Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs...

Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/... febs.onlinelibrary.wiley.com/doi/10.1002/...

🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉

www.cell.com/cell/abstrac... A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis

🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠 @thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.

🧓How aging drives neurodegenerative diseases🧠 @thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis journals.lww.com/nrronline/ci...

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social bit.ly/47b3Mjk

Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social

Learning a lot and having fun at the #OpenDay #Science @cecad.bsky.social @mpiage.bsky.social

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...

Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry. Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science. (1/4)

New work from our lab;)

Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

#NCB2024 In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis. rdcu.be/d4vk5 www.nature.com/articles/s41...

I have no words to express how much I owe to Joan for his mentorship and advice. I became a professor thanks to his unwavering support. For instance, he insisted that I take English courses—and even paid for them—because I didn’t speak English while pursuing my PhD. I will miss you tons 😢😢

Here is a brief summary of academic journals and news account. Please help me add more accounts to this list! go.bsky.app/hCfhqn

If your are having issues receiving strains from the CGC in Europe, this can really help,…Launch of the European Hub for CGC strain distribution community.alliancegenome.org/t/european-s...

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

Bioart: a cool freeware alternative to Biorender bioart.niaid.nih.gov from the NIH

New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS

We’re happy to share our latest work by Gautier Langin on how the “ER-anchored protein sorting controls the fate of two proteasome activators for intracellular organelle communication during proteotoxic stress” #proteostasis ♻️ 🌱☀️ #PlantScience 🧵 (1/18) 🧵 www.biorxiv.org/content/10.1...

📢 Job Alert 📢: Technician Position We are looking for a motivated TA in our #RNA #translation #immunology lab in Bonn, Germany. Please spread the word and RT. Find all details in the ad. Please contact me directly: kleppek AT uni-bonn DOT de. Link: karriereamukb.de/offer/techni... #hiring

Our review on 'The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes' is online! Great work by Markus Wehrmann;) www.frontiersin.org/articles/10....

I could never have imagined that we would be on the cover of Nature Aging and with a plant paper! But here we go 😜 www.nature.com/nataging/vol...

Neural signal propagation atlas of Caenorhabditis elegans www.nature.com/articles/s41...

New work from the lab!🌱🌱 We explored whether the ability of plants to suppress protein aggregation can be applied into human cell and animal models to delay or even prevent neurodegenerative diseases www.nature.com/articles/s43...