Neue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie. www.nct-heidelberg.de/das-nct/news... @dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social

👉🏼 @milsommick.bsky.social talking about the role of inflammation on HSC aging in the “Game of Clones” Scientific Session at #ASH25. #epigenomics #hematopoiesis #HemeSky @dkfz.bsky.social

Interested in DNA methylation and want to hear what we can learn from it regarding lineage commitment decisions in #hematopoiesis? #ASH25 #epigenomics #HemeSky

Very happy and proud to see this story finally published! 🎉🥳 #epigenetics #hematology #jmml #leukemia

The future of hematological genomics is here. The ASH HematOmics Program (ASHOP) developed with St. Jude & the Munich Leukemia Laboratory offers free access to powerful genomic visualization tools for blood disease research. 🔗 https://ow.ly/G7Ol50XukwQ #Genomics #HemeSky #MedSky

The figures from this book are all freely available through @figshare.com, hopefully helpful for presentations and teaching: figshare.com/projects/Epi... Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures. #EpigeneticsBook

Great to meet friends and colleagues at this year’s EWOG-MDS meeting in Berlin. We had great discussions and developed new project ideas and collaborations with the aim of improving risk stratification and patient care for JMML patients. #jmml #ewogmds #precisionmedicine www.ewogberlin2025.org

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Of interest to the #epigenomics, #dnamethylation, #neurooncology, #oncology and #precisionmedicine communities! 🧬

DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas. doi.org/10.1007/s004...

Epigenetics Update - Fluctuating DNA methylation tracks cancer evolution at clinical scale go.nature.com/3Ve4OUy #Epigenetics #Cancer #DNAme #DNAm --- Empower your research with high-res epigenetic insights at epigenometech.com

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

Still two weeks left to apply to the #postdoc position in my lab via the @dkfz.bsky.social fellowship program. #epigenomics #hematology #leukemia #computationalbiology #precisiononcology

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

+++ Postdoc Opportunity +++ My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia. www.dkfz.de/fileadmin/us... Applications via the #DKFZ postdoc program: www.dkfz.de/en/karriere/...

Epigenetics Update - Thymic epithelial cells amplify epigenetic noise to promote immune tolerance go.nature.com/45srCWG Andrew S. Koh (University of Chicago) reporting in Nature #Epigenetics #Noise #Chromatin #Immunity --- High-resolution insights without cell sorting; epigenometech.com

🧵Radiotherapy immune signaling is modular, redundant — and has a limit. Together with @joschakraske @peterhuber_hd @halama_immuno @UKHD_radonc our new study in fully human systems shows that: t.co/GzH3N6gElf 1/9

Plant #epigenetics colleagues, is this the consensus opinion? "...these methylation marks and epiallelic variations found in natural populations are mainly attributed to genetic variations in epigenetic machinery and transposable element (TE) insertions" pmc.ncbi.nlm.nih.gov/articles/PMC...

I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾 👉 rdcu.be/ezA5o

There’s still time to apply for one of our five advertised postdoctoral positions in developmental epigenetics! Click here to find out more and apply: lms.mrc.ac.uk/work/vacanci... Applications close 12th August #HiringNow #Jobs #Epigenetics

Happy to share our recent publication on benchmarking peak calling methods for CUT&RUN. academic.oup.com/bioinformati... Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social #Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome

📢 Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis – taking place November 12–14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.

Now online in Cancer Discovery: Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA - by Yuxuan Wang, Nickolas Papadopoulos, Elizabeth Platz, Bert Vogelstein, and colleagues doi.org/10.1158/2159...

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. www.embopress.org/doi/full/10....

1/ 🧬 A Hitchhiker’s Guide to Long-Read Genomic Analysis is out now! This mini-review walks through the latest advances in long-read DNA sequencing — from assemblies to variant calling to epigenetics. Link 🔗 genome.cshlp.org/content/35/4... 🧵👇

Few days left to apply for a #postdoctoral position in my team investigating the pathomechanism of IDH1 mutations at the interface of #metabolism and #epigenomics!

We are recruiting! Senior postdoc in computational cancer genomics/epigenomics @ludwigcancer.bsky.social @ox.ac.uk. Lead research into epigenetic drivers of secondary AML with rich omics data + strong clinical/wet-lab collaborations. cutt.cx/YUoB We look forward hearing from you! #epigenetics #jobs

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: www.findaphd.com/phds/project... Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social). Please share 🙏 #epigenetics

📣 Don't miss a fantastic PhD opportunity with ‪@sproullab.bsky.social to explore DNMT3B genome recruitment and alterations in rare human genetic disease using human differentiation models. I'm excited to collaborate on this project along with Daria Bunina. Apply now - deadline 16th May! #epigenetics

New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...

Hey #HemeSky and #EpiSci folks! We are hiring! For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. Interested? 👉See jobs.dkfz.de/en/jobs/1676... or DM me!

Just over 24 hours to get your abstract submitted

Congratulations to everyone!

The VAI Epigenomics Workshop is a great opportunity for #PhD students to learn the latest techniques from internationally recognized #epigenomics experts! 🗓️ July 29–31, 2025 📍 Van Andel Institute 👇 Learn more and apply

Hey #HemeSky and #EpiSci folks! We are hiring! For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. Interested? 👉See jobs.dkfz.de/en/jobs/1676... or DM me!

🗣ASH needs your help‼️ ️Congress needs to pass legislation extending funding for federal agencies and programs by THIS Friday. Reach out to your elected officials to share the importance of research funded by the #NIH. Take action today: www.hematology.org/a...#NIH. #HemeSky

Very interesting workshop highlighting recent developments in molecular #hematopoiesis #HemeSky

Register to be part of the next Cambridge Cancer Epigenetics online presentation - March 7, 2025. Get the link ➡️ bit.ly/4ijqcBn #epigenetics #genomics #cancerresearch #aacr2025

Epigenetic memory of chronic inflammation in intestinal stem cells primes for malignant transformation. #EpiSci

New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)

Great tool to dissect methylome data from bulk tumor samples at single-molecule resolution! #EpiSci

Anlässlich der #Bundestagswahl am Sonntag wird der #sv98 gegen den FC Schalke 04 in einem Sondertrikot auflaufen. Unter dem Motto "Demokratie wählen. Gegen Ausgrenzung und Rassismus", ruft der Verein dazu auf, von seinen demokratischen Rechten Gebrauch zu machen und sich an der Wahl zu beteiligen.

Cool work! 😎 Congratulations! 🎉

YOU + ME + (all your favorite people who love, do, and believe in science for all!) 🧪STAND UP FOR SCIENCE🧪 MARCH 7th, 2025 on the National Mall in DC and at your state capital! Because science is for everyone! Www.standupforscience2025.org SHARE WIDELY! #standupforscience2025 #scienceforall

👉🏻Great opportunity in an excellent lab!

Wir suchen 2 Oberärzt:Innen (Akute Leukämien und Allo-TX). Wir bieten das gesamte Spektrum der univ. Hämatologie von mol. Diagnostik bis ICU mit einem fantastischen Team. karriere.ume.de/job-finder/?... karriere.ume.de/job-finder/?... Bei Interesse melden Sie sich bitte sehr gerne bei uns!

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC

Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)