CellFluxV2: An Image Generative Foundation Model for Virtual Cell Modeling https://www.biorxiv.org/content/10.64898/2026.01.19.696785v1

Benchmarking Next-Generation Sequencing Platforms: A Comprehensive Comparison Of Single-Cell RNA-Seq from Ultima UG 100 vs. Illumina NovaSeq X Plus https://www.biorxiv.org/content/10.64898/2026.01.16.699571v1

Medea: An omics AI agent for therapeutic discovery https://www.biorxiv.org/content/10.64898/2026.01.16.696667v1

eTRex Reveals Oncogenic Transcriptional Regulatory Programs Across Human Cancers https://www.biorxiv.org/content/10.64898/2026.01.16.699950v1

Dynamics-aware Evolutionary Profiling Uncouples Structural Rigidity from Functional Motion to Enable Enhanced Variant Interpretation https://www.biorxiv.org/content/10.64898/2026.01.16.699945v1

High-PepBinder: A pLM-Guided Latent Diffusion Framework for Affinity-Aware Target-Specific Peptide Design https://www.biorxiv.org/content/10.64898/2026.01.12.698988v1

dgiLIT: A Method for Prioritization and AI Curation of Drug-Gene Interactions https://www.biorxiv.org/content/10.64898/2026.01.16.699733v1

SE3Bind: SE(3)-equivariant model for antibody-antigen binding affinity prediction https://www.biorxiv.org/content/10.64898/2026.01.17.700115v1

Structural alphabets approach performance of structural alignment in remote homology detection https://www.biorxiv.org/content/10.64898/2026.01.16.699908v1

AFsample3: Generating and selecting multipleconformational states with Alphafold3 https://www.biorxiv.org/content/10.64898/2026.01.16.699904v1

NetCrafter: Ontology-derived gene network modeling and interpretation https://www.biorxiv.org/content/10.64898/2026.01.16.699831v1

Mitigating Bias in Spatial Transcriptomic Pipelines via Human Feedback https://www.biorxiv.org/content/10.64898/2026.01.15.699786v1

TcrDesign: De novo design of epitope specific full-length T cell receptors https://www.biorxiv.org/content/10.64898/2026.01.15.699824v1

GARD: Genomic Data based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation https://www.biorxiv.org/content/10.64898/2026.01.15.699561v1

PathDiffusion: modeling protein folding pathway using evolution-guided diffusion https://www.biorxiv.org/content/10.64898/2026.01.16.699856v1

TomoSegNet: Augmented membrane segmentation for cryo-electron tomography by simulating the cellular context https://www.biorxiv.org/content/10.64898/2026.01.15.699326v1

Leveraging Unified Sequence-Structure Representations for Enhanced Protein Stability Prediction https://www.biorxiv.org/content/10.64898/2026.01.15.699740v1

mtDNA-Network: a web tool to explore mitochondrial variant profiles in complex diseases https://www.biorxiv.org/content/10.64898/2026.01.15.699732v1

Signal Strength Aware Latent Spaces Reveal Molecularly Distinct Substructures within Human Kidney Tissue https://www.biorxiv.org/content/10.64898/2026.01.15.699686v1

AtlasMap: enabling low-cost, map-style exploration of million-cell single-cell atlases https://www.biorxiv.org/content/10.64898/2026.01.14.699595v1

RAREsim2: Flexible simulation of rare variant genetic data using real haplotypes https://www.biorxiv.org/content/10.64898/2026.01.14.694480v1

Label-free detection of individual virus-infected cells using deep learning https://www.biorxiv.org/content/10.64898/2026.01.15.699499v1

Enhancing volumetric microscopy with blind computational correction of spatially variant aberrations using neural field representation https://www.biorxiv.org/content/10.64898/2026.01.15.699665v1

DeepSpaceDB 2.0: an interactive spatial transcriptomics database for large-scale Xenium data exploration https://www.biorxiv.org/content/10.64898/2026.01.15.699623v1

Extending Conformational Ensemble Prediction to Multidomain Proteins and Protein Complex https://www.biorxiv.org/content/10.64898/2026.01.14.699584v1

When CycloneSEQ meets Oxford Nanopore Technologies: a performance comparison of contemporary nanopore DNA sequencing platforms https://www.biorxiv.org/content/10.64898/2026.01.14.699587v1

Predicting Clinical Phenotypes by Growth Curve Modeling of Transcriptomic Signatures during Disease Progression https://www.biorxiv.org/content/10.64898/2026.01.13.699292v1

Empirical-Bayes and Bayesian Hierarchical Modelling forMissingness and Differential Expression in Proteomics https://www.biorxiv.org/content/10.64898/2026.01.15.699650v1

Constructing the ensemble of representative structures for a protein via neural-surrogate-guided MSA recombination https://www.biorxiv.org/content/10.64898/2026.01.14.699462v1

Spatial Regression of Morphology-Protein Coupling in Tumour Proteomics https://www.biorxiv.org/content/10.64898/2026.01.14.699547v1

Enabling automatic generation of protein-ligand complex datasets with atomistic detail https://www.biorxiv.org/content/10.64898/2026.01.15.699426v1

Real-paired single-cell/bulk RNA-seq benchmark and a practical protocol for accurate cell-type deconvolution in human BAL samples https://www.biorxiv.org/content/10.64898/2026.01.14.699304v1

On the rise of AI technologies for virtual screening https://www.biorxiv.org/content/10.64898/2026.01.14.699425v1

Automating the Construction of Contextualized Biomedical Knowledge Graphs for Scientific Inference https://www.biorxiv.org/content/10.64898/2026.01.14.699420v1

A supervised ontology-aware cell annotation method forsingle-cell transcriptomic data https://www.biorxiv.org/content/10.64898/2026.01.13.699356v1

Brain Region-Specific Oligodendrocyte States Highlight Mitochondrial Gene Upregulation and Loss of Canonical Identity Signatures in Alzheimers Disease https://www.biorxiv.org/content/10.64898/2026.01.14.699226v1

Unifying phylogenetic traversal and deep learning to guide tree exploration https://www.biorxiv.org/content/10.64898/2026.01.14.699358v1

Fusion gene discovery in single cells from high throughput long read single cell transcriptomes https://www.biorxiv.org/content/10.64898/2026.01.13.699333v1

Hypatia: a set of quantitative methods for profiling isoform across cell populations https://www.biorxiv.org/content/10.64898/2026.01.13.699341v1

Quantitative Full-length transcriptome analysis by nanopore sequencing with Error-Aware UMI mapping https://www.biorxiv.org/content/10.64898/2026.01.14.699429v1

Outlier Detection in Single-Cell Transcriptomics Reveals Disease-Enriched Cytotoxic Immune Populations https://www.biorxiv.org/content/10.64898/2026.01.12.699092v1

3D reconstruction of spatial transcriptomics with spatial pattern enhanced graph convolutional neural network https://www.biorxiv.org/content/10.64898/2026.01.13.699328v1

System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development https://www.biorxiv.org/content/10.64898/2026.01.14.699402v1

Advancing Protein Design via Multi-Agent Reinforcement Learning with Pareto-Based Collaborative Optimization https://www.biorxiv.org/content/10.64898/2026.01.13.699365v1

Integrated Multi-omics Analysis Identifies Molecular Signatures of Regular Physical Activity in Human Peripheral Blood https://www.biorxiv.org/content/10.64898/2026.01.13.699221v1

LoopBin, a VaDE-based neural network for chromatin loop classification https://www.biorxiv.org/content/10.64898/2026.01.13.699359v1

Hybrid TF-IDF and SBERT Feature Engineering with SMOTE-Tomek Resampling for Enhanced Software Requirements Classification https://www.biorxiv.org/content/10.64898/2026.01.13.699413v1

Reference-free microsatellite instability detection from tumor sequencing using intrasample variability modeling https://www.biorxiv.org/content/10.64898/2026.01.13.699258v1

Benchmarking computational decontamination of ambient RNA https://www.biorxiv.org/content/10.64898/2026.01.13.699237v1

SoftHybrid: A Hybrid Imputation Algorithm Optimised for Single-Cell Proteomics Data https://www.biorxiv.org/content/10.64898/2026.01.13.699212v1