Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

Exciting new conference!

Our lab website just got a major refresh to better present: Our research philosophy: why chromatin is central to our work. A snapshot of our culture: diverse, collaborative, impact-driven. Our priorities: how we translate discoveries into clinical reality. Check it out

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Our lab website just got a major refresh to better present: Our research philosophy: why chromatin is central to our work. A snapshot of our culture: diverse, collaborative, impact-driven. Our priorities: how we translate discoveries into clinical reality. Check it out

One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ

Lest We Forget N'oublions Jamais

DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team! Please repost! jobs.jic.ac.uk/Details.asp?...

❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

This acquisition will bring together two pioneering companies with a shared vision: to make single cell analysis more powerful, affordable and accessible to researchers worldwide. Learn more: bit.ly/4mAWAS8

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all. Regardless, the paper is a must-read:

Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.

Nice study showing how DNA mutagenesis can be driven by transcription factor (TF) competition with mismatch repair machinery: www.cell.com/cell/fulltex... Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...

Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social). jobs.sciencecareers.org/job/673968/p...

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU

Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. www.grc.org/hormone-depe...

Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov! 🎙️Talk Submission extended to 03 Sept 💰Final few $500 grants remaining Don't Miss out! bit.ly/4eRq9Mp

If you're into super-resolution microscopy, check out the new story from Myles Brown's lab showing how chromatin architecture responds to hormone signaling at enhancers. Dynamic, ligand-dependent changes in H3K27ac structure with implications for endocrine resistance. www.biorxiv.org/content/10.1...

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups! 🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!

The July issue of Cancer Discovery is now online! The cover features work by Alexandra Redding, Elda Grabocka, and colleagues on intercellular heterogeneity of stress granules and chemotherapy response - read that and much more here: aacrjournals.org/cancerdiscov...

come join us in our brand new research building! www.crc.ulaval.ca/wp-content/u...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in. mcgill.wd3.myworkdayjobs.com/en-US/McGill...

But my main point is that trans and cis regulation are two equally important fundamentally interacting components of gene regulation. "Virtual cells" that actually aim to capture a biologically consistent predictive model of cells absolutely need to nail both. 8/

Registration is now OPEN for the 11th Canadian Conference on Epigenetics! The annual meeting will be held November 12-15, 2025 at the Banff Centre in Banff, Alberta. You can register and find out more information at our website: event.fourwaves.com/ceehrc2025

In about a week we (Biological Sciences @ Monash Uni in Melbourne, Australia) will be opening a search for 3 (!!!) permanent academic positions (40% research, 40% teaching, 20% service) at Lecturer/Senior Lecturer. 1 Genomics, 2 Ecology. Please share, email me, DM, follow, send carrier pigeons…

Bonne Saint-Jean à toutes celles et ceux qui portent dans leur cœur la francophonie et toute la richesse de sa culture!

Whether you're in research, medicine, or industry, the Epigenetics and Epigenomics in Health and Disease meeting will be the place to connect, share, and explore the latest advances in epigenetics and disease in the fall. Register early to secure your spot: www.xcellsconferences.com/epigenetics2...

🚀 We’re launching Fiber-seq, a multiomic approach that combines chromatin accessibility, CpG methylation, and DNA sequence in one long-read sequencing assay. We’re inviting a limited group of early users to try Fiber-seq at no cost. Interested? Learn more 👉 explore.epicypher.com/fiber-seq-su...

🚨 New meeting this fall in Brussels! 🚨 Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩 #epigenetics2025 Registration is open!! @epicypher.bsky.social xcellsconferences.com/epigenetics2025

"There is a cohort of talent unlike we have ever seen before that we can compete for." Dr. @bradwouters.com, EVP of Science & Research at UHN, gives CBC's The National an inside look at Canada Leads, an initiative to recruit 100 top early-career scientists.

1/ What a week! The 2025 GRC on Cancer Genetics and Epigenetics just wrapped up. I'm still energized by the phenomenal science, deep discussions, and vibrant sense of community. 🔗 www.grc.org/cancer-genet... #GRCCancerGenetics #Epigenetics

1/ What a week! The 2025 GRC on Cancer Genetics and Epigenetics just wrapped up. I'm still energized by the phenomenal science, deep discussions, and vibrant sense of community. 🔗 www.grc.org/cancer-genet... #GRCCancerGenetics #Epigenetics

Safe travels to everyone making their way to the Gordon Research Conferences Cancer Genetics & Epigenetics conference! Can’t wait for the incredible science, inspiring conversations, and new connections ahead. Let’s keep pushing boundaries. Together, we’re making a difference!

@thesgc.bsky.social is generating large/open screening data and inviting data scientists to train their ML models via DREAM challenges: 1- train your model on DEL data 2- retrospectively predict 138 ASMS true positives 3- predict new hits. We will test them and publish together. bit.ly/3YXVKoT

Must read if you're interested in the conditions that make cells susceptible to transformation. In this case, the shortest cell cycle time = the highest risk. Across tissues and mutations, pace, not just mutations, defines vulnerability. rdcu.be/ekc8U

Understanding leukemia cell development in AML🩸 Our recent study revealed 12 cell states as AML cancer cells grow and develop. The findings, critical for AML classification and precision medicine, were reported by Drs. John Dick & Andy Zeng’s team at UHN. aacrjournals.org/bloodcancerd...

🚨Want to get hands-on experience on low input chromatin techniques? Join us at the @EPIBOOST22 Chromatin Explorer Summer School this July in sunny Barcelona 🧬🥼🖥️🐟☀️🏖️ ℹ️: tinyurl.com/bdzbt36z 🎯Register here: forms.gle/mBA1gkEkYrYh... 📆Application deadline: 19th May 2025

Circular RNA in aggressive tumours Abundant circRMST molecules were found in aggressive prostate and lung cancers, interacting with transcription factors SOX2 & NKX2-1 to drive oncogene ASCL1 expression, reported by @pmresearch-uhn.bsky.social & @danafarber.bsky.social www.cell.com/cancer-cell/...

🔬Exposomal determinants of non-genetic plasticity in tumor initiation. ✍️ Davide Carra, Silvana C.E. Maas, @seoaneja.bsky.social, @direnaac.bsky.social 📰 @cp-trendscancer.bsky.social  Read more here 🔗 https://shorturl.at/CaicQ 📌 DOI: https://doi.org/10.1016/j.trecan.2025.01.010 #IRBScience 🧪

EMBO workshop on Single Cell Lineage Tracing! Sept 18-21, 2025 in Girona, Spain. Registration is OPEN!!!!! Tons of opportunities for talks are available (incl. full length ones). meetings.embo.org/event/25-lineage-tracing @perielab.bsky.social @idoamitlab.bsky.social #EMBOlineagetracing