Snorre Sulheim
@sulheim.bsky.social
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SNSF postdoc fellow in Mitri lab @UNIL
pinned post!
This project wouldn't been possible without Peter Doubleday and
@nzamboni.bsky.social
at
@imsb-eth.bsky.social
. Peter conducted >10,000 mass spec analyses 🤯. So grateful for this opportunity to team up with the best of the best in metabolomics 😍 Read more:
www.biorxiv.org/content/10.1...
#microsky
add a skeleton here at some point
3 months ago
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Really elegant work showing how spatial distance can determine the net effect of two interaction mechanisms
add a skeleton here at some point
8 days ago
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Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia A nice demonstration of how cross-feeding shapes small microbial community compositions From Segré lab
@dsegre.bsky.social
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.01.11.698878v1
11 days ago
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Intra-species crossfeeding in K. pneumonia supports growth of co-cultivated partners. I think such commensal interactions are very common
journals.plos.org/plosbiology/...
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A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation
Why are there so many co-circulating Klebsiella pneumoniae clones? Using genomics and large-scale metabolic modelling of >7000 isolates, this study identifies structured, clone-specific metabolic spec...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003559
2 months ago
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Metabolic control of porin permeability
www.nature.com/articles/s41...
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Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
https://www.nature.com/articles/s41564-025-02175-5
2 months ago
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reposted by
Snorre Sulheim
Sara Mitri
3 months ago
New preprint from our lab
www.biorxiv.org/content/10.1...
! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
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This project wouldn't been possible without Peter Doubleday and
@nzamboni.bsky.social
at
@imsb-eth.bsky.social
. Peter conducted >10,000 mass spec analyses 🤯. So grateful for this opportunity to team up with the best of the best in metabolomics 😍 Read more:
www.biorxiv.org/content/10.1...
#microsky
add a skeleton here at some point
3 months ago
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Do you think transporters in E. coli contribute to metabolite release? No? Explore the effect of 66 different transporter knockout mutations on the exometabolome dynamics of ~300 metabolites yourself:
keio.unil.ch
Teaser: Increased proline in ΔputP
#microsky
#MEvoSky
3 months ago
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After two rounds of "peer review" at Scientific reports 😵💫
add a skeleton here at some point
3 months ago
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Great to see the increased use of genome-scale models in microbial ecology. Here is another recent example:
www.nature.com/articles/s41...
But why is no one questioning the often implicit assumption that growth-optimization at the community level is the driving force of cross-feeding?
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Substrate utilization and cross-feeding synergistically determine microbiome resistance to pathogen invasion - Nature Ecology & Evolution
Combining genome-scale metabolic modelling with in vitro and in planta experiments, the authors show that cross-feeding metabolites and substrate utilization synergistically determine microbial commun...
https://www.nature.com/articles/s41559-025-02908-z
3 months ago
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Great opportunity with a very nice PI👇
add a skeleton here at some point
4 months ago
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A beautiful review of the factors influencing spatial organization of microbiomes
add a skeleton here at some point
5 months ago
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Nice review of metabolic exchanges in microbiomes across environments
www.cell.com/trends/micro...
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An updated view of metabolic handoffs in microbiomes
From the human gut to the deep ocean, diverse microbial communities underpin essential ecosystem processes. Limited understanding of the dynamics and interactions that shape these communities, however...
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(25)00220-3?rss=yes
6 months ago
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Excited to share the first results from my postdoc at
@dmf-unil.bsky.social
with
@saramitri.bsky.social
www.biorxiv.org/content/10.1...
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Microbes release lower-value metabolites at higher rates
Microbes release a wide range of metabolites into their environment, yet the reasons for this release and the factors that influence release rates are not well understood. Here, using a combination of...
https://www.biorxiv.org/content/10.1101/2025.08.19.671024v1
6 months ago
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