Robert Hänsel-Hertsch
@epistrucstab.bsky.social
📤 109
📥 180
📝 21
Junior Group Leader, Center for Molecular Medicine Cologne, University of Cologne, DE
reposted by
Robert Hänsel-Hertsch
David Vilchez
20 days ago
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling.
#Aging
#Longevity
#Proteostasis
#ALSResearch
🧵
www.nature.com/articles/s43...
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The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
https://www.nature.com/articles/s43587-025-00943-w
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reposted by
Robert Hänsel-Hertsch
David Vilchez
21 days ago
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library
febs.onlinelibrary.wiley.com/doi/10.1002/...
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FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70156
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reposted by
Robert Hänsel-Hertsch
Gianmaria Liccardi
about 1 month ago
I am beyond excited and incredibly proud to share that our work is now out in
@nature.com
This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.
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STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature
Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
https://www.nature.com/articles/s41586-025-09536-4
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Congratulations Debora, fantastic news!
add a skeleton here at some point
about 2 months ago
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reposted by
Robert Hänsel-Hertsch
Waggoner Lab
about 2 months ago
DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution
@natcomms.nature.com
@epistrucstab.bsky.social
www.nature.com/articles/s41...
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DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution - Nature Communications
Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...
https://www.nature.com/articles/s41467-025-61797-9
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reposted by
Robert Hänsel-Hertsch
Stephen Matheson 🌵🚲
about 2 months ago
A great skeetorial on a new and much improved method for mapping transcription factor landscapes, with a beautiful image by our own Gloria Fuentes
@gloglita.bsky.social
from Life Science Editors
@lifescienceeditors.bsky.social
add a skeleton here at some point
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reposted by
Robert Hänsel-Hertsch
CRC1678
about 2 months ago
🚀Big news from CRC 1678! Robert Hänsel-Hertsch
@epistrucstab.bsky.social
and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN. 🧬Cancer research & gene regulation just got a major upgrade.
#Genomics
#DynaTag
#PrecisionMedicine
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reposted by
Robert Hänsel-Hertsch
CRC1678
about 2 months ago
🔬 DynaTag by CRC 1678 project leader Robert Hänsel-Hertsch
@epistrucstab.bsky.social
maps protein-DNA binding at single-cell level—boosting precision in cancer & gene research.
#CRC1678
#DynaTag
#UniCologne
add a skeleton here at some point
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reposted by
Robert Hänsel-Hertsch
Sonhita 🌞
about 2 months ago
🧪New method for anyone interested in protein-DNA interactions and TF mapping, from the lab of
@epistrucstab.bsky.social
at
@unicologne.bsky.social
!👇
add a skeleton here at some point
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reposted by
Robert Hänsel-Hertsch
Daniel Friedrich
about 2 months ago
Highly recommended read for everyone interested in interactions of proteins and DNA: Impressive new method on single cell level introduced by
@epistrucstab.bsky.social
from
@unicologne.bsky.social
!
add a skeleton here at some point
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reposted by
Robert Hänsel-Hertsch
Universität zu Köln
about 2 months ago
Die neue Methode übertrifft bestehende Methoden wie
#ChIP-seq
und
#CUT&RUN
in Bezug auf Sensitivität und Auflösung der Ergebnisse. 📈 Die Studie wurde in @natcomms.nature.com veröffentlicht👇
www.nature.com/articles/s41...
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DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution - Nature Communications
Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...
https://www.nature.com/articles/s41467-025-61797-9
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reposted by
Robert Hänsel-Hertsch
Universität zu Köln
about 2 months ago
🔬Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt💡
@epistrucstab.bsky.social
#UniKöln
hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist 🧬👇https://uni.koeln/SCLU6
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Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt
Ein Forschungsteam der Universität zu Köln hat eine Methode mit dem Namen DynaTag entwickelt, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist. Interaktionen von Prote...
https://uni.koeln/SCLU6
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🧪Move over CUT&Tag, there’s a new
#TranscriptionFactor
mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than
#ChIPseq
,
#CUT&RUN
and
#CUT&Tag
. 🔗 Our
@natcomms.nature.com
paper:
www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
about 2 months ago
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Very proud of Dalya Hiluf being among the poster prize winners at the recent EMBO | EMBL Symposium 'The ageing genome'. Great stuff and congratulations!
3 months ago
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reposted by
Robert Hänsel-Hertsch
Adlung Lab Adipose Systems Immunology
6 months ago
🧬🖥️ SARS-CoV-2 mRNA vaccination induces persistent H3K27 acetylation at macrophage promoters; especially those in guanine-rich DNA regions. Adds to my understanding of "immune training". Work by Jan Rybniker, @epistrucstab.bsky.social & teams in @molsystbiol.org
www.embopress.org/do...
🧪
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reposted by
Robert Hänsel-Hertsch
Adlung Lab Adipose Systems Immunology
6 months ago
Very nice paper showing that mRNA vaccines not merely elicit adaptive responses, but also epigenetically train innate immunity, too. 👇🏻👇🏻
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reposted by
Robert Hänsel-Hertsch
Molecular Systems Biology
6 months ago
New research by Jan Rybniker and
@epistrucstab.bsky.social
reveals that the SARS-CoV-2 mRNA vaccine triggers innate immune memory by establishing persistent H3K27ac epigenetic marks in human macrophages. Two consecutive doses are needed for this persistence ➡️
www.embopress.org/doi/full/10....
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Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders.
@crc1678.bsky.social
#crc1399
#RU5504
#CMMC
@cecad.bsky.social
@dfg.de
#Fritz_Thyssen_Foundation
add a skeleton here at some point
6 months ago
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Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders.
@crc1678.bsky.social
#crc1399
#RU5504
#CMMC
@cecad.bsky.social
@dfg.de
#Fritz_Thyssen_Foundation
add a skeleton here at some point
6 months ago
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