Not the first paper I've been a part of, but the first one I've ever written, organized, and executed! I learned a lot getting this one done. Also, Mojo! 🔥 👇

Advent of Code Day 9: codeberg.org/sstadick/aoc... Classic part B where I thought I had it solved.... and then two hours later figure out the trick.

🧬Explore the latest from Bioinformatics Advances: “Ish: SIMD and GPU accelerated local and semi-global alignment as a CLI filtering tool.”   Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292 Author: @ducktapeprogrammer.bsky.social

Advent of Code Day 8: codeberg.org/sstadick/aoc... Time to go read up on the correct way to solve this one.

Advent of Code Day 6: codeberg.org/sstadick/aoc...

Advent of Code day6! Nothing elegant about my approach today, just a "get it done before the kids wake up" solution.

A path to 1.0 for Mojo www.modular.com/blog/the-pat...

Advent of Code Day 5: codeberg.org/sstadick/aoc... Always a good time when you get to roll out the BITS algorithm!

Advent of Code day 4: github.com/sstadick/aoc... Finally a day for GPUs!

Advent of Code Day 3: codeberg.org/sstadick/aoc... Trying out codeberg with Zig migrating off of GitHub.

Advent of Code Day 2! github.com/sstadick/aoc... 12 says of advent of code feeling way more doable than the full month.

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n

It's advent of code season! Day1, parts A and B. Going with Mojo this year: github.com/sstadick/aoc...

Ever wonder why compilers use `xor eax, eax` to zero registers? It's smaller AND faster—CPUs optimise it out entirely! Day 1 of Advent of Compiler Optimisations: xania.org/202512/01-xo... Video: youtu.be/eLjZ48gqbyg #AoCO2025

Turns out the TokenStream implementation of rust-analyzer's proc-macro server is super slow when it comes to one of the most common proc-macro operations: concatenation. I noticed that in Zed's codebase, there were ~4 derives that just straight up together took 8 seconds to expand in rust-analyzer.

Pixi solves so many problems for project management that pop up with other solutions as soon as you pass out of the green field state.

Nice write up comparing Numba, C++, and Mojo going from scalar, to SIMD, to GPU implementations. Written by the stringzilla author: ashvardanian.com/posts/scalin...

A blog post on new features in Rust, covering the last year and a half (since the last one): www.ncameron.org/blog/recent-... (spoiler: a lot more new stuff than I realised!) #rustlang

A really cool walk-through of how an optimization unfolds with metaprogramming (in Mojo, but applies to any language with full comptime programming). The example is taking a regex and getting it to optimize to pretty much the same IR as the hand written fn. verdagon.dev/blog/impossi...

I'm having a talk on "40x faster binary search" at #p99conf next Wednesday, Oct 22! Register now :) p99conf.io

One highlight at the end is a skech of the crazy new language features we're going to have to teach to the 100s of JS devs. If that sounds like an exciting challenge, consider applying! We have roles in both NY and London. janestreet.com/join-jane-st... janestreet.com/join-jane-st...

Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬

#rustlang PSA: you probably don't want #[allow(dead_code)], you probably want #[expect(unused)]

Any recommendations for a github CI plugin for performance monitoring? Thinking of using github-actions-bench [0] which makes decent plots, in combination with maybe iai [1] for measuring CPU cycles (wall-time is too flaky in GH actions). 0: github.com/benchmark-ac... 1: github.com/bheisler/iai

Excited to say that we're looking to hire someone to focus on OxCaml education! We're doing enough to change the language that we have a pretty big internal education task ahead of us, and we want to hire someone to focus on it! Please share this with others! www.janestreet.com/join-jane-st...

Blogged about how zstd --long fills the gap between fast and slow-but-high-ratio genome compression methods log.bede.im/2025/09/12/z...

Some very interesting preliminary benchmarks between Stringzilla and some Rust libs from Ash: x.com/ashvardanian... Including some alignment comparisons.

Perl 👀 x.com/jxmnop/statu... To be fair, Perl was the OG write only vibe coding language.

Another deep dive in the technology behind Conda package managers: file linking! Did you know that there are symlinks, hardlinks and reflinks? Reflinks are the best – copy on write is space efficient and isolates the cache. Learn more: prefix.dev/blog/what-l...

Sassy is out now! Ever need to search for approximate matches of short DNA strings? Sassy is the tool to use! Available now wherever you get your code With @rickbitloo.bsky.social curiouscoding.nl/papers/sassy... github.com/ragnarGrootK...

TIL - zless linux.die.net/man/1/zless

Q3 Mojo roadmap looking awesome! Highlights: - apple Silicon GPU Support - requires clauses - struct extensions forum.modular.com/t/mojo-q3-ro...

@steveklabnik.com Did you write an article about ways you wish Rust Iterators had evolved differently? Or remember who wrote that? Mojo is about to start in on its iterator abstraction and I was looking for lessons learned from Rust, but can't find that article. I might be imagining this it 😬

Looking for papers to cite for tight definitions of global alignment, semi-global alignment, and mapping... I would probably be the person to ask, yet here we are.

Catching up on some releases: Perbase 0.10.3: bugfix for --mate-fix when MAPQ scores are equal github.com/sstadick/per... rust-lapper 1.2.0: fix to the BITS count algorithm for 25-30% improvement in perf github.com/sstadick/rus...

Happy if-let-chain stabilization day to all those who celebrate!

ExtraMojo update is live! Two added datastructures with BitVec and BBHash. Updated for Mojo 25.4. extramojo.github.io/ExtraMojo/Ex... extramojo.github.io/ExtraMojo/Ex... github.com/ExtraMojo/Ex...

ish v1.2.0 released and available via conda! github.com/BioRadOpenSo... Updates to Mojo 25.4 Bugfix for AVX512 on short queries Improvement for saturating arithmetic to use LLVM intrinsics.

FastGA: Fast Genome Alignment https://www.biorxiv.org/content/10.1101/2025.06.15.659750v1

Why do some have a shit time with LLMs for programming while others love it? To succeed, the latter group tacitly creates tons of scaffolding and gain weird new skills. While it works, this posts explains how doing all that is an incidental consequence of bad interaction design in coding AI agents.

Mojo 25.4 is out! This is the version where the beta version of Python bindings is live 🔥 docs.modular.com/max/changelog/

And here's a blog post, announcing the release! blog.janestreet.com/introducing-...

Well worth 10 minutes to read this. I had no idea that's how they worked.

Yearly PSA: you probably don't actually want to be using the builtin HashMap hashing algo in Rust stdlib. nnethercote.github.io/perf-book/ha...

It's very cool to me that this is possible. Mojo doesn't have saturating add/sub ops (yet). But you can add them yourself with inline llvm intrinsics. Delivering on the promise of "moving the magic out of compilers and into libraries". Notably, this implementation will work for both scalar simd.

I presented on ish at the Modular Community meeting today! It’s geared toward non-BFX people and covers what ish does at a high level. youtu.be/1Q4RNVOSAH0?...

ish is a grep-like CLI tool that uses optimal alignment instead of exact matching. It’s record-type aware, supporting line, FASTA, and FASTQ records. Built in Mojo as a proof of concept for bioinformatics. 🧵1/5

Slides from my talk (with @kamilsjaron.bsky.social) on an history of k-mers in bioinformatics: rayan.chikhi.name/pdf/2025-kme...

“A program is a shared mental construct that lives in the minds of the people who work on it. If you lose the people, you lose the program. The code is merely a written representation of the program, and it's lossy, so you can't reconstruct a program from its code.” gist.github.com/onlurking/fc...

Always odd to imagine that some of the superstar engineers I look up to also have managers and meetings and are generally normal people. > I summarize each week for my manager. www.brendangregg.com/blog/2025-05...