What a resource!

Another example showing how common it is for microbes to release metabolites way beyond what's thought of as waste products Characterization of phytoplankton-excreted metabolites mediating carbon flux through the surface ocean | PNAS www.pnas.org/doi/10.1073/...

One of the biggest challenges in microbial biotechnology? Unlocking the potential of non-model microbes and synthetic communities! Glad to share our review @sonjablasche.bsky.social @simonemozzachiodi.bsky.social @kiranrpatil.bsky.social @cambridgebiosci.bsky.social🧵(1/7) doi.org/10.1016/j.co...

Cells maintain low metabolite pools to: - enable substrate level regulation - prevent competitive inhibition - avoid side reactions #microsky www.cell.com/cell-systems...

Imbalance in gut microbial interactions as a marker of health and disease www.science.org/doi/10.1126/...

Nice thread on the importance of spatial structure in microbial communities

Really elegant work showing how spatial distance can determine the net effect of two interaction mechanisms

Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia A nice demonstration of how cross-feeding shapes small microbial community compositions From Segré lab @dsegre.bsky.social www.biorxiv.org/content/10.6...

Intra-species crossfeeding in K. pneumonia supports growth of co-cultivated partners. I think such commensal interactions are very common journals.plos.org/plosbiology/...

Metabolic control of porin permeability www.nature.com/articles/s41...

New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!

This project wouldn't been possible without Peter Doubleday and @nzamboni.bsky.social at @imsb-eth.bsky.social. Peter conducted >10,000 mass spec analyses 🤯. So grateful for this opportunity to team up with the best of the best in metabolomics 😍 Read more: www.biorxiv.org/content/10.1... #microsky

Do you think transporters in E. coli contribute to metabolite release? No? Explore the effect of 66 different transporter knockout mutations on the exometabolome dynamics of ~300 metabolites yourself: keio.unil.ch Teaser: Increased proline in ΔputP #microsky #MEvoSky

After two rounds of "peer review" at Scientific reports 😵‍💫

Great to see the increased use of genome-scale models in microbial ecology. Here is another recent example: www.nature.com/articles/s41... But why is no one questioning the often implicit assumption that growth-optimization at the community level is the driving force of cross-feeding?

Great opportunity with a very nice PI👇

A beautiful review of the factors influencing spatial organization of microbiomes

Nice review of metabolic exchanges in microbiomes across environments www.cell.com/trends/micro...

Excited to share the first results from my postdoc at @dmf-unil.bsky.social with @saramitri.bsky.social www.biorxiv.org/content/10.1...