Was really great to host a workshop / "hackathon" for mathematical modelling of single-cell data in Hamburg, I think the pictures speak for themselves:

"Healthy obese" in UK biobank. 266 genetic variants linked to body fat distribution & metabolic health. 8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪

I‘m very happy that our recent publication was selected as Paper Of the Month by the dean’s office. Paid off that I insisted to submit an application even though we knew it’s gonna be a tough competition. www.sciencedirect.com/science/arti... 🧪

Wow, @pascual-reguant.bsky.social, very impressive talk at #EMBLSpatialBiology! Presented preprint with @hoheyn.bsky.social: www.biorxiv.org/content/10.1... You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪

Very interesting talk by @orrlaboratory.bsky.social at #EMBLSpatialBiology. In preparation, I read their recent paper, and found some decent astrocyte signalling and proteinopathy in it 👇🏻👇🏻 www.sciencedirect.com/science/arti... 🧪

Clostridium butyricum targets colorectal cancer via secD–GRP78. Suppression of IL-6 reactivates CD8⁺ T cells & boosts anti-PD-1. Validated in humanized mice and patient organoids in co-culture with tumor-infiltrating lymphocytes: doi.org/10.1016/j.cc... 🧪 @cp-cancercell.bsky.social

Awesome talk by @halloulab.bsky.social at #EMBLSpatialBiology. May the force be with you in biophysical phenotypes of spatial transcriptomics; out now in @natmethods.nature.com: www.nature.com/articles/s41... 🧪

Stunning, what @sabrinalewis.bsky.social just showed at #EMBLSpatialBiology! LeGO depicts cell populations in lung metastases in 3D: www.researchsquare.com/article/rs-6... 🧪 Soon out in npj Imaging @natureportfolio.nature.com

🧬 miR-10a liposomes rewire macrophage mitochondrial metabolism (↑OXPHOS), boost H3 acetylation, inducing epigenetic M1→M2 shift. Liposome injection leads to shrinkage of plaques in ApoE−/− mice. Fei Fang et al. in @natcomms.nature.com: doi.org/10.1038/s414... 🧪

Really cool talk (even though confidential) by @pathologop.bsky.social at #EMBLSpatialBiology! So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol: journals.plos.org/ploscompbiol... 🧪

Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology! Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪

Ressource of chronic sinus inflammation shows that M2-like macrophages attract eosinophils, mast and tuft (!) cells amplifying Th2 response. Airway stem cells drive tissue remodeling; effects are reduced by dupilumab. @cp-immunity.bsky.social by Guanrui Liao et al. doi.org/10.1016/j.im... 🧪

The one-and-only @hoheyn.bsky.social showcases "the power of millions" using (sub-)STAMP Imaging at #EMBLSpatialBiology @cp-cell.bsky.social www.cell.com/cell/fulltex... 🧪

Too bad I couldn’t make it in person to beautiful Heidelberg, but virtual participation from home is definitely the second-best option! #EMBLSpatialBiology

I just gave an impulse presentation at our bAIome here 🤓

Adipose tissue (AT) macrophages in space and time: Nerve-associated macs (NAMs) in AT sustain metabolic balance and curb inflammaging. Loss of these impairs lipolysis and drives age-related inflammation. From the lab of Vishwa Deep Dixit, out in @nataging.nature.com: doi.org/10.1038/s435... 🧪

Eislmayr et al. find neutrophils are *not* key to clearing Shigella. Instead, macrophages trigger IL-12 → IFN-γ, restricting bacterial replication in intestinal epithelial cells. New innate immunity from the lab of Russell Vance in @cp-cellhostmicrobe.bsky.social doi.org/10.1016/j.ch... 🧪

Great reference to get up to speed on B cells in IBD from our good friend @ejvillablanca.bsky.social TL;DR B cells aren’t just bystanders in IBD, they’re active players in both gut protection, pathology and mucosal healing. doi.org/10.1016/j.im... 🧪

Late to the party, but: Host-oxidized phospholipids (oxPLs) form during infection & epigenetically silence IL-10 via AKT→EZH2→H3K27me3, driving lethal inflammation. Blocking oxPLs boosts IL-10 + survival. Kudos, @lozanzi.bsky.social; out in @cp-immunity.bsky.social: doi.org/10.1016/j.im... 🧪

And another LYVE1⁺ macrophages! Here at septa of white fat, which guide adipocyte stem cells toward "white" fate via TGFβ1. Depleting septal LYVE1⁺ macrophages boosts beiging and counteracts obesity. From labs of Florent Ginhoux & Svetoslav Chakarov @science.org doi.org/10.1126/scie... 🧪

Oral HO-1 inhibitor KCL-HO-1i targets LYVE-1+ perivascular TAMs, turns “cold” tumors hot, and synergizes with gemcitabine/5-FU to boost CD8+ T cells in mice, with low toxicity. Science Translational Medicine paper from the labs of Khondaker Miraz Rahman & James N. Arnold: www.science.org/doi/... 🧪

Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure www.sciencedirect.com/science/arti... 🧪

Clair Crewe et al. offer a roadmap for studying extracellular vesicles (EVs), emphasizing plasma preparation, lipoprotein clearance, accurate particle dosing, and uptake validation to ensure reproducible results. @natmetabolism.nature.com doi.org/10.1038/s422... 🧪

Very cool to have @iannaconelab.bsky.social here in Hamburg. Really looking forward to his talk on immune surveillance of the liver 🧪 #CRC1700

An analysis in Nature Medicine shows that prediabetes remission is possible without total weight loss, providing weight is distributed to subcutaneous deposits as opposed to visceral ones. go.nature.com/42SXQZe #medsky 🧪

Yesterday in Mainz at a Science Slam, I was speaking about Rosi(glitazone). In a new @cp-cell.bsky.social paper, Das Adhikari et al. use PPARg agonist to restore CD8 T mediated barrier integrity in the context of people living with HIV: www.cell.com/cell/fu... 🧪

🏎️ We wrote a N&Vs on the great new work from Shalev Itzkovitz lab in @molsystbiol.org. Barkai et al. calculate a turnover score and map it into spatial transcriptomics maps of intestinal tissues, informing us about dynamic biological processes in static atlases: www.embopress.org/do... 🧪

Macrophage glutamine uptake via SLC7A7 fuels glutaminolysis and supports plaque-stabilizing functions. Loss of Slc7a7 in mice worsens atherosclerosis by impairing restorative macrophage activity. Work from the lab of Laurent Yvan-Charvet. doi.org/10.1038/s422... 🧪 @natmetabolism.nature.com

From my own experience, I can only warmly recommend all the five tips: www.nature.com/articles/d41...

Delphi-2M: GPT-style model learns lifetime disease paths from UK Biobank (0.4M) and generalises to Danish cohort (1.9M). Predicts 1k+ diseases; even 20 years into the future. Great Nature paper from the team of Moritz Gerstung: doi.org/10.1038/s415... 🧪

Interesting: HIV persistence mostly mirrors natural memory CD4 dynamics, with mild negative selection (~2–6%) against infected cells. Intact proviruses decay faster than defective ones. From the lab of Annukka Antar: doi.org/10.1016/j.ce... 🧪 @cp-cellsystems.bsky.social

Interesting Nature Medicine paper on how LLMs predict biological age from routine examination reports from over 10 million participants. Concordance index ~75% for mortality (better than eight epigenetic markers!) doi.org/10.1038/s415... 🧪 @natmed.nature.com

Recently, I read a lot about mechanosensitive channels. Now new Cell paper from Michael Longaker (Stanford) on CTHRC1+ mechanosensitive fibroblasts, which migrate from creeping fat to bowel, deposit ECM via YAP/TAZ, and drive strictures in Crohn's disease: doi.org/10.1016/j.ce... 🧪

CD4 T cells stimulated by previous infections inhibit neutrophils and thus granuloma formation while activating macrophages in tuberculosis. Great work by @bengern.bsky.social et al. out now in @jem.org: rupress.org/jem/arti...

Mitochondrial metabolism required for T cell proliferation; mitochondrial-derived ROS necessary for T cell memory responses. Great Nature Immunology paper by lab of Navdeep Chandel: www.nature.com/artic... 🧪 (open access!)

Shivering & myocardial thermogenesis increase linearly in healthy human adults with skin cooling. No stark sex differences. Adipose tissue non-shivering thermogenesis reveals a rather switch-like behaviour. Cool work from Denis P. Blondin in @cp-cellmetabolism.bsky.social www.cell.com/cell-me... 🧪

Moderated a symposium on new frontiers in biomedical AI today. We discussed a lot about interpretability (of latent space representations etc.) Next generation of interdisciplinary computer scientists with many great ideas!

Theoretical framework for deriving single cell (gene) transcriptome dynamics, interpretable and quantitative:

Wow, super cool, seeing these approaches to match epitope and cognate TCR sequences for specific predictions becoming better and better. Definitely worth a thorough read. 🧪

Interesting Nature News: On Bluesky, the scientific community is smaller, but therefore more densely connected, which cranks up legit reactions and responses (compared to X)...

Paper accepted! To many more! 📷 @tiredmegafauna.com

Another great paper adding to our understanding of macrophage-neuron interactions shaping myeloid and nerve identity (here via TGFb signalling). Led by @philipp359.bsky.social from Freiburg. Out now open access in @cp-immunity.bsky.social:

This work by Norris et al. from Daniel Kopinke made it (deservedly) to the cover of @cp-cellreports.bsky.social. They show intramuscular fat (IMAT) blocks muscle regeneration by physically restricting new fiber growth. Repair and strength improve through IMAT inhibition: doi.org/10.1016/j.ce... 🧪

A microbial community-scale metabolic model predicts C. difficile colonization risk & probiotic response in gut communities. Clinicians dreamed about this for a long time! @gibbological.bsky.social and team in @cp-cellsystems.bsky.social: doi.org/10.1016/j.ce... 🧪

Classical macrophage activation reprograms nucleotide metabolism by suppressing de novo synthesis and enhancing salvage pathways (through nitric oxide...) @natmetabolism.nature.com doi.org/10.1038/s422... 🧪 Great N&V's on metabolic immune control by @ryanlab.bsky.social www.nature.com/artic...

Really cool insights (literally!) on how resident TH2 cells + multipotent stromal cells reshape adipose tissue near gut infections! Decent analysis from one of our group's idols @dominicgrun.bsky.social et al. on how adipose tissue (re)acts upon helminth immunity. www.science.org/doi/... 🧪

I must admit, I never quite knew how to imagine functional immune–brain crosstalk in situ. Thanks to our good friends at @aleksdelab.bsky.social, I can now read and see in @natrevimmunol.nature.com! doi.org/10.1038/s415... 🧪

Ageing & leukemia reshape metabolism of hematopoietic stem and progenitor cells. Mapping lipidomic and metabolomic shifts in human bone marrow, spotlighting choline as a key player in stemness to restore physiology! @natcellbio.nature.com @ninacabezas.bsky.social doi.org/10.1038/s415... 🧪

Skin vs. inguinal fat: same precursors, different fates! Single-cell lineage tracing reveals depot-specific adipogenesis routes & a key role for Sox9 in skin doi.org/10.1016/j.st... 🧪 @cp-cellstemcell.bsky.social

Feeding mice galactose rewires hepatocyte metabolism to boost CD8+ T cell function via IGFBP-1, relieving exhaustion, thus suppressing tumors. Neat diet-immunity link with an interesting mechanism @natcellbio.nature.com: doi.org/10.1038/s415... 🧪