Trump, MAGA, Musk and Fox rewrote history - that this is what the entire country agreed had happened five years ago today:

That is a lot of news to wake up to.

we reproduce asexually, releasing clouds of spores at certain points in our lifecycles, like some species of fungi

Funny Numbers xkcd.com/3184/

There's an opening in our CompBio group at #PacBio. Apply below if you're interested in method / tool development for long-read sequencing applications! #Bioinformatics pacbio.wd12.myworkdayjobs.com/PacBio-/job/...

CiFi: accurate long-read chromosome conformation capture with low-input requirements. #HiFi #LongRead #Sequencing @natcomms.nature.com 🧪🧬 🖥️ www.nature.com/articles/s41...

There's an opening in our CompBio group at #PacBio. Apply below if you're interested in method / tool development for long-read sequencing applications! #Bioinformatics pacbio.wd12.myworkdayjobs.com/PacBio-/job/...

I can't stay quiet about what RFK jr is doing to the CDC and FDA: stevensalzberg.substack.com/p/dont-trust...

At the start of the year, did anyone predict k-pop as a featured part of the macys thanksgiving day parade?

If you're looking to use some of aardvark's functionality in your own code, we've made aardvark available on crates.io for easier access under the `aardvark-bio` name: crates.io/crates/aardv...

Gotta say, it’s a hard time to be a historian of medicine whose focus was pre-antiseptic / pre-vaccine era.

We have released StarPhase v2.0! The key addition is support for PGx sub-allele definitions for genes from PharmVar. While we were in there, we made some other QoL upgrades as part of v2. Let us know what you think! Full release notes: github.com/PacificBiosc...

Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social. www.radboudumc.nl/en/news-item... (1/n)

Over Lansing, MI!

What we know, final edition of the night: [Now in 3 parts] —Prop 50 wins —VA Dems flip Gov, LG, AG —Dems gain leg seats in VA, NJ, & MS —Dems defend NJ-Gov —Dems win NJ+VA trifectas —Mamdani wins —PA Dems win state supreme court —ME anti-mail voting measure loses —GA Dems flip 2 statewide offices

Looking at code from 12+ months ago always feels like the uncanny valley of code self-review. There's evidence of my coding fingerprint, and I *know* I wrote the code, but it's not quite how I would do it today.

About half the GigaScience editorial board (incl me) just resigned (academic.oup.com/gigascience/... is not yet updated). I resigned because it is very unclear what is happening and why - see @scedmunds.bsky.social blog post gigasciencejournal.com/blog/and-its..., for eg

Hurricane Melissa is the THIRD Category 5 storm of 2025, tying the record set by the legendary 2005 season. And get this, 80% of this season's hurricanes have reached Category 4 or 5 strength. That's the highest percentage in Atlantic history.

Want a rare look inside @pacbio.bsky.social facility and hear how customers use HiFi for HLA typing and PGx? We made a 6-min documentary this summer. Check it out! www.youtube.com/watch?si=nXb...

Our first major update for Aardvark since the pre-print is now available. We added an optional "record basepair" score type which may better match historical tandem repeat metrics, and also made some of the less-used metrics optional as well. Full release notes here: github.com/PacificBiosc...

I think I just found my first AI generated preprint on bioRxiv. Unclear methodology, invalid citations, and dead links. Are these supposed to get reported somewhere?

Good evening. We estimate that between 4.2 and 7.6 million people turned out for the No Kings Day demonstrations held around the country on Saturday. This makes Oct 18 very likely the biggest single-day U.S. protest event since 1970. www.gelliottmorris.com/p/second-no-...

I should have stayed an extra day after #ASHG25

Our third #ASHG25 CoLab begins in one hour at 10:15 am in Theater 1! Hear from #PacBio and @epicypher.bsky.social#ASHG25#PacBion Fiber-seq epigenomics for integrated chromatin, genome, and methylome insights, plus Revio workflow updates and big announcements on what’s next for #Revio and #Vega in 2026 👀.

I’ll be presenting a poster on Mitorsaw for #PacBio HiFi mitochondrial analysis today! Come see me this afternoon at #ASHG25 poster #4050 to chat about that or other topics!

Eric Green receiving the ASHG Leadership Award. Talks about being the first institute or center director to lose his leadership role. Said that he failed to doge the bullet. #ASHG25

ASHG Plenary Session starting with the awards ceremony honoring Eric Green with the Leadership Award of @geneticssociety.bsky.social reflecting on his career in human genetics & genomics leading the Human Genome Project & the NHGRI and the leadership principles he has learned throughout #ASHG25