New in Science Magazine Science Advances from the Doudna Lab, Rubin Lab and Cress Lab —Identification of proteins influencing #CRISPR-associated #transposases for enhanced #GenomeEditing. Read here: https://ow.ly/U0s450XS82n#CRISPR-associated

"I wanted to be an ecologist and protect nature — that was always my dream." IGI's Moi Expósito-Alonso on his path to running a research group at Berkeley, studying plant adaptation to climate change. Read here: https://ow.ly/8BuU50XAjpe

Plant synthetic biology explained in 101 seconds, featuring IGI Investigator Patrick Shih! Watch here: https://youtu.be/yf8Zt4LHnhI?si=6MGoC71CdZTfom7N

The world of genome editing is moving at a fast pace, and the IGI is right in the middle of the action. Here’s a look back at some of our most exciting news stories you don't want to miss from 2025. Read here: https://ow.ly/Z1n650XJXGS #CRISPR

National Geographic names CRISPR among the biggest scientific breakthroughs of the last 25 years and gives @jenniferdoudna.bsky.social @innovativegenomics.bsky.social the last word on what's next. www.nationalgeographic.com/science/arti...

Neurons are trickier to edit than most other cell types. A study from IGI's Bruce Conklin sheds lights on why, which could impact how new brain-based editors are designed. Read here: https://ow.ly/J0Aj50XAjLr

Congrats to #BioEGSB affiliate scientist Ben Rubin and team on publication of @therubinlab.bsky.social's first lead paper!

ICYMI: #CRISPR co-inventor Jennifer Doudna joins @euanashley.bsky.social on Episode 3 of The Future of Medicine for a deep, wide-ranging conversation about how #GeneEditing is reshaping the landscape of modern medicine. Watch on our YouTube or stream here: https://bit.ly/43LGRZv

Heartwarming news for the holiday season: KJ continues to thrive and recently took his first steps! See more pics and video here: https://ow.ly/PZQX50XLCor #CRISPR #GeneEditing #RareDisease

Out in Nature Biotechnology from IGI's Patrick Shih — a new "speed scanner" can test 1000s of plant gene activators at once. Read here: https://ow.ly/foy650XLAxh P.S. The image is in fact not a watermelon radish slice from Berkeley Bowl, but a tobacco cell with fluorescent reporters!

New in Nucleic Acids Research from the Rubin Lab — OriGen, a language model that can generate plasmid origins of replication. 🔄🦠 The model makes sequences that are remarkably different from wild type origins, yet still replicate in vivo. Read here: https://ow.ly/jjOt50XIBxb

Our award-winning, NYTimes Critics’ Pick film, HUMAN NATURE, is now free for K-12 classrooms! It explores the science, ethics, and human impact of #CRISPR. Deemed “essential viewing” by Nobel laureate Jennifer Doudna. ▶️ bit.ly/humannatureedu #ScienceEducation #STEMEd #K12Education

🎧 Episode 3 of The Future of Medicine is now LIVE, featuring Jennifer Doudna, a Nobel laureate, pioneer of #CRISPR gene editing & one of the most influential scientists of our time. Watch on our YouTube or stream here (https://bit.ly/4rQmq85) or anywhere you listen to podcasts!

Out now in Nature Communications, from IGI's Jill Banfield (The Banfield Lab) and collaborators: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses Read here: https://www.nature.com/articles/s41467-025-65646-7

🎺New paper alert🎺 Out now in Nature Chemical Biology from IGI's Jennifer Doudna (Doudna Lab) and collaborators: Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap Read here: https://ow.ly/izGo50XAkog

[email protected] and @urnov.bsky.social at the @innovativegenomics.bsky.social in @theatlantic.com on how a platform approach to CRISPR could finally change the economics of treating rare diseases and why Baby KJ’s treatment is the proof of concept. www.theatlantic.com/science/2025...

New from IGI's @marsonlab.bsky.social and @juliacarnevale.bsky.social, with co-authors @jenniferdoudna.bsky.social, @j-eyquem.bsky.social, James Nuñez!

The first-ever personalized CRISPR medicine, genomics meets AI + automation, editing gut microbes for health + climate applications, field trials for climate-resistant crops — 2025 has been an exciting year for the IGI! Learn about these + more in our annual Impact Report: https://ow.ly/h2OA50XIAVV

Cow farming is a major source of greenhouse gases. New research from IGI Investigators at UC Berkeley and UC Davis uncovers a microbial blueprint for climate-friendly cows. Read here: https://ow.ly/4wbu50XAkzZ

A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the remarkable people chosen for Nature’s 10 2025 Check out the full list: go.nature.com/4rIQH8H

A very nice Preview of our work in @cp-cellhostmicrobe.bsky.social this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...

Congrats to IGI's Jill Banfield, Jennifer Doudna, Mary Firestone, Patrick Hsu, Alex Marson, Kris Niyogi, Eva Nogales, Dan Nomura, and Jennifer Puck — each is on Clarivate's Highly Cited Researchers 2025 list for ranking in the top 1% in their field by citations!

Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫

🥂Congrats to IGI's Venkatesan Sundaresan and Imtiyaz Khanday on being awarded the VinFuture Prize in recognition of their work developing self-cloning crops! Read more: https://ow.ly/JbPO50XFWgm

You've heard of elf on a shelf. Now get ready for gene editor on a green predator...

Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon

Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0

New from IGI's Carlotta Ronda and collaborators at Columbia University — a new method for editing gut bacteria in vivo using transposases. Read now in Science Magazine: https://ow.ly/U5uV50XAkfQ

Out now in Nature Communications: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses www.nature.com/articles/s41... @luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social

This paper was a wonderful collaborative effort between the wetlab and computational sides of our lab, and we look forward to our future projects building upon this model!

We're excited to share our lab's first lead paper! We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠 The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo. Read it here ⬇️

The ability to edit neurons could open new doors to treating brain disorders, but so far has proved challenging. A new study from IGI's Bruce Conklin sheds lights on why it's so tricky, which could impact how new brain-based editors are designed. Read here: https://ow.ly/qczT50XAjLq

We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE

IGI's Moi Expósito-Alonso (MOILAB) on his path from growing up in Spain and dreaming of becoming an ecologist to running a research group at Berkeley, studying plant adaptation to #ClimateChange. New from IGI's Emma MacKenzie! Read here: https://ow.ly/g4ph50XAjp4

I named my fists pH and buffer because ya basic

Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️

Plant synthetic biology explained in 101 seconds, featuring IGI Investigator Patrick Shih! Watch here: https://youtu.be/yf8Zt4LHnhI?si=6MGoC71CdZTfom7N

For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California#NDiSTEM

Such a privilege to see my summer mentee present her work at #ABRCMS2025!

So happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!

New from @banfieldlab.bsky.social and collab Alanna Schepartz!

1/2 New from co-first authors @erinedoherty.bsky.social and @jnoms.bsky.social of the @doudna-lab.bsky.social — Bacteria fight off viruses using tiny molecular “alarm signals” made of nucleotides. To survive, viruses must find ways to shut these signals down.

New in @natgenet.nature.com from IGI's Claire Clelland (@ucsanfrancisco.bsky.social) and @giannikopoulosp.bsky.social (@ucberkeleyofficial.bsky.social): Measurement and clinical interpretation of CRISPR off-targets Read here: www.nature.com/articles/s41...

📣 New preprint from the Doudna and Savage labs, looking at improving #CRISPR efficiency in human and plant cells! Read here: Latent activity in TnpB revealed by mutational scanning https://ow.ly/iz4050XtHca#CRISPR

A future without chocolate seems almost unimaginable. But according to UC Berkeley’s Brian Staskawicz, it is a very real possibility. Learn more in this thread.🧵

ICYMI: Can red seaweed reduce methane emissions from cattle? Marketplace recently featured the IGI Investigator Ermias Kebreab. Listen here: https://ow.ly/1u8o50XtGLm

Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0

And another new one from IGI's Carlotta Ronda!

New from IGI's Carlotta Ronda!