Lifespan stops at death, but when does healthspan stop? link.springer.com/article/10.1...

Mosaic ageing: from organ-specific decline to the cause of death www.authorea.com/doi/full/10....

Looking forward to the Targeting Longevity conference in Berlin next week! Excited to present and discuss the current state of ageing research, including systems biology approaches and future directions for the field. targeting-longevity.com

A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes www.medrxiv.org/content/10.6...

Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target www.nature.com/articles/s41...

A combination of senolytics causes neuropathology in mice 👀 Dasatinib and quercetin trigger oligodendrocyte dysfunction and white matter injury in the CNS. Senolytics under more scrutiny? www.nature.com/articles/s41...

There are definitely worse places to discuss frailty, ageing, and using AI to discover drugs that preserve health.

The therapeutic potential of natural killer (NK) cells to combat aging and age-related diseases link.springer.com/article/10.1...

Had a great time visiting Coventry University! Exciting collaborations ahead 🚀

Communication breakdown: senescent cells in interorgan communication of aging www.cell.com/trends/endoc...

Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank www.medrxiv.org/content/10.6...

A hierarchy of causes of death in senescent C. elegans www.nature.com/articles/s41...

Molecular evolution of animal aging link.springer.com/article/10.1...

Excited to share our new preprint on multi-omics signatures of accelerated PhenoAge. By integrating plasma proteomics and metabolomics, we identified pathways associated with faster aging, including immune-inflammatory activity. www.medrxiv.org/content/10.6...

For 20+ years the Human Ageing Genomic Resources (HAGR) have supported ageing research worldwide (200k+ users/year, 1,000+ citations). After losing UK government funding, we’ve launched a fundraiser to keep HAGR online. Please support or share! www.justgiving.com/page/human-a...

The Human Ageing Genomic Resources are vital open-source databases on longevity genes and drugs, and animal lifespans. It would be a loss to the field if they go offline due to funding cuts. See @jpsenescence.bsky.social’s post here for more details and how to support:

🚨 The Human Ageing Genomic Resources Are at Risk For over 20 years, our Human Ageing Genomic Resources (HAGR) have supported ageing and longevity research. We are raising funds to secure their continuity while we pursue long-term funding. www.justgiving.com/page/human-a...

A pleasure to visit beautiful Norwich and the @uniofeastanglia.bsky.social Lovely place and wonderful colleagues. Looking forward to future collaborations!

Cuproptosis and Aging: Molecular Mechanisms and Therapeutic Implications www.aginganddisease.org/EN/10.14336/...

ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement link.springer.com/article/10.1...

A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives www.frontiersin.org/journals/agi...

Excited to share our latest paper on the future of AI in biology 🚀🧬 We argue that decoding the genome and modelling gene interactions across space and time (from development to ageing) should be the ultimate goal for building predictive models of human biology. www.preprints.org/manuscript/2...

Academia is great training for dating because you get so used to rejection.

Epigenetic markers of ageing and cancer risk www.sciencedirect.com/science/arti...

Great discussion earlier this week at the Oxford Biohacking Society on ageing biology and where longevity science may be heading. Thank you for the thoughtful questions and lively debate 🙏

Excited to share our ethical case for longevity science. We address concerns about overpopulation, inequality, and loss of meaning, and argue that life extension is ethically grounded in autonomy and the intrinsic value of life. www.sciencedirect.com/science/arti...

Greenland sharks survive for centuries with diseased hearts www.newscientist.com/article/2511...

Great piece on the recent study of the heritability of human lifespan, with some of my thoughts.

A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives www.frontiersin.org/journals/agi...

Pan-Epigenetic Age Prediction in Mammals onlinelibrary.wiley.com/doi/full/10....

I'm excited to be speaking in Oxford next week on recent breakthroughs in ageing and what they mean for the future of longevity. Hosted by the Oxford Biohacking Society 🗓 Tuesday, February 3, at 5:30pm. Details & registration below 👇 www.oxfordbiohackingsociety.com/event-detail...

Wow, mind-blowing study showing that immune T cells release “telomere Rivers” into circulation after acquiring them from other cells. In aged mice, telomere Rivers extended lifespan by 17 months (though n = 10), with some mice living nearly 5 years 🤯

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages aacrjournals.org/cancerdiscov...

Cellular senescence as a therapeutic target for aging intervention www.sciencedirect.com/science/arti...

Unlocking neuronal health: leveraging C. elegans for drug repurposing studies link.springer.com/article/10.1...

What the World’s Longest-Lived Animals Can Teach Us About Aging time.com/collections/...

Aging as a multifactorial disorder with two stages www.aging-us.com/article/2063...

New single rejuvenation factors 🚀 They used a transcriptional rejuvenation platform, based on replicative ageing, to identify single transcription factors that promote rejuvenation. They then validated hits in vitro and, for one factor (EZH2), in the liver of aged mice.

Restoring information in aged gene regulatory networks by single knock-ins arxiv.org/abs/2601.04016

A reminder that senescent cells can be functional and play important physiological roles. So, when labs and companies talk about therapies that remove senescent cells, the devil is in the details: how, when, and which senescent cells? www.science.org/doi/10.1126/...

Integrative transcriptomic identification of cellular senescence beyond marker limitations www.biorxiv.org/content/10.6...

Wow, an accelerated aging syndrome in the long-lived naked mole-rat! This was not on my bingo card for 2026 🤯

Northern Portugal is beautiful ❤️

Codon bias coevolves with longevity www.biorxiv.org/content/10.6...

Great study on the aging transcriptome. Their results suggest that, in flies, many age-related gene expression changes likely mitigate rather than accelerate aging. So, many age-related epigenetic and transcriptional changes may be responses to aging and therefore protective.

Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology academic.oup.com/emph/advance...

Prediction and analysis of anti-aging peptides using data augmentation and machine learning algorithms link.springer.com/article/10.1...

Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila www.nature.com/articles/s41...

Blood aging: From definition and mechanisms to clinical practice www.sciencedirect.com/science/arti...

Do we actually need aging clocks? www.nature.com/articles/s41...