My my this hurts 😅

Having a PhD means you can find the word “unfortunately” in an email faster that the search function

📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways www.biorxiv.org/content/10.1...

Big congrats Ueli ! Such an amazing mentor, person and scientist

I love the exquisitely targeted ads on linkedin 😂

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Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.

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We are hiring! If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland! More information on www.epfl.ch/labs/gr-schu...

British information campaign: Know Your Parasites #UK #Britain #parasites #politics #GreedyBastards #tyranny #elites #ObsceneWealth

🤯 Thinking what to do when having > 26 panels in a supp figure...label AA, AB, AC ? Cannot split it, journal limits number of supp figures...

Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr

For many people (me included) writing is thinking If you're not thinking you're just the pretty front (wo)man in the band Do you want to be Noel or Liam? www.nature.com/articles/d41...

😂😄 - but this writing design could also be a cool way for budding researchers to learn the art of navigating their project

My next paper is going to be written like a Choose your own Adventure: To do a Western Blot from the pulldown, go to page 7 To CRISPR out the functional domains, go to page 46 To skip till the Acknowledgements, go to page 52

Shameless non-scientific self-promotion - thrilled to be selected for the final of the Lavaux piano competition happening on November 8 in Pully 🎉🥳 www.lavauxclassic.ch/concours/con... One of the pieces I played during the semis last Sunday (here recorded at home www.youtube.com/watch?v=cPwv... )

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Beautiful piece ! Full of science wisdom and humanity

This is incredibly sad...I strongly believe that pivoting to different fields is a cornerstone of creativity and originality www.nature.com/articles/s41...

"The number one reason small businesses fail has nothing to do with the quality of product or reputation: it’s when they run out of cash, and it’s a fate that befalls junior research groups as much as small businesses."

Switzerland rocks !

This is the best graph I've seen in a while 📊

Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social! You can register at: us06web.zoom.us/webinar/regi...

I appreciate how the GRC Epigenetics is elevating a lot of the truly exciting research from up-and-coming scientists (mixed with plenty of more established folks). Would be great if some of the other major conferences could follow suit (cough... EMBL Chromatin & Epigenetics cough.. cough)

How is it end of April already? Excited to share that the Kribelbauer Lab is up and running @USC/MCB. Grateful for my first two PhD students @m-finegan.bsky.social @christinagirgis.bsky.social. We are dev scalable, genome-int. tools to study TF & enhancer regulation. Website now live bit.ly/4jo8Tjg

Did you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...

We have been doing conferences the same way for 100 years... time for a change!

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

📢 Our work on the orchestration of pluripotent stem cell genome reactivation during mitotic exit is now out www.sciencedirect.com/science/arti... A short 🧵

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

🚀 Thrilled to share our latest research! With the labs of Yansheng Liu and Junmin Peng we’ve built the largest in vivo protein turnover resource across multiple tissues and brain regions, now published in Cell @cellpress.bsky.social 🔬💡 #Proteomics Check it out! 👇 authors.elsevier.com/c/1koBJL7PXu...

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

Very interesting work from @longchrom.bsky.social and @molinalab.bsky.social lab ! Importance of Synthesis/export/degradation cross-talk at the mRNA but also protein levels cannot be overstated - relevant to virtually any work involving active manipulation of gene expression

📣 New preprint from the lab – Massive work entirely driven by super-talented @simsakong.bsky.social , jointly betw. @beatfierz.bsky.social lab and mine – combining in vitro and in vivo TF single molecule imaging www.biorxiv.org/content/10.1...

Shameless non-scientific promotion - 🥳 to go into semi-final of Lavaux piano competition - comments most welcome - will most likely play one of these pieces again (video quality is shitty I know, but sound ok - semis will be on site anyway) #piano www.youtube.com/watch?v=Xl1E...

Today is International Women’s Day! It’s an important day for us (although the R-Ladies mission is not limited to women). 💜Who are we? R-Ladies is a worldwide organization whose mission is to promote gender diversity in the R community.

1/ Preprint haiku alert 🤓✍🏻 Cells walk a tightrope— proteins made and then destroyed, balance must be kept. Yet how is this done? A mystery in the cell, we set out to ask. Live imaging helps, plus models and omics, too— data tells the tale.

Important paper showing that acetylation of trans-acting factors rather than histones controls transcriptional bursting dynamics www.cell.com/molecular-ce...

A simple model that explains a lot ! We demonstrate that simple mechanisms -- growth-rate dependent dilution and cell-type specific protein degradation -- explain much of the protein variation across proteins and across cell & tissue types.

The dance of chromatin— Remodelers and histones, Who leads, who follows? 🧵 (1/6)

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters www.science.org/doi/10.1126/...

Genome architecture folks, this perspective is really worth your time www.cell.com/molecular-ce...

Please repost if you agree with Ursula.

Just because of this, this paper deserves attention 😮💪

Donate to Wikipedia. Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it

Best advice ever in life and even more when submitting a paper: Low expectations = High satisfaction

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

Wow, very important piece of work

Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful