RT si tu aimes les profs de sociologie à Nanterre, moches, mal coiffées et aigries.

Il faut prendre le temps de goûter tout le sel contenu dans cette déclaration : si Sarkozy continue à se dédouaner sur le dos de Guéant, celui-ci le balance. Si l’ancien président de la République se fait doux comme un agneau, tout le monde comprendra qu’il se sait coupable… Perdant-perdant.

Il s'agit donc de poursuivre la politique de destruction des conditions de travail des enseignants et d'étude des élèves. Il était au contraire possible de saisir l'opportunité démographique pour faire tout le contraire, en améliorant la qualité pour toutes et tous. Ce risque est écarté.

Is April 13 the new April 12? #keydate

France is switching from Microsoft to Linux "We must become less reliant on American tools and regain control of our digital destiny. We can no longer accept that our data, our infrastructure, our strategic decisions depend on solutions whose rules, pricing, evolution, and risks we do not control."

The great news from Hungary isn't so much that Orbán was defeated (yes, that is good news, but I'm not persuaded his replacement will be so much better): the really encouraging thing is that it was possible to defeat Orbán despite all his efforts to cement his grip on power.

Bonjour à tous.tes Nous avons l'indicible douleur de vous faire part du décès de Séverine Erhel, survenu ce lundi 13 avril 2026 à Rennes. (information diffusée à la demande / avec l'autorisation de la famille)

Accepted to ISMB'26. Revised paper is here: jermp.github.io/assets/pdf/p.... I'd like to thank @robp.bsky.social once again and all the received feedback from the reviewers. To me, ISMB has had the highest quality review process over the past few years!

Le généticien Andrew Sinclair conteste la décision du Comité International Olympique d'utiliser le gène qu'il a découvert pour déterminer l'éligibilité des athlètes aux compétitions féminines. "Cela repose sur l'idée simpliste que la présence du gène SRY suffit à définir le sexe masculin" 1/2

Non mais sérieusement.

"History will judge-" let me stop you right fucking there, history doesn't do fucking shit, I'm a historian, let's be clear here: elected officials need to do their fucking jobs, right now, before it happens, or future historians will judge THEM. Everyone knows and knew who Trump was.

The "ethical" alternative to OpenAI everybody. www.wired.com/story/anthro...

I find it super frustrating, we were that close to modularity with Rust, and you port nice librairies with fine APIs to C? I'm judging you. 👀 If you wish to vibe code then Claude can interface the Rust for you instead?

A quick rant on people vibe-translating our Rust libraries to other languages That's the second time in a week that I see new bioinformatics tools with a vibe-coded translation of our Rust libraries to C/C++. I have two major issues with that:

Back in the noughties when I was an academic, my lab did quite a bit of work on (conserved) alternative transcripts. This study in @plosbiology.org presents compelling evidence that most alternative transcripts are deleterious noise journals.plos.org/plosbiology/...

Hierarchical genomic feature annotation with variable-length queries https://www.biorxiv.org/content/10.64898/2026.03.15.711907v1

NYX: Format-aware, learned compression across omics file types https://www.biorxiv.org/content/10.64898/2026.03.16.712193v1

Sensitive and scalable metagenomic classification using spaced metamers, reduced alphabets, and syncmers https://www.biorxiv.org/content/10.64898/2026.03.13.711249v1

Sassy2: Batch Searching of Short DNA Patterns https://www.biorxiv.org/content/10.64898/2026.03.10.710811v1

Super Bloom: Fast and precise filter for streaming k-mer queries https://www.biorxiv.org/content/10.64898/2026.03.17.712354v1

From my pangenomics story in @natmethods.nature.com, It's a colorful pangenome world, which is here www.nature.com/articles/s41... and here: rdcu.be/e8ZYC A comment from @camillemrcht.bsky.social

In the late February Epstein Files drop, new information came out indicating that Harvard scientist (and Colossal Biosciences co-founder) George Church continued to take money from Epstein long after he knew about Epstein’s crimes.

C'est la fin d'un cycle, un nouveau cycle peut commencer à n'importe quel moment !

Qui était #QuentinDeranque, à qui l’Assemblée nationale a rendu hommage ? @mediapart.fr a retrouvé son compte sur X. Racisme, antisémitisme, apologie du nazisme. «Moi je soutiens Adolf». Révélations @alexandreberteau.bsky.social et @turcanmarie.bsky.social 👇 www.mediapart.fr/journal/fran...

UPDATE: The European Parliament voted today to *end* untargeted mass scanning of private communications, firmly rejecting the error-prone and unconstitutional surveillance practices of recent years! Next: trilogue negotiations w/ Commission and Council.

On ne confie pas la défense des victimes à ceux qui les ont fait trembler. Non à la nomination d’Éric Dupond-Moretti au poste de Défenseur des Droits !

It's that time of the year on the campus (feat Zora)

1/ Our paper on Multi-Context Seeds is now out, with @tolyan.bsky.social spearheading the work and contributions from Nicolas and @marcelm.net. We introduce a new seeding concept that improves read alignment accuracy while maintaining speed. link.springer.com/article/10.1...

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

Quelle déchéance, morale comme intellectuelle.

Dans les écoles et les crèches de ma commune, j’exige que mes futur·es élu·es s’engagent à inscrire les enfants sans discrimination, ni pénalité. et ce quelle que soit leur situation administrative ou familiale. 👉️ J’interpelle mes candidat·es : municipales-2026.nosservicespublics.fr

IA générative ou pas, les États-Unis de Puritanie (comme j'aime bien les appeler) sont en train d'imposer à la planète entière leur vision de ce qui est acceptable ou pas, «safe for work» ou pas, et c'est plutôt problématique pour qui ne partage pas ces normes et jugements.

I had the occasion of presenting nice results about the detection of biological events in De Bruijn Graph at #DSB2026, in the context of my PhD work on #Vizitig ! Thanks to the organizers and colleagues for this amazing and super-inspiring event (and @camillemrcht.bsky.social for the picture).

Were you aware that these are available for the community: - an efficient fasta/q parser in Rust - a quick rolling hash library - a minimizer library All in Rust 🦀

Federico Martín Aramburú Éric Casado-Lopez Emine Kara Aburrahman Kizil Sirin Ayd Angela Rostas Djamel Bendjaballah Hichem Miraoui Ismaël Aali Ces personnes ont été assassinées par l'extrême droite entre 2022 et 2025 et n'ont reçu aucune minute de silence à l'Assemblée nationale.

How would you design a *multithreaded*, *concurrent* & *dynamic* hash table if you are focused specifically on common k-mer workloads, where streaming query & insertion are common? Jamshed, Prashant and I explore this in kache-hash, a cache-friendly k-mer hash table! www.biorxiv.org/content/10.6...

📌 Enquête MERIT-SFBI sur les conditions de travail des bioinformaticien·ne·s dans les instituts de recherche, universités, établissements d’enseignement et recherche, secteur associatif ou privé 📎 framaforms.org/enquete-meri... ⏳ temps estimé : 20 minutes 📅 date limite de réponse : 31/03/2026

Off to a promising #DSB2026

As my friend says, should we separate the man from the bitvector? Thoughts ladies?

"Have your best babies" n’est plus de la SF : c’est le marketing de la sélection embryonnaire aux US. La montée de l’eugénisme libertarien est un projet politique contre l’école et la solidarité - partout dans le monde. Analyse du lien avec la "génétique du QI" ici 👇 rogueesr.fr/techno-fasci...

no foreign foe has ever dreamed of being able to sack and pillaging this country the way Trump admin and its congressional and scotus enablers do every day.

Et encore une personne en "zrr positive sous réserve" pour qui on me dit de laisser tomber. Mail aux syndicats bienvenu ce soir. Vous devriez faire pareil. Gardons trace.

"They go to the breeding gulags.” what the heck did I just watch

Les données biologiques de 20 000 enfants récupérées par des pseudo-scientifiques racistes next.ink/223756/les-d... Je reviens avec @jeremie-n.bsky.social et Hervé Perdry sur la récupération de données par Lasker, Kirkegaard and co mais aussi sur le racisme qui s'insinue dans la recherche

Ça ne sert pas a grand chose visiblement car le déni de démocratie est puissant! Mais tant pis. J'ai resigné quand même 👇 petitions.assemblee-nationale.fr/initiatives/...

What's the best place to look up current estimates of how many truncated/non-functional genes each of us have? there was a paper from @dgmacarthur.bsky.social and co around 2014 that had an estimate from the 1000 genomes project (around 40 per person?), but I guess we have better estimates now.

How do bacterial pangenomes evolve, what controls their dynamics, why do they exist? Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle

At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...

Anyone in my circles attending IGGSy? July 5-9 in super pretty Ascona, Ticino, Switzerland. Honestly, you should go just for the views. iggsy.org

I purchased a PI laptop recently. What's a PI laptop you ask? It's a laptop that does not hurt your back when in your backpack, but that sounds like an airplane about to take off after a single minimap2 run.