Exciting to see our latest story out in print — with @sandramcallister.bsky.social — on how breast cancer differs between younger and older patients, leading the way to tailored management to improve outcomes 💻🔬🧬🧪

Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬

This new way of looking at cellular diversity in single-cell sequencing is transformative imo, which is why we've taken a similar approach to study aging blood stem cells. Congratulations @dkotliar.bsky.social and @soumya-boston.bsky.social! 🩸🧪🧬 #hemesky

Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5

New insights into the Unfolded Protein Response in hematopoietic stem cells in @bloodjournal.bsky.social this week + commentary from @basitsalik.bsky.social and me🩸🐁 #hemesky doi.org/10.1182/bloo...

Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in @natrevcancer.nature.com 🧬 Great to work with @sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...

This may be my favorite paper of the year so far: integrating single-cell leukemia datasets to reveal how differentiation and mutations interact to drive disease, along with a tool that speeds up bone marrow cell annotation from ~4 weeks to ~4 hours..! aacrjournals.org/bloodcancerd... 🔬🩸🧬 #hemesky

Whenever the team @posit.co brings out a new feature, it’s exactly how I wished it would be. AI integration done right 🧠 positron.posit.co/assistant @anthropic.com

📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Had a great time catching up with friends and learning new science at FASEB Hematologic Malignancies! #hemesky @faseborg.bsky.social #HEMSRC

At the FASEB Heme Malignancies meeting with old friends and new - Pam Sung, Peter Van Galen (@vangalenlab.bsky.social), Julia Maxson (@juliamaxson.bsky.social), Johnathon Shafer. Trying out ales at the @treehousebrewing.bsky.social! #HEMSRC

#positron is rapidly replacing programs and websites I used with a customizable multilingual coding environment for data science (local+cluster+virtual machines) #bash #rstats #python @posit.co

Delighted to share our #hematology review article on mutant calreticulin in #MPN Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social link.springer.com/article/10.1...

Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...

Just a reminder of what is easily in my top 5 of favorite papers from 2023 www.cell.com/iscience/ful... @bailee-kain.bsky.social @thekinglab.bsky.social

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

Boston’s North End ❄️

Our new review “Insights into Leukemia from Single-Cell Genomics” is out! Great work by Nurefsan Sariipek @nursariipek.bsky.social 📝 www.annualreviews.org/content/jour... #hemesky 🩸🧬

Office plants are watered, almost ready to hit the road #ASH24 🩸🧬 #HemeSky

Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...

On Thanksgiving day, what is the effect of frequent blood donations? Donors may have a higher prevalence of EPO-responsive clonal hematopoiesis, but there is no increased risk for malignant clones, underscoring safety of repetitive blood donations. www.medrxiv.org/content/10.1... 🩸🧪 #hemesky

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1

Bad use case 🫠 (and reminder to carefully check everything ChatGPT generates)

Finally- the starter pack we have all been waiting for is here … Hematopoiesis 🎉❤️🩸🦴 So excited to have reached a critical mass of this community on here. 🙌🏻 Let me know if you want to be added!! go.bsky.app/KWdX5w7

Not many papers change the way I think about AML, but this exceptional work shows how cell states and genetics intertwine to mediate venetoclax resistance, unifying previous studies by identifying RAS-mutated LSCs that are primed to produce myeloid cells #hemesky 🩸🧪 www.nature.com/articles/s41...

Ok let’s give social media another try. I’ll share advances in blood/cancer/aging/bioinformatics research and pictures of my daily commute along Boston’s Esplanade like this one

Python ≠ my forte, but with the help of ChatGPT I created this nice little script to count files stored in Google Cloud Storage (GCS) buckets, categorized by their storage class (e.g., STANDARD, NEARLINE, COLDLINE, ARCHIVE). I hope it helps someone like it does me! 🐍 github.com/petervangale...

Special seminars! @bloodsky.bsky.social www.iseh.org/page/isehweb...

Briefly went on X to look something up and on top of my feed was a video making fun of someone’s medical condition. Such a relief to be here 😇

Proud to be part of the innovative work on blood stem cell dynamics published with Vijay Sankaran @bloodgenes.bsky.social, Chen Weng and Jonathan Weissman out in Nature today titled “Deciphering cell states and genealogies of human hematopoiesis” doi.org/10.1038/s415...

When you paste something from ChatGPT and Grammarly tries to correct it

Analysis of somatic mutations from single-cell RNA-sequencing libraries is crucial to understand (pre) cancer biology @livius.bsky.social www.nature.com/articles/s41...

Another great line up at one of my favorite (publicly accessible) seminar series 📺 Mondays 4 PM CET / 10 AM EST us06web.zoom.us/j/83009472100

So happy with the CURE Mentor Appreciation Award! Getting a mentor award is really something different 😊 and thanks to my trainees who are the real reason we gave the students a good experience! www.dfhcc.harvard.edu/news-archive...

Thanks @paralkarlab.bsky.social for the invite! Let's hope this will be a more benign environment. We just have to get the community to join!