This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility. Happy to be part of this exciting study!

1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social microbiomejournal.biomedcentral.com/articles/10....

🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social 🧬 Social stress shapes RNA/TE activity across generations #Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social rdcu.be/eeAwB

A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪

Happy International Women in Science day! I owe a lot to all of you that I met along the way, as my supervisors, mentors, friends, colleagues, PhD students, postdocs, research assistants, daughters, mothers and… and.. and…

Celebrate 'International Day of Women and Girls in Science Day' by strengthening your timeline with these outstanding Scientists! *Now in two volumes below* 🧪 #WomenInScience (Volume 1): go.bsky.app/4BegEjv #WomenInScience (Volume 2): go.bsky.app/VoebYrt

🚀 Join us to learn about genome assembly, and annotation, exploring cutting-edge sequencing tech like Illumina @pacbio.bsky.social , @nanoporetech.com 🧬🔬 Don't miss out—join us: www.physalia-courses.org/courses-work... #Genomics #Bioinformatics #GenomeAssembly

IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social 10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED. #theconferencetoendallconferences

New model of premature #aging in #zebrafish 👏 "Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration." Go Fish! 🐟 www.pnas.org/doi/10.1073/...

Join our online course on Genome-Wide Prediction of Complex Traits with @oscargenomics.bsky.social & Evangelina (March 24-28). You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans Limited spots! 👉 www.physalia-courses.org/courses-work...

Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪

Try our new in silico PCR (sPCR) tool sharkmer- github.com/caseywdunn/s.... You give it primers and fastq reads, it gives you sequences that would be amplified by PCR. Works in minutes on a laptop for high copy regions like rRNA, great for species id etc. Feedback welcome. #bioinformatics #ngs

If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea! And enjoy the fish 🐟 eating the Pi(e) 🥧

FishPi software is freely available here: github.com/alicegodden/...

If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea! And enjoy the fish 🐟 eating the Pi(e) 🥧

Apple: podcasts.apple.com/us/podcast/n... Spotify: open.spotify.com/episode/5vDS...

The maintenance of genetic polymorphism underlying sexually antagonistic traits doi.org/10.1093/evle... Now in @evolletters.bsky.social by Ewan Flintham et al.

Reversing Type 2 diabetes A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group

Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come! www.cell.com/cell/fulltex...

I still enjoy looking at zebrafish embryos even after many years. New lab members and students seeing them for the first time never fail to express their amazement

A great end to 2024: The Zebrafish Sperm Proteome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... We described >5400 sperm proteins! Spearheaded by PhD student Jayme Cohen in collaboration with many people at @uniofeastanglia.bsky.social @johninnescentre.bsky.social

A great end to 2024: The Zebrafish Sperm Proteome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... We described >5400 sperm proteins! Spearheaded by PhD student Jayme Cohen in collaboration with many people at @uniofeastanglia.bsky.social @johninnescentre.bsky.social

🚨New paper from @immler.bsky.social lab Led by Jayme Cohen doi.org/10.1002/pmic... On the #Zebrafish #sperm proteome out now! 🐠

Sorry, better quality picture:

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Just accepted #EcologyLetters! Exciting work by recent grad Rebecca Schalkowski with @katjakasimatis.bsky.social and Megan Greischar linking 2 species community coexistence to sperm cell mediated reproductive interference! Preprint here www.authorea.com/users/804447...

New paper in J Exp Bio on the heat tolerance of sperm in the brown anole lizard. PhD student Wayne Wang developed a way to measure sperm cell LT50, found that sperm heat tolerance is repeatable across males, and that episodic male heat stress reduces sperm motility 🦎 #anolis doi.org/10.1242/jeb....

A few newbies (to Bluesky) added 💪 Welcome to: @uribelab.bsky.social @acoffin.bsky.social @dagansegal.bsky.social @immler.bsky.social #WomenInScience

New paper led by @yadirapga.bsky.social! Even though opossums have kids at 0.5 years, they still have typical male-biased mutation (though not quite as high as humans). "Low mutation rate but high male-bias in the germline of a short-lived opossum" www.biorxiv.org/content/10.1...

The final version of our latest Starship manuscript is out!🚀We study the evolution of a gene cluster for formaldehyde resistance to show that #HGT mediated by giant Starship #transposons is a recurrent force in #fungal adaptation. www.science.org/doi/full/10....

We have just updated FishPi with more functionality- check it out! #TESky

🚨Pleased to share our latest preprint on #zebrafish #geneexpression and #transposons in #sperm & #embryos exposed to social stress

🚨 Happy to share my latest preprint on #polarbear #transposon activity in response to diverging climates in #Greenland #TEsky 🐻‍❄🌞❄️🧬👩‍💻