New clinical trial registered: PREVENTION-IN-PD - The development of a multidomain lifestyle intervention study for 99 people with prodromal & clinical #Parkinsons in Germany; Support in 4 areas: exercise, Mediterranean diet, sleep, & cognitive training clinicaltrials.gov/study/NCT072...

New clinical trial registered: Annovis Bio initiate an open-label Phase 2/3,36 month clinical trial investigating the long-term safety of Buntanetap in treating 500 participants with #Parkinsons clinicaltrials.gov/study/NCT072...

New clinical trial registered: @narayananlab.bsky.social & collaborators initiate the Terazosin And Metabolic Engagement in Parkinson's Disease (or TAME-PD) study - a Phase 1/2 study assessing 26 weeks of terazosin in 100 people with early #Parkinsons clinicaltrials.gov/study/NCT072...

New review highlights new research on alpha synuclein–lipid interactions across different experimental models & proposes that early disruptions in neuronal lipid metabolism may lead to altered membrane composition & aggregation of aSyn movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

New research reports that distinct digital mobility outcomes patterns across #Parkinsons severity & between PD & controls support their utility as sensitive, scalable outcome measures for future clinical trials journals.sagepub.com/doi/10.1177/...

Researchers present a novel cell-penetrating PEP-1-Phosphoglycerate mutase 5 (PGAM5) fusion protein that rescues models of #Parkinsons onlinelibrary.wiley.com/doi/10.1111/...

A prospective, blinded study evaluating phosphorylated alpha-synuclein detection from skin biopsies finds 96.0% (48/50) positive results in dementia with Lewy bodies cases, 31% (8/26) of controls with⬇️MoCA, & 3.3% (4/120) of controls with normal MoCA. onlinelibrary.wiley.com/doi/10.1002/...

Walter Koroshetz, director of the National Institute of Neurological Disorders & Stroke, emailed NINDS staff late Friday night explaining that a request to reappoint him was denied, adding that his current temporary extension ends Sunday www.statnews.com/2025/12/27/n...

Researchers report that "dopamine caused α-synuclein oligomerization via oxidation of methionine residues" can be inhibited by Pyridoxamine (a form of vitamin B6) in a dose-dependent manner, through stable adduct formation (scavenging dopamine o-quinone) www.nature.com/articles/s41...

New research finds that #Parkinsons -associated alpha-synuclein amyloids can degrade adenosine triphosphate (ATP) in a catalytic fashion (producing adenosine diphosphate & adenosine monophosphate); Upon prolonged incubation, all ATP is irreversibly consumed www.nature.com/articles/s41...

New review explores the historical developments & key milestones in ubiquitination research, with a focus on its roles in both health & disease ( #Parkinsons gets a mention); Fascinating evolution of potential therapeutic approaches www.nature.com/articles/s41...

By analysing the membrane proteome for α-syn fibril binding, researchers propose that a cell surface mGluR4–NPDC1 complex participates in the neurodegeneration induced by #Parkinsons -associated alpha synuclein; Transgenic KO mice = protection www.nature.com/articles/s41...

#Parkinsons -associated alpha-synuclein co-pathology drives tau accumulation in #Alzheimers patients & iPSCs-derived models alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers analyzed GRN variants in >18K PD patients and compared sociodemographic, genetic, & clinical data between individuals with & without GRN variants; 24 (0.13%) PD cases harbored 16 unique pathogenic or likely pathogenic GRN variants movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

The results of first-in-human, single ascending dose & food-effect study in healthy volunteers of SUL-238, an inhibitor of mitochondrial reverse electron flux & ROS, have been presented; Safe & well-tolerated alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Bulk RNA sequencing was performed on frozen human amygdala of 20 #Parkinsons & 20 controls w/o dementia or any other neurodegen disorder; Results suggest cellular alterations related to mitochondrial dysfunc., oxygen homeostasis, & inflammation alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

New review explores insights into PINK1/Parkin function & dysfunction from Drosophila models; How good is this as a model of #Parkinsons? Very thorough overview - my weekend reading portlandpress.com/biochemj/art...

Hope Biosciences Research Foundation reports encouraging data from their randomized, double-blind, single center Phase 2 trial of allogeneic adipose‑derived mesenchymal stem cell therapy in 60 people with #Parkinsons (NCT04995081 - 17 primary outcomes?) www.businesswire.com/news/home/20...

Webinar to look out for in the new year: The first @cureparkinsons.org.uk #Parkinsons webinar for 2026 will focus on young onset PD - about 5-10% of people with PD are diagnosed before the age of 50, tune in to learn more: cureparkinsons.org.uk/2025/12/webi...

I'm 4 episodes in. And it is soooo good! @cureparkinsons.org.uk has released the audiobook of Tom Isaacs' "Shake well before use" for FREE! If nothing else, just listen to the first 5 mins of episode 2 where Tom describes his #Parkinsons diagnosis experience cureparkinsons.org.uk/2025/12/shak...

Jean-Martin Charcot at 200 years Who is Jean-Martin Charcot? Shame on you for asking! "The founder of modern neurology" who took a particular interest in #Parkinsons Understand that everyone in the field of neurology passed through his classes! www.thieme-connect.de/products/ejo...

New research reports the results of an epigenome-wide association study of enriched neurons from postmortem #Parkinsons brains; Highlights epigenetic regulation of genes related to LRRK2 & endolysosomal sorting, as well as neuroinflammation genes www.nature.com/articles/s41...

Using samples from the Norwegian population-based Trøndelag Health (HUNT) study (11K blood samples of participants >58 years of age); 33% exhibited #Alzheimers neuropath. changes, with 10% classified as preclinical AD, 10% as prodromal AD & 9% as dementia www.nature.com/articles/s41...

Interesting: Cross-sectional plasma concentrations of UCH-L1 & NfL over the human lifespan become exponentially higher starting from childhood, especially in females, & halted in #Alzheimers by GM-CSF treatment; GFAP goes exponentially higher after age 40 www.cell.com/cell-reports...

New paper reports Helicobacter pylori infection & #Parkinsons -associated α-synuclein pathology drive parallel neurodegen. pathways in the substantia nigra; H. pylori infection doesn't exacerbate α-synucleinopathy link.springer.com/article/10.1...

"#Alzheimers (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD" - where are the editors on this stuff??? P7C3-A20 (NAMPT activator) restores NAD+ homeostasis in AD mice www.cell.com/cell-reports...

By reanalyzing single-nucleus RNA sequencing data from postmortem #Parkinsons brains, researchers identified a border-associated macrophages subset expressing CD169 that was significantly⬇️in patients (vs controls) www.frontiersin.org/journals/neu...

"A phased therapeutic roadmap: GLP-1RA monotherapy for pre-symptomatic prophylaxis, combination therapy with anti-Aβ immunotherapies in the early symptomatic stages, & GLP-1RA-driven maintenance after plaque clearance to preserve brain homeostasis" academic.oup.com/lifemedi/art...

The COPPADIS Study Group report that cognitive function in #Parkinsons is influenced by the level of education link.springer.com/article/10.1...

A large review of case reports, case series, & clinicopathological cohorts published between 1990 & 2024 finds #Parkinsons -associated Lewy body pathology is not universally present in genetic variant-associted PD, particularly in LRRK2 & PARKIN mutations link.springer.com/article/10.1...

Researchers examined the associations of Lewy bodies, nigral neuronal loss, & co-pathologies with cogn. decline in 1717 elderly brains without clinical #Parkinsons during life; "Synucleinopathies in older adults without clinical PD may be underestimated" link.springer.com/article/10.1...

How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...

Researchers report the #Parkinsons -associated LRRK2 P1446L mutation triggers dopaminergic neurodegeneration, via DAPK1-mediated microglial neuroinflammation & neuronal apoptosis; DAPK1 inhibition as a promising therapeutic strategy? www.nature.com/articles/s41...

New research explores immune & metabolic signatures that characterise constipation-driven endophenotypes in #Parkinsons; 2 PD endophenotypes identified by gastro symptoms & T cell phenotypes associated with gut- & brain-tropism www.nature.com/articles/s41...

Using DNA from 940 Vietnamese leprosy cases, researchers identify shared biological processes involving excessive inflammatory responses in leprosy with known #Parkinsons-linked genes. www.nature.com/articles/s41...

Researchers propose that cyclin-dependent kinase 3 (CDK3) is a key driver of neurodegen. in #Alzheimers; It is⬆️in human AD brains & correlates with disease severity; An inhibitor of CDK3, BMX330, rescued neuronal death & cognitive decline in AD mice www.nature.com/articles/s43...

Cognition Therapeutics publishes the results of their 26 week multi-center, double-blind, placebo-controlled, parallel-design Phase 2a trial of two doses of zervimesine (CT1812) in 130 participants with mild-to-moderate dementia with Lewy bodies alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

An electronic health record–based cohort study finds obstructive sleep apnea appears to be an independent risk factor for the later development of #Parkinsons, but this risk could be modified by early treatment with continuous positive airway pressure jamanetwork.com/journals/jam...

New research reports that the #Parkinsons -associated gene FAM49B is critically expressed in microglia of the human substantia nigra pars compacta & it is downregulated with age & PD (associated with⬆️microglial activation) www.nature.com/articles/s41...

New perspective summarizes data supporting the use of glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative diseases, with a focus on #Alzheimers (but #Parkinsons also gets a mention) www.nature.com/articles/s43...

Using data from the UK Biobank, researchers report "distinct neuroprotective profiles for Omega-3 & Omega-6 fatty acids in neurodegenerative disorders"; Higher Omega-6 level at baseline were associated with a⬇️risk of incident #Parkinsons (HR=0.76) www.prd-journal.com/article/S135...

Researchers investigated the genetic landscape of #Parkinsons on the island of Crete, using DNA from 360 PD patients & 251 controls; About 10.3% of patients carried a GBA1 variant - substantially higher than on the Greek mainland www.nature.com/articles/s41...

#Parkinsons on a chip! A microfluidic model replicates neuroinflammation-induced neurodegeneration of PD; polydopamine nanoparticles serve as a stimulator of neuroinflammation; New drug screening tool for anti-neuroinflammatory agents www.cell.com/cell-biomate...

New research reports that GPNMB is secreted in response to lysosomal stress via lysosomal exocytosis & highlights the #Parkinsons disease risk factor LRRK2 as a strong modulator of GPNMB secretion; A biomarker of lysosomal stress? www.science.org/doi/10.1126/...

New research explores the impact of aging on the central & enteric nervous system in a #Parkinsons mouse model (MPTP); Results hint that immunosenescence in the gastrointestinal tract could potentially contribute to the development & progression of PD www.frontiersin.org/journals/agi...

Researchers present scMORE (single-cell MultiOmics Regulon Enrichment), a network-based polygenic enrichment method that integrates single-cell multiomics & GWAS data to identify cell type-specific eRegulons relevant to complex diseases www.nature.com/articles/s43...

Could phosphorylated ubiquitin in cerebrospinal fluid be used as a clinical biomarker for mitochondrial damage in #Parkinsons? New research indicate that pS65-Ub shows promise www.aginganddisease.org/EN/10.14336/...

As an audiobook addict, I have been looking forward to this for a long time! As a thank you to all of our incredible supporters at the end of our 20th anniversary year, @cureparkinsons.org.uk brings you an audiobook journey of where it all began...

"Dundee has received international recognition after becoming one of the first places in the world to launch a major phase 3 clinical trial for a potential new treatment for #Parkinsons The Roche PARAISO study of Prasinezumab in 900 people has begun! www.dundeeculture.com/post/dundee-...

New research finds #Parkinsons-associated familial mutations in α-synuclein uniquely alter the proteins interactions with lipid bilayers, resulting in an altered rate of protein aggregation in the presence of lipid bilayers febs.onlinelibrary.wiley.com/doi/10.1111/...