Academia is great training for dating because you get so used to rejection.

Epigenetic markers of ageing and cancer risk www.sciencedirect.com/science/arti...

Great discussion earlier this week at the Oxford Biohacking Society on ageing biology and where longevity science may be heading. Thank you for the thoughtful questions and lively debate 🙏

Excited to share our ethical case for longevity science. We address concerns about overpopulation, inequality, and loss of meaning, and argue that life extension is ethically grounded in autonomy and the intrinsic value of life. www.sciencedirect.com/science/arti...

Greenland sharks survive for centuries with diseased hearts www.newscientist.com/article/2511...

Great piece on the recent study of the heritability of human lifespan, with some of my thoughts.

A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives www.frontiersin.org/journals/agi...

Pan-Epigenetic Age Prediction in Mammals onlinelibrary.wiley.com/doi/full/10....

I'm excited to be speaking in Oxford next week on recent breakthroughs in ageing and what they mean for the future of longevity. Hosted by the Oxford Biohacking Society 🗓 Tuesday, February 3, at 5:30pm. Details & registration below 👇 www.oxfordbiohackingsociety.com/event-detail...

Wow, mind-blowing study showing that immune T cells release “telomere Rivers” into circulation after acquiring them from other cells. In aged mice, telomere Rivers extended lifespan by 17 months (though n = 10), with some mice living nearly 5 years 🤯

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages aacrjournals.org/cancerdiscov...

Cellular senescence as a therapeutic target for aging intervention www.sciencedirect.com/science/arti...

Unlocking neuronal health: leveraging C. elegans for drug repurposing studies link.springer.com/article/10.1...

What the World’s Longest-Lived Animals Can Teach Us About Aging time.com/collections/...

Aging as a multifactorial disorder with two stages www.aging-us.com/article/2063...

New single rejuvenation factors 🚀 They used a transcriptional rejuvenation platform, based on replicative ageing, to identify single transcription factors that promote rejuvenation. They then validated hits in vitro and, for one factor (EZH2), in the liver of aged mice.

Restoring information in aged gene regulatory networks by single knock-ins arxiv.org/abs/2601.04016

A reminder that senescent cells can be functional and play important physiological roles. So, when labs and companies talk about therapies that remove senescent cells, the devil is in the details: how, when, and which senescent cells? www.science.org/doi/10.1126/...

Integrative transcriptomic identification of cellular senescence beyond marker limitations www.biorxiv.org/content/10.6...

Wow, an accelerated aging syndrome in the long-lived naked mole-rat! This was not on my bingo card for 2026 🤯

Northern Portugal is beautiful ❤️

Codon bias coevolves with longevity www.biorxiv.org/content/10.6...

Great study on the aging transcriptome. Their results suggest that, in flies, many age-related gene expression changes likely mitigate rather than accelerate aging. So, many age-related epigenetic and transcriptional changes may be responses to aging and therefore protective.

Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology academic.oup.com/emph/advance...

Prediction and analysis of anti-aging peptides using data augmentation and machine learning algorithms link.springer.com/article/10.1...

Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila www.nature.com/articles/s41...

Blood aging: From definition and mechanisms to clinical practice www.sciencedirect.com/science/arti...

Do we actually need aging clocks? www.nature.com/articles/s41...

Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies www.nature.com/articles/s41...

Vadim was a wonderful colleague and scientist. We collaborated on several projects, including on our aging-related databases GenAge and CellAge. His passing is a great loss, both personally and to our scientific community. He will be deeply missed.

I've just set up my out-of-office reply for the holidays. Which means I can finally work on all the manuscripts and projects I've been postponing during the year.

More than one species of the naked mole-rat, a new biomedical model www.nature.com/articles/s42...

Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers www.biorxiv.org/content/10.6...

A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibility www.biorxiv.org/content/10.6...

RNA degradation modulates unique aging-related gene expression in naked mole-rats www.biorxiv.org/content/10.1...

Aging As a Software Design Flaw What if ageing is not an accumulation of molecular damage to the hardware, but a process driven by our developmental software program? Great explainer video by Aleksey Belikov using NotebookLM. www.youtube.com/watch?v=Hqxe...

Atavistic Genetic Expression Dissociation (AGED) During Aging: Meta-Phylostratigraphic Evidence of Cellular and Tissue-Level Phylogenetic Dissociation onlinelibrary.wiley.com/doi/full/10....

Hematopoietic (stem) cells—The elixir of life? febs.onlinelibrary.wiley.com/doi/10.1002/...

Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation link.springer.com/article/10.1...

Wow, Retro Bio is raising $1B on a $5B valuation 🤯

Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects link.springer.com/article/10.1...

New methodological appraisal of the DrugAge database of longevity drugs 💊 Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals. Work led by Austin Parish with many great collaborators. www.nature.com/articles/s41...

Why we age is still longevity’s biggest question longevity.technology/news/why-we-...

Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches www.annualreviews.org/content/jour...

An average person in an industrialized country lives better than the kings and ultra-rich did 100 years ago. And an average person 100 years from now will live a better life than today's billionaires.

miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function link.springer.com/article/10.1...

circHERC1—A telomerase activator www.science.org/doi/10.1126/...

Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals www.science.org/doi/10.1126/...

Entropy and Human Aging onlinelibrary.wiley.com/doi/full/10....

Open problems in ageing science: a roadmap for biogerontology link.springer.com/article/10.1...