Interesting - new data "provides a detailed evaluation of the relationship between human leukocyte antigen alleles & Lewy body disease pathology" highlighting the importance of immune-related genetic factors in etiology onlinelibrary.wiley.com/doi/10.1002/...

More real world data (214K matched individuals with a multinational representation) finds people living with T2 diabetes who initiate GLP-1 R agonists (vs DPP4i or basal insulin) have a lower risk of new-onset neurodegeneration ( #Parkinsons data is muddy) cardiab.biomedcentral.com/articles/10....

New research from BioArctic shows that their monoclonal antibody Exidavnemab binds to aggregated α-synuclein in human brains affected by α-synucleinopathies (including #Parkinsons) www.neurotherapeuticsjournal.org/article/S187...

A systematic review & meta-analysis of table tennis finds it to be "a safe, feasible, & effective non-pharmacological intervention for enhancing cognitive & motor outcomes in individuals" with #Alzheimers & #Parkinsons www.sciencedirect.com/science/arti...

Researchers profile extracellular vesicles (EV) proteomes & lipidomes from plasma across life, & identify both age-independent & age-dependent EV-based biomarkers predictive of prodromal #Parkinsons - also distinguishing PD from multiple system atrophy www.cell.com/cell-reports...

Gain Therapeutics publish their glucocerebrosidase target engagement & therapeutic plasma & cerebrospinal fluid levels data from their Phase 1 clinical testing of GT-02287 (their allosteric GCase enzyme modulator) in 73 healthy volunteers movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Really looking forward to presenting at the @neurologyacademy.bsky.social Cutting Edge Science for #Parkinsons clinicians event in Sheffield on the 26th Nov - Lots of really impressive speakers!

Synthetic α-synuclein fibrils replicate in mice causing Multiple-system atrophy-like path. Researchers report hi-res. structural analyses of synthetic α-synuclein fibrils (1B fibrils) that developed glial cytoplasmic inclusions in vivo www.nature.com/articles/s41...

A really nice piece from @aucklanduni.bsky.social on Prof Sir Richard Faull - I worked in his labs a lifetime ago, and much of his positivity that comes through this story still resonates with me. Shame to see him stepping away, but what an amazing legacy! stories.auckland.ac.nz/sir-richard-...

People of the United Kingdom! Support the Movers & Shakers with their parliamentary debate! Write to your local MP using the template that the team have provided you, & get them focused on #Parkinsons matters! www.moversandshakerspodcast.com/post/write-t...

New review evaluated the role of digital health technologies as outcome tools in pharmacological trials for #Parkinsons; 42 studies were included, covering 26 distinct DHTs (11 wearable sensors & 15 nonwearable systems); Only Opal=Level 1a movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Researchers analyse adverse events (AE) reported for Catechol-O-MethylTransferase (COMT) inhibitors used in #Parkinsons treatment using data from the FDA Adverse Event Reporting System (FAERS - 2018 to 2023); Entacapone appears to be the safest link.springer.com/article/10.1...

A useful review of the wonderful world of induced proximity-based therapeutic modalities (Arvinas' LRRK2-targeting PROTAC ARV-102 - which is being developed for #Parkinsons - gets a mention) www.nature.com/articles/s41...

New research reports that mitochondrial localization in the developing proximal tubule depends on the activity of #Parkinsons-associated LRRK2 www.nature.com/articles/s41...

Could soft magnetoelastic balls represent a quantitative diagnostic tool for #Parkinsons? The ball "converts movements into magnetic fields, & magnetic induction, which transforms the magnetic fields into measurable electrical signals" www.cell.com/cell-biomate...

Continuous delivery: Oral administration (with benserazide) of bioengineered gut bacterium producing L-DOPA maintains therapeutic plasma L-DOPA concentrations &⬆️CNS dopamine levels while transiently residing in the gut; Improves mouse model of #Parkinsons www.cell.com/cell-host-mi...

Investigating localization of αSyn proteoforms, researchers report lysosomal αSyn was detected solely by targeting the N-terminus or the NAC domain, & not with antibodies targeting Serine 129-PαSyn or other epitopes at the C-terminus molecularneurodegeneration.biomedcentral.com/articles/10....

New clinical trial registered: Medtronic have initiated the Adaptive DBS Algorithm for Personalized therapy in #Parkinsons (ADAPT-PD) China study; They will be recruiting 62 participants clinicaltrials.gov/study/NCT072...

New clinical trial registered: The study will investigate the use of ultra-low, anti-inflammatory doses of radiation therapy for the treatment of #Parkinsons; N=20 by invitation clinicaltrials.gov/study/NCT072...

A study investigating the role of irisin in an MPTP-induced mouse model of #Parkinsons finds it inhibits dopaminergic neuron lactate metabolism & repairs mitochondrial function by activating SIRT1 signaling pathway www.nature.com/articles/s42...

New paper presents "BrainSTEM" (Brain Single-cell Two tiEr Mapping): A single-cell multiresolution fetal brain atlas reveals transcriptomic fidelity of human midbrain cultures www.science.org/doi/10.1126/...

Using cryo-ET, researchers show that both normal human LRRK2 & #Parkinsons -associated LRRK2 mutants can oligomerize on microtubules in their autoinhibited states; The new interface involves N-terminal repeats that were disordered in the active-LRRK2 elifesciences.org/articles/100...

New research indicates that high household exposure to herbicides & other pesticides may increase the risk of developing #Parkinsons & lead to an earlier onset of the disease link.springer.com/article/10.1...

New clinical trial registered: Belief BioMed initiate Phase 1 testing of BBM-P002 (AAV-based gene therapy "to deliver genes that are crucial for dopamine production") in 18 people with #Parkinsons clinicaltrials.gov/study/NCT071...

New clinical trial registered: iCamuno Biotherapeutics initiates Phase 1 testing of their allogenic induced pluripotent stem cell-derived dopamine progenitor cells (iPSC-DAPs) in 12 people with #Parkinsons clinicaltrials.gov/study/NCT072...

New clinical trial registered: The Edmond J. Safra Accelerating Clinical Trials in #Parkinsons Disease: A Multi-arm Multi-stage Platform Trial (EJS ACT-PD) - largest clinical trial for PD ever in the UK! Check it out: clinicaltrials.gov/study/NCT072...

Using normative modeling, researchers quantified individual trajectories of progressive neurodegen. in 408 #Parkinsons cases (42%♀️) against 58K controls; Longitudinal atrophy patterns were associated with changes in clinical features www.nature.com/articles/s41...

"Phase 2 futility trials using the Simon 2-stage design offer an efficient strategy to evaluate candidate treatments in an early #Parkinsons population"; Researchers assess the feasibility of this idea using historical clinical trial datasets movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

"Recent evidence indicates a marked downregulation of circulating D- & L-amino acids involved in regulating glutamatergic NMDAR function in #Parkinsons" And STN-DBS normalizes the blood concentrations of these amino acids to those observed in controls (?) www.sciencedirect.com/science/arti...

A PLAN to address the #Parkinsons pandemic from Ray Dorsey @michaelokun.bsky.social & Bas Bloem: (1) Prevents the disease (2) Learns why it starts (3) Amplifies the voices of persons with the disease & their caregivers (4) Navigates the frontier of new treatments journals.sagepub.com/doi/10.1177/...

Researchers report that dysregulation of mitochondria-associated genes & hyperactive striatal mitochondria are induced by the microbiome in α-synuclein- #Parkinsons (Thy1-ASO) mouse model; Treatment with N-Acetyl cysteine (NAC) ameliorates motor deficits www.nature.com/articles/s41...

I don't give opinions on much here, but I am becoming concerned about the cell therapy field Unixell Biotech press release 1st patient data in an ongoing phase 1 open-label dose-escalation trial (NCT06778265): 21 points in the OFF state after 3 months???? www.neurologylive.com/view/early-r...

Two tech companies (Indivi & Clouds of Care) form a collaboration with the goal of leveraging precision medicine tools to boost the early phase of treatments targeting neurodegenerative diseases like #Alzheimers & #Parkinsons www.fiercebiotech.com/medtech/pair...

It's only Monday & I have my weekend reading: An expert panel from the COST Action IMMUPARKNET (CA21117) provide guidance recommendations for conducting optimal immune profiling in #Parkinsons www.nature.com/articles/s41...

New review looks at mechanistic insights & therapeutic opportunities in glycosylation research into neurodegenerative conditions; Section 4.2 briefly summarises the role of glycosylation in #Parkinsons; faseb.onlinelibrary.wiley.com/doi/10.1096/...

New review looks at recent evidence, risks, & prevention opportunities in terms of environmental toxicants & their influence/impact on #Parkinsons www.thelancet.com/journals/lan...

New review on the role of lifestyle interventions in symptom management & disease modification in #Parkinsons; "Integrating lifestyle modifications into routine care offers a promising, accessible avenue to improve quality of life" www.thelancet.com/journals/lan...

Korean biotech company Glaceum has published preclinical data demonstrating the neurotherapeutic effects of Vutiglabridin (a Paraoxonase-2 modulator) in preclinical models of #Parkinsons, via reduced reactive oxygen species (ROS) levels molecularneurodegeneration.biomedcentral.com/articles/10....

Scientists report the #Parkinsons "pathophysiology is associated with imbalanced excitatory & inhibitory neuronal responses & a slower response in the primary motor cortex during movement execution" www.pnas.org/doi/10.1073/...

Researchers propose that "inhibition of the subthalamic nucleus, caused by differential depression of glutamatergic & GABAergic synapses, is a key mechanism of therapeutic deep brain stimulation" www.nature.com/articles/s41...

New research reports that host GBA1 genotype does not impact gut microbiome structure & composition in the presented GBA1L444P/WT mouse model www.frontiersin.org/journals/neu...

Deep phenotyping of the RAB32 p.Ser71Arg variant in 11 cases of monogenic #Parkinsons "underscores the importance of carefully assessing non-motor symptoms in this newly described form of PD" movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

New research finds that enhancing nucleotide metabolism could improve DNA repair & serve as an adjunct therapy to delay #Alzheimers progression; MR reveals⬆️DGUOK expression is linked to a lower risk of developing AD www.nature.com/articles/s41...

A cross-sectional Rasch model was applied to PPMI untreated #Parkinsons cohort data (N = 423) finds a sub-score of 15 MDS-UPDRS Part III items focusing on limb-related bradykinesia & rigidity demonstrated good measurement properties in early-stage PD www.nature.com/articles/s41...

"The presence of GBA1 variants did not exert a detrimental effect on axial signs in #Parkinsons patients up to 5 years following STN-DBS, supporting its consideration as a valid therapeutic option in this genetic subgroup" www.nature.com/articles/s41...

New paper finds L-Dopa unexpectedly alters the postsynaptic architecture of cultured mouse neurons through its incorporation into α-tubulin via tubulin tyrosine ligase; A novel mechanism of L-Dopa-induced synaptotoxicity? www.nature.com/articles/s41...

Researchers report distinct cutaneous α-synuclein signatures in body-first & brain-first #Parkinsons subtypes; Using samples from 126 brain-first PD patients, 79 body-first PD patients, & 60 healthy controls academic.oup.com/brain/advanc...

Individuals diagnosed with #Parkinsons & mild cognitive impairment (MCI) who exhibit cholinergic nucleus 4 degeneration may represent a distinct, clinically severe PD-MCI subtype with faster progression www.prd-journal.com/article/S135...

New research presents a novel AI-enabled Quantum Refinement ("AQuaRef") based on AIMNet2 machine learned interatomic potential mimicking quantum mechanical at substantially lower computational costs; #Parkinsons -associated DJ-1 is used as a case study www.nature.com/articles/s41...

Amazing! New paper presents a cryo electron tomography workflow to visualize lysosomal membrane proteins within intact, native lysosomal membranes; "Establishes a powerful platform for studying lysosomal membrane protein function in health & disease" www.nature.com/articles/s41...