Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

So Marbury vs. Madison was THE landmark case that established constitutional review by SCOTUS in the US. What case should we record as the one where SCOTUS abrogates that responsibility & delegates constitutional review to the executive (or maybe even just a specific executive)?

Love this! My younger son was hanging out at a friend's house and the dad told me that he kept asking "can you put on Green Day?" when they were listening to music ;P.

Not going to lie; I'm kind of living it how close-minded and technically-mid devs are absolutely losing it over the Ubuntu uutils adoption and the announcement that Rust will replace Perl in Git 3 (and will be required). Welcome to the future, pal; you lost the argument & you were wrong.

www.biorxiv.org/content/10.1... Fun paper title alert!

Tl;dr = No. www.science.org/content/blog...

This isn't even a slight exaggeration. He is actively working on destroying the US's entire vaccine infrastructure. The HepB vote will be tomorrow, where they will get rid of the birth dose and recommend it at 30 days, dooming a bunch of infants to chronic infection ft. cirrhosis, cancer, and death.

Ohhh, everyone is definitely getting a pox thanks to RFK Jr.; it's just a question of what pox you'll get!

Rust 1.90.0 is out! blog.rust-lang.org/2025/09/18/R... Major features: * lld as the default linker on x86_64-unknown-linux-gnu * cargo workspace publishing support built into cargo * more const context APIs, and stabilization of new useful APIs

Yes; that's what they believe. But I disagree that publicizing this is a bad use of time. I'm the polarized online world, we often forget how many people are not terminally online or who are not hardline one one "side" or the other. Pointing out rank and obvious hypocrisy is good, actually.

It's been a hot minute since I've stretched those (little l) libertarian muscles but, here it goes: Abolish the FCC!

Debate isn't a way of arguing rationally to arrive at the most likely correct conclusion. Debate is a skill and set of strategies to "win", and try to convince other people. Yet, it's a totally permissible activity, and it's something people do. You can choose to engage with it or not.

imagine, as a C++ standards committee member in this Year of our Lord, 2025, voting to keep the language inherently unsafe, even as !!!SEVENTY-FIVE PERCENT!!! of zero-day exploits rely on mismanaged memory to implant and execute their malicious payloads.

Profiles are a milquetoast half-measure that will ensure that C++ will never be competitive where safety becomes increasingly important and expected. Sad, but good riddance, I guess. search.app/Gv2BG

It feels like society is the living embodiment of those who do not learn from history are doomed to repeat it. Justification to limit free speech is almost always more dangerous than the speech it seeks to limit, and the greater harm is almost always to those groups not in power....

Student acceptance of violence to silence speakers is at a record high. In 2020, 1 in 5 students said violence was acceptable to stop a speaker. In 2025, that number is 1 in 3. That’s a 79% increase in just five years. And it’s chilling.

Profiles are a milquetoast half-measure that will ensure that C++ will never be competitive where safety becomes increasingly important and expected. Sad, but good riddance, I guess. search.app/Gv2BG

The attorney general would be wise to read the words of the Supreme Court, which has repeatedly held that the "proudest boast" of America's free speech tradition is "freedom for the thought that we hate."

There is no hate speech exception to the First Amendment. Nevertheless, the attorney general says "there's free speech, and then there's hate speech," and the government will "target you, go after you, if you are targeting anyone with hate speech."

Last week was a whirlwind of online information, drowning out all stories not related to the dominating topic. As a result, I missed the publication of this paper that demonstrates effects that are difficult to explain without the previous existence of LIFE ON MARS www.nature.com/articles/s41...!

Ohh, OK Ravens, so THIS week you can get the 41 points. Where was that last week?

Make a band singular: The Atari

Make a band singular: Blink (Though that already existed and is why they had to add 182 in the first place ;P)

My favorite part of last-year #scverse conference was to finally meet in-person many developers that I only knew from their GitHub username! Submissions and travel grant applications close in 3 days. Find out more and apply at scverse.org/conference2025 @scverse.bsky.social

PSA: don't fall for the crates.io phishing campaign: fasterthanli.me/articles/cra... #rustlang

We received reports of a phishing campaign targeting crates​.io users. Do not click on links asking to authenticate to protect your account. More information: blog.rust-lang.org/2025/09/12/c...

In which @sophieehill.bsky.social rips apart yet another bad study on artificial sweeteners, so I don't have to. She won't make any assertions about the authors' intent, but I will. They *want* to show that diet soda is bad, like so many researchers before them. But it isn't. It just isn't.

FREEDOM, at last

So excited to be in person and about to watch my collaborator @coevolvinglab.bsky.social present soon on our newly funded collaborative research. ORWH Intramural innovation awards in women’s midlife health 2025 NIH Research Festival September 10, 2025, 10 - 11 AM ET #Research #Aging

Watching talks on CMake while working out. I truly appreciate the work folks put in to keep trying to explain the "modern" CMake way. But in every case, I quit watching in disgust. CMake is an example of how to do everything wrong, and when cutting your losses is the best course of action.

Now preprinted at arxiv.org/abs/2509.07357

More youtube videos coming soon to www.youtube.com/BenLangmead! New recording setup. I've got a couple videos in the editing phase and hope to keep up a rhythm of 1 new video per week.

minimap2.com is potentially a phishing site. Please don't use anything from that website. github.com/lh3/minimap2...

More of "The AI Coming For Us". Well, one way it's going to take us out is if the next generation of folks relies on this slop for anything serious ....

America Prays while the President Preys ...

Our first Fall #tidyomics meeting will be this Wed 10 September, early in US / noon in Europe / late in Australia. Feel free to join if you're interested in what we are doing to make omics data more amenable to tidy data analysis. Organized with Stefano @stemang.bsky.social

Bro… please reinspect and change the acronym.

A federal appeals court has upheld a civil jury’s finding that Donald Trump must pay $83.3 million to E. Jean Carroll for his repeated social media attacks against the longtime advice columnist after she accused him of sexual assault. https://to.pbs.org/41DNDzu

Instead, I think he should be covered as what he is. A narcissistic authoritarian, who has committed basically every impeachable constitutional crime that exists, making naked and illegal power grabs, destroying the country in every way, and surrounded by strategic, anti-American sycophants.

Look. I'm all in favor of covering his fascism and his absolutely unconstitutional actions daily. I reject the cowing to his demands of the press corp. I think he should be immediately impeached. But to pretend he's a weak, sitting duck is wishful projection. He leads a cult, & has captured SCOTUS.

There are two recent papers that use sourmash in creative ways - and it gladdens my heart! pubmed.ncbi.nlm.nih.gov/40812187/ by @silask.bsky.social et al looks cleverly at human gut subspecies. www.biorxiv.org/content/10.1... by @rayanchikhi.bsky.social et al counts billions of k-mers. Super neat!

Mark your calendars for the Paint Branch Distinguished Lecture by @stevenstrogatz.com on October 14, 4pm, IREAP, James Clark Hall, 8278 Paint Branch Dr., UMD, College Park, MD "Synchronization in Nature" ireap.umd.edu/events/paint...

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

Hashing vs. sorting; interesting! reiner.org/hashed-sorting. Also I wonder if, depending on your use case, semi-sorting provides an even greater benefit? 🧬🖥️

Well, that fucking sucked....

Wow, Zay, Hopkins, Lamar - the Ravens are just so fun to watch. So much raw talent!

Aaannnd, that's a Zay play! 🏈

King Henry!!!! 🏈

Preprint out for myloasm, our new nanopore / HiFi metagenome assembler! Nanopore's getting accurate, but 1. Can this lead to better metagenome assemblies? 2. How, algorithmically, to leverage them? with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social 1 / N

Oh noes, the AI is getting smarter and coming for us! The AI that is coming for us: