Happy and proud with our lab’s presentations at Second @frenchzebrafish.bsky.social meeting in Toulouse! Go Fish 🇫🇷🐟!

📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please. Focus: intestine aging & immunity in fish 🐟 Start Nov–Dec 2025 • ~€3,175/mo Apply: ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks GUTPOWER (reef fish) → tinyurl.com/mt2ekpks

📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please. Focus: intestine aging & immunity in fish 🐟 Start Nov–Dec 2025 • ~€3,175/mo Apply: ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks GUTPOWER (reef fish) → tinyurl.com/mt2ekpks

Interested in cGAS-STING? Come and join us on 21st of October 2025 (9:30-12:30) in Nice, France! univ-cotedazur.fr/recherche-in...

In London, hate will never win.

Aging: “So far, no one has managed to rejuvenate anyone.” What are #telomeres? How can #zebrafish help in the study of #aging? Miguel Godinho Ferreira, a Portuguese scientist working in France, answers. Let's talk about longevity and aging. (Portuguese only) www.publico.pt/2025/09/16/c...

Great opportunity to meet with French zebrafish community! Our lab will gladly join! Go fish! 🐟

It is so nice to have this trail on our recent work. Thank you, @cyrilpedia.bsky.social! The follow up is just around the corner! 🙂

Comment in issue 17: Making sense of oxygen sensing Glutamine sensing by mTORC1 via GCN2 Androgen signaling control via Parp7 and an ADP-ribosyl degron Dendrite-like pseudopods let macrophages ingest bacteria Cover by @miguelgf.bsky.social et al www.embopress.org/toc/14602075...

Our paper was offered the cover of The EMBO Journal. 😀 We discovered that activation of cGAS-STING causes aging in response to very short telomeres. Zebrafish deficient in telomerase and sting, reverse premature death, reduced fertility, frailty and cancer. 👉 tinyurl.com/nhd4bfb9

Not all species age the same way 😉 “We conclude that M. musculus maintains long telomeres in blood and tail throughout life” Congrats Rhian and Dudy et al! 👏 House mouse maintains constant telomere length throughout life url: academic.oup.com/nar/article/...

What’s on at #GIMMFest Day 1 & 2? We’ll kick things off with big ideas to spark your curiosity, then dive into fresh perspectives on the future of aging and the everyday experiences that shape it. 🔗 gimm.pt/pt-pt/gimm-festival/#program

Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation. Go Fish! 🐟🐟🐟 www.thno.org/v15p7308.htm

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish #preLight prepared by Jawdat Sandakly⬇️ 👀 prelights.biologists.com/highlights/t...

Highlights work from @miguelgf.bsky.social et al. 🐟

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author manuscript of Bruno Lopes-Bastos. We are very happy for this!

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts. Secure your spot on: gimm.pt/gimm-festival/ @nataging.nature.com

Here’s the EMBO Journal highlight on our paper!

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish www.embopress.org/doi/full/10....

It was a pleasure to invite our neighbour Corine BERTOLOTTO to IRCAN. It was a great review of the lab's work and a very nice return to Hopital Pasteur, Nice. "Uveal melanomas: identification of new prognosis biomarkers and therapeutic targets"

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

TODAY - You are still on time for early bird registration for the GIMM Festival on #Aging and #Longevity! Lisbon from 4–6 September 2025.

GIMM Fest | Aging and Longevity: Registrations open now! September 4-6 2025, Portugal, Lisbon. The brand new Gulbenkian Institute, launching – the very first GIMM Festival – "Aging and Longevity" to explore the future of aging through science. gimm.pt/gimm-festival/

Our latest preprint! We show that telomeric antisense oligonucleotides alleviate premature #aging in #telomerase mutant #zebrafish. A collaboration with the labs of Fabrizio d'Adda di Fagagna and Marina Mione. Congrats Bruno for his first corresponding author paper!👏 www.biorxiv.org/content/10.1...

"CERN (..) was created in the 1950s by physicists, who persuaded governments to invest in shared infrastructure and long-term collaboration. Now, it (...) thrives thanks to stable funding, open science and a culture of international partnership." www.nature.com/articles/d41...

This is a fantastic symposium on the Biology of Aging organized by the GIMM in Lisbon next September 4-6, and with an opportunity for non-specialists to join the discussions. Stellar speaker lineup in beautiful Lisbon: gimm.pt/gimm-festival/

Joao will be one of our discussion leaders! Join us: Lisbon, 4–6 Sept 2025! 🇵🇹 👉 gimm.pt/gimm-festival/

Absolutely thrilled to join the @gimmfoundation.bsky.social GIMM Festival 2025 in Lisbon at the Pavilhão Portugal from 4-6 September 2025. What questions do we need to ask to build a unifying theory of aging? Join a great lineup of speakers to discuss concepts of the biology gimm.pt/gimm-festiva...

Join the GIMM Festival on #Aging and #Longevity! 🌟 Over three days, we’ll explore key questions: 1️⃣ Can we move toward a unifying theory of aging? 2️⃣ What are the top targets for longevity therapies? 3️⃣ How will aging research reshape society? Lisbon, 4–6 Sept 2025! 🇵🇹 👉 gimm.pt/gimm-festival/

I am happy to contribute to this important initiative on how to improve #REPRODUCIBILITY in #AGING research using #zebrafish. Thank you ZHA for inviting me. Go Fish! 🐟

"Significantly, in HGPS, inhibition of the non-canonical cGAS-STING pathway ameliorates cellular hallmarks of aging, reduces tissue degeneration, and extends the lifespan of progeria mice." Congratulations! 👏

🗣️ #killifish researchers & facilities: The community (led by Dr. Beate Hoppe @leibnizfli.bsky.social) is conducting an anonymous survey on husbandry of the African turquoise killifish (Nothobranchius furzeri) in hopes to standardize care & refinement. 🔗 to help: survey.lamapoll.de/Global-Surve...

"Altogether, our findings uncover in response to oxidative stress major remodelling of telomeric DNA, RNA, and shelterin complexes, and they unravel a physiological role of TRF2’s ability to stimulate TERRA R-loop formation." From the Lingner and Doksani Labs 👏 academic.oup.com/nar/article/...

😳 “Lastly, we find that the microbiome is associated with multiple health parameters, including body composition, immune components and frailty, but not lifespan.” #aging www.nature.com/articles/s41...

A cautionary tale for the USA. "When national science funding becomes uncertain, researchers leave, new talent refrains from joining and infrastructure deteriorates." www.nature.com/articles/d41...

Lifetime quotes.

Are you passionate about live-imaging microscopy? Do you have a special talent for working with iPSCs? Or are you simply a zebrafish aficionado? 🐟 We have 2 funded postdoctoral positions in our lab (cbi-toulouse.fr/eng/equipe-b...). Join us and apply now! Please spread the word 🙏

Are the longevity crowd barking up the wrong tree because they have mistaken the chicken for the egg? Evidence that epigenetic 'clocks' are driven by somatic mutations www.nature.com/articles/s43... #biosky

"Eukaryotes have linear DNA and their telomeres are hotspots for transposons (...). Here we identify several families of independently evolved telomeric transposons in linear chromosomes and plasmids of cyanobacteria and Streptomyces." www.science.org/doi/10.1126/...

👏"We found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue #regeneration during aging in mammals. Inhibition of ATM and ATR kinases revealed that #DDR is essential for #zebrafish heart regeneration."🐟 www.nature.com/articles/s41...

For many years, we knew that #telomerase has multiple #splicing isoforms that are differently expressed in #cancer cells. This study now shows the impact of retaining or skipping specific introns on cellular longevity, replicative potential, and germline cancer risk. www.nature.com/articles/s41...

The Dog Aging Project is an innovative research initiative that brings together a community of dogs, owners, veterinarians, researchers, and volunteers to carry out the most ambitious canine health study in the world. dogagingproject.org

Happy to join the ZHA initiative to improve #reproducibility (in #aging). #Zebrafish are great models for Dev Biology and most facilities use protocols for high, early #fecundity, but these often hurt #longevity and #healthspan. Help promote reproducibility in science! zhaonline.org/reporting-re...

New model of premature #aging in #zebrafish 👏 "Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration." Go Fish! 🐟 www.pnas.org/doi/10.1073/...

We are looking for a #Postdoc to join our team to work on a funded project by La Ligue investigating the role of #gut permeability as a cause of #cancer with #age. 🐟🐟🐟 #zebrafish #telomerase #microbiome DEADLINE: 29/Jan/2025 Please help us spread the word! 🙏

With our lab’s inaugural Blue Sky post we celebrate our latest publication, a review in Nature Reviews Molecular Cell Biology (@natrevmcb.bsky.social) 🥳 Here, we review our current understanding of telomere biology, discussing differences between human and mouse. www.nature.com/articles/s41...

My latest review👇 #zebrafish🐟 surpass #mice as models of telomere-driven aging! With human-like #telomere dynamics🧬, they reveal how organ-specific short telomeres activate #cGAS-STING #inflammation 🔥, systemic organ dysfunction and #aging. 🐟 Go Fish! 🐟 cshperspectives.cshlp.org/content/earl...

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵