Online now: Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary protein

Online now: Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Online now: DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

Online now: Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury

Explore our April issue online: www.cell.com/issue/S1550-... Hernandez-Leyva et al. show that volatile metabolites generated by gut microbes appear in exhaled breath and carry information on microbial activity. On the cover, a child blows bubbles filled with bacteria and volatile organic compounds.

Looking back at a clinical report published in 2025 that examined the effects of ultra-processed food consumption on metabolic and reproductive health www.sciencedirect.com/science/arti...

Online now: Oxytocin signaling in adipocytes is required for normal milk fat production

Online now: Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Online now: The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors

Don’t miss @jourdainlab.bsky.social present his talk “Harnessing nutrients and auxotrophies to study mitochondria” at Cell Press Symposia #CSMito2026 Early bird registration ends Friday! http://dlvr.it/TRw8wJ

In our April issue, two complementary Forums discuss the value and limitations of purified and whole food diets and how to best utilize each diet in alignment with research goals. www.cell.com/cell-metabol... www.cell.com/cell-metabol...

Lipid-rich tissues trigger lipid droplet-dependent, gasdermin D-mediated pyroptosis in metabolically exhausted CD4+ T cells, thereby sustaining inflammatory pathology during chronic autoimmune diseases. www.cell.com/cell-metabol... www.cell.com/cell-metabol...

Read about how Vitamin C suppresses ACSL4 mediated iron-driven lipid peroxidation to slow down primate aging in our April issue! www.cell.com/cell-metabol... www.cell.com/cell-metabol...

Online now: How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research

Online now: Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia

Online now: Body-wide multi-omic counteraction of aging with GLP-1R agonism

Online now: Gut microbial metabolism via hippocampal indole-AhR signaling regulates emotional symptoms

Online now: Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin availability at night

Online now: The gut microbiota alleviates depression by remodeling gut-brain energy metabolism

Online now: Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling

Online now: Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise

Online now: Mitochondrial lactate venting limits oxidative stress

Online now: Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia

Online now: The many pathways driving liver inflammation in MASH

Online now: Exercise as a therapeutic intervention for long-lasting and chronic diseases

Online now: Tissue and CD4 T cell subset dependence on the amino acid transporter SLC38A1

Online now: Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages

Online now: Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization

Online now: Plasma proteomic signature of frailty in 50,506 adults

Online now: Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities

Online now: Large-scale metaproteomics of human gut microbiota reveals microbial functions in metabolic diseases and aging

Cell Press: Championing real-world impact. www.cell.com/about?utm_so...

Online now: Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates

Online now: Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts

Last call for abstracts — deadline today (March 9)! Submit now for the chance to present your research in Glasgow to a global audience united in advancing the study of mitochondrial biology. http://dlvr.it/TRNNSv @cellpressevents.bsky.social #CSMito2026

One year ago, Li et al. demonstrated that isoform usage constitutes a distinct and dynamic regulatory layer in metabolic adaptation, which is compromised in obesity and aging. Now free to read: www.sciencedirect.com/science/arti...

Starvation triggers an organismal adaptive response that is orchestrated by endocrine factors. One year ago, Long et al. identified a famsin-glucagon axis that relays gut-derived hormonal cues to systemic glucose homeostasis during fasting. www.sciencedirect.com/science/arti...

Two Letters in our March issue offer complementary perspectives on the evolving role of New Approach Methodologies (NAMs) in cardiometabolic research. NAMs are important tools to complement, but not replace the use of animal models. www.cell.com/cell-metabol... www.cell.com/cell-metabol...

Caloric restriction confers several benefits in cancer, but the underlying mechanisms are not understood. Read the Preview of Gao et al. from our March issue, highlighting a newly identified neutrophil-dependent pathway modulated by caloric restriction. www.cell.com/cell-metabol...

MASLD is emerging as a disorder of time-of-day-dependent metabolic vulnerability, with reduced insulin availability and worsening multisystem insulin resistance in the evening compared to the morning. Read the Preview of the work by Marjot et al. in our March issue www.cell.com/cell-metabol...

Read our March issue online: www.cell.com/cell-metabol... The cover depicts a wavering butterfly kite, symbolizing the injured septic lung, tethered to a ribbon-like intestinal tract illustrating ketogenic foods, microbiota, and azelaic acid production.

Online now: The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice

Online now: Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease

Online now: Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance

Online now: Neuroimmunometabolic co-evolution in the tumor micro- and macroenvironment

Online now: Purified diets enable experimental rigor through compositional control in animal research

Online now: Scientific value and limitations of purified diets in animal research

Excited to hear @nataliekrahmer.bsky.social discuss "Elucidating the cell architecture of metabolic liver disease" at Cell Press Symposia #CSMito2026 (June 21–23, 2026, Glasgow, Scotland) Submit an abstract before March 9 to join her: http://dlvr.it/TRBjsD

Online now: Microbial-derived 3-phenylpropionic acid orchestrates immune-progenitor cell crosstalk to promote beige adipogenesis and energy expenditure

Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis