Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀 Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA) www.biorxiv.org/content/10.6...

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development. These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention. www.embl.org/news/science...

📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways www.biorxiv.org/content/10.1...

❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

🤩🤩 it’s been a while

Awhh, my lab are absolute legends!

We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training. The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social. #job #internship; see info below...

Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome? Funding call with deadline 15 June, decisions in July. www.embl.org/about/info/s...

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Last day to apply for a postdoc in systems epigenomics in sunny Rome! www.embl.org/jobs/positio...

As an "EIPOD" interdisciplinary postdoc in @jamiehackett.bsky.social and our lab, @denbobalab.bsky.social found that "Paternal microbiome perturbations impact offspring fitness" (2024): antibiotic treatment of male mice led to low birth weight & higher mortality in offspring www.nature.com/artic...

Strongly recommend DNAme researchers to take a look at this important study. Consistent with work from Schubeler lab: higher-order mut in DNAme reader proteins lead to only minor transcriptional changes. Reinforces the idea that DNAme does not establish heterochromatin through reader proteins

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup. ➡️Register now www.grc.org/histone-and-...

Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:

One of my illustrations made an appearance at the MPI #epigenetics conference! thanks to the boss @jamiehackett.bsky.social presenting the cool science we do in the lab 🔥

Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city: institute-genetics-cancer.ed.ac.uk/igc-graduate... Please share 🙏 (1/2)

The good news: you only click on the "join" button once and then you following all the pack persists in the absence of the initiating stimulus. 😀 In all seriousness, a stellar group of folks to follow.

Protein-based inheritance could be the new frontier in understanding transgenerational epigenetic inheritance. Great preview from @odedrechavi.bsky.social and @ethanewe.bsky.social on a very interesting new paper from @wbderry.bsky.social lab.

We are beginning to understand how the full repertoire of inheritable units can affect phenotypic variability Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

Please check out this upcoming Gordon Conference (GRC) on Developmental Biology - March 2025 Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts) www.grc.org/developmenta...

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

Many other super lab members not (yet) on Bluesky! So finally, two postdocs that just moved on... @denbobalab.bsky.social has established his group at MPI on #microbiome-germline axis. @mdura.bsky.social has just preprinted on #intergenerational-inheritance and is on the market! Check them out!

Looks like a really interesting preprint from James Turner’s lab (who needs to migrate over here!) www.biorxiv.org/content/10.1...

Don’t miss @steliostsagkris.bsky.social for infinite technical knowledge of CRISPR perturbation screening! Stelios is also the lab gastruloid guru 🧫 Always has interesting and constructive takes on papers so keep an eye on this one!

Fearless grad student @catrinteleri.bsky.social leads a major computational analysis project. Want to discuss polycomb function, ask Catrin! More of a silent scroller than prolific poster, if we all follow Catrin - apart from being quite funny - we’ll hear more of her insights!

We are blessed to have @bbbranjan.bsky.social. Follow Bobby for hot takes on preprints, microbiome and ML. Original computational biologist now wetlab guru! He also just co-first published a cracking preprint Oh, and he’s looking for ML/AI positions later next year👌

The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring? Apply before Feb 15th 📌

Next up, newest lab postdoc @gemnov.bsky.social. If you want the latest takes on quantitative biology, modelling or degrons this is your account! Also Gemma developed CasTuner with Edda Schulz - an amazing work

Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇

Placental-specific deletion of Slc25a1 - but not cardiac deletion - leads to heart defects. As Miguel indicates… placenta is the source of much unappreciated phenotypic variation and dev functions

Our lab members are off to cool new jobs (including faculty 🎉) so we are looking for new team members. Experimental postdoc prioritized, but do get in touch if you think you are a good fit. Also, our PhD program is currently accepting applications: www.molgen.mpg.de/IMPRS/applic...

This seems incredible from @mitchguttman.bsky.social and colleagues 👏...it opens up so many possibilities ChIP continues to push back at CUT&RUN! 🍿

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.

📢 Preprint! How does the environment of a father before conception influence offspring? Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales🧵... www.biorxiv.org/content/10.1...

📢 Must must listen. As well as setting up her lab to do great science, Ana is a beacon of sound advice, scientific knowledge and ever-amusing anecdotes. ... she is also the only person in Italy that will join me to have a cappuccino after the sacred 11am deadline, so extra kudos!

Welcome on board @embl.org 👋.... learn a bit more about what EMBL does and stands for in the vid 👇👇👇

Back at the EMBL mothership this week for the Quantitative Biology symposium Looks a cracking speaker lineup and set of posters on diverse topics… and it’s definitely fresh in Heidelberg 🥶 www.embl.org/about/info/c...

Hi all, just to say thanks for all the enthusiasm about the #epigenetics, Chromatin and Gene Regulation starter pack. The interface is a bit unreliable so a few people I added got missed off 😬. If you notice this applies to you, just message me and I'll try again. go.bsky.app/TKp9YAn

Our new-ish preprint: RNA Polymerase II coordinates histone deacetylation at active promoters www.biorxiv.org/content/10.1...

Fantastically engaging talk on #microbiome -brain axis from @jfcryan.bsky.social in Rome this morning. Full of thought-provoking ideas and some sage advice: “If you’re thinking of having a midlife crises… forget about the motorbikes and think about leeks instead” 😂

We have 15 PhD positions available as part of the DANIO-ReCODE MSCA DN 🇪🇸🇩🇪🇸🇮🇭🇷🇦🇹🇬🇧 Great opportunity for anyone interested in developmental biology, regeneration, genomics, and computational sciences. For project descriptions and how to apply, check: euraxess.ec.europa.eu/jobs/290548

A stimulating workshop on the subject of Waddington Landscapes in Lyon last week, prompted me to compose some thoughts on dynamical landscapes, gene regulatory networks, and single cell transcriptomics briscoelab.org/morphogenalia/

Maybe we should do more science in whisky bars! 😀 🤔 This👇is part of a open and honest thread on the challenges, and joys of epigenome editing.

Been here half a day and it is... so much better. It's like the good old days where you actually see the science and +ve community interactions. X does not, apparently, mark the spot.