Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers bit.ly/4kgWMF3

Epigenetics Review - Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications bit.ly/4aY7a39 Linghua Wang reporting in Cancer Cell #Epigenetics #Review #SpatialOmics --- Discover the breakthrough at epigenometech.com

Epigenetics Update - BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation bit.ly/497Jcj2 Bin Zheng and Ali Shilatifard reporting in Mol Cell #Epigenetics #Acetylation #BRD2 #MOF --- High-resolution insights without cell sorting; epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4ptPJLq “How Does Stress Induce Cellular Adaptation: Can Epigenetic Alterations Influence Transcription and Translation?” Based on a Nature Cell Biology paper from Ola Larsson and Lynne-Marie Postovit #Epigenetics #Stress #TSSSwitching

Epigenetics Update - Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer’s disease AppNL-G-F knock-in mouse model go.nature.com/4plDdgS #Epigenetics #Chromatin #Alzheimers --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - H2AK119ub dynamics control hair follicle stem cell quiescence go.nature.com/44GKO1X Elena Ezhkova (Icahn School of Medicine at Mount Sinai) in Nat Commun #Epigenetics #StemCells #H2AK119ub --- Empower your research with high-res epigenetic insights at epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics bit.ly/4kgWMF3

Epigenetics Update - DNA methylation shapes transcription factor binding beyond canonical CpG contexts bit.ly/4s54ruK Ariel Afek (Weizmann Institute of Science) reporting in PNAS #Epigenetics #DNAm --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update – Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair bit.ly/4qhWgJP #Epigenetics #DNADamage #DNARepair #HistoneVariants --- Gain deeper insights into gene regulation; epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks from preparation to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics bit.ly/3HWFoaw

Epigenetics Update - Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice go.nature.com/4sd4NQ1 Takuro Horii and Izuho Hatada in Nat Commun #Epigenetics #H3K9me3 #DNAme #IEI --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis bit.ly/48VsIMn Doron Merkler (University of Geneva) reported in Neuron #Epigenetics #Encephalitis #Interferongamma --- High-resolution insights without cell sorting; epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: bit.ly/4efqM1Y

Epigenetics Update – Hepatic adaptation to chronic metabolic stress primes tumorigenesis bit.ly/4sak6ZG Wolfram Goessling, Ömer H. Yilmaz, and Alex K. Shalek reporting in Cell #Epigenetics #Metabolism #Chromatin --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Two distinct chromatin modules regulate proinflammatory gene expression go.nature.com/45oJKQu Karsten Rippe (DKFZ/BioQuant) reporting in Nat Cell Biol #Epigenetics #Chromatin #Inflammation --- Discover the breakthrough at epigenometech.com

New Epigenome Technologies Blog post! bit.ly/4s8hD21 "Sex-bias in Multiple Sclerosis: Is There an Epigenetic Reason?" Based on a Science Translational Medicine paper from Rhonda R. Voskuhl (University of California, Los Angeles) #Epigenetics #MultipleSclerosis #SexBias

Epigenetics Update - MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages go.nature.com/44xIxpN Study reported in Nat Commun #Epigenetics #MAT2A #Atherosclerosis --- High-resolution insights without cell sorting; epigenometech.com

Epigenetic Perspective - Do we actually need aging clocks? go.nature.com/499rtrD Dmitrii Kriukov reporting in Nature Aging #Epigenetics #Aging #AgingClocks --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4kPxe2i

Epigenetic Update - Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm go.nature.com/494u467 #Epigenetics #Chromatin #EpigeneticInheritance --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes go.nature.com/49dB6GW (News - bit.ly/3N9XW9O) #Epigenetics #Chromatin #EpigeneticClocks #Aging --- Gain deeper insights into gene regulation; epigenometech.com

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC) or Fluent PiP-seq® #Epigenetics #SingleCell #CUTandTag Find out more at: bit.ly/4lquJDv

Epigenetics Update - H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations bit.ly/459lS3k Robert Schneider (Helmholtz München) in Mol Cell #Epigenetics #Chromatin #Metabolism --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Chromatin buffers torsional stress during transcription bit.ly/44FZdvo Michelle D. Wang (Cornell University) reporting in Science #Epigenetics #Chromatin #Stress --- High-resolution insights without cell sorting; epigenometech.com

January 7th 2-1pm in MSRBIII or online, #DukeSCIRIP seminar series continues! @epigenometech.bsky.social's Chris Hartle will be presenting the talk '‘Deciphering Single-Cell Chromatin Landscapes in the Human Immune System: A First Look’ 🧬 For more information: dmpi.duke.edu/duke-single-...

Learn more about single-cell epigenetic profiling by downloading our guide to single-cell CUT&Tag and single-cell Paired-Tag that provides comparisons to other methods and bioinformatic insight! bit.ly/4r7CGRD #Epigenetics #Multiomics #CUTandTag #10XGgenomics #ChIPSeq #SingleCell #PairedTag

Epigenetics Update - Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases go.nature.com/4pRHWb5 #Epigenetics #SingleCell #Multiomics #Aging --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Causal modelling of gene effects from regulators to programs to traits go.nature.com/3MOWedT #Epigenetics #Modeling #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Our expansion of single-cell epigenetics assays continues! The Epigenome Technologies scCUT&Tag assay is now compatible with the BD Rhapsody platform Learn more here: lnkd.in/g3YqPrWY #Epigenetics #BDrhapsody #CUTandTag #Chromatin #Multiomics #Singlecell #CUTandRUN #ChIPseq #ATACseq

Epigenetics Update - Spatiotemporal cellular map of the developing human reproductive tract go.nature.com/4p1DGEL Luz Garcia-Alonso, John C. Marioni, and Roser Vento-Tormo In Nature #Epigenetics #Reproduction #SingleCell #Multiomics --- Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - An integrated view of the structure and function of the human 4D nucleome go.nature.com/4aniupc #Epigenetics #Nucelome #4DNucleome #Chromatin #ChromatinConformation --- Gain deeper insights into gene regulation; epigenometech.com

The Epigenome Technologies website has had a facelift! epigenometech.com Check out the new design and see what we can do for your research! #Epigenetics #Chromatin #PairedTag #SingleCell #Multiomics

New Epigenome Technologies Blog post! bit.ly/4aiWY4T "Can RENDER Move Epigenome Editing Closer to Therapeutic Applications?" Based on a Nature Communications paper from James K. Nuez (University of California, Berkeley) #Epigenetics #Blog #EpigenomeTech #EpigenomeEditing #RENDER

Epigenetics Update - JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation go.nature.com/45b2mTY #Epigenetics #BiomolecularCondensates #JMJD2 #HistoneDemethylase #Chromatin --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics Update - Escape from X inactivation is directly modulated by Xist noncoding RNA go.nature.com/49jeLH5 Edith Heard and Agnese Loda (EMBL) reporting in Nat Cell Biol #Epigenetics #Xist #XInactivation #Chromatin --- Perfect for cancer, immunology, and aging research; epigenometech.com

We have recently expanded our single-cell epigenetics assays! Our Emulsion scCUT&Tag assay is now compatible with the Illumina PIPseq platform Learn more at lnkd.in/g3YqPrWY #SingleCell #EpigenomeTech #PairedTag #Multiomics #Epigenetics #scCUTandTag #PIPseq

Epigenetics Update - GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging go.nature.com/3KIy3gF #Epigenetics #Aging #Chromatin --- Empower your research with hi-res epigenetic insights at epigenometech.com

Epigenetics Update - Fasting boosts breast cancer therapy efficacy via glucocorticoid activation go.nature.com/3KXpaQe Irene Caffa and Wilbert Zwart reporting in Nature #Epigenetics #Cancer #Fasting --- Perfect for cancer, immunology, and aging research; epigenometech.com

Download our poster to learn how we applied Droplet Paired-Tag to Alzheimer's disease post-mortem brain tissue to reveal specific cellular changes and potential therapeutic targets #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers bit.ly/4kgWMF3

Epigenetics Update - The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer bit.ly/4a8C1cI #Epigenetics #KMT2D #Cancer #CRPC --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Age- and cell-type-specific effects of histone variant H2BE in the brain bit.ly/4oM02Kd Erica Korb (University of Pennsylvania) reporting in Cell Rep #Epigenetics #HistoneVariants #H2BE #Aging --- High-resolution insights without cell sorting; epigenometech.com

Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers bit.ly/4kgWMF3

Epigenetics Update – Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models go.nature.com/4rWwxIG Marc Zuckermann/Ulrich Schüller in Nat Genet #Epigenetic #DNAm #Cancer --- Gain deeper insights at epigenometech.com

Epigenetics Update - CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1 bit.ly/4pAjdbg #Epigenetics #DNAm #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics bit.ly/4kgWMF3

Epigenetics Update - Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex go.nature.com/4acm9WM #Epigenetic #Chromatin #Macaque #SingleCell #Multiomics --- Discover the breakthrough at epigenometech.com

Epigenetic Update - HERVH-derived eRNA activates a super-enhancer–driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development bit.ly/3YnTIxG #Epigenetics #Chromatin #Cancer --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics Update - Generative epigenetic landscapes map the topology and topography of cell fates bit.ly/4515eml Paul François (Université de Montréal) reporting in PNAS #Epigenetics #Chromatin #CellFate --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice go.nature.com/3KCEYrI Emiliana Borrelli (University of California, Irvine) #Epigenetics #Cocaine --- Gain deeper insights into gene regulation; epigenometech.com

Epigenome Technologies offers an end-to-end single-cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks - we run the entire workflow - from preparation to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics bit.ly/3HWFoaw