🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Online now! ✨Chiche, Djoual, Charifou et al identify a dual role for senescence in postpartum tissue remodelling: senescent cells drive mammary gland involution, yet predispose to postpartum tumor initiation @hanli-pasteur.bsky.social @pasteur.fr

Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0) doi.org/10.1038/s435...

Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217. doi.org/10.1038/s435...

Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ) doi.org/10.1038/s435...

Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. doi.org/10.1038/s435...

🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...

🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...

🗞️Our November issue is live, featuring multilingualism and healthy aging on the cover!📷The issue also includes work on biomarkers of aging, clinical interventions, the interplay between cancer and aging, and much more. Read it all here: www.nature.com/nataging/vol...

Online now! Emily Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of inactivating many tumor suppressor genes doi.org/10.1038/s435...

Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy. doi.org/10.1038/s435...

Online now! A new study shows that hospital-treated infectious diseases have a lasting impact on the development of epilepsy in older age, and that cardiovascular risk factors may exacerbate this impact. doi.org/10.1038/s435...

Online now!✨Parsons et al profile age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer nature.com/articles/s43... rdcu.be/eOc8t @vangalenlab.bsky.social @sandramcallister.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Online now! In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress in a heme- and iron-rich microenvironment. doi.org/10.1038/s435...

Genomic study of brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and phys health, and suggests high blood pressure and T2D as causal factors of brain aging #brainage @pjawinski.bsky.social @humboldtuni.bsky.social @mpicbs.bsky.social www.nature.com/articles/s43...

In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...

🗞️Our October issue is live!📷This month, we're featuring work on regulators of cognitive decline, senescence – immune interplay, herb-derived geroprotectors and more. Read it all here: nature.com/nataging/vol...

Online now! A new study shows that degraded elastin fragments, which increase in the circulation over time, promote aging. Counteracting elastin fragment signals alleviates inflammation, promotes healthy aging, and extends lifespan. (rdcu.be/eITno) doi.org/10.1038/s435...

🗞️Our September issue is live!📷This month, we're featuring work on somatic mutations, clocks, and more. Read it all here: nature.com/nataging/vol...

Online now! In this Perspective members of the Aging Biomarker Consortium (ABC) outline the X-Age project, an ABC plan for building standardized aging clocks in China. (rdcu.be/eGFV0) doi.org/10.1038/s435...

Online now! Study identifies a blood-based DNA damage signature in Parkinson’s disease patients that associates with disease progression. (rdcu.be/eES51) doi.org/10.1038/s435...

🎉 We’re thrilled to present our August issue, which includes a Focus on immune aging! 🎉Here, you’ll find a series of reviews and opinion pieces on recent advances in immune aging research nature.com/nataging/vol... 🎨by Alex Whitworth

Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets. www.nature.com/articles/s43...

Online now! A genetic study of frailty identifies 45 additional variants and implicates MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism, and cellular signaling. doi.org/10.1038/s435...

Online now! A new study shows that with age bone marrow fat cells become senescent and secrete SAP/PTX2, driving amyloid buildup and bone loss. (rdcu.be/ezbVV) doi.org/10.1038/s435...

Online now! Study identifies NCOA7 as a facilitator of autophagic clearance of stress granules in granulosa cells, thereby protecting against ovarian aging. Loss of NCOA7 promotes ovarian aging, while its expression delays aging. (rdcu.be/ezbT4) doi.org/10.1038/s435...

🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...

Online now! A Singapore-based simulation study projects rising chronic disease and healthcare costs, and shows that long-term lifestyle interventions can reduce future diseases and reduce healthcare spending by 2050. (rdcu.be/ewOLs) doi.org/10.1038/s435...

We are #hiring! Please repost! If you have a PhD, are passionate about aging research and curious about other disciplines than your own, consider joining the journal’s editorial team. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Online now! ✨COMMENT: Simon Lovestone & Farhad Imam highlight the Global Neurodegeneration Proteomics Consortium initiative and its potential resource value for biomarker discovery and mechanistic insight in neurodegenerative diseases. doi.org/10.1038/s435...

🗞️Our June issue is live!📷 This month, we're featuring work on editing epigenetic age, somatic mutation, senescence, Alzheimer’s biomarkers and much more. Read it all here: nature.com/nataging/vol...

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts. Secure your spot on: gimm.pt/gimm-festival/ @nataging.nature.com

Online now! Researchers @ki.se show that the progeria-causing mutation, LMNA 38 c.1824C>T, is a somatic mutation in arteries from patients with chronic kidney disease, clonal propagation of the mutation in the vascular wall results in vascular aging in mice (rdcu.be/eqv2M) doi.org/10.1038/s435...

Online now!✨RESEARCH: Fuentealba et al build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging nature.com/articles/s43... rdcu.be/eprz3

Online now! Wang et al present the human universal senescence index (hUSI), a robust transcriptome-based tool that accurately predicts cellular senescence across diverse conditions, offering insights into aging and therapeutic strategies. doi.org/10.1038/s435...

Online now! Hu et al., show an aging-related navigational decline owed to deterioration of the excitatory PVMVN → DTN pathway in brainstem. Targeted chemo-genetic pathway activation in aged mice rectified the deficit, highlighting a therapeutic avenue for cognitive aging. doi.org/10.1038/s435...

Online now! P-selectin has been considered as a biomarker of hematopoietic stem cell (HSC) aging. Here, Yang et al., uncovered a novel functional role of P-selectin engagement in regulating HSC regeneration and driving stem cell aging when perturbed. doi.org/10.1038/s435...

Online now!✨RESEARCH: Gkioni et al @mpiage.bsky.social show that trametinib and rapamycin treatment combine additively to extend lifespan and healthspan in female and male mice, reducing tumor growth and inflammation www.nature.com/articles/s43... rdcu.be/eo3gS

Online now!✨RESEARCH: Zhou, Novak et al show that the hypodermis regulates memory in C. elegans via insulin/IGF-1 and Notch signaling; activating this pathway rescues CREB-dependent memory in aged worms @ctmurphy1.bsky.social www.nature.com/articles/s43... rdcu.be/eo3Pd

Online now! Guo et al., identify human antigen R (HuR) as a regulator of age-related hearing loss (ARHL) in aged mice, and demonstrates that cochlear HuR overexpression alleviates ARHL, highlighting it as a therapeutic target for the condition. doi.org/10.1038/s435...

Online now! The authors identify, in a cohort of patients undergoing preimplantation genetic testing for aneuploidy, H3K27ac loss as a hallmark of endometrial aging linked to endometrial receptivity. (rdcu.be/em7mT) doi.org/10.1038/s435...

🗞️Our May issue is live!📷 This month, we're featuring work on planarians and rejuvenation, how ancient viruses factor into mammalian reproduction, mitochondrial biology in aging, age-related hearing loss, and much more. Read it all here 👇https://nature.com/nataging/volumes/5/issues/5

Online now! Zhang et al., identify GLP-1 receptor agonists mitigating Alzheimer’s disease-related cognitive decline and amyloid pathology in a transgenic mouse model via promoting phagocytosis and through activation of the CaMKK2-AMPK signalling pathway. doi.org/10.1038/s435...

Online now! Saloner et al. used large-scale CSF proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression. doi.org/10.1038/s435...

Online now! Madrer et al. identify a Parkinson’s disease-specific increase in tRNA fragments in the human biospecimen; demonstrating the ability of blood-based tRNA fragments quantification to identify pre-symptomatic patients. doi.org/10.1038/s435...

Online now! Using real-world intrinsic capacity (IC) screening data from implementation of WHO ICOPE program in primary care, de Souto Barreto, Lu et al., developed clinically friendly IC scores and centile values to monitor functional health during aging. doi.org/10.1038/s435...

Join us, @natneuro.nature.com, and @natmetabolism.nature.com in Daegu, South Korea, Dec 9-11 for a Nature Conference on brain aging: Towards Healthy Brain Aging: Bridging Biology, Lifestyle, and Therapeutics, in partnership with DGIST - natureconferences.streamgo.live/towards-heal...

A new perspective in @nataging.nature.com posits a new unified framework of replacement for aging. It is a significant contribution to the field of aging with a stellar group of coauthors. Our latest blog post gives you highlights. www.buckinstitute.org/blog/replace...

Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype. doi.org/10.1038/s435...

Online now! Study presents FiNi-seq, a method that enriches fibrotic tissue based on its physical properties and captures aging-associated cell types to enable the characterization of early fibrotic changes. doi.org/10.1038/s435...