New study showing that aging rewires muscle microRNAs, but calorie restriction reverses many of these changes! In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation. link.springer.com/article/10.1...

Integrated Analysis of Proteomic Marker Databases and Studies Associated with Aging Processes and Age-Dependent Conditions: Optimization Proposals for Biomedical Research www.mdpi.com/2227-7382/13...

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy link.springer.com/article/10.1...

An Integrative Perspective on Bat Evolution www.annualreviews.org/content/jour...

Microvascular Health as a Key Determinant of Organismal Aging advanced.onlinelibrary.wiley.com/doi/10.1002/...

Nuclear-lamin-guided plastic positioning and folding of the human genome www.cell.com/cell-reports...

I'm delighted to share our curated list of 100 open problems in ageing science. This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience. link.springer.com/article/10.1...

Defining Microbiota-Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell Senescence onlinelibrary.wiley.com/doi/full/10....

Cellular senescence and cell therapy in cardiovascular diseases stemcellres.biomedcentral.com/articles/10....

Cellular Senescence and Inter-Organ Communication in Health and Disease journals.physiology.org/doi/abs/10.1...

Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends www.mdpi.com/2079-6374/15...

FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers www.biorxiv.org/content/10.1...

Post-reproductive lifespan in wild mountain gorillas www.pnas.org/doi/10.1073/...

Against “Extending Healthspan but Not Lifespan” as a Goal for Biogerontology www.preprints.org/manuscript/2...

Aging alters genomic instability at endogenous mutation hotspots in mice www.nature.com/articles/s41...

Prepupal diapause reduces adult lifespan in the solitary alfalfa leafcutter bee www.nature.com/articles/s41...

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial www.nature.com/articles/s43...

Immunosenescence and organoids: pathophysiology and therapeutic opportunities link.springer.com/article/10.1...

Human immune aging www.cell.com/immunity/ful...

Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance www.science.org/doi/full/10....

Longevity clinics: between promise and peril www.aging-us.com/article/2063...

Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon royalsocietypublishing.org/doi/full/10....

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Cognitive Decline by Restoring Senescent Microglial Function via NF-κB-SREBP1 Pathway Inhibition onlinelibrary.wiley.com/doi/10.1111/...

Excited to share my new piece @clarkesworldmagazine.com 🚀 I discuss the future of human longevity and its depiction in science fiction. And how the eventual medical control of aging and lifespan will reshape both society and storytelling. clarkesworldmagazine.com/de_magalhaes...

HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men genomemedicine.biomedcentral.com/articles/10....

Developmental senescence profiling reveals Eda2r as a common mediator in the core senescence program www.biorxiv.org/content/10.1...

The leaves fall, yet the tree endures link.springer.com/article/10.1...

This whale lives for centuries: its secret could help extend human lifespan www.nature.com/articles/d41...

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues www.embopress.org/doi/full/10....

FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse link.springer.com/article/10.1...

Integrative Omics Reveal Female-Specific Benefits of p16+ Cell Clearance in Aging Mice advanced.onlinelibrary.wiley.com/doi/10.1002/...

A full life cycle biological clock based on routine clinical data and its impact in health and diseases www.nature.com/articles/s41...

An Unbiased Cell-Culture Selection Yields DNA Aptamers as Novel Senescent Cell-Specific Reagents onlinelibrary.wiley.com/doi/10.1111/...

Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study www.nature.com/articles/s41...

Principles of protein abundance regulation across single cells in a mammalian tissue www.biorxiv.org/content/10.1...

New (and provocative) piece with David Gems 🚨 Extending healthspan rather than lifespan should not be the goal of aging research. Rather, our goal is to understand and intervene in aging to improve late-life health and save of lives: i.e. life-extension. www.preprints.org/manuscript/2...

The dissipation theory of aging: a quantitative analysis using a cellular aging map www.nature.com/articles/s41...

Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice link.springer.com/article/10.1...

Evidence for improved DNA repair in long-lived bowhead whale www.nature.com/articles/s41...

Multi-omic profiling reveals age-related immune dynamics in healthy adults www.nature.com/articles/s41...

Telomerase Depletion Accelerates Ageing of the Zebrafish Brain onlinelibrary.wiley.com/doi/full/10....

Living healthily to 120: Implications for entrepreneurship www.sciencedirect.com/science/arti...

Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast www.nature.com/articles/s42...

Protein restriction reprograms the multi-organ proteomic landscape of mouse aging www.cell.com/cell/abstrac...

Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases onlinelibrary.wiley.com/doi/full/10....

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future www.aginganddisease.org/EN/10.14336/...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging www.nature.com/articles/s43...

Protein Catabolites as Blood-Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project onlinelibrary.wiley.com/doi/full/10....

Circadian system and aging: where both times interact www.frontiersin.org/journals/agi...

Lilly invests in epigenetic reprogramming biotech longevity.technology/news/lilly-i...