Online now! Janssens et al. analyze age, physical function, and acute exercise in the context of multi-omics of human skeletal muscle, linking fitness to distinct aging profiles. (rdcu.be/fsJ0V) doi.org/10.1038/s435...

Online now! A new study shows that IL-11, which is elevated in aging ovaries of mice, rats and humans, activates fibroblasts to secrete extracellular matrix, increasing ovarian stiffness. IL-11 is implicated as a potential therapeutic target for ovarian aging. doi.org/10.1038/s435...

Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation @fdadf.bsky.social @ifomresearch.bsky.social www.nature.com/articles/s43...

Online now! Spatial atlas of aging mouse ovary shows that reproductive decline reflects progressive loss of spatiotemporal coordination #OvarianAging #WomensHealth @hattaca.bsky.social @davidsebfischer.bsky.social @akochersberger.bsky.social @jennifergarrison.bsky.social doi.org/10.1038/s435...

Online now! A Meeting Report from the Progeria Research Foundation’s 12th International Scientific Workshop reviews recent scientific advances and identifies strategic pillars to accelerate the development of Hutchinson–Gilford progeria syndrome therapies. rdcu.be/fpe5N doi.org/10.1038/s435...

🗞️Our June issue is live!✨Read about the healthspan and lifespan effects of time-restricted feeding in mice, insights from mathematical models of aging, how R-loops drive the SASP & much more nature.com/nataging/vol...

Online now!✨Raz et al fit survival data across species to a stochastic model of damage accumulation and removal; damage production rate best predicts lifespan, and species fall into two distinct aging regimes @navehr.bsky.social @urialonlab.bsky.social www.nature.com/articles/s43...

🗞️Our May issue is live!✨Read about immune mechanisms of calorie restriction identified from clinical trial data, tools to detect senescence burden via urine samples, asynchronous aging across female reproductive organs & much more www.nature.com/nataging/vol...

Online now! ✨Soldatkina, Ventura-San Pedro et al apply deep learning to histological and transcriptomic data from female reproductive organs across ages, reporting distinct and asynchronous aging trajectories detectable in independent plasma proteomics www.nature.com/articles/s43...

🗞️Our April issue is live! ✨The cover art depicts work on macrophage senescence as postage stamps 🎨The issue includes studies on improving vaccine efficacy in aging, endogenous regulation of cGAS, repurposing drugs for vascular dementia & much more nature.com/nataging/vol...

Online now! ✨Sopena-Rios, Ripoll-Cladellas use single cell transcriptomic data from nearly 1,000 female and male participants across the adult lifespan to profile sex-specific immune aging dynamics www.nature.com/articles/s43...

Online now! To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multi-omics screen perturbing 32 aging- and senescence-associated lncRNAs, and measuring matched changes in gene expression and chromatin accessibility. (rdcu.be/fblsB) doi.org/10.1038/s435...

Online now! Here the authors show that the killifish exhibit age-related transformation in the immune system which rapidly develops inflammation, genome instability, and functional decline. doi.org/10.1038/s435...

🗞️Our March issue is live, with killifish artwork by Dario Valenzano on the cover!🎨Read work on senescence in mammary gland remodelling, structural protein changes as readouts of Alzheimer’s disease, the 201 Parkinson’s disease trial & more ✨https://nature.com/nataging/volumes/6/issues/3

Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social doi.org/10.1038/s435...

Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social doi.org/10.1038/s435...

🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Online now! ✨Chiche, Djoual, Charifou et al identify a dual role for senescence in postpartum tissue remodelling: senescent cells drive mammary gland involution, yet predispose to postpartum tumor initiation @hanli-pasteur.bsky.social @pasteur.fr

Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0) doi.org/10.1038/s435...

Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217. doi.org/10.1038/s435...

Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ) doi.org/10.1038/s435...

Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. doi.org/10.1038/s435...

🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...

🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...

🗞️Our November issue is live, featuring multilingualism and healthy aging on the cover!📷The issue also includes work on biomarkers of aging, clinical interventions, the interplay between cancer and aging, and much more. Read it all here: www.nature.com/nataging/vol...

Online now! Emily Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of inactivating many tumor suppressor genes doi.org/10.1038/s435...

Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy. doi.org/10.1038/s435...

Online now! A new study shows that hospital-treated infectious diseases have a lasting impact on the development of epilepsy in older age, and that cardiovascular risk factors may exacerbate this impact. doi.org/10.1038/s435...

Online now!✨Parsons et al profile age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer nature.com/articles/s43... rdcu.be/eOc8t @vangalenlab.bsky.social @sandramcallister.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Online now! In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress in a heme- and iron-rich microenvironment. doi.org/10.1038/s435...

Genomic study of brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and phys health, and suggests high blood pressure and T2D as causal factors of brain aging #brainage @pjawinski.bsky.social @humboldtuni.bsky.social @mpicbs.bsky.social www.nature.com/articles/s43...

In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...

🗞️Our October issue is live!📷This month, we're featuring work on regulators of cognitive decline, senescence – immune interplay, herb-derived geroprotectors and more. Read it all here: nature.com/nataging/vol...

Online now! A new study shows that degraded elastin fragments, which increase in the circulation over time, promote aging. Counteracting elastin fragment signals alleviates inflammation, promotes healthy aging, and extends lifespan. (rdcu.be/eITno) doi.org/10.1038/s435...

🗞️Our September issue is live!📷This month, we're featuring work on somatic mutations, clocks, and more. Read it all here: nature.com/nataging/vol...

Online now! In this Perspective members of the Aging Biomarker Consortium (ABC) outline the X-Age project, an ABC plan for building standardized aging clocks in China. (rdcu.be/eGFV0) doi.org/10.1038/s435...

Online now! Study identifies a blood-based DNA damage signature in Parkinson’s disease patients that associates with disease progression. (rdcu.be/eES51) doi.org/10.1038/s435...

🎉 We’re thrilled to present our August issue, which includes a Focus on immune aging! 🎉Here, you’ll find a series of reviews and opinion pieces on recent advances in immune aging research nature.com/nataging/vol... 🎨by Alex Whitworth

Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets. www.nature.com/articles/s43...

Online now! A genetic study of frailty identifies 45 additional variants and implicates MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism, and cellular signaling. doi.org/10.1038/s435...

Online now! A new study shows that with age bone marrow fat cells become senescent and secrete SAP/PTX2, driving amyloid buildup and bone loss. (rdcu.be/ezbVV) doi.org/10.1038/s435...

Online now! Study identifies NCOA7 as a facilitator of autophagic clearance of stress granules in granulosa cells, thereby protecting against ovarian aging. Loss of NCOA7 promotes ovarian aging, while its expression delays aging. (rdcu.be/ezbT4) doi.org/10.1038/s435...

🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...

Online now! A Singapore-based simulation study projects rising chronic disease and healthcare costs, and shows that long-term lifestyle interventions can reduce future diseases and reduce healthcare spending by 2050. (rdcu.be/ewOLs) doi.org/10.1038/s435...

We are #hiring! Please repost! If you have a PhD, are passionate about aging research and curious about other disciplines than your own, consider joining the journal’s editorial team. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Online now! ✨COMMENT: Simon Lovestone & Farhad Imam highlight the Global Neurodegeneration Proteomics Consortium initiative and its potential resource value for biomarker discovery and mechanistic insight in neurodegenerative diseases. doi.org/10.1038/s435...

🗞️Our June issue is live!📷 This month, we're featuring work on editing epigenetic age, somatic mutation, senescence, Alzheimer’s biomarkers and much more. Read it all here: nature.com/nataging/vol...

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts. Secure your spot on: gimm.pt/gimm-festival/ @nataging.nature.com

Online now! Researchers @ki.se show that the progeria-causing mutation, LMNA 38 c.1824C>T, is a somatic mutation in arteries from patients with chronic kidney disease, clonal propagation of the mutation in the vascular wall results in vascular aging in mice (rdcu.be/eqv2M) doi.org/10.1038/s435...

Online now!✨RESEARCH: Fuentealba et al build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging nature.com/articles/s43... rdcu.be/eprz3