Alexei Maklakov
@alexeimaklakov.bsky.social
š¤ 941
š„ 510
š 77
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
reposted by
Alexei Maklakov
Sendoel Lab
6 days ago
Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at
@cp-molcell.bsky.social
. Fantastic work by
@claradure.bsky.social
and all co-authors involved.
www.cell.com/molecular-ce...
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In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging
In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, lin...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00271-6
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Alexei Maklakov
The Cecere Laboratory
6 days ago
Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation.
rdcu.be/fj8Er
#Epigenetics
#microRNA
#Inheritance
@pasteur.fr
@devstempasteur.bsky.social
@erc.europa.eu
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Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology
In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...
https://www.nature.com/articles/s41594-026-01816-5
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Alexei Maklakov
Nature
14 days ago
An antiviral pill has, for the first time, been shown to prevent COVID-19 in people exposed to the SARS-CoV-2 virus
go.nature.com/3P50GXD
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At last, a pill that can prevent COVID after exposure to infected people
Drug arrives years after pandemicās peak, but could still offer critical protection to vulnerable populations.
https://go.nature.com/3P50GXD
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Alexei Maklakov
Aging Science News
16 days ago
Evolutionary genetics of ageing
www.nature.com/articles/s41...
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Evolutionary genetics of ageing - Nature Reviews Genetics
Modern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary geneti...
https://www.nature.com/articles/s41576-026-00959-x
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Alexei Maklakov
Karen S Wilcox, PhD (she/her)
16 days ago
Gift link because this is important stuff. Pancreatic cancer is horrific and breakthroughs in treatment need to be shared around. Also, science.
#PancreaticCancer
Explore this gift article from The New York Times. You can read it for free without a subscription.
www.nytimes.com/2026/05/12/h...
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How an āImpossibleā Idea Led to a Pancreatic Cancer Breakthrough
https://www.nytimes.com/2026/05/12/health/pancreatic-cancer-daraxonrasib-kras.html?unlocked_article_code=1.h1A.e-NF.LBCrRsf40-8a&smid=bs-share
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reposted by
Alexei Maklakov
PLOS Biology
16 days ago
Aging can reshape the immune systems of men and women in unique, sex-specific ways.
@bbparis1984.bsky.social
&co argue that accounting for both sex and age is essential to advance personalized medicine. š§Ŗ
#aging
#immunity
#SexDifferencesDay
#WomensHealthWeek
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The problem with one-size-fits-all medicine: Biological sex and the aging immune system
Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken intoā¦
https://plos.io/4wkqdgd
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Alexei Maklakov
David Berger
16 days ago
Still 10 days left to apply - Come join us in Uppsala! Fully funded Phd position in Evolutionary Biology. Deadline 22nd of May.
add a skeleton here at some point
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Alexei Maklakov
European Research Council (ERC)
29 days ago
NEWS: The ERC Scientific Council has listened to the concerns from members of the research community about changes to the re-submission rules, intended to manage the surge in demand for grants. The Scientific Council will readjust some of the changes:
link.europa.eu/TBqRQJ
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ERC Scientific Council readjusts rules for reapplication
The ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules. The changes, intended to manage the ...
https://link.europa.eu/TBqRQJ
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Alexei Maklakov
Ben Auxier
30 days ago
The red line in Figure 6B (% of 6-authors papers in all IEEE proceedings) is unreal
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Alexei Maklakov
Mozes Blom
about 1 month ago
šØ Wanted: PhD student excited about population genomics, Natural History Collections and birds! š Museum für Naturkunde, Berlin, Germany š 3 Years, funded by the Leibniz Junior Researchgroup program Details and Application portal š
jobs.museumfuernaturkunde.berlin/jobposting/d...
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12/2026 PhD student (f/m/d)
https://jobs.museumfuernaturkunde.berlin/jobposting/d336fa105b57b451e0f2f310c4b961d478f4805a0
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Alexei Maklakov
Eric Topol
about 1 month ago
This NYT magazine article on longevity science, reversing aging with cellular reprogramming, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing cancer. gift link
www.nytimes.com/2026/04/27/m...
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reposted by
Alexei Maklakov
Aging Science News
about 1 month ago
Sex differences in response to longevity interventions
www.sciencedirect.com/science/arti...
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Sex differences in response to longevity interventions
Interventions to extend lifespan and healthspan are of major interest, but such interventions may affect male and female organisms differently. Whetheā¦
https://www.sciencedirect.com/science/article/pii/S1568163726001157
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reposted by
Alexei Maklakov
Emily Mullin
about 1 month ago
NEW: A biotech startup says it has grown functional human sperm in a lab and successfully fertilized eggs with it. The technique could eventually help men with certain types of infertility have biological children.
@wired.com
is the first to report this advance:
www.wired.com/story/startu...
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A Startup Says It Grew Human Sperm in a Labāand Used It to Make Embryos
Paterna Biosciences says it has determined the set of instructions needed to turn sperm-making stem cells into "normal, mature" sperm.
https://www.wired.com/story/startup-says-it-grew-human-sperm-in-a-lab-and-used-it-to-make-embryos/
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doi.org/10.1038/s415...
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Dynamics of genetic and somatic trade-offs in ageing and mortality - Nature
Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that influence lifespan and mortality with divergent age-...
https://doi.org/10.1038/s41586-026-10407-9
about 1 month ago
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Alexei Maklakov
Aging Science News
about 1 month ago
Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes
link.springer.com/article/10.1...
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Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes - BMC Biology
Background Despite the extraordinary diversity in mammalian lifespans, the evolutionary trajectories and underlying molecular mechanisms governing this variation remain largely uncharacterized. Result...
https://link.springer.com/article/10.1186/s12915-026-02599-3
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Alexei Maklakov
PLOS Biology
about 1 month ago
Could the
#ribosome
be a selfish element?
@mkrupovic.bsky.social
& Eugene Koonin propose that the
#evolution
of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cellās resources. š§Ŗ
#OriginsOfLife
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The selfish ribosome
In this Essay, the evolution of life is construed as a ribosomal takeover, whereby the ribosome evolved to consume most of the cellās resources, while other cellular componentry ensured theā¦
https://plos.io/3OPZszf
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rdcu.be/feEOy
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Ancient DNA reveals pervasive directional selection across West Eurasia
Nature - Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than...
https://rdcu.be/feEOy
about 1 month ago
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Alexei Maklakov
Nature
about 1 month ago
Most of the individuals in a seventeenth-century-Switzerland burial site had performed strenuous manual labour and died before the age of 20
go.nature.com/4tTj2tg
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Graves reveal plagueās inequitable toll
Most of the individuals in a seventeenth-century-Switzerland burial site had performed strenuous manual labour and died before the age of 20.
https://go.nature.com/4tTj2tg
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Alexei Maklakov
Nature Portfolio
about 1 month ago
An analysis in Nature Aging identifies sex-specific changes in inflammation, autoimmunity and disease risk over the adult lifespan, with more widespread age-related immune remodeling in females.
go.nature.com/4mwYVyJ
#medsky
š§Ŗ
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reposted by
Alexei Maklakov
Inigo Martincorena
about 1 month ago
Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n]
rdcu.be/fdqbr
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Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
https://rdcu.be/fdqbr
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reposted by
Alexei Maklakov
Dominique Baker
about 1 month ago
"More than 100,000 people are expected to benefit in the scheme's first year alone, according to the British government, which negotiated to contribute £570 million towards the scheme's costs in 2027."
www.lemonde.fr/en/internati...
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UK signs deal to rejoin EU's Erasmus student exchange program
More than 100,000 students are expected to benefit in the scheme's first year alone, according to the British government, which negotiated to contribute £570 million towards the scheme's costs in 2027...
https://www.lemonde.fr/en/international/article/2026/04/15/uk-signs-deal-to-rejoin-eu-s-erasmus-student-exchange-program_6752466_4.html
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Excellent paper with very clear and important results - selection on relative egg size (maternal investement) reduces lifespan and accelerates ageing in females.
add a skeleton here at some point
about 1 month ago
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Alexei Maklakov
EU Science, Research & Innovation
about 2 months ago
ā¬399M in EU funding is available to support around 1,600 researchers in their postdoctoral journey. You can choose your path: š§Ŗ European fellowships: 12-24 months in Europe š§Ŗ Global fellowships: 12-24 months abroad + return Deadline: 9 September (17:00 CEST) More info:
link.europa.eu/t6jYb3
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Alexei Maklakov
David Berger
about 1 month ago
PhD-position ALERT! š§ŖšŖ² 𧬠Interested in studying the genomics of local adaptation and niche breadth using long-term experimental evolution? Come join me and
@gmkov.bsky.social
at
@animecol-uu.bsky.social
, Uppsala Univ. Read more and apply here:
uu.varbi.com/en/what:job/...
Deadline 22nd of May!
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Alexei Maklakov
Euan Angus Young
about 1 month ago
New preprint looking at the associations between maternal mortality and having sons in preindustrial Finland from work with León van Dorp during his masterās project. Also with Mirkka Lahdenpera,
@lummaalab.bsky.social
, and
@hannahdugdale.bsky.social
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Alexei Maklakov
European Commission
about 2 months ago
Big opportunities for researchers š We are investing nearly ā¬400 million to help researchers share their work and collaborate with the best scientific teams across the EU. The 2026 Marie SkÅodowska-Curie Actions Postdoctoral Fellowships are now open. More:
link.europa.eu/PNxpxw
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Alexei Maklakov
Gavin Woodruff
about 1 month ago
Caenorhabditis elegans populations shape their microbial environment
www.nature.com/articles/s41...
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Caenorhabditis elegans populations shape their microbial environment - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Caenorhabditis elegans populations shape their microbial environment
https://www.nature.com/articles/s41522-026-00975-z
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Alexei Maklakov
Nature
about 2 months ago
This researcher created a fictional illness, and fake studies funded by the Professor Sideshow Bob Foundation and University of the Fellowship of the Ring and the Galactic Triad. LLMs warned people the illness was real.
go.nature.com/48mAyh9
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Scientists invented a fake disease. AI told people it was real
Bixonimania doesnāt exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?
https://go.nature.com/48mAyh9
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Alexei Maklakov
British Society for Research on Ageing
about 2 months ago
For our 75th annual meeting we are pleased to announce an additional grant call for Travel Grants to attend our 75th ASM in Oxford from 9-11 September. CALL NOW OPEN. Closing date 1st May 2026
bsra.org.uk/2026_travel_...
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Alexei Maklakov
British Society for Research on Ageing
2 months ago
šØ
#BSRA2026
is LIVE! Registration now open for our 75th Annual Meeting š Oxford (Keble College) Great science, great people, and some special 75th year surprises š Tag someone who should be there! š
meetinghand.com/e/75th-asm-o...
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Alexei Maklakov
Life Science Alliance
2 months ago
Using EMS mutagenesis, authors generated & sequenced 12,069 viable C. elegans strains, identifying 541,102 missense mutations. They developed TaoChongBao, an open-access database integrating mutation data, greatly expanding functional variant resources.
www.life-science-alliance.org/content/9/6/...
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Alexei Maklakov
Anders Bergstrƶm
2 months ago
Out today is our paper 'Genomic history of early dogs in Europe', in which we uncover the identity of the dogs that lived in Europe before agricultureāduring the Paleolithic & Mesolithic periods:
doi.org/10.1038/s415...
. A thread ā¬ļø (10)
@biouea.bsky.social
@crick.ac.uk
@mpi-eva-leipzig.bsky.social
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Alexei Maklakov
Dario Riccardo Valenzano
2 months ago
Aging killifish show systemic inflammation and accumulating DNA damage in progenitor-like immune cells, offering a window into the evolutionarily conserved mechanisms of vertebrate immune aging. Great work from Gabriele,
@mdonertas.bsky.social
, and the whole team.
www.nature.com/articles/s43...
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Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish - Nature Aging
Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...
https://www.nature.com/articles/s43587-026-01086-2
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Alexei Maklakov
Ed Ivimey-Cook
2 months ago
Massive thanks to
@danielwanoble.bsky.social
and
@gwendeconninck.bsky.social
for some awesome quality of life additions to metRscreen (a shiny app for paper screening in R). Now updated:
github.com/EIvimeyCook/...
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GitHub - EIvimeyCook/metRscreen: The metRscreen shiny app - screening for meta-analysis and systematic reviews in R
The metRscreen shiny app - screening for meta-analysis and systematic reviews in R - EIvimeyCook/metRscreen
https://github.com/EIvimeyCook/metRscreen
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jjffh.com/tribute/deta...
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Robert Trivers Obituary | John J. Fox Funeral Home Inc | Larchmont, NY
View Robert Trivers's complete obituary, share memories, and explore 11 tribute posts from the community.
https://jjffh.com/tribute/details/1239/Robert-Trivers
2 months ago
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Alexei Maklakov
Daniel Promislow
2 months ago
Happy to share our new paper from the
#dogagingproject
.
academic.oup.com/biomedgeront...
It turns out that metabolite predictors of mortality in dogs overlap significantly with those in humans.
@smacklab.bsky.social
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Dogs and humans share biomarkers of mortality
Abstract. There is growing interest in the use of molecular features as predictors of age, age-related disease risk and mortality. A major shortcoming of t
https://academic.oup.com/biomedgerontology/article/81/4/glaf279/8402140
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journals.plos.org/plosbiology/...
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Translocation of bacteria from the gut to the brain in mice
Recent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial transloc...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003652
3 months ago
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Impacts of parental age and inbreeding on fitness in a wild insect
Parental age and inbreeding have substantial fitness effects in animals both in nature and lab conditions, and can change with temperature, but how these factors affect fitness in insects remain uncle...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003713
3 months ago
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Alexei Maklakov
UNSW Biological, Earth and Environmental Sciences
3 months ago
Our tribute to colleague Emma Johnston - published in Nature Ecology and Evolution
@natecoevo.nature.com
www.nature.com/articles/s41...
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Emma Johnston (1973ā2025) - Nature Ecology & Evolution
Innovative marine ecologist, passionate science communicator and visionary leader in higher education.
https://www.nature.com/articles/s41559-026-03018-0
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Alexei Maklakov
UEA Biological Sciences
3 months ago
TODAY! We are looking forward to welcoming Dr Jennifer Frost, King's College London to the BIO Open Lecture on Wednesday 11th March, 2-3pm, EFRY 01.08. Talk title "The role of transposable elements in pregnancy complications". Hosted by Prof. David Monk. All welcome
#BioOpenLectures
#UEAScience
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Alexei Maklakov
Jordy F. Botello
3 months ago
Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)
www.biorxiv.org/content/10.6...
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It was great to host
@jpsenescence.bsky.social
over a couple of days
@biouea.bsky.social
, great seminar on the new approaches to the old problem of ageing )
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3 months ago
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Great Revolution at
@animecol-uu.bsky.social
: thank you for inviting me, fun to be on the other side of the barricades this time š
add a skeleton here at some point
3 months ago
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Alexei Maklakov
Bjƶrn Schumacher
4 months ago
Do natural substances from blueberries and blue grapes protect nerve cells from aging?A
www.bionity.com/en/news/1188...
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Do natural substances from blueberries and blue grapes protect nerve cells from aging?
Using an aging clock, researchers from the University of Cologne have used the Caenorhabditis elegans model organism to demonstrate that nerve cells age differently. They identified both the cause ...
https://www.bionity.com/en/news/1188022/do-natural-substances-from-blueberries-and-blue-grapes-protect-nerve-cells-from-aging.html
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Alexei Maklakov
Richard Jones
4 months ago
The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding. My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
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UK science policy in transition ā Soft Machines, by Richard Jones
https://softmachines.org/?p=3252
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Alexei Maklakov
Bjƶrn Schumacher
4 months ago
š§ ā°our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration
@cecad.bsky.social
@unicologne.bsky.social
@uniklinikkoeln.bsky.social
@meyerdh.bsky.social
www.nature.com/articles/s43...
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Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
https://www.nature.com/articles/s43587-026-01067-5
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Alexei Maklakov
Barbara Tschirren
4 months ago
How does pre- and post-natal environmental stress affect the seminal foam proteome of Japanese quail? Find out here, Chloe Masonās second PhD thesis paper:
onlinelibrary.wiley.com/doi/10.1111/...
@martingarlovsky.bsky.social
@oscarvedder.bsky.social
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Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird
Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early-life developmental stress. Japanese quail C...
https://onlinelibrary.wiley.com/doi/10.1111/mec.70257
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Alexei Maklakov
Sean Carroll
4 months ago
The bots populating Moltbook apparently all come to sound like a familiar kind of internet denizen with delusions of philosophical grandeur. Manifestos and declarations all over the place.
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Alexei Maklakov
Waggoner Lab
4 months ago
DNA-protein cross-links promote cGAS-STINGādriven premature aging and embryonic lethality
www.science.org/doi/10.1126/...
@science.org
@idikic.bsky.social
@goetheuni.bsky.social
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Alexei Maklakov
Eric Topol
4 months ago
The largest randomized trial of medical A.I. āOver 100,000 women in Sweden āradiologist + AI vs 2 radiologists, in follow-up āAI added led to 29% more cancer detected, 44% reduced workload, and āLess cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
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