📽️ G&D Tapes 📽️ G&D Author, Aishwarya Pawar, tells us about their new study showing that PHF6 and PHIP function together to suppress stemness programs and leukemia progression. @aishwarya2510.bsky.social @paralkarlab.bsky.social Learn more here: ➡️ genesdev.cshlp.org/content/39/1...

This is beautiful! 🥲

RESEARCH PAPER: Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness By Pawar et al. and Vikram Paralkar Aishwarya Pawar Vikram Paralkar Learn more here:  ➡️ https://genesdev.cshlp.org/content/39/19-20/1219.abstract

What an incredible and impactful life!

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

WAIT there's actually a bacterial culture medium called TERRIFIC BROTH?!? I thought it was just a joke that members in my lab were making... 😵‍💫

My cartoon for this week’s @newscientist.com

Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.

Not really an overstatement to say that the test of a free society is whether or not comedians can make fun of the country's leader on TV without repurcussions.

A random bit of history (for modern analogies). Lysenko set back genetics in USSR by ~50 years. Hundreds of geneticists imprisoned or died. Cybernetics was also named "reactionary pseudoscience", and about to undergo similar fate, but got lucky that this started close to the end of the Stalin era.

Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5

Actually, Frankenstein is a doctor success at the Venice film festival

Final version of Bingbing Duan’s main thesis work is out now now in Nature Communications @natureportfolio.nature.com www.nature.com/articles/s41... I’m so pleased with this study that we’ve been working on for so long #epistasis #transcription #geneexpression 1/

Delighted to present our work on Pol I in hematopoiesis at the @cshlnews.bsky.social meeting on Eukaryotic Transcription. Thanks to Mustafa Mir (my collaborator in the Penn Epigenetics Institute @pennepigenetics.bsky.social) for his lab's amazing single molecule imaging platform, and for this photo!

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

Thank you to ASH for supporting our lab as we await a decision on a normally-fundable-percentile R01 that is currently in limbo! #Fight4Hematology

With potential NIH budget cuts and funding freezes putting vital work at risk, the ASH Bridge Grant is helping researchers, and their discoveries stay on track to improve patient care. #Fight4Hematology

New updates from the NIH

Curious about new approaches to protein synthesis research? This @embl.org symposium will explore topics on pathogens and diseases, translation regulation, emerging technologies, and more. Virtual registration is open until August 27. Learn more at plos.io/4klYTrm #EMBLProtein

Sugar is the fuel of life, but we are drowning in it in the modern world. Where does all that excess sugar go, and what quiet damage might it be causing inside us?

Given the ChatGPT "Blueberry" discussion, here's what I got when I ran this question with ChatGPT o4-mini (my account isn't yet updated to GPT-5 - they seem to be rolling it out in phases). It seems to have got it right...

Nascent and mature Ribosomal RNA Unbalanced in parts #ChromatinHaiku #RNAsky #28S #Chromatinsky www.biorxiv.org/content/10.1...

📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Happy RNA Day to those who celebrate! 🧪 It’s AUG 1: the day we Met 🤓

As stressful as it is to run a laboratory in the US right now, my thoughts are often with the NIH staff living in the awful chaos trying to preserve the whole enterprise. I’m grateful for every moment they choose not to give up. These people are the only thing keeping it from entirely collapsing.

At the FASEB Heme Malignancies meeting with old friends and new - Pam Sung, Peter Van Galen (@vangalenlab.bsky.social), Julia Maxson (@juliamaxson.bsky.social), Johnathon Shafer. Trying out ales at the @treehousebrewing.bsky.social! #HEMSRC

Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪

📣 New publication from our group! 📣 Our work showing that the leukemia mutated genes PHF6 and PHIP act as a chromatin complex to repress AML stemness is now out in @genesdev.bsky.social. Congratulations to first author @aishwarya2510.bsky.social, who defended her PhD on this work this month!

The NIH is one of America's greatest accomplishments!

I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.

Charles Antony from our group presents work on live cell imaging of RNA Pol I and ribosomal RNA transcription in AML at the FASEB Heme Malignancies meeting. #HEMSRC. This work is part of an incredibly fruitful collaboration with my colleague Mustafa Mir in @pennepigenetics.bsky.social!

Legend says the ancient Babylonians once tried to sequence and annotate God's own genome, and for their ambition and hubris they were forever cursed to have different annotation formats and standards so they could never do genomics with ease again.

Looking forward to welcoming everyone to the FASEB Heme Malignancies meeting on Sunday! As you are packing, we wanted to let you know that there is a gym, basketball court, and pool on site! Also, options for hiking at the brewery social event! 🏊‍♀️🏀🏋️‍♀️ Safe travels! #HEMSRC

Good grief, the US National Cancer Institute projects it will fund only one in 25 RO1 grant applications in 2026. This is massively defunding cancer research. Despicable vandalism. www.cancer.gov/grants-train...

Heading to Orlando this December for ASH 2025? Have cool unpublished science about myeloid/hematopoietic stem cell biology you'd like to present at this year's Myeloid Workshop? Then get in touch - send me an email or message on this platform! Seriously. Do it.

Really fascinating work from Grant Challan's group reporting that increased HSC self-renewal seen with Dnmt3a knockout is potentially due to non-methyltransferase roles.

Progress takes all of us! Support the #Fight4Hematology and help fuel the next breakthrough. Donate Now! donate.hematology.org/s/

As a #childhoodcancer doctor, I'm proud to be able to advocate for children with cancer in any way that I can. Here is a piece that I recently wrote for #TheDetroitNews, who kindly published it. #PEDCan #CANSky www.detroitnews.com/story/opinio...

Politics aside, anyone with a shred of empathy must feel absolutely gutted for the tremendous loss and grief felt by so many families and parents in Texas. The sense of grief that communities face over needless deaths of young people is visceral and shared. 1/

"Indeed, the adult traits I acquired surviving dinosaurs will make me an enthusiastic and passionate member of a college community, whether I brave a Friday night dance or experiment in a new discipline, such as figure drawing." 😂

Just received the NoA for an NIGMS MIRA R35 renewal. After two grants being in limbo since February, this is a HUGE relief!

Just learned something amazing: The members of my lab (Paralkar lab) and those of my neighboring lab (Nancy Speck's lab) play Quizzo together, and their team name is THE PARASPECKLES! 😭

Congratulations to DOCTOR Aishwarya Pawar @aishwarya2510.bsky.social (of ‪@cambupenn.bsky.social Cancer Biology graduate group) for defending her thesis with flying colors, and for her first-author paper in press in @genesdev.bsky.social! We are so proud of you!

Aishwarya Pawar (@aishwarya2510.bsky.social‬) in the ‪@paralkarlab.bsky.social defends her thesis tomorrow!

This makes me so sad...

OMG the little Okazaki fragments! ❤️

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

Congratulations to Nancy Speck, @mafdawson.bsky.social, @dianekrause.bsky.social, and others for their amazing contributions! 😀😀😀👏🏼👏🏼👏🏼