Cell Metabolism (@cp-cellmetabolism.bsky.social)

Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn’s disease The long-chain fatty acid receptor RXRα exhibits transcriptional activation in the intestinal epithelium of patients with Crohn’s disease (CD). Dietary polyunsaturated fatty acids induce intestinal epithelial RXRα activity in susceptible mice, which instigates chronic enteritis emanating from Paneth cells. This study reveals a cellular and molecular framework for fatty acid sensing in intestinal inflammation, which could be exploited to prevent or treat CD. http://dlvr.it/TPj4Kl