Alexei Maklakov
@alexeimaklakov.bsky.social
📤 940
📥 510
📝 81
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
doi.org/10.1111/ele....
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Biological Sex Is Binary and Rooted in Anisogamy
Drawing on empirical evidence and evolutionary theory, we argue that biological sex is most coherently defined as a binary classification of reproductive strategies rooted in anisogamy (the productio...
https://doi.org/10.1111/ele.70426
about 2 hours ago
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Joao Pedro Magalhaes
24 days ago
Another fantastic GRC Systems Aging conference comes to a close in Maine, USA. Thank you and congratulations to the chair and vice-chairs for organizing another incredible event, with outstanding science, networking, and discussions. My favourite conference in the field!
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Brian J. Enquist
about 1 month ago
Sad to hear of the passing of Robert Ricklefs - a giant of Ecology who simultaneously pushed forward big ideas at multiple biological levels yet took time for detailed natural history .. McGill does a nice job summarizing his impressive contributions 🌐🧪
dynamicecology.wordpress.com/2026/06/11/r...
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Robert Ricklefs – in memoriam
Robert Ricklefs, a giant of ecology, passed away on Sunday. It is hard to overstate the extensive impact Bob had on the field. He was elected a member of the National Academy of Sciences in the US,…
https://dynamicecology.wordpress.com/2026/06/11/robert-ricklefs-in-memoriam/
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Science X / Phys.org
about 1 month ago
Longer human lives may be making an old evolutionary pattern harder to ignore. Late-acting harmful variants and youth-tuned pathways can now shape health on a scale selection never removed.
doi.org/hb7fmz
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'Selection shadow' may explain why longer lives bring more age-related disease
A review article now published in Nature Reviews Genetics brings together evolutionary theory, comparative genomics and large-scale human genetics to explain why we age and why aging rates differ among individuals and species.
https://phys.org/news/2026-06-shadow-longer-age-disease.html?utm_source=bsky.app&utm_medium=social&utm_campaign=v2
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Alice Godden
about 1 month ago
New preprint from my PhD is out! We show that loss of miR‑219 disrupts neural border gene programs and prevents neural crest specification. Excited to finally share it 🚀
www.biorxiv.org/content/10.6...
#xenopus
#miRNA
#genomics
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MicroRNA miR-219 is required for neural border and neural crest development in Xenopus neurulas
Neural crest (NC) multipotent stem cells give rise to many tissues including most of the peripheral nervous system, pigment cells and the craniofacial mesenchyme and skeleton. During gastrulation and ...
https://www.biorxiv.org/content/10.64898/2026.06.09.730798v1
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Judith Mank
about 1 month ago
And the press release is at
www.su.se/english/news...
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Rahul Gupta
about 1 month ago
We took ~750,000 whole genomes and found the putative mechanism by which mitochondrial DNA mutations accumulate with age in blood. Spoiler: we think these mutations arise by replication error and tag age-related clonal hematopoiesis. Read
@nature.com
broad.io/ob2jft
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Mechanism of age-related accumulation of mtDNA mutations in human blood - Nature
Genome-wide analyses indicate that accumulation of mitochondrial DNA mutations, a hallmark of ageing, may be caused by cryptic replication errors, which act as passenger mutations that eventually become detectable with age owing to age-related somatic mosaicism, rather than oxidative damage.
http://broad.io/ob2jft
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Job advert! There is microbiology lectureship at
@biouea.bsky.social
with a focus on non-academic impact:
vacancies.uea.ac.uk/vacancies/20...
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Impact Lecturer in Microbiology (ATR1737) in University of East Anglia | UEA
View details and apply for this Impact Lecturer in Microbiology (ATR1737) vacancy in University of East Anglia. Faculty of Science School of Biological Sciences Impact Lecturer in Microbiology...
https://vacancies.uea.ac.uk/vacancies/2001/impact-lecturer-in-microbiology-atr1737.html
about 1 month ago
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An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan Great first post by
@itamarh.bsky.social
😀 Very happy to contribute to this cool study!
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about 1 month ago
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Physalia-courses@Online
about 1 month ago
🚀 The new edition of Beyond Beginner R course is now underway. A few improvements this time: -
@philipleftwich.bsky.social
&
@eivimeycook.bsky.social
l as instructors -More R reproducibility examples - Quarto workflows - Handling large datasets - Integration of AI tools
shorturl.at/R97jw
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Nature
about 1 month ago
Book review 📚 How long can humans live? We simply don’t know
go.nature.com/3QelWur
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How long can humans live? We simply don’t know
Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says longevity researcher Saul Newman.
https://go.nature.com/3QelWur
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Arvid Ågren
about 1 month ago
"Unlike my good friends Dobzhansky and Simpson, I did not think that the only role I could take in a society was that of president." Ernst Mayr on why he became the first editor of Evolution.
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Laura Bertola
about 1 month ago
Very cool to see that the forensic tool is now actively being used and the first conviction of poachers through individual identification of the poached lion is a fact. 🦁 🧬 👮 Read the whole story on our website:
tinyurl.com/3vybce3b
#LeoFoundation
#StichtingLeo
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CSI-style ‘lion DNA fingerprinting’ leads to conviction of poachers - Leo Foundation
Wildlife crime is a multi-billion-dollar industry. After drug, arms, and human trafficking, the illegal trade in wildlife is among the most lucrative forms of crime, with an estimated value of over $2...
https://tinyurl.com/3vybce3b
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Nature
about 1 month ago
Nature research paper: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
go.nature.com/3POPIFZ
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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications for chemoresistant cancers.
https://go.nature.com/3POPIFZ
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Susan Johnston
about 1 month ago
📣🧬 Postdoc Alert🧬📣 We are hiring a 2+ year NERC-funded postdoc at Edinburgh Uni investigating causes and consequences of sex differences in recombination in house sparrows in Norway. Informal enquiries welcome at
[email protected]
🙂 Details here:
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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doi.org/10.1111/acel...
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Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals
Supplement users have lower epigenetic biological age than non-users. Several supplements or supplement classes are associated with some benefit on epigenetic age in either cross-sectional or longitu...
https://doi.org/10.1111/acel.70517
about 1 month ago
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Ella Rees-Baylis
about 2 months ago
Check out my first PhD paper, a model investigating life-history trade-offs and the evolution of sex differences in longevity, just out in
@natcomms.nature.com
!
doi.org/10.1038/s414...
Big thanks to Xiang-Yi Li Richter and
@lottedevries.bsky.social
!
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Asymmetric life-history trade-offs shape sex-biased longevity patterns - Nature Communications
Males and females often live different lengths of time, but why remains unclear. Here, the authors present a theoretical model showing that trade-offs between survival and reproduction, together with ...
https://doi.org/10.1038/s41467-026-73633-9
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Alexei Maklakov
Sendoel Lab
about 2 months ago
Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at
@cp-molcell.bsky.social
. Fantastic work by
@claradure.bsky.social
and all co-authors involved.
www.cell.com/molecular-ce...
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In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging
In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, lin...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00271-6
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Alexei Maklakov
The Cecere Laboratory
about 2 months ago
Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation.
rdcu.be/fj8Er
#Epigenetics
#microRNA
#Inheritance
@pasteur.fr
@devstempasteur.bsky.social
@erc.europa.eu
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Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology
In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...
https://www.nature.com/articles/s41594-026-01816-5
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Alexei Maklakov
Nature
2 months ago
An antiviral pill has, for the first time, been shown to prevent COVID-19 in people exposed to the SARS-CoV-2 virus
go.nature.com/3P50GXD
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At last, a pill that can prevent COVID after exposure to infected people
Drug arrives years after pandemic’s peak, but could still offer critical protection to vulnerable populations.
https://go.nature.com/3P50GXD
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Aging Science News
2 months ago
Evolutionary genetics of ageing
www.nature.com/articles/s41...
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Evolutionary genetics of ageing - Nature Reviews Genetics
Modern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary geneti...
https://www.nature.com/articles/s41576-026-00959-x
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Karen S Wilcox, PhD (she/her)
2 months ago
Gift link because this is important stuff. Pancreatic cancer is horrific and breakthroughs in treatment need to be shared around. Also, science.
#PancreaticCancer
Explore this gift article from The New York Times. You can read it for free without a subscription.
www.nytimes.com/2026/05/12/h...
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How an ‘Impossible’ Idea Led to a Pancreatic Cancer Breakthrough
https://www.nytimes.com/2026/05/12/health/pancreatic-cancer-daraxonrasib-kras.html?unlocked_article_code=1.h1A.e-NF.LBCrRsf40-8a&smid=bs-share
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Alexei Maklakov
PLOS Biology
2 months ago
Aging can reshape the immune systems of men and women in unique, sex-specific ways.
@bbparis1984.bsky.social
&co argue that accounting for both sex and age is essential to advance personalized medicine. 🧪
#aging
#immunity
#SexDifferencesDay
#WomensHealthWeek
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The problem with one-size-fits-all medicine: Biological sex and the aging immune system
Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into…
https://plos.io/4wkqdgd
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David Berger
2 months ago
Still 10 days left to apply - Come join us in Uppsala! Fully funded Phd position in Evolutionary Biology. Deadline 22nd of May.
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Alexei Maklakov
European Research Council (ERC)
3 months ago
NEWS: The ERC Scientific Council has listened to the concerns from members of the research community about changes to the re-submission rules, intended to manage the surge in demand for grants. The Scientific Council will readjust some of the changes:
link.europa.eu/TBqRQJ
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ERC Scientific Council readjusts rules for reapplication
The ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules. The changes, intended to manage the ...
https://link.europa.eu/TBqRQJ
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Ben Auxier
3 months ago
The red line in Figure 6B (% of 6-authors papers in all IEEE proceedings) is unreal
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Mozes Blom
3 months ago
🚨 Wanted: PhD student excited about population genomics, Natural History Collections and birds! 📍 Museum für Naturkunde, Berlin, Germany 🕒 3 Years, funded by the Leibniz Junior Researchgroup program Details and Application portal 👇
jobs.museumfuernaturkunde.berlin/jobposting/d...
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12/2026 PhD student (f/m/d)
https://jobs.museumfuernaturkunde.berlin/jobposting/d336fa105b57b451e0f2f310c4b961d478f4805a0
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Eric Topol
3 months ago
This NYT magazine article on longevity science, reversing aging with cellular reprogramming, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing cancer. gift link
www.nytimes.com/2026/04/27/m...
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Aging Science News
3 months ago
Sex differences in response to longevity interventions
www.sciencedirect.com/science/arti...
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Sex differences in response to longevity interventions
Interventions to extend lifespan and healthspan are of major interest, but such interventions may affect male and female organisms differently. Whethe…
https://www.sciencedirect.com/science/article/pii/S1568163726001157
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Emily Mullin
3 months ago
NEW: A biotech startup says it has grown functional human sperm in a lab and successfully fertilized eggs with it. The technique could eventually help men with certain types of infertility have biological children.
@wired.com
is the first to report this advance:
www.wired.com/story/startu...
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A Startup Says It Grew Human Sperm in a Lab—and Used It to Make Embryos
Paterna Biosciences says it has determined the set of instructions needed to turn sperm-making stem cells into "normal, mature" sperm.
https://www.wired.com/story/startup-says-it-grew-human-sperm-in-a-lab-and-used-it-to-make-embryos/
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Dynamics of genetic and somatic trade-offs in ageing and mortality - Nature
Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that influence lifespan and mortality with divergent age-...
https://doi.org/10.1038/s41586-026-10407-9
3 months ago
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Aging Science News
3 months ago
Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes
link.springer.com/article/10.1...
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Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes - BMC Biology
Background Despite the extraordinary diversity in mammalian lifespans, the evolutionary trajectories and underlying molecular mechanisms governing this variation remain largely uncharacterized. Result...
https://link.springer.com/article/10.1186/s12915-026-02599-3
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PLOS Biology
3 months ago
Could the
#ribosome
be a selfish element?
@mkrupovic.bsky.social
& Eugene Koonin propose that the
#evolution
of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources. 🧪
#OriginsOfLife
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The selfish ribosome
In this Essay, the evolution of life is construed as a ribosomal takeover, whereby the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensured the…
https://plos.io/3OPZszf
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Ancient DNA reveals pervasive directional selection across West Eurasia
Nature - Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than...
https://rdcu.be/feEOy
3 months ago
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Nature
3 months ago
Most of the individuals in a seventeenth-century-Switzerland burial site had performed strenuous manual labour and died before the age of 20
go.nature.com/4tTj2tg
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Graves reveal plague’s inequitable toll
Most of the individuals in a seventeenth-century-Switzerland burial site had performed strenuous manual labour and died before the age of 20.
https://go.nature.com/4tTj2tg
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Alexei Maklakov
Nature Portfolio
3 months ago
An analysis in Nature Aging identifies sex-specific changes in inflammation, autoimmunity and disease risk over the adult lifespan, with more widespread age-related immune remodeling in females.
go.nature.com/4mwYVyJ
#medsky
🧪
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Inigo Martincorena
3 months ago
Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n]
rdcu.be/fdqbr
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Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
https://rdcu.be/fdqbr
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Dominique Baker
3 months ago
"More than 100,000 people are expected to benefit in the scheme's first year alone, according to the British government, which negotiated to contribute £570 million towards the scheme's costs in 2027."
www.lemonde.fr/en/internati...
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UK signs deal to rejoin EU's Erasmus student exchange program
More than 100,000 students are expected to benefit in the scheme's first year alone, according to the British government, which negotiated to contribute £570 million towards the scheme's costs in 2027...
https://www.lemonde.fr/en/international/article/2026/04/15/uk-signs-deal-to-rejoin-eu-s-erasmus-student-exchange-program_6752466_4.html
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Excellent paper with very clear and important results - selection on relative egg size (maternal investement) reduces lifespan and accelerates ageing in females.
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3 months ago
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Alexei Maklakov
EU Science, Research & Innovation
3 months ago
€399M in EU funding is available to support around 1,600 researchers in their postdoctoral journey. You can choose your path: 🧪 European fellowships: 12-24 months in Europe 🧪 Global fellowships: 12-24 months abroad + return Deadline: 9 September (17:00 CEST) More info:
link.europa.eu/t6jYb3
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David Berger
3 months ago
PhD-position ALERT! 🧪🪲 🧬 Interested in studying the genomics of local adaptation and niche breadth using long-term experimental evolution? Come join me and
@gmkov.bsky.social
at
@animecol-uu.bsky.social
, Uppsala Univ. Read more and apply here:
uu.varbi.com/en/what:job/...
Deadline 22nd of May!
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Euan Angus Young
3 months ago
New preprint looking at the associations between maternal mortality and having sons in preindustrial Finland from work with León van Dorp during his master’s project. Also with Mirkka Lahdenpera,
@lummaalab.bsky.social
, and
@hannahdugdale.bsky.social
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European Commission
3 months ago
Big opportunities for researchers 🌍 We are investing nearly €400 million to help researchers share their work and collaborate with the best scientific teams across the EU. The 2026 Marie Skłodowska-Curie Actions Postdoctoral Fellowships are now open. More:
link.europa.eu/PNxpxw
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Gavin Woodruff
3 months ago
Caenorhabditis elegans populations shape their microbial environment
www.nature.com/articles/s41...
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Caenorhabditis elegans populations shape their microbial environment - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Caenorhabditis elegans populations shape their microbial environment
https://www.nature.com/articles/s41522-026-00975-z
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Alexei Maklakov
Nature
3 months ago
This researcher created a fictional illness, and fake studies funded by the Professor Sideshow Bob Foundation and University of the Fellowship of the Ring and the Galactic Triad. LLMs warned people the illness was real.
go.nature.com/48mAyh9
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Scientists invented a fake disease. AI told people it was real
Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?
https://go.nature.com/48mAyh9
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Alexei Maklakov
British Society for Research on Ageing
4 months ago
For our 75th annual meeting we are pleased to announce an additional grant call for Travel Grants to attend our 75th ASM in Oxford from 9-11 September. CALL NOW OPEN. Closing date 1st May 2026
bsra.org.uk/2026_travel_...
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Alexei Maklakov
British Society for Research on Ageing
4 months ago
🚨
#BSRA2026
is LIVE! Registration now open for our 75th Annual Meeting 📍 Oxford (Keble College) Great science, great people, and some special 75th year surprises 👀 Tag someone who should be there! 🔗
meetinghand.com/e/75th-asm-o...
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Alexei Maklakov
Life Science Alliance
4 months ago
Using EMS mutagenesis, authors generated & sequenced 12,069 viable C. elegans strains, identifying 541,102 missense mutations. They developed TaoChongBao, an open-access database integrating mutation data, greatly expanding functional variant resources.
www.life-science-alliance.org/content/9/6/...
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Anders Bergström
4 months ago
Out today is our paper 'Genomic history of early dogs in Europe', in which we uncover the identity of the dogs that lived in Europe before agriculture—during the Paleolithic & Mesolithic periods:
doi.org/10.1038/s415...
. A thread ⬇️ (10)
@biouea.bsky.social
@crick.ac.uk
@mpi-eva-leipzig.bsky.social
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Dario Riccardo Valenzano
4 months ago
Aging killifish show systemic inflammation and accumulating DNA damage in progenitor-like immune cells, offering a window into the evolutionarily conserved mechanisms of vertebrate immune aging. Great work from Gabriele,
@mdonertas.bsky.social
, and the whole team.
www.nature.com/articles/s43...
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Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish - Nature Aging
Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...
https://www.nature.com/articles/s43587-026-01086-2
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