Download our poster to learn how we applied Droplet Paired-Tag to Alzheimer's disease post-mortem brain tissue to reveal specific cellular changes and potential therapeutic targets #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers bit.ly/4kgWMF3

Epigenetics Update – A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection go.nature.com/4qGhUaj #Epigenetics #cfDNA #Cancer #DNAm --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Preprint - The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A bit.ly/4cl6sxB #Epigenetics #ESCs #HistoneDemethylation #KDM3A --- Empower your research with high-res epigenetic insights at epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4qFE5xl "Mesenchymal Drift: A Novel, Targetable Mechanism at Play During Human Aging and Disease Development" Based on an article from Juan Carlos Izpisua Belmonte (Alto Labs/Salk) #EpigenomeTech #Blog #Cancer #MesenchymalDrift #Aging

Epigenetics Update - Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR go.nature.com/4qNpNea Inkyung Jung and Yarui Diao in Nat Biotech #Epigenetics #SingleCell #Multiomics --- Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo bit.ly/46anfiQ #Epigenetics #SETDB1 #Totipotency --- Discover the breakthrough at epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4ashyOo "NSD2 and H3K36me2: Revealing the Basis for Prostate Cancer Cell Lineage Plasticity and Uncovering Therapeutic Strategies" Based on a Nature article by Chao Lu and Michael M. Shen #EpigenomeTech #Blog #ProstateCancer #Cancer #NSD2 #H3K36me2

Epigenetics Update - Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization go.nature.com/3OxrAXf Jack-Christophe Cossec in NSMB #Epigenetics #Totipotency #Chromatin Hi-res insights without cell sorting; epigenometech.com

Epigenetics Update - M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors go.nature.com/3ZCyugn Paul A. Northcott reporting in Nat Cancer #Epigenetics #DNAm #Cancer --- Empower your research with high-res epigenetic insights at epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4rfD3JA "What Can Epigenomic Foundation Models Reveal About Biology?" Part 2: Modeling DNA Methylation #EpigenomeTech #Blog #FoundationModels #DNAm

Epigenetics Update - Chromatin binding and N-terminal domains of DNMT3B1 confer specificity for developmentally regulated CpG island methylation bit.ly/4aqP086 Neil Brockdorff reporting in Genes Dev #Epigenetics #Chromatin #DNAm --- Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation go.nature.com/4qIOxnH Tessa M. Popay and Jesse R. Dixon (Salk) in Nat Genet #Epigenetics #ChromatinLoops --- Gain deeper insights into gene regulation; epigenometech.com

Some good news at the start of a new week – Epigenome Technologies is now on Substack! Find us a epigenometech.substack.com, subscribe, and enjoy reading our blogs and articles!!! #Substack #EpigenomeTech #Epigenetics #PairedTag #Epigenetics #SingleCell #Multiomics

Epigenetics Update - BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes bit.ly/4kxXPSa Costas A. Lyssiotis and Yatrik M. Shah (University of Michigan) reporting in Mol Cell #Epigenetics #BRD4 #Mitochondria --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Cognitive rejuvenation through partial reprogramming of engram cells bit.ly/4qDqMgZ Johannes Gräff and Gabriel Berdugo-Vega (EPFL) reporting in Neuron #Epigenetics #Aging #Reprogramming --- High-resolution insights without cell sorting; epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements. #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics bit.ly/4kgWMF3

Epigenetics Update - Matrix-bound nanovesicles as epigenetic modulators of myeloid cells bit.ly/3O8T5GE Stephen F. Badylak (University of Pittsburgh) reporting in Sci Adv #Epigenetics #Nanovesicles #ExtracellularVesicles #Chromatin --- Empower your research at epigenometech.com

Epigenetics News - Growth of Spreading Pancreatic Cancer Fueled By "Under-Appreciated" Epigenetic Changes bit.ly/4bOQzPx #Epigenetics #News #Cancer #PancreaticCancer --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks from preparation to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics bit.ly/3HWFoaw

Epigenetics Update - The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 bit.ly/4aJoxDY Nicolas H. Thomä (EPFL) reporting in Mol Cell #Epigenetics #BAF #OCT4 #SOX2 --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics News - Worrying About Aging May Actually Age Women Faster bit.ly/46LletB Anxiety about growing older, declining health linked to aging-related biological changes #Epigenetics #News #Aging --- Discover the breakthrough at epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4a8XOR5 "Exploration of a Novel Epigenetic Mechanism Contributing to Cancer Metastasis" Based on a Mol Cell study by Ruhul Amin and Kent W. Hunter #Epigenetics #Blogs #Cancer #Metastasis #Chromatin

Epigenetics Update - TTNPB Promotes Human Pluripotent Stem Cell-to-Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S-(5′-adenosyl)-L-homocysteine/Choline Metabolic Network bit.ly/3M3sWZd #Epigenetics #PluripotentStemCells #Metabolism #NSCs --- epigenometech.com

Epigenetics Update - The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity bit.ly/460jVa1 Agata L. Patriotis (Rockefeller University) reporting in Genes Dev #Epigenetics #EZH2 #PRC2 --- Perfect for cancer, immunology, and aging research; epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: bit.ly/4efqM1Y

Epigenetics Update - A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification go.nature.com/4aHhxra #Epigenetics #Meningioma #Cancer --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders bit.ly/3ObNmzE Lluis Morey (University of Miami) reporting in Mol Cell #Epigenetics #Chromatin #Polycomb #Neurodevelopment --- Gain deeper insights into gene regulation; epigenometech.com

Learn more about single-cell epigenetic profiling by downloading our guide to scCUT&Tag and scPaired-Tag, which provides comparisons to other methods and bioinformatic insight Learn more here: bit.ly/4r7CGRD #Epigenetics #Multiomics #CUTandTag #10XGgenomics #ChIPSeq #SingleCell #PairedTag

Epigenetics Update - Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability bit.ly/3NWpeB3 Joshua C. Saldivar in Mol Cell #Epigenetics #Histones --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding go.nature.com/4ae5JeL #Epigenetics #Chromatin #GenomeFolding --- High-resolution insights without cell sorting; epigenometech.com

We offer an end-to-end single-cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks - our scientists run the entire workflow on your samples - from prep to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics bit.ly/3HWFoaw

Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol #Epigenetics #DOT1L #PolyComb --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression go.nature.com/49Ydk2b Sriram Venneti (University of Michigan) reporting in Nature #Epigenetics #Ependymoma #Itaconate --- Discover the breakthrough at epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: bit.ly/4efqM1Y

Epigenetics Update - Regulatory grammar in human promoters uncovered by MPRA-based deep learning go.nature.com/4agam7Y Jeroen de Ridder and Bas van Steensel reporting in Nature #Epigenetics #Model #MPRA --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Atlas-guided discovery of transcription factors for T cell programming go.nature.com/46mVZxz H. Kay Chung (UNC), Susan M. Kaech (Allen Institute), and Wei Wang (UCSD) reporting in Nature #Epigenetics #Reprogramming #Atlas --- Empower your research at: epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4khsu6a "Single-Cell Epigenetic Analyses Implicate Dynamic Oligodendroglial Cell Activity during Multiple Sclerosis Progression" Based on a Nat Neurosci study from Gonçalo Castelo-Branco #Epigenetics #Blogs #MultipleSclerosis #SingleCell

Paired-Tag in the Wild! – “An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia” bit.ly/49VSUXA A bioRxiv article from Daofeng Li analyzes data from Paired-Tag from #EpigenomeTech #Epigenetics #PairedTag #Multiomics #SingleCell #Chromatin

Paired-Tag in the Wild! – “Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain” bit.ly/4kbZdK2 A new bioRxiv article from Bing Ren/Lei Chang employs Droplet Paired-Tag from #EpigenomeTech #Epigenetics #PairedTag #Multiomics #SingleCell #Chromatin

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4kPxe2i

Epigenetics Update - EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticity bit.ly/4qOfmYw William J Muller (McGill University) reporting in EMBO Rep #Epigenetics #EZH2 #BreastCancer --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Review - The environmental exposome in heart failure risk and progression go.nature.com/4ar8h9F Sadeer Al-Kindi (Houston Methodist) reporting in Nat Rev Cardiol #Epigenetics #Exposome #Cardiology #Review --- Gain deeper insights into gene regulation; epigenometech.com

"Deciphering Single-Cell Chromatin Landscapes in the Human Immune System: A First Look" Check out this talk from our CTO, Christopher Hartl, at the UNC Department of Genetics on Wednesday, 4th February at 12 pm if you are in the area! #EpigenomeTech #Epigenetics #SingleCell #PairedTag

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC) or Fluent PiP-seq® #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4lquJDv

Epigenetics Review - Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications go.nature.com/4t8LSGi Ming Cui, Lei You, and Yupei Zhao reporting in Signal Transduct Target Ther #Epigenetics #Review --- Discover the breakthrough at epigenometech.com

Epigenetics Preprint - Mechanoepigenetic Targeting of Histone Methyltransferase EZH2 Increases Potential of Scalable Manufacturing in Human Derived Primary Mesenchymal Stromal Cells bit.ly/4qCbw4P #Epigenetics #Preprint #StemCells --- High-res insights without cell sorting; epigenometech.com

Learn about single-cell epigenetic profiling by downloading our guide to single-cell CUT&Tag and single-cell Paired-Tag, which provides comparisons to other methods and bioinformatic insight at: bit.ly/4r7CGRD #Epigenetics #Multiomics #CUTandTag #10XGgenomics #ChIPSeq #SingleCell #PairedTag

Epigenetics Preprint - Engineered Allosteric Control Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors bit.ly/4jTfe7H Jason D Fernandes (Scribe Therapeutics) in bioRxiv #Epigenetics #Preprint #CRISPR --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Aging drives a program of DNA methylation decay in plant organs bit.ly/3NNXiiL Ben P. Williams (University of California, Berkeley) reporting in Science #Epigenetics #Aging #Plants #DNAm --- Discover the breakthrough at epigenometech.com

Our expansion of single-cell epigenetics assays continues! The Epigenome Technologies scCUT&Tag assay is now compatible with the BD Rhapsody platform Learn more here: bit.ly/4lquJDv #Epigenetics #BDrhapsody #CUTandTag #Chromatin #Multiomics #Singlecell #CUTandRUN #ChIPseq #ATACseq