Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation

Thrilled to make the cover of @natimmunol.nature.com this month. A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social

Check out the August issue of Nature Aging featuring a focus on immune aging. See www.nature.com/nataging and rdcu.be/eC58o

Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e www.nature.com/articles/s41...

Sun and colleagues show that the transcription factor TCF19 drives a transcriptional program that coordinates both innate and adaptive NK cell responses against viral infection. Read it here:https://rdcu.be/eBB3K www.nature.com/articles/s41...

Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here: rdcu.be/etDy2 www.nature.com/articles/s41...

Fang and colleagues find that succinate can suppress Foxp3 expression and enhance colitis severity. Read it here: rdcu.be/etDuE www.nature.com/articles/s41...

Amarnath and colleagues find that PD-1 controls coinhibitory receptor expression in Tregs. Read it here: rdcu.be/etDtN www.nature.com/articles/s41...

We Stand Up for Science!!!

Joulia et al use single cell spatial transcriptomics to profile the lung in health and during asthma and identify discrete proinflammatory spatial niches that produce alarmins and chemokines. Read it here: rdcu.be/epjN7 www.nature.com/articles/s41...

Mak and colleagues find that double positive thymocytes express α9 nicotinic ACh receptors and these control negative selection. Read it here: rdcu.be/epjNm www.nature.com/articles/s41...

Penninger and colleagues developed bat respiratory and intestinal organoids and find there are type I and III IFN responses to viruses, including Marburg virus. Read it here: rdcu.be/epjMK www.nature.com/articles/s41...

Congratulations to all of the trainee awardees at the recent Aegean Conference on Innate Immunity. Well done all!!!

Chaudhry et al show that the transcriptional repressor GFI1 is required for the generation and maintenance of stem cell memory CD8+ T cells. Read it here: www.nature.com/articles/s41...

Paul Klenerman and colleagues combine single cell and spatial transcriptomics to provide a resource of the immune environment in adults and children with celiac disease. Read it here: rdcu.be/el8rn www.nature.com/articles/s41...

Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur www.nature.com/articles/s41...

Sanders et al find that T cells in the tumor can take up adenosine via ENT1 and this suppresses their anti-tumor response, ENT1 inhibition combined with anti-PD1 could control tumor growth in models resistant to immune checkpoint blockade. Read it here: rdcu.be/elTq8 www.nature.com/articles/s41...

A Review in Nature provides an overview of progress and future directions in the development of nasally administered vaccines for respiratory infections. go.nature.com/44PuKMr #medsky 🧪

Exciting news...Nature Methods is hiring a new editor! This exciting and dynamic role will be shared with the Nature Research Cross-Journal Editorial Team. Apply here by June 1! springernature.wd3.myworkdayjobs.com/SpringerNatu...

On the Covid SARS-CoV-2 variant front, new CDC update today —LP.8.1 furthers its dominance —No new emerging one of concern (some increase in XFC noted and will keep an eye on that) —good, important for these reports to continue

Our application for the 2026 Vilcek Prizes in Creative Promise is now open through June 9th!! This year, we will be awarding 9 immigrants $50K prizes in Biomedical Science, Fashion & Culture, and Fashion & Design. Learn more and apply! vilcek.co/3FgJWYb

Join me at the @aai.org ASPIRE awards symposium and networking in room 312 starting now with @cobarnes27.bsky.social @guthmillerjenna.bsky.social and Mohammad Arifuzzaman #AAI2025

😱 Tumors sabotaging the immune system! New study in @natcellbio.nature.com shows that phosphoethanolamine in tumor interstitial fluid disables T cells by depleting diacylglycerol, crippling their signaling. Big find from @delgoffelab.bsky.social. 🧪 doi.org/10.1038/s415...

Viral immune evasion: Cytomegalovirus Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity #virology #immunology

GlycoCaging, a targeted drug delivery system using plant oligosaccharide glycoconjugates, enables microbiota-activated colonic drug release, reducing off-target effects while maintaining drug efficacy in inflammatory bowel disease #NBThighlight www.science.org/doi/10.1126/...

Last Chance to Submit! Late-breaking abstract submissions for #IUIS2025 close May 6! Share your research with the global immunology community and help shape the science of tomorrow. 🔗 Submit here: iuis2025.org/abstracts/ #Immunology #Science2025 #CallForAbstracts #IUIS

Thimerosal is no longer used as a preservative in childhood vaccines. It has no relationship to autism and rates of autism have continued to rise even though it is not used anymore. Learn more: ow.ly/FwBx50VyRkh. #ImmunologyExplained #Vaccines

Nature research paper: Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines https://go.nature.com/4cAPx85

Looking forward to discussing #innate_immunity at the upcoming conference in Sissi.

Looking forward to discussing research in #systems_immunology at CSHL (meetings.cshl.edu/meetings.asp...)

Applications are open for the 2026 Vilcek Creative Promise Prize in Biomedical Sciences. See below for more information on eligibility and application deadlines.