Alexei Maklakov
@alexeimaklakov.bsky.social
📤 933
📥 510
📝 74
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
reposted by
Alexei Maklakov
British Society for Research on Ageing
5 days ago
For our 75th annual meeting we are pleased to announce an additional grant call for Travel Grants to attend our 75th ASM in Oxford from 9-11 September. CALL NOW OPEN. Closing date 1st May 2026
bsra.org.uk/2026_travel_...
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Alexei Maklakov
British Society for Research on Ageing
8 days ago
🚨
#BSRA2026
is LIVE! Registration now open for our 75th Annual Meeting 📍 Oxford (Keble College) Great science, great people, and some special 75th year surprises 👀 Tag someone who should be there! 🔗
meetinghand.com/e/75th-asm-o...
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Alexei Maklakov
Life Science Alliance
8 days ago
Using EMS mutagenesis, authors generated & sequenced 12,069 viable C. elegans strains, identifying 541,102 missense mutations. They developed TaoChongBao, an open-access database integrating mutation data, greatly expanding functional variant resources.
www.life-science-alliance.org/content/9/6/...
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Alexei Maklakov
Anders Bergström
10 days ago
Out today is our paper 'Genomic history of early dogs in Europe', in which we uncover the identity of the dogs that lived in Europe before agriculture—during the Paleolithic & Mesolithic periods:
doi.org/10.1038/s415...
. A thread ⬇️ (10)
@biouea.bsky.social
@crick.ac.uk
@mpi-eva-leipzig.bsky.social
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Dario Riccardo Valenzano
14 days ago
Aging killifish show systemic inflammation and accumulating DNA damage in progenitor-like immune cells, offering a window into the evolutionarily conserved mechanisms of vertebrate immune aging. Great work from Gabriele,
@mdonertas.bsky.social
, and the whole team.
www.nature.com/articles/s43...
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Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish - Nature Aging
Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...
https://www.nature.com/articles/s43587-026-01086-2
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Alexei Maklakov
Ed Ivimey-Cook
14 days ago
Massive thanks to
@danielwanoble.bsky.social
and
@gwendeconninck.bsky.social
for some awesome quality of life additions to metRscreen (a shiny app for paper screening in R). Now updated:
github.com/EIvimeyCook/...
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GitHub - EIvimeyCook/metRscreen: The metRscreen shiny app - screening for meta-analysis and systematic reviews in R
The metRscreen shiny app - screening for meta-analysis and systematic reviews in R - EIvimeyCook/metRscreen
https://github.com/EIvimeyCook/metRscreen
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jjffh.com/tribute/deta...
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Robert Trivers Obituary | John J. Fox Funeral Home Inc | Larchmont, NY
View Robert Trivers's complete obituary, share memories, and explore 11 tribute posts from the community.
https://jjffh.com/tribute/details/1239/Robert-Trivers
15 days ago
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Alexei Maklakov
Daniel Promislow
19 days ago
Happy to share our new paper from the
#dogagingproject
.
academic.oup.com/biomedgeront...
It turns out that metabolite predictors of mortality in dogs overlap significantly with those in humans.
@smacklab.bsky.social
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Dogs and humans share biomarkers of mortality
Abstract. There is growing interest in the use of molecular features as predictors of age, age-related disease risk and mortality. A major shortcoming of t
https://academic.oup.com/biomedgerontology/article/81/4/glaf279/8402140
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Translocation of bacteria from the gut to the brain in mice
Recent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial transloc...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003652
23 days ago
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Impacts of parental age and inbreeding on fitness in a wild insect
Parental age and inbreeding have substantial fitness effects in animals both in nature and lab conditions, and can change with temperature, but how these factors affect fitness in insects remain uncle...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003713
23 days ago
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Alexei Maklakov
UNSW Biological, Earth and Environmental Sciences
24 days ago
Our tribute to colleague Emma Johnston - published in Nature Ecology and Evolution
@natecoevo.nature.com
www.nature.com/articles/s41...
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Emma Johnston (1973–2025) - Nature Ecology & Evolution
Innovative marine ecologist, passionate science communicator and visionary leader in higher education.
https://www.nature.com/articles/s41559-026-03018-0
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Alexei Maklakov
UEA Biological Sciences
25 days ago
TODAY! We are looking forward to welcoming Dr Jennifer Frost, King's College London to the BIO Open Lecture on Wednesday 11th March, 2-3pm, EFRY 01.08. Talk title "The role of transposable elements in pregnancy complications". Hosted by Prof. David Monk. All welcome
#BioOpenLectures
#UEAScience
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Alexei Maklakov
Jordy F. Botello
25 days ago
Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)
www.biorxiv.org/content/10.6...
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It was great to host
@jpsenescence.bsky.social
over a couple of days
@biouea.bsky.social
, great seminar on the new approaches to the old problem of ageing )
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about 1 month ago
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Great Revolution at
@animecol-uu.bsky.social
: thank you for inviting me, fun to be on the other side of the barricades this time 😀
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about 2 months ago
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Alexei Maklakov
Björn Schumacher
about 2 months ago
Do natural substances from blueberries and blue grapes protect nerve cells from aging?A
www.bionity.com/en/news/1188...
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Do natural substances from blueberries and blue grapes protect nerve cells from aging?
Using an aging clock, researchers from the University of Cologne have used the Caenorhabditis elegans model organism to demonstrate that nerve cells age differently. They identified both the cause ...
https://www.bionity.com/en/news/1188022/do-natural-substances-from-blueberries-and-blue-grapes-protect-nerve-cells-from-aging.html
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Alexei Maklakov
Richard Jones
about 2 months ago
The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding. My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
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UK science policy in transition – Soft Machines, by Richard Jones
https://softmachines.org/?p=3252
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Björn Schumacher
2 months ago
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration
@cecad.bsky.social
@unicologne.bsky.social
@uniklinikkoeln.bsky.social
@meyerdh.bsky.social
www.nature.com/articles/s43...
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Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
https://www.nature.com/articles/s43587-026-01067-5
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reposted by
Alexei Maklakov
Barbara Tschirren
2 months ago
How does pre- and post-natal environmental stress affect the seminal foam proteome of Japanese quail? Find out here, Chloe Mason’s second PhD thesis paper:
onlinelibrary.wiley.com/doi/10.1111/...
@martingarlovsky.bsky.social
@oscarvedder.bsky.social
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Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird
Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early-life developmental stress. Japanese quail C...
https://onlinelibrary.wiley.com/doi/10.1111/mec.70257
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Alexei Maklakov
Sean Carroll
2 months ago
The bots populating Moltbook apparently all come to sound like a familiar kind of internet denizen with delusions of philosophical grandeur. Manifestos and declarations all over the place.
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reposted by
Alexei Maklakov
Waggoner Lab
2 months ago
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
www.science.org/doi/10.1126/...
@science.org
@idikic.bsky.social
@goetheuni.bsky.social
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Alexei Maklakov
Eric Topol
2 months ago
The largest randomized trial of medical A.I. —Over 100,000 women in Sweden —radiologist + AI vs 2 radiologists, in follow-up —AI added led to 29% more cancer detected, 44% reduced workload, and —Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
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reposted by
Alexei Maklakov
Eric Topol
2 months ago
🆕
@science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
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Alexei Maklakov
Ed Ivimey-Cook
2 months ago
Thanks to some great comments and suggestions, we've updated TADA! Read it here:
ecoevorxiv.org/repository/v...
Transferable, Available, Documented, Annotated.
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Alexei Maklakov
Ed Ivimey-Cook
8 months ago
🎉New preprint! "TADA! Simple guidelines to improve code sharing"
tinyurl.com/8rmnwjrk
We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA! Transferable, Accessible, Documented, Annotated.
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TADA! Simple guidelines to improve code sharing
https://ecoevorxiv.org/repository/view/9806/
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Alexei Maklakov
Javier Apfeld
2 months ago
Friends! I am so happy to share our new preprint! Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago. How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
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Alexei Maklakov
Ed Ivimey-Cook
2 months ago
Just renewed my membership for the 5th year with
@sortee.bsky.social
. A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!
sortee.org/join/
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Join
Join Society for Open, Reliable, and Transparent Ecology and Evolutionary biology (SORTEE)
https://sortee.org/join/
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Alexei Maklakov
Oded Rechavi
2 months ago
Finding an em dash in the rejection email
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Alexei Maklakov
James Lightfoot
2 months ago
Why do some worms graze on bacteria while others hunt and kill? Our study, published today in Nature, reveals how predatory aggression evolved in nematodes. Led by
@gunizgozeeren.bsky.social
and
@leoboeger.bsky.social
across the
@jameslightfoot.bsky.social
and
@monikakscholz.bsky.social
labs.
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Predatory aggression evolved through adaptations to noradrenergic circuits - Nature
Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of comp...
https://www.nature.com/articles/s41586-025-10009-x
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Alexei Maklakov
Nature
3 months ago
Nature research paper: Disease tolerance and infection pathogenesis age-related tradeoffs in mice
go.nature.com/4pBODwV
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Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature
Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.
https://go.nature.com/4pBODwV
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Alexei Maklakov
Natalie Pilakouta
3 months ago
Hot off the press! New paper in Biology Letters (
@royalsocietypublishing.org
) showing that heatwaves impair female but not male fertility in burying beetles 🐞🌡️ Huge congratulations to Izzy (
@izzygrieve.bsky.social
) on her first first-authored paper! 🥳🙌
royalsocietypublishing.org/rsbl/article...
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youtu.be/bAk4PFEuWKQ?...
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Flexible use of a multi-purpose tool by a cow
YouTube video by Antonio Jose Osuna Mascaró
https://youtu.be/bAk4PFEuWKQ?si=pDJF2NWdyk10ok5M
3 months ago
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Jennifer Ouellette
3 months ago
Meet Veronika, the tool-using cow. Veronika uses sticks to scratch herself, using different orientations and motions, an example of multi-purpose tool use. This suggests scientists may have underestimated cows' cognitive abilities.
arstechnica.com/science/2026...
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Meet Veronika, the tool-using cow
Veronika uses sticks to scratch herself, suggesting scientists have underestimated cow cognition...
https://arstechnica.com/science/2026/01/meet-veronika-the-tool-using-cow/
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Alexei Maklakov
Surojit Sural
3 months ago
Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
journals.biologists.com/dev/article/...
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Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, C. elegans nematodes form dauer larvae, in which development arrests until conditions improv...
https://journals.biologists.com/dev/article/doi/10.1242/dev.204972/370333/Pre-dauer-starvation-rapidly-and-reversibly
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Alexei Maklakov
Maya Voichek
3 months ago
The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪
www.weizmann.ac.il/plants/voichek
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Alexei Maklakov
Eric Topol
3 months ago
Hoping the pivotal finding of increased inflammation with
#LongCovid
will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41...
@natimmunol.nature.com
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Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology
Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...
https://www.nature.com/articles/s41590-025-02353-x
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Alexei Maklakov
Aging Science News
3 months ago
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
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A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports
Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
https://www.nature.com/articles/s41598-025-27478-9
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Alexei Maklakov
UEA Biological Sciences
3 months ago
Merry Christmas, Happy Holidays and a Peaceful New Year from everyone in the School of Biological Sciences. Have a wonderful break. 🎄🥳
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Alexei Maklakov
Eric Topol
4 months ago
The one validated intervention to slow aging and extend healthspan is not for sale. It's exercise.
sciencedirect.com/science/arti...
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Excellent news!!!
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4 months ago
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Alexei Maklakov
Nick Stroustrup
4 months ago
What tools do we need to start engineering
#aging
and
#longevity
? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the
@crg.eu
: technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
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Alexei Maklakov
Philip Leftwich
4 months ago
Please share 📢 We have a Postdoc position available here
@uniofeastanglia.bsky.social
to develop innovative genetic control strategies for insect agricultural pests in collaboration with
@imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...
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Alexei Maklakov
Alice Godden
4 months ago
🐻❄️❄️ New paper alert! From me Ben &
@immler.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉
link.springer.com/article/10.1...
A thread 🧵.
#climate
#transposons
#TESky
#polarbear
#ursus
@biouea.bsky.social
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Diverging transposon activity among polar bear sub-populations inhabiting different climate zones - Mobile DNA
Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...
https://link.springer.com/article/10.1186/s13100-025-00387-4
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1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by
@eduxbury.bsky.social
with
@alicegodden.bsky.social
@immler.bsky.social
Johnny de Coriolis Hanne Carlsson
www.biorxiv.org/content/10.6...
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Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
https://www.biorxiv.org/content/10.64898/2025.12.05.692572v1
4 months ago
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Alexei Maklakov
MPI for Biology of Ageing
4 months ago
🚨 Job alert! The Fish Facility is looking for a student/research assistant (m/f/d)! Apply now!
www.age.mpg.de/open-positions
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Alexei Maklakov
Björn Schumacher
4 months ago
🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and
@meyerdavid.bsky.social
!
@cecad.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
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Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
https://onlinelibrary.wiley.com/doi/10.1111/acel.70253
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Controlled settings may offer limited insight into the complexities of ageing in natural and variable ecosystems, and why (and how) ageing patterns vary so widely across individuals, populations, and species. We call for more research on ecology of ageing!
onlinelibrary.wiley.com/doi/10.1111/...
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Ecological Perspectives on Aging
Controlled settings may offer limited insight into the complexities of aging in natural and variable ecosystems. Artwork by Zahida Sultanova.
https://onlinelibrary.wiley.com/doi/10.1111/acel.70308
4 months ago
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Alexei Maklakov
Asher Cutter
4 months ago
EEB Postdoctoral Fellowship @ U.Toronto app deadline Jan 15 2026. Opportunity for independent research, encourages collab across labs/disciplines. Lots of great folks to interact with, Come join us!
eeb.utoronto.ca/employment-2/
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Employment - Ecology & Evolutionary Biology
https://eeb.utoronto.ca/employment-2/
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Alexei Maklakov
David S Richardson
4 months ago
a wonderful, fully funded PhD opportunity Deadline approaching (ok not that quickly but you may forget over Christmas!) 7th January
www.uea.ac.uk/course/phd-d...
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Alexei Maklakov
Pankaj Kapahi
4 months ago
The Kapahi Lab is looking for two creative, motivated postdocs to join our team. We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
[email protected]
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