🚀 New on the #CRC1678 Website! 🌐 Explore Job Opportunities + Fellowships: - Postdoc Position🔬 - Medical Research Fellowship (6 months)👩‍⚕️ - PhD Orientation Fellowship(4 months)🎓 📅 Open year-round, no deadline, open to all! 👉 crc1678.uni-koeln.de/job-opportun...

Looking for some Thanksgiving reading? 🦃🦃🦃 🚨Check out our new preprint on CRISPore-seq!🚨 Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.

Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl Submit your abstract by 7 July and present your research at #EESRNA 🥼

🚨Speaker Alert 🚨 We’re excited to welcome @landthalerm.bsky.social for the upcoming #CRC1678 Seminar! 🧬 He’ll dive into: "Posttranscriptional Regulation in Cellular Time and Space" 📅 November 25 📍 Auditorium, MPI-Age ⏰ 2:00 PM Explore how RNA dynamics shape cellular behavior across time and space!

Happy to see this work published! Thanks to everyone who contributed 🙏

Dusa’s study is on the cover of this month’s #CellGenomics! Check it out if you haven’t had the chance yet! www.cell.com/issue/S2666-...

🛑Guille's @guillepalou.bsky.social no-nonsense 😉 paper is out in @springernature.com Genome Biology! We report variable activity of the NMD pathway (mRNA QC) across tissues & individuals: 🧠less active in the nervous system & in reproductive tissues 🩸more active in digestive tract, muscle, blood

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

wrong bioRxiv link here, sorry. the correct link to the collaboration with Torben and Clemens is: www.biorxiv.org/content/10.1...

The team of Prof. Dr Niels Gehring @volkerboehm.bsky.social records a comprehensive database that records systematically which genes and gene variants are directly affected by "Nonsense-mediated mRNA Decay" which opens up new avenues for RNA and genome research. The database ➡️ nmdrht.uni-koeln.de

🥳 Congratulations from #CRC1678 to @volkerboehm.bsky.social and the Gehring lab for their publication in @cp-molcell.bsky.social on how “Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome” 🧬🧫

Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...

🎉 Congratulations to our new Vice-Rector for Research, Professor Dr. Carien Niessen! 🙌 The University Council has elected Professor Niessen as Vice-Rector for Research to support the advancement of excellent research at the #UniCologne. 🎓 Read more 👇 uni.koeln/9FCEC @cecad.bsky.social

Online Now: Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome Online now:

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

"m6A in the coding sequence: linking deposition, translation and decay" by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues "This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..." Read it here: authors.elsevier.com/sd/article/S...

The latest human GENCODE releases for Human (49) and Mouse (M38), have just been released. They're available via gencodegenes.org and visible in @ensembl genome browser as part of Ensembl 115 ensembl.org

Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...

Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear. www.nature.com/articles/s41...

In bulk RNA-seq, @plbaldoni.bsky.social et al showed that correcting overdispersion (OD) from read-to-transcript mapping ambiguity improves downstream analyses. Here I extend this to scRNA-seq using @mikelove.bsky.social et al Alevin’s bootstraps to correct per-cell OD github.com/sbresnahan/O...

Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link: mbg.au.dk/en/news-and-...

Excited for this to be out officially! It was a great team effort and has a lot of useful tidbits for studying isoform function. www.nature.com/articles/s41...

🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇

1/ 🧬 Exciting news! Our group just published a paper in Nature Communications on using serum proteomics to predict disease progression in #ADPKD (Autosomal Dominant Polycystic Kidney Disease) 🔬 — enhancing risk stratification beyond currently available models 🎯 rdcu.be/exbNq

Hi #RNAsky, #ChromatinSky! It is a pleasure to announce that the @ox.ac.uk RNA & transcription club is now on Bluesky. Follow us to stay in touch with everything RNA and transcription from gene regulation to disease. Join us here: rna.web.ox.ac.uk/home

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

Freshly launched! 🚀 Check out the new CRC 1678 website 🌐 👉 crc1678.uni-koeln.de

Congratulations to our biochemistry professor Utz Fischer: he has been elected to @embo.org ! His research focuses on the macromolecular machines of the cell. 📷 Christoph Weiss www.uni-wuerzburg.de/en/news-and-...

Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA. Paper: academic.oup.com/nar/article/...

🆕 publication! Cells don’t just fight infection - they fine-tune their immune response. A new study from the Versteeg lab in @narjournal.bsky.social led by Adrian Söderholm uncovers how RNA processing of JAK2 helps regulate immune signals ➡️ tinyurl.com/2py27c8u @univie.ac.at @meduniwien.ac.at

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

If you are interested in cellular RNA transport, check out Simone Heber's first corresponding author paper: www.cell.com/cell-reports... Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.

Feeling grateful to have received a fun goodie bag from #Lexogen for participating in their #RNA salon survey - special shoutout for the super cool sport shirt! 🎁🧬 Big thanks to the @rhinelandrna.bsky.social‬ as well—always a pleasure to be part of this vibrant RNA community! #RNAsky

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...

We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky

Sad that #RNA2025 is almost over? Join us in August in the UK for another fun meeting on RNA! #RNAsky #RNAdecay

🎉Celebrating five Clusters of Excellence! Congratulations to our Clusters: @cecad.bsky.social for aging research🧬, @ceplas.bsky.social for plant sciences🌱, @econtribute.bsky.social for economics, ML4Q for quantum research⚛️ and 🆕DYNAVERSE for astrophysics🌌 Read more ➡️https://uni.koeln/2AKU3

CECAD receives renewed DFG funding! 🎉 We continue to unlock the biology of aging 🧬 and advance healthy aging for all! 👵👴 ➡️ uni.koeln/GAPGK #CECAD #AgingResearch #ExcellenceCluster #DFG #HealthyAging @unicologne.bsky.social

This preprint is now out after peer review! Check it out: www.cell.com/cell-genomic.... Huge congrats (and thanks!) to the whole team that contributed!

Please join us for an exciting meeting on "Eukaryotic RNA turnover: from fundamentals to applications" in Brighton, UK this August! We have an exciting lineup of speakers, and will feature many selected talks. Abstract deadline is June 27! www.eventsforce.net/biochemsoc/f...

Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.

Our latest research on #Coronavirus Nsp1 found its home (and a new name) at @cp-cellreports.bsky.social www.cell.com/cell-reports... Thankful to the first (dream) team of my lab and funding for making this happen. @nccr-rna-disease.bsky.social @mcid-unibe.bsky.social @unibe.ch

The 8th Rhineland RNA Club with great local speakers and Julian König @koenig-lab.bsky.social as invited speaker was a fun and well attended event with lots of #RNA discussions and networking. Organized and hosted by @inahuppertz.bsky.social at @mpiage.bsky.social. #RNAsky

Check out our new paper in @narjournal.bsky.social on discovering extensive conservation of human introns across hundreds of other mammals, with Ilia Minkin academic.oup.com/nar/article/...

The first paper from the Leppek lab is published today at @embojournal.org!! 🎉 We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues. www.embopress.org/doi/full/10....

Discover how ribosomes shape mRNA decay! 🧬 They empower Ccr4-Not & more to manage mRNA homeostasis. Dive into the latest insights. #mRNA Retweet if you're intrigued! PMID:39921564, Nucleic Acids Res 2025, @NAR_Open https://doi.org/10.1093/nar/gkaf049 #Medsky 🧪

We are very happy to invite you to our 8th edition of the Rhineland RNA Club @mpiage.bsky.social with great local speakers and Julian König @koenig-lab.bsky.social as our invited speaker. All #RNA enthusiasts are welcome. Organized by @katleppek.bsky.social and @inahuppertz.bsky.social. #RNAsky

We are excited to share the work of Nataliia Stefanyshena who showed that maintenance of an optimal Mex67 level in nuclear mRNPs is required for efficient mRNA export: www.biorxiv.org/content/10.1...

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬 More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...