Looking forward to Naama Barkai's visit tomorrow - all in copenhagen interested in biological specificity should come to hear her talk tomorrow!!!!

Very happy to see this nice collaboration with @niakanlab.bsky.social bear fruit. Beautiful work by @clairesimon.bsky.social culturing human embryos in the presence of FGF/ERK stimulation/inhibition. www.nature.com/articles/s41...

Back from the ISDB, Clearly my presence in the lab was missed!

Why combat aging with enhancers at 11? Why not just make 10 louder? It wouldn't be 11. For transcription, all the other processes (translation, splicing etc) are on ten, on ten, etc…where do they go? For Enhancers, everything on ten, the transcription factors deacetylate and go one higher, 11.

Another chapter from Martin Proks PhD. The first chapter in our nf-core saga and a new pipeline for MARS-seq! academic.oup.com/bioinformati...

Very nice paper - all principles at the heart of molecular biology although the logic with which evolution implements them was a mystery.

Alba Redo Riveiro - an amazing PhD student. One chapter in her PhD is described here. It was a great paper and a very long evolving story - www.cell.com/stem-cell-re...

Very excited to see Melissa elected to the Royal Society. Nice triumph for old school developmental biology entering the modern world of translation. Way to go Melissa!!!! renew.ku.dk/latest-news/...

And here I was thinking I need to modernize my references with Taylor - perhaps the Last Dance is further away then we think!

Two days left to apply to do fantastic science in a great place - come join us as a new group leader at reNEW - employment.ku.dk/faculty/?sho...

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. www.embopress.org/doi/full/10....

Altering metabolism programs cell identity via NAD+-dependent deacetylation @josh-brickman.bsky.social et al show enforced OXPHOS dependence in embryonic stem cells drives deacetylation of essential transcription factors & inner-cell-mass-like gene expression www.embopress.org/doi/full/10....

Really looking forward to a day in Sheffield - one of the first places In the world to work with human pluripotent cells!

PRC2 promotes canalisation during endodermal differentiation journals.plos.org/plosgenetics... @Robertillingwo7 @wbickmor.bsky.social @josh-brickman.bsky.social

Transcription ahead of chromatin regulation? Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators @wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust! journals.plos.org/plosgenetics...

Superb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive #machinelearning models & interpretation tools that use #scRNAseq + #scATACseq data to better understand how chromatin accessibility relates to gene expression doi.org/10.1038/s414... Happy 2025 everyone 🎆 !

In the next few weeks we will start advertising for PhD students and/or post docs. We are looking for two people to join our group, one focused in pancreatic organoids and the other to join our computational team. DM if you are interested in coming to @ucph.bsky.social

We have an amazing programme with fantastic speakers! @chribue.bsky.social @wbickmor.bsky.social @robklose.bsky.social @mariekeoudelaar.bsky.social @eileen-furlong.bsky.social @josh-brickman.bsky.social @parinazmehdipour.bsky.social @edchuong.bsky.social @jorge-ferrer.bsky.social @helink.bsky.social

Browsing through the literature as things calm down, thinking about posting now that the twittersphere has turned blue, I discover the next step change in chromatin analysis....an incredible data deluge! www.nature.com/articles/s41...

Embryologists from Amager Hvidovre Hospital visiting Brickman and @jzylicz.bsky.social labs learning about stem cell based embryo models!