New from the Epigenome Technologies Blog! “Linking CCND1 Expression in Senescent Cells and DNA Damage and Inflammation Highlights a Therapeutic Target for Aging” bit.ly/42mRPnz #Epigenetics #Blog #EpigenomeTech #CCND1 #ChromatinFragmentation #DNADamage #Senescence #inflammation

Epigenetics Update - A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression go.nature.com/3WaeGPw #Epigenetics #Chromatin #Aging #Cancer --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance go.nature.com/46qdNsh #Epigenetics #Chromatin #SingleCell #Multiomics #DNAm --- Empower your research at epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics bit.ly/4kgWMF3

Epigenetics Update - Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex bit.ly/4gH3vYd Alice Franklin/Jonathan Mill (University of Exeter) reporting in Cell Genomics #Epigenetics #DNAme #DNAm --- Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - The multiomics blueprint of the individual with the most extreme lifespan bit.ly/3VDaEz0 Manel Esteller (Josep Carreras Leukaemia Research Institute) #Epigenetics #Aging #Multiomics #ExtremeLifespan --- Gain deeper insights into gene regulation; epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks from preparation to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics bit.ly/3HWFoaw

Epigenetics Update - SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence go.nature.com/47VUKan #Epigenetics #Cancer #Metastasis #SMAD4 --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging go.nature.com/3Khblvu #Epigenetics #Aging #Terpenoids --- Hi-res insights without cell sorting; epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: bit.ly/4efqM1Y

Epigenetics Update - Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate bit.ly/428vwlq #Epigenetics #Metabolism #NeuropsychiatricDisorders --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics Update - PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites go.nature.com/3IDnLNA #Epigenetics #Chromatin --- Perfect for cancer, immunology, and aging; epigenometech.com

Epigenome Technologies brought Paired-Tag technology to this year's "Transcription and Chromatin UK" conference from the @biochemsoc.bsky.social that took place at The Midland Hotel, Manchester (UK). Thanks for having us! #Epigenetics #SingleCell #Multiomics #PairedTag #EpigenomeTech

Our CTO Dr Chris Hartl will be discussing Paired-Tag @mskcancercenter.bsky.social! Be there!!! #Epigenetics #SingleCell #Multiomics #PairedTag #EpigenomeTech

Check out part 3 of 3 of our new blog on the "Single-cell Epigenetics of Tau Dementia" Part 3 – Exploring Disease-enriched Glial States, Disease-Reactive Microglia and Astrocytes, and Genetic Heritability bit.ly/4mZq6l7 #Epigenetics #Tauopathies #Chromatin #Dementia

Epigenetics Update - NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice go.nature.com/4nCF9AU Won-Suk Chung and Inkyung Jung (KAIST) reporting in Nat Commun #Epigenetics #Astrocytes #Immunity --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Lymphoma accelerates T cell and tissue aging bit.ly/423KMjz John L. Cleveland (Moffitt Cancer Center & Research Institute) reporting in Cancer Cell #Epigenetics #Cancer #Chromatin #Aging #Lymphoma --- Discover the breakthrough at epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4kPxe2i

Epigenetics Update - Myeloperoxidase transforms chromatin into neutrophil extracellular traps go.nature.com/4mo2ntC Stefan Raunser and Arturo Zychlinsky reporting in Nature #Epigenetics #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Requirements for establishment and epigenetic stability of mammalian heterochromatin bit.ly/425mFRw Danesh Moazed (Harvard) reporting in Mol Cell #Epigenetics #Heterochromatin #Chromatin --- Empower your research with high-res epigenetic insights at epigenometech.com

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC) or Fluent PiP-seq® #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4lquJDv

Epigenetics Update - Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription bit.ly/3K9CAIo #Epigenetics #Chromatin #Cancer --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Transposable elements are vectors of recurrent transgenerational epigenetic inheritance bit.ly/4pt8tLY Vincent Colot reporting in Science #Epigenetics #EpigeneticInheritance #Transposons --- Gain deeper insights into gene regulation; epigenometech.com

Download our poster to learn how we applied Droplet Paired-Tag to Alzheimer's disease post-mortem brain tissue to reveal specific cellular changes and potential therapeutic targets #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers bit.ly/4kgWMF3

Epigenetics Update - Epigenetic imprinting in innate lymphoid cell precursors directs the lineage segregation of innate lymphoid cells go.nature.com/42sqQqA Shuo Wang (CAS) reported in Nat Immunol #Epigenetics #Imprinting #Immunity --- Discover the breakthrough at epigenometech.com

Epigenetics Update - A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate go.nature.com/3VkhNEj Yarui Diao (Duke University) in Nat Cell Biol #Epigenetics #StemCells --- High-res insights without cell sorting; epigenometech.com

Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers bit.ly/4kgWMF3

Epigenetics Update - Learning the cellular origins across cancers using single-cell chromatin landscapes go.nature.com/3VSQpxh #Epigenetics #Chromatin #SingleCell #Cancer --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics Update - Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems go.nature.com/42qOLqf #Epigenetics #Aging #DNAme #DNAm #EpigeneticAging --- Perfect for cancer, immunology, and aging research; epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements. #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics bit.ly/4kgWMF3

Epigenetics Update - Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate bit.ly/46B7YYP #Epigenetics #SingleCell #CellFate --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Gene body methylation regulates gene expression and mediates phenotypic diversity in natural Arabidopsis populations go.nature.com/46jktqU Zaigham Shahzad/Daniel Zilberman (John Innes Centre) #Epigenetics #Chromatin #DNAme --- Discover the breakthrough at epigenometech.com

Check out part 2 of 3 of our new blog on the "Single-cell Epigenetics of Tau Dementia" Part 2 – "Exploring Disease-associated Dynamic Peaks, Functional Variants, eQTLs, and Cellular Subcluster Diversity" bit.ly/47kwxKx #Epigenetics #Tauopathies #Chromatin #Dementia

Epigenetics Update - Replication stress–induced nuclear hypertrophy alters chromatin topology and impacts cancer cell fitness bit.ly/4nsuFUO #Epigenetics #Chromatin #Cancer --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Review - Non-CG DNA methylation in animal genomes go.nature.com/41NGOLH Alex de Mendoza and Ozren Bogdanovic reporting in Nat Genet #Epigenetics #DNAme #DNAm #Reviews --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks from preparation to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics bit.ly/3HWFoaw

Epigenetics News - Study finds cell memory can be more like a dimmer dial than an on/off switch bit.ly/46f6imn #Epigenetics #News #EpigneticMemory --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours go.nature.com/4gljtqD Miriam Merad (Icahn School of Medicine at Mount Sinai) in Nature #Epigenetics #Cancer #ChromatinAccessibility --- Gain deep insights into gene regulation; epigenometech.com

Calling all UK Epigenetics researchers! Join us at "Transcription and Chromatin UK 2025" in Manchester, UK from 17-19 September. Don't miss this opportunity to explore the future of epigenetics research! #BiochemEvent #Epigenetics #Research #TranscriptionChromatinUK2025

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: bit.ly/4efqM1Y

Epigenetics Update - DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution go.nature.com/4m7ipYV Peter Van Loo and Nnennaya Kanu reporting in Nat Genet #Epigenetics #DNAme #DNAm #Cancer --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression bit.ly/4m3BHOB #Epigenetics #SingleCell #Multiomics #Diabetes #T1D --- High-resolution insights without cell sorting; epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4kPxe2i

Epigenetics Update - Fluctuating DNA methylation tracks cancer evolution at clinical scale go.nature.com/3Ve4OUy #Epigenetics #Cancer #DNAme #DNAm --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics Update - Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism bit.ly/47CxVs3 #Epigenetics #Butyrate #Amphetamine --- Perfect for cancer, immunology, and aging research; epigenometech.com

Calling all UK Epigenetics researchers! Join us at "Transcription and Chromatin UK 2025" in Manchester, UK from 17-19 September. #BiochemEvent #Epigenetics #Research #TranscriptionChromatinUK2025

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC) or Fluent PiP-seq® #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4lquJDv

Epigenetics Update - Dynamic association of H3K36me3 with pericentromeric heterochromatin regulates its replication time bit.ly/3IhhrLw From M Cristina Cardoso (University of Darmstadt) #Epigenetics #H3K36me3 #Heterochromatin --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis bit.ly/489VzfD #Epigenetics #DNADemthylation #HeartFailure #CardiacFibrosis #TET3 --- Discover the breakthrough at epigenometech.com

Check out part 1 of 3 of our new blog on the "Single-cell Epigenetics of Tau Dementia" Part 1 – "Understanding Cell-specific CREs, Chromatin Accessibility, and Differentially-Accessible Regions in Tauopathies" bit.ly/47MFOLs #Epigenetics #Tauopathies #Chromatin #Dementia