Yannis Ntekas
@ntekasi.bsky.social
📤 71
📥 185
📝 19
Spatial Biology x Microbiome | Postdoc at Xavier lab
@mskcancercenter.bsky.social
Thank you for highlighting our work!
add a skeleton here at some point
18 days ago
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reposted by
Yannis Ntekas
Hao Yin
about 1 month ago
Spatial Gut-Microbiome MegaTranscriptomics Use in situ polyadenylation on
#Visium
#StereoSeq
to enhance host & bacterial RNA recovery (⏫99-fold) Fresh-frozen🐭GI Non-coding RNAs enriched to gut wall Microorganisms enriched at CRC tumor boundary
#NatMicrobiol
2026
www.nature.com/articles/s41...
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reposted by
Yannis Ntekas
Nature Microbiology
about 2 months ago
Out Now! Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
#MicroSky
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Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
Nature Microbiology, Published online: 06 March 2026; doi:10.1038/s41564-026-02286-7Bulk polyadenylation improves the capture of microbial RNA, enabling host–microorganism interactions to be visualized at a high resolution when combined with commercially available spatial transcriptomics platforms.
https://go.nature.com/4u8YhKZ
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Our work with Lena Takayasu and
@dwmckellar.bsky.social
in Iwijn De Vlaminck's lab is now out in
@natmicrobiol.nature.com
! 🎉 Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
rdcu.be/e7i7o
about 2 months ago
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reposted by
Yannis Ntekas
Waggoner Lab
about 2 months ago
Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
www.nature.com/articles/s41...
@natmicrobiol.nature.com
@dwmckellar.bsky.social
@ntekasi.bsky.social
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reposted by
Yannis Ntekas
Ran Blekhman
5 months ago
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
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The Autism-Microbiome Hypothesis Is Falling Apart
Why this new review paper should be required reading for every microbiome researcher
https://open.substack.com/pub/blekhman/p/the-autism-microbiome-hypothesis?r=ptsy3&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
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reposted by
Yannis Ntekas
Harris Wang
5 months ago
Introducing Foli-seq in
@natbiotech.nature.com
today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠
www.nature.com/articles/s41...
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Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology
Profiling host RNA shed in feces reveals disease states in the gut.
https://www.nature.com/articles/s41587-025-02894-4
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reposted by
Yannis Ntekas
Sean Gibbons 🦠💩
5 months ago
Another banger from the
@harriswang.bsky.social
Lab this month! “Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut”
www.nature.com/articles/s41...
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Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology
Profiling host RNA shed in feces reveals disease states in the gut.
https://www.nature.com/articles/s41587-025-02894-4
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reposted by
Yannis Ntekas
Carolyn Bertozzi
about 1 year ago
Exciting discovery by Svensson lab and collaborators
@stanfordmedicine.bsky.social
, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice!
www.nature.com/articles/s41...
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Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature
Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...
https://www.nature.com/articles/s41586-025-08683-y
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reposted by
Yannis Ntekas
Itai Yanai
about 1 year ago
Contributions from: Jeffrey Moffitt,
@drmingyaoli.bsky.social
, Qing Nie, Kazumasa Kanemaru, Sarah Teichmann, Daniel Dar,
@ltkagohara.bsky.social
, Shalev Itzkovitz, Roser Vento-Tormo,
@fertiglab.bsky.social
,
@fabiantheis.bsky.social
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reposted by
Yannis Ntekas
bioRxivpreprint
over 1 year ago
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1
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Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1
The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from m
https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1
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reposted by
Yannis Ntekas
Tim Straub
over 1 year ago
New research from the Xavier lab at Broad reveals the gut's adaptability and immune-driven control in specific regions. A spatial map of the mouse intestines highlights its resilience to perturbations like inflammation, with implications for understanding diet, food allergies, and IBD in humans 🧬🦠
add a skeleton here at some point
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Spatial structure shapes the host-microbiome interactome. Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv! Co-led with Lena Takayasu &
@dwmckellar.bsky.social
collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
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High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing
Inter–microbial and host–microbial interactions are thought to be critical for the functioning of the gut microbiome, but few tools are available to measure these interactions. Here, we report a metho...
https://doi.org/10.1101/2024.11.18.624127
over 1 year ago
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