🚨 Speaker Alert! 🚨 We’re excited to welcome Dr. Ranen Aviner for the next joint #CRC1678 / @mpiage.bsky.social Friday Seminar! 🧬 He will talk about "Guardians of the Proteome: How Ribosome Interactions Shape Cellular Resilience" 📅 October 17 📍 Auditorium, MPI Age ⏰ 1:30 PM

💡Check out this new perspectives article from the group of our #CRC1678 project leader @bjornschumacher.bsky.social in Nature Drug Discovery about directly targeting DNA damage in ageing. Congratulations! 🎉

📢 Check out this podcast episode with our #CRC1678 project leader @bjornschumacher.bsky.social talking about his career path as a scientist and why tiny worms are a perfect model to study ageing!

🚨 Speaker Alert! 🚨 We’re thrilled to announce the next #CRC1678 Seminar featuring Prof. Vera Gorbunova from Rochester University! Join us for her talk about "Mechanisms of Longevity - Lessons from Evolution" 📅 October 16 📍 #CECAD Lecture Hall ⏰ 2:30 PM

🌍👩‍🔬🤝 At #CECAD, excellence starts with #people! This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery. ✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥

// Panel Discussion // Would you like to know how to obtain funding to set up your own junior research group? Then listen to our five panel speakers who were successful in obtaining third-party funds! #DFG #UniKöln #ERC ▶️ verwaltung.uni-koeln.de/d7_events

📹 Here's a small glimpse into daily lab life at CGA! 🧪 This is just one of the many methods our PhD students use at our institutes. Curious? Watch our full video for even more insights about your possibilities at our graduate programme. Link to full video: www.ageing-grad-school.de/about-us/cal...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

🚨 Speaker Alert! 🚨 We’re excited to welcome Prof. Utz Fischer for the next #CRC1678 Seminar! 🧬 Talking About Making mRNA in the Wrong Compartment: How Poxviruses Express Their Genes in the Cytoplasm of a Host 📅 October 7 📍 CECAD Lecture Hall ⏰ 2:00 PM

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

📖Read about the transition of patients with hereditary nephropathies from pediatric to adult care in this new article by our #CRC1678 project leader @muellerrom.bsky.social. Congratualtions! 🎉

📢Check out this brand new preprint from @akispapantonis.bsky.social on how Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells. Congratulations 🥳

⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health. #HealthyAging @unicologne.bsky.social youtu.be/9ALNLpG3oYc

🥳 Congratulations from #CRC1678 to @volkerboehm.bsky.social and the Gehring lab for their publication in @cp-molcell.bsky.social on how “Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome” 🧬🧫

🧐 This is how quality control works in our cells 🧬 Researchers from the #unicologne and the @mdc-berlin.bsky.social have cracked the code of a crucial mechanism of cellular quality control in humans. 👇 uni.koeln/RRCLZ

💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻

🚨 Speaker Alert! 🚨 We’re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social ! Join us to dive into the fascinating role of mRNA 3′UTRs in chaperoning intrinsically disordered regions to regulate protein activity. 📅 September 16 📍 CECAD Lecture Hall ⏰ 2:00 PM

Most read, I hear! Here is your chance to read what @mariekeoudelaar.bsky.social and I had in mind when writing this together.

🎉 Congratulations to our new Vice-Rector for Research, Professor Dr. Carien Niessen! 🙌 The University Council has elected Professor Niessen as Vice-Rector for Research to support the advancement of excellent research at the #UniCologne. 🎓 Read more 👇 uni.koeln/9FCEC @cecad.bsky.social

🚨Speaker Alert 🚨 🧬 Dr. Tilman Schneider-Poetsch is presenting today’s #CRC 1678 Seminar on "Girolline as a sequence-selective probe into eIF5A function" 📍Don’t miss it and join us at the MPI-Age Auditorium at 10 AM!

Our PhD student @larahi.bsky.social l is now in Zurich @ethz.ch in the @picottilab.bsky.social with funding from @crc1678.bsky.social Lara, enjoy your time on the Hönggerberg 🏔️ in one of the best proteomics labs of the world!! 🧪

🚀 Don’t miss out the poster of our #CRC1678 member @nishahemandhar.bsky.social at the #EMBL Protein Conference — hands down, one of the most mind-blowing presentations out there! 🤯🤯

🧓How aging drives neurodegenerative diseases🧠 @thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

🥁Aaaaand, another one — @thevilchezlab.bsky.social is on a publication roll! Check out this fantastic work from the team led by our #CRC1678 project leader David Vilchez, exploring how the aging factor EPS8 triggers disease-related protein aggregation through RAC signaling hyperactivation.🚀

CRC 1678 is thrilled to collaborate with fellow Life Science CRCs in Cologne to empower our members through hands-on workshops! Huge thanks to @crc1218.bsky.social for launching the series with an inspiring Adobe Illustrator training.🚀 #SciComm #LifeSciences #CollaborationInScience

🚨Check out this brand new publication from the lab of our CRC 1678 project leader @thevilchezlab.bsky.social about how C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules! Congrationlations to this achievement!🥳

Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis journals.lww.com/nrronline/ci...

📣Check out this review by our CRC 1678 members from @ignatovalab.bsky.social about the emerging role of suppressor tRNAs (sup-tRNAs) as a promising personalized therapy to counteract nonsense mutations by restoring protein synthesis through engineered decoding of premature stop codons. 🧬💪🎉

📣CRC 1678 is funding research visits for three early career scientists! 🔬 @thancbn.bsky.social visits @landthalerm.bsky.social @ MDC Berlin 🧬 @larahi.bsky.social & Car Elias Kutzner visit @picottilab.bsky.social @ ETH Zürich We wish our fellows an inspiring and productive time abroad!

📹 Interested in a PhD position in aging research starting in 2026? Then watch our new short video for some tips from our wonderful PhD students and faculty. Don't miss the deadline: November 3, 2025. Apply now and start your journey with us!

🥳 Check out this brand new preprint from the lab of our CRC 1678 project leader @inahuppertz.bsky.social on how the GlcNAc 6-P deacetylase AMDHD2 couples the hexosamine biosynthetic pathway to Acetyl-CoA homeostasis in pluripotent stem cells. Congratualtions on this great work! 👏

🚨 Speaker alert 🚨 Together with the Cologne Seminars on Ageing we are excited to welcome Vadim Gladyshev to the Cologne on September 1! He will share fresh perspectives from his pioneering work in ageing research.

The study was published in @nature.com www.nature.com/articles/s41... #uniköln #unicologne #savi #sting #research

Can't wait to be at the #ARDD2025 next week! agingpharma.org I'm presenting "Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session. If you're at the conference, let's grab a coffee and chat! 🧪 #AgingResearch #Longevity #Science

🎉💪Congratualations to our CRC 1678 postdoc @nishahemandhar.bsky.social for this great achievement! Check out her publication on proteo-transcriptomic reprogramming and resource reallocation in the aging brain🤩

Registration open now! Join us for the most exciting Gordon Research Conferences on Systems Aging in 2026. Super exciting program with outstanding speakers from across the entire field. Ample opportunity to discuss your science with leaders in the Systems Aging Feld. www.grc.org/systems-agin...

🌟 What an incredible event! Amazing location & fantastic science. 🌟 Our Graduation Symposium PhDone last Friday was a great success! Huge thanks to our speakers for their insightful and emotional presentations, and to everyone for the valuable networking. #ECR #mitoCRC #PhDone

🎉Wer are proud to share that CRC 1678 project leader Andreas Mayer has joined the Medical University of Innsbruck as Professor for RNA Biology and Genomics and Director of the new Institute for Genomics and RNAomics. A major milestone—CRC 1678 congratulates him on this exciting step! 🧬👏

Predicting kidney disease trajectories with a simple blood test🩸 A research team around @muellerrom.bsky.social has developed a new approach to predict the progression of kidney disease via 29 proteins in the blood that are associated with the decline of kidney function. ▶️https://uni.koeln/3U6M5

#DynaTag outperforms existing methods like #ChIP-seq and #CUT&RUN in terms of sensitivity and resolution. 📈 The study was published in @natcomms.nature.com 👇 www.nature.com/articles/s41...

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny. 🗓️ Deadline: November 3, 2025. ℹ️ More info: www.ageing-grad-school.de 📣 Spread the news!

🥳 Congratulations to our CRC project leader @trentini-lab.bsky.social on this brand new pre-print on how protein processing via the ER influences translation dynamics of RQC targets 🧬🔬

Check out this publication on brain ageing in killifish by our CRC postdoc Domenico DiFraia from the @beyerlab.bsky.social. Congratulations to this nice work 🥂🚀

Happy to share the nice video @unicologne.bsky.social has produced on our recent publication identifying novel protein biomarkers for #ADPKD. www.youtube.com/watch?v=FDGN... rdcu.be/ezvN4 @cecad.bsky.social @uniklinikkoeln.bsky.social

🔬 DynaTag by CRC 1678 project leader Robert Hänsel-Hertsch @epistrucstab.bsky.social maps protein-DNA binding at single-cell level—boosting precision in cancer & gene research. #CRC1678 #DynaTag #UniCologne

🚀Big news from CRC 1678! Robert Hänsel-Hertsch @epistrucstab.bsky.social and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN. 🧬Cancer research & gene regulation just got a major upgrade. #Genomics #DynaTag #PrecisionMedicine

Great thanks to Jörg Bernards-Stiftung and @dfg.de (Excellence Strategy @cecad.bsky.social) for supporting this work and to all patients participating.

1/ 🧬 Exciting news! Our group just published a paper in Nature Communications on using serum proteomics to predict disease progression in #ADPKD (Autosomal Dominant Polycystic Kidney Disease) 🔬 — enhancing risk stratification beyond currently available models 🎯 rdcu.be/exbNq