1/4 🌍 We are looking for a passionate #PhD student in #Metabolic #Microbiome #Modeling in the Marie Skłodowska-Curie Doctoral Network MenoBrain. Join us at one of Europe’s microbiome research hubs and push the boundaries of microbiome science! @uni-kiel.de 🔗 www.uniklinikum-jena.de/menobrain/en...

Excited to share a review on metabolic modelling of host-microbiome-interactions by Natchapon Srinak (@snatchapon.bsky.social) and Jan Taubenheim from the lab: www.sciencedirect.com/science/arti...

Excellent article on quantitative production of fermentation products by the microbiota. Key takeaway: microbial fermentation products may be more important in mice than humans, amplifying microbiome effects in mice. www.cell.com/cell/fulltex...

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Interested in the design of defined microbial communities for fundamental research and applications? Hope this work & tool will help you 👇 As always @tcahitch.bsky.social has been a driving factor ⭐⭐⭐! github.com/ClavelLab/Mi...; academic.oup.com/ismej/advanc...

So, is this bacterial metabolite relevant in humans? With help from @kaletalab.bsky.social we predicted its production is significantly higher in the gut microbiomes of colorectal cancer patients. It is also present in cancer-associated microbiomes. What does it actually do to cancer cells?

Happy to have contributed!

Excited to share our latest work at Cabreiro lab! Chemotherapy modulation by a cancer-associated microbiota metabolite www.cell.com/cell-systems... Here's what we discovered 🧵

🚨New paper published today on cancer bugs and drugs!🚨 “Chemotherapy modulation by a cancer-associated microbiota metabolite” Congrats to the Cabreiro lab on this exciting study! #Cancer #Microbiome #Metabolism #Chemotherapy #MRC_LMS #ImperialCollege #CECAD_Cologne www.cell.com/cell-systems...

Delighted to share: "Metatranscriptomics-based Metabolic Modeling of Patient-Specific Urinary Microbiomes during Infection". Great work led by Jonathan Josephs-Spaulding, in collaboration with the Rupp lab. @uni-kiel.de @crc1182.bsky.social @uniluebeck.bsky.social (1/7) rdcu.be/eFnXZ

Only 10 days left to apply: We are searching for a senior postdoc (3 +3 years) in the field of theoretical ecology and evolution. The position provides the opportunity to closely interact with experimentalists and develop own research projects. Please RT. Details 👇: shorturl.at/iiiOv

I am excited to announce that the position of a senior postdoc (3 +3 years) in the field of theoretical biology is available in my group. The position provides the opportunity to closely interact with experimentalists and develop own research projects. Please RT. Details 👇: shorturl.at/iiiOv

💥Personalized C. difficile colonization risk prediction and probiotic therapy assessment in the human gut💥 I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com @cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social www.cell.com/cell-systems... 🧵...

Out stody Is now on National Geographic!!! www.nationalgeographic.com/animals/arti...

You can get an accurate estimate of total bacterial biomass from stool metagenomes by simply normalizing by host read count, without needing any additional measurements. Excellent work by UW Master's student Gechlang Tang in @asm.org #mSystems Journal. journals.asm.org/doi/10.1128/... 🧵

(1/5) 🧠 Excited to share our new preprint on molecular drivers of cognitive function in aging mice! Led by Stefano Flor & @sciwitch.bsky.social, with the Frahm lab @uni-kiel.de @crc1182.bsky.social 📄 www.biorxiv.org/content/10.1...

Interesting perspective calling into question the hologenome/holobiont concept. They argue that the holobiont does not qualify as a unit of selection and rather traditional approaches from genetics and ecology are more suitable to study host-microbiome-interactions: journals.asm.org/doi/10.1128/...

www.nature.com/articles/s41... The role of metabolism in shaping enzyme structures over 400 million years

Very excited to share the first paper out of my Postdoc @CMR: GenomeFISH: genome-based fluorescence in situ hybridisation for strain-level visualisation of microbial communities. @sjmcilroy.bsky.social @jamesvolmer.bsky.social @benjwoodcroft.bsky.social doi.org/10.1093/isme... 🧵1/7

🧬🖥️ Postdoc positions available SOON!! Looking for researchers with strong computational skills (programming essential) to work on microbiome & phylogenetics projects. 📅 Start on Nov 1, 2025 (flexible) 📍 Trento, Italy DM me for details or share! #postdocjobs #microbiome #metagenomics #phylogenetics

Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.

www.nature.com/articles/s41... Our new paper on the risks and socio-demographic dimensions of antibiotic resistance in the human gut is now out in @natcomms.nature.com!

Well what do you know!? This might be the most interesting unorthodox orthodox metabolism paper this year.

The #CRC1182 was represented again at the 2025 #KielerWoche together with KLS and PMI Cluster of Excellence. Here are a few images from the #KielerUniLive @uni-kiel.de event featuring our Digital Meta Poster, Sponge Pop-Up Cards and more: www.metaorganism-research.com/news/crc-118...

Exciting discovery of the smallest Archaeon so far, lacking virtually all of metabolism and only retaining it's core replicative machinery: www.biorxiv.org/content/10.1...

Happy to share our new comment on How #spatial #metabolomics is transforming #microbiology and gives insights into #microbe-microbe and #host-microbe interactions. #OpenAccess in @molsystbiol.org @crc1182.bsky.social @uni-kiel.de @mpimarinemicrobio.bsky.social doi.org/10.1038/s443...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social. This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8 www.medrxiv.org/content/10.1...

Bei #kielerunilive auf der #KielerWoche stellen sie ihre Arbeiten im gemeinsamen Zelt der beiden #Exzellenzcluster ROOTS und #PMI vor - und zeigen Euch DNA-Stränge, die man mit bloßem Auge sehen kann. Kommt vorbei! Das ganze Programm: www.precisionmedicine.de/de/detailans... #kiwo25 #kiel #WissKomm

Another review from my lab out this week, on analyzing gut microbiome data from global populations -- tackling computational challenges and providing practical frameworks and resources for the field With Sabrina Arif, @richabdill.com, @samanthagraham.bsky.social www.cell.com/trends/micro...

Great article about Medical Systems Biology by Ann Homscheid and @maringos.bsky.social from the lab in BIOspektrum (in German): link.springer.com/article/10.1...

It’s a bacterium-eats-bacterium world… www.science.org/doi/10.1126/...

Thrilled to see our review out in @natrevimmunol.nature.com together with my amazing mentors @jfcryan.bsky.social and Ger Clarke. @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social @uccresearch.bsky.social www.nature.com/articles/s41...

Exciting paper by @nonresidentdesi.bsky.social about a not so nice microbial interactions. Bacterial species containing T6SS can survive on substrates they cannot metabolize by killing bacteria that can. And they do that slowly to get most out of their prey: www.science.org/doi/10.1126/...

Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours. www.science.org/doi/10.1126/... #MicroSKy #Microbiology

🚨 New preprint alert! We report what might be the first mechanistic link between gut Archaea and human disease. Methanobrevibacter smithii is enriched in CRC patients—and boosts growth of cancer-associated bacteria like F. nucleatum. www.biorxiv.org/content/10.1... @archaeasky @microbiomesky

This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...

#DZIF #researchers developed computer models of #RNA #virus replication in the #cell metabolic context and predicted drug targets. Comparison to drug databases revealed two broad-spectrum candidates: phenformin and atpenin A5. 👉 t1p.de/9nkyo #InfectionResearch #Science @kaletalab.bsky.social

See our new paper, headed by Katja Dierking and her team, esp. Lena Peters, on microbiota protection against pathogens @crc1182.bsky.social @uni-kiel.de @manuelliebeke.bsky.social @kaletalab.bsky.social doi.org/10.1038/s414...

Thrilled to share that our new paper is out. Thanks to all the people involved in this study!

(1/5) Excited to share our latest study in Nature Communications! We dissect how IBD disrupts host–microbiome metabolic networks using multi-omics & constraint-based modeling. Great work led by Jan Taubenheim @ EXC PMI @ru5042mitarget.bsky.social‬ @uni-kiel.de 🔗 www.nature.com/articles/s41...

Happy to share this new article, combining things like: #celegans and #lipidomics: www.nature.com/articles/s41... Thanks to all the people involved, we have played a small part, but really enjoyed it.

Excited to share our new paper in Nature Communications! 🎉 We uncovered how polyketide synthase-derived sphingolipids from gut microbiota protect C. elegans against pathogens. Great collaborative work led by Katja Dierking from @schulenburglab.bsky.social @crc1182.bsky.social 🔗 rdcu.be/epm6Q

🧬🖥️Drug response prediction is a machine learning challenge with immense potential for precision medicine. Our latest preprint introduces DrEval, a comprehensive benchmarking framework to evaluate state-of-the-art methods, uncover widespread issues, and guide the development of more robust models.

📢 Big day for archaeal microbiology! Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com ‬ in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.

🥁NEW publication from our lab: the largest meta-analysis of gut microbiome associations with CRC! www.nature.com/articles/s41... 🧵⬇️ 1/6

And here is the press release to our discovery of broadly-acting antivirals by the DZIF: www.dzif.de/en/broad-spe...

A metabolic modeling approach reveals druggable host cell pathways essential for viral replication across various viruses with minimal cytotoxicity. These findings highlight cellular metabolism as a promising target for antiviral therapy. @kaletalab.bsky.social www.nature.com/articles/s42...

(1/7) Ever wondered whether there are compounds that broadly inhibit viral replication like antibiotics do in bacteria? We identified several compounds broadly active against quite diverse viruses using metabolic modeling and wet-lab experiments. Manuscript available at rdcu.be/enhSp