Alexei Maklakov
@alexeimaklakov.bsky.social
📤 911
📥 502
📝 69
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
reposted by
Alexei Maklakov
Björn Schumacher
3 days ago
Do natural substances from blueberries and blue grapes protect nerve cells from aging?A
www.bionity.com/en/news/1188...
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Do natural substances from blueberries and blue grapes protect nerve cells from aging?
Using an aging clock, researchers from the University of Cologne have used the Caenorhabditis elegans model organism to demonstrate that nerve cells age differently. They identified both the cause ...
https://www.bionity.com/en/news/1188022/do-natural-substances-from-blueberries-and-blue-grapes-protect-nerve-cells-from-aging.html
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Alexei Maklakov
Richard Jones
4 days ago
The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding. My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
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UK science policy in transition – Soft Machines, by Richard Jones
https://softmachines.org/?p=3252
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Alexei Maklakov
Björn Schumacher
7 days ago
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration
@cecad.bsky.social
@unicologne.bsky.social
@uniklinikkoeln.bsky.social
@meyerdh.bsky.social
www.nature.com/articles/s43...
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Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
https://www.nature.com/articles/s43587-026-01067-5
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Alexei Maklakov
Barbara Tschirren
9 days ago
How does pre- and post-natal environmental stress affect the seminal foam proteome of Japanese quail? Find out here, Chloe Mason’s second PhD thesis paper:
onlinelibrary.wiley.com/doi/10.1111/...
@martingarlovsky.bsky.social
@oscarvedder.bsky.social
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Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird
Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early-life developmental stress. Japanese quail C...
https://onlinelibrary.wiley.com/doi/10.1111/mec.70257
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Alexei Maklakov
Sean Carroll
10 days ago
The bots populating Moltbook apparently all come to sound like a familiar kind of internet denizen with delusions of philosophical grandeur. Manifestos and declarations all over the place.
add a skeleton here at some point
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Alexei Maklakov
Waggoner Lab
11 days ago
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
www.science.org/doi/10.1126/...
@science.org
@idikic.bsky.social
@goetheuni.bsky.social
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Alexei Maklakov
Eric Topol
11 days ago
The largest randomized trial of medical A.I. —Over 100,000 women in Sweden —radiologist + AI vs 2 radiologists, in follow-up —AI added led to 29% more cancer detected, 44% reduced workload, and —Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
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Alexei Maklakov
Eric Topol
11 days ago
🆕
@science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
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Alexei Maklakov
Ed Ivimey-Cook
13 days ago
Thanks to some great comments and suggestions, we've updated TADA! Read it here:
ecoevorxiv.org/repository/v...
Transferable, Available, Documented, Annotated.
add a skeleton here at some point
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Alexei Maklakov
Ed Ivimey-Cook
6 months ago
🎉New preprint! "TADA! Simple guidelines to improve code sharing"
tinyurl.com/8rmnwjrk
We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA! Transferable, Accessible, Documented, Annotated.
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TADA! Simple guidelines to improve code sharing
https://ecoevorxiv.org/repository/view/9806/
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Alexei Maklakov
Javier Apfeld
13 days ago
Friends! I am so happy to share our new preprint! Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago. How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
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Alexei Maklakov
Ed Ivimey-Cook
18 days ago
Just renewed my membership for the 5th year with
@sortee.bsky.social
. A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!
sortee.org/join/
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Join
Join Society for Open, Reliable, and Transparent Ecology and Evolutionary biology (SORTEE)
https://sortee.org/join/
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Alexei Maklakov
Oded Rechavi
18 days ago
Finding an em dash in the rejection email
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Alexei Maklakov
James Lightfoot
20 days ago
Why do some worms graze on bacteria while others hunt and kill? Our study, published today in Nature, reveals how predatory aggression evolved in nematodes. Led by
@gunizgozeeren.bsky.social
and
@leoboeger.bsky.social
across the
@jameslightfoot.bsky.social
and
@monikakscholz.bsky.social
labs.
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Predatory aggression evolved through adaptations to noradrenergic circuits - Nature
Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of comp...
https://www.nature.com/articles/s41586-025-10009-x
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Alexei Maklakov
Nature
21 days ago
Nature research paper: Disease tolerance and infection pathogenesis age-related tradeoffs in mice
go.nature.com/4pBODwV
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Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature
Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.
https://go.nature.com/4pBODwV
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Alexei Maklakov
Natalie Pilakouta
22 days ago
Hot off the press! New paper in Biology Letters (
@royalsocietypublishing.org
) showing that heatwaves impair female but not male fertility in burying beetles 🐞🌡️ Huge congratulations to Izzy (
@izzygrieve.bsky.social
) on her first first-authored paper! 🥳🙌
royalsocietypublishing.org/rsbl/article...
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youtu.be/bAk4PFEuWKQ?...
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Flexible use of a multi-purpose tool by a cow
YouTube video by Antonio Jose Osuna Mascaró
https://youtu.be/bAk4PFEuWKQ?si=pDJF2NWdyk10ok5M
21 days ago
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Alexei Maklakov
Jennifer Ouellette
22 days ago
Meet Veronika, the tool-using cow. Veronika uses sticks to scratch herself, using different orientations and motions, an example of multi-purpose tool use. This suggests scientists may have underestimated cows' cognitive abilities.
arstechnica.com/science/2026...
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Meet Veronika, the tool-using cow
Veronika uses sticks to scratch herself, suggesting scientists have underestimated cow cognition...
https://arstechnica.com/science/2026/01/meet-veronika-the-tool-using-cow/
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Alexei Maklakov
Surojit Sural
22 days ago
Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
journals.biologists.com/dev/article/...
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Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, C. elegans nematodes form dauer larvae, in which development arrests until conditions improv...
https://journals.biologists.com/dev/article/doi/10.1242/dev.204972/370333/Pre-dauer-starvation-rapidly-and-reversibly
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Alexei Maklakov
Maya Voichek
29 days ago
The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪
www.weizmann.ac.il/plants/voichek
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Alexei Maklakov
Eric Topol
about 1 month ago
Hoping the pivotal finding of increased inflammation with
#LongCovid
will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41...
@natimmunol.nature.com
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Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology
Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...
https://www.nature.com/articles/s41590-025-02353-x
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Alexei Maklakov
Aging Science News
about 1 month ago
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
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A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports
Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
https://www.nature.com/articles/s41598-025-27478-9
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Alexei Maklakov
UEA Biological Sciences
about 2 months ago
Merry Christmas, Happy Holidays and a Peaceful New Year from everyone in the School of Biological Sciences. Have a wonderful break. 🎄🥳
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Alexei Maklakov
Eric Topol
about 2 months ago
The one validated intervention to slow aging and extend healthspan is not for sale. It's exercise.
sciencedirect.com/science/arti...
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Excellent news!!!
add a skeleton here at some point
about 2 months ago
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Alexei Maklakov
Nick Stroustrup
about 2 months ago
What tools do we need to start engineering
#aging
and
#longevity
? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the
@crg.eu
: technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
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Alexei Maklakov
Philip Leftwich
about 2 months ago
Please share 📢 We have a Postdoc position available here
@uniofeastanglia.bsky.social
to develop innovative genetic control strategies for insect agricultural pests in collaboration with
@imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...
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Alexei Maklakov
Alice Godden
about 2 months ago
🐻❄️❄️ New paper alert! From me Ben &
@immler.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉
link.springer.com/article/10.1...
A thread 🧵.
#climate
#transposons
#TESky
#polarbear
#ursus
@biouea.bsky.social
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Diverging transposon activity among polar bear sub-populations inhabiting different climate zones - Mobile DNA
Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...
https://link.springer.com/article/10.1186/s13100-025-00387-4
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1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by
@eduxbury.bsky.social
with
@alicegodden.bsky.social
@immler.bsky.social
Johnny de Coriolis Hanne Carlsson
www.biorxiv.org/content/10.6...
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Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
https://www.biorxiv.org/content/10.64898/2025.12.05.692572v1
2 months ago
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Alexei Maklakov
MPI for Biology of Ageing
2 months ago
🚨 Job alert! The Fish Facility is looking for a student/research assistant (m/f/d)! Apply now!
www.age.mpg.de/open-positions
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Alexei Maklakov
Björn Schumacher
2 months ago
🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and
@meyerdavid.bsky.social
!
@cecad.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
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Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
https://onlinelibrary.wiley.com/doi/10.1111/acel.70253
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Controlled settings may offer limited insight into the complexities of ageing in natural and variable ecosystems, and why (and how) ageing patterns vary so widely across individuals, populations, and species. We call for more research on ecology of ageing!
onlinelibrary.wiley.com/doi/10.1111/...
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Ecological Perspectives on Aging
Controlled settings may offer limited insight into the complexities of aging in natural and variable ecosystems. Artwork by Zahida Sultanova.
https://onlinelibrary.wiley.com/doi/10.1111/acel.70308
2 months ago
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Alexei Maklakov
Asher Cutter
2 months ago
EEB Postdoctoral Fellowship @ U.Toronto app deadline Jan 15 2026. Opportunity for independent research, encourages collab across labs/disciplines. Lots of great folks to interact with, Come join us!
eeb.utoronto.ca/employment-2/
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Employment - Ecology & Evolutionary Biology
https://eeb.utoronto.ca/employment-2/
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Alexei Maklakov
David S Richardson
2 months ago
a wonderful, fully funded PhD opportunity Deadline approaching (ok not that quickly but you may forget over Christmas!) 7th January
www.uea.ac.uk/course/phd-d...
add a skeleton here at some point
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Alexei Maklakov
Pankaj Kapahi
2 months ago
The Kapahi Lab is looking for two creative, motivated postdocs to join our team. We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
[email protected]
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Alexei Maklakov
Alice Godden
3 months ago
Gave a talk at UEA Norwich Med School: “Selfish Elements and Selective Sperm: Impact of Haploid Selection on Zebrafish Fitness.” Part of my broader focus on genomics and fertility/reproduction for all—exploring how genetics shapes reproductive success. Great discussion!
@slicescienceuea.bsky.social
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Alexei Maklakov
Vivek Nityananda
3 months ago
Wondering if insects feel pain? Here's our critique of work that looked at this in bees. We were unconvinced of the evidence, and built a model to think through these issues. Their response is published alongside and we'll have a response to that out soon.
www.sciencedirect.com/science/arti...
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Motivational trade-offs as evidence for sentience in bees: a critique
https://www.sciencedirect.com/science/article/pii/S0003347225003161
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Alexei Maklakov
eLife
3 months ago
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly/gMbJWcX
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Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
https://buff.ly/gMbJWcX
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Alexei Maklakov
Daniel Promislow
3 months ago
We have a new postdoc position available in the Promislow lab at the HNRCA at
#Tufts
in
#Boston
, to work on the
#systemsbiology
of
#aging
in
#Drosophila
. Come join us! For info on the position and to apply, see
promislowlab.org/wp-content/u...
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https://promislowlab.org/wp-content/uploads/2025/11/postdoc_hnrca_2025.pdf
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Alexei Maklakov
Oded Rechavi
3 months ago
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas)
www.pnas.org/doi/10.1073/...
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Alexei Maklakov
Eric Topol
3 months ago
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials
novonordisk.com/content/nnco...
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News Details
https://novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=916462#
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Alexei Maklakov
Eric Topol
3 months ago
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.” Genes-> Medicine
nature.com/articles/s41...
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1/6 In a new preprint we ask a question: Why do males and females so often age and die at different rates? We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:
ecoevorxiv.org/repository/v...
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Sex-specific mutation accumulation: A parsimonious explanation for sex differences in lifespan and ageing
https://ecoevorxiv.org/repository/view/10825/
3 months ago
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Alexei Maklakov
Barbara Tschirren
3 months ago
*PhD opportunity
@uniexecec.bsky.social
* How does antimicrobial resistance spread through ecosystems? Combine fieldwork (rodent trapping 🐭, habitat surveys 🌳, pheasant sampling 🦤), molecular techniques, GIS, and spatial modelling to understand AMR evolution and spread. 🔬🦠🧪 Please repost!
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Antimicrobial Resistance (AMR) in Gamebirds: A One Health Approach to Understanding and Mitigating the Risk of AMR Evolution and Spread through Ecosystems at University of Exeter on FindAPhD.com
PhD Project - Antimicrobial Resistance (AMR) in Gamebirds: A One Health Approach to Understanding and Mitigating the Risk of AMR Evolution and Spread through Ecosystems at University of Exeter, list...
https://shorturl.at/dEy1g
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Alexei Maklakov
Euan Angus Young
3 months ago
1/13 New paper out!
www.science.org/doi/10.1126/...
Historical records across thousands of women showed that mothers with more children had shorter lifespans during a famine, fitting an evolutionary explanation for why we age
@hannahdugdale.bsky.social
@lummaalab.bsky.social
@erikpostma.bsky.social
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Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments url:
academic.oup.com/evlett/artic...
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Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments
Abstract. Females and males typically differ in lifespan, patterns of ageing, and reproduction. General explanations for variation in the magnitude of this
https://academic.oup.com/evlett/article/doi/10.1093/evlett/qraf041/8317098
3 months ago
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Alexei Maklakov
Nick Stroustrup
3 months ago
A detIled account of all the characters involved.
www.nature.com/articles/d41...
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What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
https://www.nature.com/articles/d41586-023-01313-5
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Alexei Maklakov
Oded Rechavi
3 months ago
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
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Alexei Maklakov
Oded Rechavi
3 months ago
Let's go! Super excited to partner with
@richardsever.bsky.social
and the fantastic
@openrxiv.bsky.social
team - Preprints have been the best thing that happened to science publishing during my lifetime, and we're happy
@qedscience.bsky.social
can make preprints do more 👊
add a skeleton here at some point
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Alexei Maklakov
Oded Rechavi
3 months ago
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between
@qedscience.bsky.social
&
@openrxiv.bsky.social
@biorxivpreprint.bsky.social
! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
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