Check out our new review article on Beyond the mouse: 3R-guided alternative animal models transforming cancer research link.springer.com/article/10.1... Great collaboration with @amatrudalab.bsky.social @bjornschumacher.bsky.social & Tobias Reiff

🧬🧬🧬 REGISTRATION JUST OPENED! Make sure you join our DNA REPAIR MEETING 2026 ON PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY in Cologne, September 7-9, organized by the German Society for DNA Repair (DGDR) and the @dfg.de Research Unit 5504. www.for-5504.com/en/197/Confe...

“One of the Greatest Challenges of Our Time”: Preventing Neurodegeneration | Technology Networks www.technologynetworks.com/neuroscience...

🚀Our new preprint:🧠Neuronal 🧬DNA 🧬repair mediates systemic mitochondrial maintenance through acetylcholine signaling. Neuronal repair is sufficient for the overall health amid DNA damage! @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social www.biorxiv.org/content/10.6...

How Aging clock reveals molecules that protect against neurodegeneration healthmedicinet.com/aging-clock-...

Do natural substances from blueberries and blue grapes protect nerve cells from aging?A www.bionity.com/en/news/1188...

A clock that measures the aging of nerve cells finds molecules that protect against age-related neurodegeneration | EurekAlert! www.eurekalert.org/news-release...

🚨Thrilled to share this exciting new paper by our #FOR5762 project leader @bjornschumacher.bsky.social, published in #NatureAging! The study uncovers neuron-specific aging patterns and points to potential neuroprotective interventions. Congratulations! 🎉 www.nature.com/articles/s43...

To elucidate whether diff. neuron types differ in their biological aging process, researchers applied "BitAge" (binarized transcriptomic age clock) to 128 different neuron types in C. elegans & found that distinct neurons differ in their biological age www.nature.com/articles/s43...

Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions www.nature.com/articles/s43...

🧠 Nerve cells age differently Researchers led by @bjornschumacher.bsky.social‬ @cecad.bsky.social have used C. elegans to prove for the first time that nerve cells age differently. Using an “aging clock” they were able to precisely determine the biological age of individual neurons👇 uni.koeln/FKJ35

⏰🧠 Nervenzellen altern unterschiedlich Forschende um @bjornschumacher.bsky.social @cecad.bsky.social haben in C. elegans erstmals nachgewiesen, dass Nervenzellen unterschiedlich altern. Mit einer „Alternsuhr“ konnten sie das biologische Alter einzelner Neuronen präzise bestimmen👇 uni.koeln/BWMMP

Eine Alternsuhr der Nervenzellen findet Moleküle, die vor altersbedingter Neurodegeneration schützen www.idw-online.de/-DTSBAA

Big thanks to @bjornschumacher.bsky.social for his guidance and all co-authors. This was a great team effort. Paper: www.nature.com/articles/s43... (9/n) #aging

🚨Publication Alert🚨 New work from our #CRC1678 members @bjornschumacher.bsky.social and @meyerdh.bsky.social reveals why some neurons age faster. Using neuron‑specific aging clocks, they identified vulnerable neurons and highlight syringic acid and vanoxerine as promising neuroprotective hits.🧬

Why do some neuron types degenerate early while others stay intact? We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability. 🧪 www.nature.com/articles/s43... #Neurodegeneration 🧵👇 (1/n)

🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...

Curious about the role our genetic traits 🧬 and our lifestyle 🏄‍♀️ play in healthy ageing? In the latest episode of the Bild der Wissenschaft podcast, our #CRC1678 project leader @bjornschumacher.bsky.social explains the science behind longevity! 🎙️Listen here: www.wissenschaft.de/gesundheit-m...

Die großen Fragen der Wissenschaft | Können wir ewig leben? Im Gespräch geht es um die tiefgreifenden biologischen Mechanismen hinter dem Altern, ethische Grenzen bei der Lebensverlängerung und um sinnvolle Strategien, länger gesund zu leben detektor.fm/wissen/die-g...

Hier der Podcast: mein Gespräch über »Altersuhren«, Fadenwürmer, den Traum von der ewigen Jugend und die richtige Medizin youtube.com/watch?v=Q6ey...

Heute im @spektrum.de der Wissenschaft: mein Gespräch über »Altersuhren«, Fadenwürmer, den Traum von der ewigen Jugend und die richtige Medizin www.spektrum.de/news/longevi...

Merry Christmas 🎄🎁 and happy new year 🎆🎈🎊 with all the best wishes for a great 2026

🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and @meyerdavid.bsky.social! @cecad.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

This was a great start of the @erc.europa.eu Synergy funded @batprotect.bsky.social BATPROTECT workshop @cecad.bsky.social @unicologne.bsky.social in Cologne

🔥🔥🔥Now out in print: how do germ cells instruct the soma and how does the soma impact inheritance? Together with Shoma Ishikawa we provide a comprehensive overview of The Somatic Impact on Inheritance and the Germline Control of the Soma - www.annualreviews.org/content/jour...

It's a great pleasure to introduce the RACE ERA Chair Initiative for Establishing a Research and Innovation Program of Excellence on Ageing and Longevity at the University of Crete with @garinis.bsky.social

🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp

🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉

📢 Check out this new paper by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt: Age Deceleration and Reversal Gene Patterns in Dauer Diapause! Nature shows us how aging can slow—and even reverse—at the whole-organism level.

🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated. onlinelibrary.wiley.com/doi/10.1111/...

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny. 🗓️ Deadline: November 3, 2025. ℹ️ More info: www.ageing-grad-school.de 📣 Spread the news!

What Jane Goodall Taught Us About Living a Long Life The scientist, who died at 91 on Wednesday, was a model for healthy aging. www.nytimes.com/2025/10/02/w...

Now out in print: Targeting DNA damage in ageing: towards supercharging DNA repair. New perspectives how we could tackle cancer and aging at their mechanistic root cause: I www.nature.com/articles/s41...

Amazing retreat of the @dfg.de Research Unit FOR5504 on the Physiological Causes and Consequences of Genome Instability and the Institute for Genome Stability in Aging and Disease with keynotes by @apoetsch.bsky.social and @garinis.bsky.social

It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

Aging by the clock and yet without a program [perspective by David Meyer, Alexei Maklakov & Björn Schumacher] www.nature.com/articles/s43...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Registration open now! Join us for the most exciting Gordon Research Conferences on Systems Aging in 2026. Super exciting program with outstanding speakers from across the entire field. Ample opportunity to discuss your science with leaders in the Systems Aging Feld. www.grc.org/systems-agin...

🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...

mtor and DNA damage in kidney health 👇

🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

Paradigmenwechsel in der Medizin, um gesunde Lebenszeit verlängern www.nd-aktuell.de/artikel/1191...

Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin nachrichten.idw-online.de/pressrelease...

Enabling healthy ageing: @leopoldina.org discussion paper recommends shift in focus in research and medicine. We are proposing a Health-Extending Medicine in an Aging Society and define Prospects for Medical Research and Practice www.leopoldina.org/en/press-1/p...

Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin. Hier sind die Ergebnisse unserer Diskussionen bei der @leopoldina.org für eine neue Medizin in einer alternden Gesellschaft. Lebenslange Gesundheit und Prävention ist erreichbar.

Targeting DNA damage in ageing: towards supercharging DNA repair www.nature.com/articles/s41... rdcu.be/eqQ7R This new Perspective discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases