Today is International Day of Women and Girls in Science. Grateful for the women who design studies, wrangle messy data & ask the hard questions that move research forward. Your expertise makes science stronger every day. #WomenInScience

In translational/clinical work we see bioinformatics projects fail not due to science, but because early assumptions box the data in. We plan with downstream reality in mind: biology, existing data, constraints that matter. That’s how teams move fast without rework. Let’s chat & scope your project

A new *Nature Genetics* paper co-authored by Alison Meynert maps the signalling effects of every possible CTNNB1 exon 3 missense mutation. Variants in the same hotspot can differ substantially in effect. More in our blog post ↓ blog.fulcrumgenomics.com/p/why-functi...

In this final edition of our Meet the Team series, we introduce a teammate whose perspective reflects a simple premise: molecules don’t lie. After these brief interviews we hope you feel like you know each of us a little better — or want to. Meet Jess Smith: blog.fulcrumgenomics.com/p/meet-jess-...

Most teams don’t struggle with ideas, just the momentum to get there quickly. We can help. “Start with a concept, describe the desired outcome and they can build the tools to make you successful.” — Keith Brown, Founder, Jumpcode Genomics

UMI consensus isn’t hard. Making it reproducible is. Our answer to reproducibility is fastquorum, an nf-core pipeline that turns fragile, one-off UMI workflows into something boring and reliable. No hype. Just infrastructure that works. 👉 www.linkedin.com/pulse/fastqu...

New case study out: Fulcrum Genomics + Belay Diagnostics. We helped take an ECS pipeline from prototype → CAP/CLIA-ready clinical deployment, with auditability, testing to prevent regressions & cloud architecture fixes that reduced cost + avoided resource exhaustion. 👉 tinyurl.com/mtkwup9b

Most ECS pipelines focus on clean error-corrected reads. What happens after variant calling is often ad hoc. MutSeqR picks up there for mutation frequency modeling, spectrum analysis, & benchmark dose estimation across ECS platforms. More detail here: 🔗 blog.fulcrumgenomics.com/p/mutseqr-op...

Today we feature a teammate balancing rigor and delivery in complex projects. He shares views on data-driven development, disciplined iteration, and connecting lab and computational teams. We hope you’ll feel like you’ve met us — or want to. Meet Matt Stone: blog.fulcrumgenomics.com/p/meet-matt-...

Genomics is set for a big 2026: AI agents, GA4GH standards, Rust‑native workflows, long reads/ECS/SVs, and protein sequencing + AI design.

Thank you to our clients - for the challenging problems, the good questions, and the partnerships. Thank you to our team - for showing up with curiosity, rigor, and heart every single day.

ICYMI: Last week we announced MutSeqR, an open-source R package for error-corrected sequencing analysis, co-authored by our own Clint Valentine with Health Canada and U Ottawa. It brings much-needed standardization to genetic toxicology research. 🧬 🖥️ blog.fulcrumgenomics.com/p/mutseqr-op...

Proud to share that our own Clint Valentine co-authored MutSeqR, an open-source R package for analyzing error-corrected sequencing (ECS) data. Developed with Health Canada & U Ottawa, it helps bring consistency to genetic safety research. 🔗 doi.org/10.1093/bioa... #Genomics #OpenSource #MutSeqR 🧬🖥️

The whole picture: How our values connect Over the past weeks we shared our core values. If you followed this series, or worked with us as a client, collaborator, teammate, or friend, thank you. Today and every day we are thankful for you. Read more here: blog.fulcrumgenomics.com/p/10th-anniv...

At Fulcrum Genomics, Public Benefit isn’t just a principle, it's our purpose. Public Benefit has two levels, the commitment to working in biomedicine, and the daily acts of craftsmanship making the scientific ecosystem stronger. Both matter. Read more here: blog.fulcrumgenomics.com/p/core-value...

Some colleagues can to do everything and make it look effortless. This teammate reflects on balancing humility with confidence, and the power of giving your mind space to wander. By the end, you’ll feel like you’ve met us - or want to. Meet Alison Meynert: blog.fulcrumgenomics.com/p/meet-aliso...

10th Anniversary Core Values blog series: Client Focus Beyond just execution, we strive to understand the strategic context: What's the client's real need? What are the goals, constraints, and blind spots? How can we help them see around corners? Read More: blog.fulcrumgenomics.com/p/core-value...

Today we feature a teammate whose way of thinking connects games and science. It’s that mix of strategy and lightness that makes working with him such a pleasure. By the end we hope you’ll feel like you’ve met us — or want to. Meet Zach Norgaard: blog.fulcrumgenomics.com/p/meet-zach-...

10th Anniversary Core Values blog series: Valuing People Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in. Read More: blog.fulcrumgenomics.com/p/core-value...

The best part of our work is the people who make discovery possible — thoughtful, curious, and generous with their insight. In this series we hope you’ll feel like you’ve met us — or want to. Meet Yossi Farjoun: blog.fulcrumgenomics.com/p/meet-yossi...

@nilshomer.com , @tfenne.bsky.social , and Yossi Farjoun will be in Boston for #ASHG25. If you're going to be there, let us know! #ASHG2025

10th Anniversary Core Values blog series: Excellence Excellence is a mindset and a practice. It’s not somewhere you arrive, but something you strive for, continually refining. It emerges from a culture of openness, curiosity, and accountability. Read More: blog.fulcrumgenomics.com/p/core-value...

10th Anniversary Core Values blog series: Openness Openness is an action. It’s a positive, and proactive, choice to lean-in. It begins with a simple but powerful question: What do I know that others need to know? Read more: blog.fulcrumgenomics.com/p/core-value...

@nilshomer.com, Yossi Farjoun, and @tfenne.bsky.social will be attending #ASHG25 in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!

Yesterday marked ten years since Fulcrum Genomics was founded. We took a moment to reflect: blog.fulcrumgenomics.com/p/ten-years-... Thanks to everyone who’s been part of the journey.

We love working with people who notice how things fit together, who make unwieldy problems work better. The 'Meet the Team' series spotlights humans behind our bioinformatics work. We hope you'll feel like you've met us — or want to. Meet Erin McAuley: blog.fulcrumgenomics.com/p/meet-erin-...

This edition of our 'Meet the Team' features a teammate with a deep expertise in long-read sequencing. Just a few questions to glimpse the person behind the work. By the end of the series we hope you’ll feel like you’ve met us — or want to. Meet Tim Dunn: blog.fulcrumgenomics.com/p/meet-tim-d...

Today we hear from our VP of Operations, who keeps the big picture moving while staying grounded in the work itself. Here's a quick look at how he thinks and works. By the end, we hope you’ll feel like you’ve met us — or want to. Meet Clint Valentine: blog.fulcrumgenomics.com/p/meet-clint...

We’re lucky to work with people who are not just skilled, but thoughtful, curious, and quietly surprising. This series of short interviews offers a window into who we are. By the end, we hope you’ll feel like you’ve met us — or want to. Meet Ted Brookings: blog.fulcrumgenomics.com/p/meet-ted-b...

Making bioinformatics tools widely available is one of the most important tasks a bioinformatician can undertake. In this post @nilshomer.com shows how to use Grayskull to quickly and reliably create conda recipes to distribute your bioinformatics software. blog.fulcrumgenomics.com/p/create-con...

There’s no single way to do what we do. This series aims to share glimpses of people at Fulcrum Genomics: how they think, what drives them, and what makes them laugh. By the end, we hope you’ll feel like you’ve met us — or want to. Meet Juliann Chmielecki: blog.fulcrumgenomics.com/p/meet-julia...

🧪 Good Enough Practices in Scientific Computing: Co-developed by our colleague Alison Meynert, this framework for an instructor-led, half-day module will help researchers build practical skills in data analysis, computing, and collaboration. jose.theoj.org/papers/10.21...

We believe in leaving things in a better state than we find them. Founding Partner @tfenne.bsky.social shares how our team contributes back to the open source ecosystem, strengthening the foundations on which many scientific and technical projects are built. blog.fulcrumgenomics.com/p/recent-ope...

We think the best part of our work is the people who do it, curious, sharp-minded, and genuinely enjoyable to talk to. This blog series offers brief glimpses into who they are. By the end, we hope you’ll feel like you’ve met us — or want to. Meet Jeff Gentry: blog.fulcrumgenomics.com/p/meet-jeff-...

Our people are our greatest asset — sharp, thoughtful, and pretty fun to get to know. We have short interviews on our blog to offer a view of each of our colleagues. By the end, we hope you’ll feel like you’ve met us — or want to. Please meet Jason Fan: blog.fulcrumgenomics.com/p/meet-jason...

Congratulations to Nick Bailey for finishing his PhD with: “Correcting for Bias in Estimates of Watterson’s θ and Tajima's D From Missing Data in Next-Generation Sequencing”. Projects like this remind us why we love what we do. Read the paper: t.co/BhMEHxlX73 Try the software: github.com/ksamuk/pixy

How to use Conda without running afoul of Anaconda licensing. Read more on our blog: #bioinformatics #conda #software open.substack.com/pub/fulcrumg...

New release of fastquorum! This nf-core #nextflow fgbio Best Practices FASTQ to Consensus Pipeline to produce consensus reads using unique molecular indexes/barcodes (UMIs).

Fulcrum Genomics is now a registered supplier on Scientist.com! Connect with us on Scientist.com and start your project with a click. Visit our profile here: app.scientist.com/providers/fu...

John Didion @jdidion.bsky.social and Tim Fennell from the Fulcrum Genomics team will be at #ASHG2024 in Denver from November 5-9. Drop us a line if you’d like to connect in person! #ASHG24 #HumanGenetics #Bioinformatics #Genomics #NGS