Alexei Maklakov
@alexeimaklakov.bsky.social
📤 904
📥 500
📝 66
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
reposted by
Alexei Maklakov
UEA Biological Sciences
2 days ago
Merry Christmas, Happy Holidays and a Peaceful New Year from everyone in the School of Biological Sciences. Have a wonderful break. 🎄🥳
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Eric Topol
5 days ago
The one validated intervention to slow aging and extend healthspan is not for sale. It's exercise.
sciencedirect.com/science/arti...
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Excellent news!!!
add a skeleton here at some point
8 days ago
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Nick Stroustrup
9 days ago
What tools do we need to start engineering
#aging
and
#longevity
? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the
@crg.eu
: technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
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Philip Leftwich
10 days ago
Please share 📢 We have a Postdoc position available here
@uniofeastanglia.bsky.social
to develop innovative genetic control strategies for insect agricultural pests in collaboration with
@imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...
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Alice Godden
12 days ago
🐻❄️❄️ New paper alert! From me Ben &
@immler.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉
link.springer.com/article/10.1...
A thread 🧵.
#climate
#transposons
#TESky
#polarbear
#ursus
@biouea.bsky.social
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Diverging transposon activity among polar bear sub-populations inhabiting different climate zones - Mobile DNA
Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...
https://link.springer.com/article/10.1186/s13100-025-00387-4
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1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by
@eduxbury.bsky.social
with
@alicegodden.bsky.social
@immler.bsky.social
Johnny de Coriolis Hanne Carlsson
www.biorxiv.org/content/10.6...
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Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
https://www.biorxiv.org/content/10.64898/2025.12.05.692572v1
14 days ago
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Alexei Maklakov
MPI for Biology of Ageing
14 days ago
🚨 Job alert! The Fish Facility is looking for a student/research assistant (m/f/d)! Apply now!
www.age.mpg.de/open-positions
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Björn Schumacher
16 days ago
🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and
@meyerdavid.bsky.social
!
@cecad.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
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Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
https://onlinelibrary.wiley.com/doi/10.1111/acel.70253
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Controlled settings may offer limited insight into the complexities of ageing in natural and variable ecosystems, and why (and how) ageing patterns vary so widely across individuals, populations, and species. We call for more research on ecology of ageing!
onlinelibrary.wiley.com/doi/10.1111/...
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Ecological Perspectives on Aging
Controlled settings may offer limited insight into the complexities of aging in natural and variable ecosystems. Artwork by Zahida Sultanova.
https://onlinelibrary.wiley.com/doi/10.1111/acel.70308
20 days ago
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Asher Cutter
23 days ago
EEB Postdoctoral Fellowship @ U.Toronto app deadline Jan 15 2026. Opportunity for independent research, encourages collab across labs/disciplines. Lots of great folks to interact with, Come join us!
eeb.utoronto.ca/employment-2/
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Employment - Ecology & Evolutionary Biology
https://eeb.utoronto.ca/employment-2/
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David S Richardson
27 days ago
a wonderful, fully funded PhD opportunity Deadline approaching (ok not that quickly but you may forget over Christmas!) 7th January
www.uea.ac.uk/course/phd-d...
add a skeleton here at some point
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Pankaj Kapahi
27 days ago
The Kapahi Lab is looking for two creative, motivated postdocs to join our team. We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
[email protected]
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Alice Godden
29 days ago
Gave a talk at UEA Norwich Med School: “Selfish Elements and Selective Sperm: Impact of Haploid Selection on Zebrafish Fitness.” Part of my broader focus on genomics and fertility/reproduction for all—exploring how genetics shapes reproductive success. Great discussion!
@slicescienceuea.bsky.social
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Vivek Nityananda
30 days ago
Wondering if insects feel pain? Here's our critique of work that looked at this in bees. We were unconvinced of the evidence, and built a model to think through these issues. Their response is published alongside and we'll have a response to that out soon.
www.sciencedirect.com/science/arti...
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Motivational trade-offs as evidence for sentience in bees: a critique
https://www.sciencedirect.com/science/article/pii/S0003347225003161
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Alexei Maklakov
eLife
about 1 month ago
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly/gMbJWcX
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Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
https://buff.ly/gMbJWcX
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Alexei Maklakov
Daniel Promislow
about 1 month ago
We have a new postdoc position available in the Promislow lab at the HNRCA at
#Tufts
in
#Boston
, to work on the
#systemsbiology
of
#aging
in
#Drosophila
. Come join us! For info on the position and to apply, see
promislowlab.org/wp-content/u...
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https://promislowlab.org/wp-content/uploads/2025/11/postdoc_hnrca_2025.pdf
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Alexei Maklakov
Oded Rechavi
about 1 month ago
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas)
www.pnas.org/doi/10.1073/...
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Eric Topol
about 1 month ago
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials
novonordisk.com/content/nnco...
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News Details
https://novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=916462#
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Alexei Maklakov
Eric Topol
about 1 month ago
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.” Genes-> Medicine
nature.com/articles/s41...
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1/6 In a new preprint we ask a question: Why do males and females so often age and die at different rates? We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:
ecoevorxiv.org/repository/v...
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Sex-specific mutation accumulation: A parsimonious explanation for sex differences in lifespan and ageing
https://ecoevorxiv.org/repository/view/10825/
about 1 month ago
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Barbara Tschirren
about 1 month ago
*PhD opportunity
@uniexecec.bsky.social
* How does antimicrobial resistance spread through ecosystems? Combine fieldwork (rodent trapping 🐭, habitat surveys 🌳, pheasant sampling 🦤), molecular techniques, GIS, and spatial modelling to understand AMR evolution and spread. 🔬🦠🧪 Please repost!
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Antimicrobial Resistance (AMR) in Gamebirds: A One Health Approach to Understanding and Mitigating the Risk of AMR Evolution and Spread through Ecosystems at University of Exeter on FindAPhD.com
PhD Project - Antimicrobial Resistance (AMR) in Gamebirds: A One Health Approach to Understanding and Mitigating the Risk of AMR Evolution and Spread through Ecosystems at University of Exeter, list...
https://shorturl.at/dEy1g
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Alexei Maklakov
Euan Angus Young
about 1 month ago
1/13 New paper out!
www.science.org/doi/10.1126/...
Historical records across thousands of women showed that mothers with more children had shorter lifespans during a famine, fitting an evolutionary explanation for why we age
@hannahdugdale.bsky.social
@lummaalab.bsky.social
@erikpostma.bsky.social
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Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments url:
academic.oup.com/evlett/artic...
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Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments
Abstract. Females and males typically differ in lifespan, patterns of ageing, and reproduction. General explanations for variation in the magnitude of this
https://academic.oup.com/evlett/article/doi/10.1093/evlett/qraf041/8317098
about 2 months ago
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Nick Stroustrup
about 2 months ago
A detIled account of all the characters involved.
www.nature.com/articles/d41...
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What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
https://www.nature.com/articles/d41586-023-01313-5
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Alexei Maklakov
Oded Rechavi
about 2 months ago
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
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Alexei Maklakov
Oded Rechavi
about 2 months ago
Let's go! Super excited to partner with
@richardsever.bsky.social
and the fantastic
@openrxiv.bsky.social
team - Preprints have been the best thing that happened to science publishing during my lifetime, and we're happy
@qedscience.bsky.social
can make preprints do more 👊
add a skeleton here at some point
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Alexei Maklakov
Oded Rechavi
about 2 months ago
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between
@qedscience.bsky.social
&
@openrxiv.bsky.social
@biorxivpreprint.bsky.social
! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
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1/ Evolutionary trade-offs between intergenerational and transgenerational fitness effects Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other: New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
about 2 months ago
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Gavin Woodruff
about 2 months ago
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
www.biorxiv.org/content/10.1...
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Transposon Regulation in the Caenorhabditis elegans Germline and Soma
Transposons are parasitic nucleic acids present in most genomes. The ability of transposons to mobilize makes them a source of genetic diversity and a threat to genome integrity. Interestingly, mutati...
https://www.biorxiv.org/content/10.1101/2025.10.09.681459v1.abstract
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Alexei Maklakov
Arvid Ågren
about 2 months ago
Very excited for the arrival of Oren Harman’s latest book. Few combine deep knowledge of the history of biology with such compelling writing.
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Alexei Maklakov
Dr Selena Wisnom
about 2 months ago
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
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Eric Topol
about 2 months ago
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity? Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
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Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
https://www.nature.com/articles/s41586-025-09694-5
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Alexei Maklakov
Oded Rechavi
about 2 months ago
Not everybody knows that B.B. King wrote The Thrill Is Gone during the 2nd round of revisions
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Science X / Phys.org
2 months ago
Certain goby fish species remain miniature by overexpressing genes that inhibit growth, a genetic mechanism conserved for over 50 million years and shared across diverse vertebrates.
doi.org/g97pqp
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They might not be giants: The genetics behind why some fish remain tiny
Imagine you are a kind of fish called a goby, part of a huge family of more than 2,000 species. Maybe you're of average size for a goby, about three to four inches long.
https://phys.org/news/2025-10-giants-genetics-fish-tiny.html?utm_source=bsky.app&utm_medium=social&utm_campaign=v2
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Alexei Maklakov
Gabrielle Davidson
3 months ago
📢🚨Please share! We’re hiring! 📢🚨Have a strong interests in wildlife ecology and gut microbiome bioinformatics? 3 year Senior Research Associate for NERC Pushing the Frontiers grant. Apply here:
vacancies.uea.ac.uk/vacancies/18...
. Informal enquiries welcome!
drgldavidson.github.io/ACMEresearch
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Tim Janicke
2 months ago
Does
#SexualSelection
fuel
#Speciation
? Our new
#meta-analysis
of comparative studies finds support for a positive relationship, but the rather moderate global effect suggests it’s not necessarily a dominant force.
doi.org/10.1093/evle...
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Sexual selection and speciation: a meta-analysis of comparative studies
Abstract. Understanding the drivers of biodiversity is a central goal in evolutionary biology. In particular, sexual selection has long been proposed as a
https://doi.org/10.1093/evlett/qraf038
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Nature
2 months ago
A gene that causes obesity is paradoxically linked to a reduced risk of having heart disease and high cholesterol
go.nature.com/4qgX9mz
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This gene causes obesity — and shields against heart disease
Nature - People with certain forms of the MC4R gene have lower cholesterol levels than do other individuals with a high body-mass index.
https://go.nature.com/4qgX9mz
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Gabrielle Davidson
3 months ago
🚨🔊 Fully funded PhD!! 🚨🔊 Are you interested in wildlife gut microbiomes? Love birds, fieldwork and bioinformatics? Want to join a collaborative and supportive team? Looking for training to become an independent scientist? Please apply! Informal enquiries welcome!
www.uea.ac.uk/course/phd-d...
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Björn Schumacher
2 months ago
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
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Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
https://onlinelibrary.wiley.com/doi/10.1111/acel.70253
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Alexei Maklakov
Dom Cram
2 months ago
🚨Fully-funded PhD opportunity in my group🚨 🧬How does parental ageing shape the next generation?🐾 Find out by studying meerkats! 🧪Epigenetic clocks ✨Bioinformatics 📊Long-term data 🌍Kalahari fieldwork 💡Big evolutionary questions Get in touch or APPLY NOW Please share!
www.uea.ac.uk/course/phd-d...
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Karl Grieshop
2 months ago
Please RT! 🚨 4-year PhD position in my lab (Oct 2026 start) 🚨 Molecular and genomic insights to sexually antagonistic genes Application deadline: Dec 2, 2025
biodtp.norwichresearchpark.ac.uk/projects/mol...
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Molecular and genomic insights to sexually antagonistic genes (GRIESHOP_U26DTP) | Doctoral Training Partnership
Why do harmful genes persist in populations instead of being removed by natural selection? One answer lies in sexual antagonism: when a genetic variant benefits males but harms females, or vice versa.
https://biodtp.norwichresearchpark.ac.uk/projects/molecular-and-genomic-insights-to-sexually-antagonistic-genes-grieshop_u26dtp/
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Oded Rechavi
2 months ago
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
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www.science.org/doi/10.1126/...
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A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
https://www.science.org/doi/10.1126/science.adp5056
3 months ago
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Alexei Maklakov
Eric Topol
3 months ago
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
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Naomi Moris
3 months ago
The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍
add a skeleton here at some point
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Jonathan C Slaght
3 months ago
super cool study found human artifacts in Bearded vulture nests, incl. "weaponry like a crossbow bolt and wooden lance, decorated sheep leather, and parts of a slingshot....a shoe made from twigs and grass is ~675-years-old." link to paper:
doi.org/10.1002/ecy....
.
www.popsci.com/environment/...
🧪🌍🦉
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Multi-generational vulture nests hold 700 years of human artifacts
Crossbow bolts, sandals, slingshots, and more.
https://www.popsci.com/environment/bearded-vulture-nest-archaeology/
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Alexei Maklakov
EvolDir
3 months ago
The University of East Anglia seeks a Senior Research Associate in evolutionary ecology of animal behaviour and gut microbiome, with a salary of £38,784 to £46,049. Apply by 31 Oct 2025. Details:
https://www.uea.ac.uk
.
#job
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Find your place at UEA
The University of East Anglia is a home for everyone, a champion of interdisciplinarity that stands for equal opportunity in higher education. Join us at an Open Day.
https://www.uea.ac.uk
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Jay 🦋
3 months ago
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.” ― Jane Goodall 💙 RIP to a real one. My childhood hero
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Alexei Maklakov
UEA Biological Sciences
3 months ago
"Everything is connected. Everyone can make a difference." Rest in peace, Jane Goodall. We are proud to have known you.
#UEAScience
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