1/ Excited to share our new paper in Science @science.org: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” A great collab w/ Sergey's group @sokrypton.org at MIT @columbiasysbio.bsky.social science.org/doi/10.1126/... 🦠🧬🛠️🖥️💥

SEED2026 abstract deadline extended to 3/15!! there's still time to submit an abstract for a talk or poster! #SEED2026 #synbio

SEED 2026 Abstract due in 3 days! We've got an excellent line up of keynotes & invited speakers. Join us to present your work & hear the latest SynBio breakthroughs. A major theme this year is AI+Bio! 🧬🔬🤖💻🦠 synbioconference.org/2026

I'm very excited to announce my official appointment as Chair of the Department of Systems Biology at Columbia @columbiauniversity.bsky.social @columbiamed.bsky.social @columbiasysbio.bsky.social. Looking forward to more SysBio growth in NY! systemsbiology.columbia.edu

10 days until the deadline!

We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE

Highlighting another recent paper from the lab in Science Advances on engineering a gut probiotic to modulate GLP-1 levels and ameliorating colitis. Led by Leonie Brockmann & @carlottaronda.bsky.social . @columbiasysbio.bsky.social @columbiauniversity.bsky.social 🧬🦠💊 www.science.org/doi/full/10....

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - @harriswang.bsky.social go.nature.com/4i7XnZR

Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠 www.nature.com/articles/s41...

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. apply.interfolio.com/177622 Suggested deadline: 12/15/2025. @columbiasysbio.bsky.social

1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge. Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...

Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️ www.science.org/doi/10.1126/...

Grateful to work with the wonderful @vilcekfoundation.bsky.social and the super talented Hiroki Otsuka on a short manga highlighting our research and my journey as an immigrant scientist! 🧪🦠🧬 vilcek.org/news/microbe...

Yikes… NIH dropping IC to 15% grants.nih.gov/grants/guide...

Happy to share our new paper in @naturemicrobiol.bsky.social on mapping spatial relationships of the human gut microbiome. We identified distinct spatial hubs between gut bacteria that reflect sub-community assemblies at the micron-scale. Led by Miles Richardson & co. www.nature.com/articles/s41...

💡💥Here’s a modest proposal I’ve been pondering for a while on how to change the PEER REVIEW process and start more community-driven SCIENCE FUNDING. Lots of feedback/discussion welcomed! Other variants of the idea might exist already—not claiming originality. (a long 🧵) (1/9)

One under-appreciated challenge of mid-career PI’s is that after a decade or more, the big equipments you originally bought all break down and need replacement. People don’t necessarily have discretionary funds at this point and it’s hard to bootstrap through grants.

New paper from the lab out in Cell Systems. “Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut” www.cell.com/cell-systems...