Interaction with AK2A links AIFM1 to cellular energy metabolism

New work in a great team effort with the @poepsel-lab.bsky.social. We identified novel interactors of AIFM1 and found that this protein once only associated with cell death is a master organizer of the mito-IMS: By interaction with AK2 and SLC25 family members ensuring metabolic adaptation.

@dfg.de retreats are great, especially when they come with a foosball table with integrated shot glasses - best networking! Cheers to that, SPP2453 @warscheidlab.bsky.social @cmunch.bsky.social @herrmannlab.bsky.social @riemerlab.bsky.social @jaelab.bsky.social

Join us at the EMBO/FEBS lecture course: The evolving role of mitochondria in metabolism 14 – 18 September 2025 | Belgrade, Serbia: meetings.embo.org/event/25-mit...

A new tool from our lab :-). Together with the Brachvogel, Bogeski and Mielenz labs. We developed a genetically encoded sensor to monitor activity of the dipeptidases DPP8 and DPP9 in cells allowing us to ask fundamental questions about their spatiotemporal regulation. DOI: 10.26508/lsa.202403076

A new study from the @riemerlab.bsky.social and the bange lab. We found a new mode how specific degradation motifs become unmasked by DPP8/9. Really nice work by Kim, Konstantin and Franziska. As usual accompanied by a special graphical abstract. doi.org/10.1038/s443...

Monitoring subcellular NADP redox state with NAPstar biosensors @riemerlab.bsky.social @morganlab-saarland.bsky.social @jan-oleniemeier.bsky.social www.sciencedirect.com/science/arti...

A new biosensor is born 👼 The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫 Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱 Where to go next? @naturecomms.bsky.social doi.org/10.1038/s414...

Again, glutathione comes to the rescue. In yeast, Tsa1 oxidizes glutathione at moderate H2O2 concentrations when the TRX system becomes inactivated by oxidation. A study together with the Morganlab and the Depontelab. doi.org/10.1016/j.fr...

We just published a study on the first endogenous cysteine-free interactor of the mitochondrial disulfide relay - HAX1. HAX1 relies on MIA40 for folding and stability and does not require the redox fxn of MIA40. Nice collaboration w/ #ulrichlab. doi.org/10.1111/febs...

This week, the @crc1678 kick-off retreat brought all the project leaders together! 🚀 A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! 💡👩‍🔬🧑‍🔬 #Research #Collaboration