Peter Sarkies
@psarkies.bsky.social
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Epigenetics and Evolution
Most nematodes don't have piRNAs?!!
23 days ago
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This is really interesting. Tony Blair condemned Saddam Hussein's execution publicly. Was this genuine or was he perhaps happy with it behind the scenes? If he was genuinely opposed, what would he have preferred? UN trial might not have gone the way he would have wanted.
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23 days ago
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the current Greenland thing shows that fawning to Trump like Starmer has been doing is totally pointless as well as degrading.
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29 days ago
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Peter Sarkies
Matt Higgins
29 days ago
Check out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
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The EMBO Journal
about 1 month ago
Epimutations: raw material for evolution? Nabeel Ganem &
@psarkies.bsky.social
explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
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Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
https://link.springer.com/article/10.1038/s44318-025-00682-z
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Incredibly cool- a must read!
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about 1 month ago
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don't miss this! will be very interesting
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about 1 month ago
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Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
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Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
https://link.springer.com/article/10.1038/s44318-025-00682-z?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20260106&utm_content=10.1038/s44318-025-00682-z
about 1 month ago
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Worth a read. In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm.
www.cell.com/trends/genet...
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If we could turn back time
De-extinction critiques focus on animal welfare, ecosystem disruption, threats to traditional conservation, and anxiety about human hubris. Respondents argue that humanity is obligated to reverse dama...
https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00240-9
about 1 month ago
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Peter Sarkies
Zack Polanski
about 1 month ago
On BBC News today: striking that itâs the two old establishment parties - Labour and the Conservatives - refusing to condemn the US breaking international law and doing what it wants. Feels like politics stuck in the past, while the public has clearly moved on.
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Zack Polanski
about 1 month ago
Starmer and Farage both drape themselves in flags but once again it's really clear where their loyalty really is. It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime. This is not patriotism. It's subservience.
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George Monbiot
about 1 month ago
Whatever you might think of Maduro, the seizure and kidnapping of a head of state takes us to a very dark place. Vast, arbitrary, extra-legal power, which could be exercised almost anywhere, regardless of the character of the target government.
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Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from
@reneketting.bsky.social
lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.
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about 1 month ago
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RIP international law.
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about 1 month ago
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about 2 months ago
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Nibbler or Trimmer?
www.bbc.co.uk/news/article...
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Wigan pie-eating champion polishes off pie in 64 seconds
Tom O'Neil is crowned pie-eating champion after the annual contest in Wigan, Greater Manchester.
https://www.bbc.co.uk/news/articles/cdd5p7q273mo
about 2 months ago
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Very exciting to see this published- opens lots of real interesting possibilities about how memory works!
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about 2 months ago
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Truly a great meeting with so many highlights- thanks to
@embo.org
and all organisers for inspiring science program!
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2 months ago
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Peter Sarkies
Elliott Lab
2 months ago
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising
#ubiquitin
transfer,biochemistry,evolution
@labhofmann.bsky.social
& tissue expression analyses
@psarkies.bsky.social
Big thanks to the team,reviewers & handling editor
@dimitristypas.bsky.social
rdcu.be/eTRdR
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UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...
https://rdcu.be/eTRdR
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I had heard of the trial of Lady Chatterley's Lover but had no idea of the details. The whole case is so strange it's amazing it took place during my parents' lifetime- today DH Lawrence would not be considered even edgy let alone obscene. Fascinating episode.
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2 months ago
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RIP Tom Stoppard. Forever with Rosencrantz and Guildenstern now.
3 months ago
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Great seminar in
@oxfordbiochemistry.bsky.social
today from Laura Landweber on the awesome world of ciliate DNA elimination- so many different gene regulation/repair pathways come together to achieve this remarkable feat
3 months ago
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baffled that Black Friday deals seem to have spread to companies selling PCR reagents.
3 months ago
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Iâm fairly sure we donât have to go back to Farageâs schooldays to find evidence of racism.
3 months ago
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Peter Sarkies
Dorian Lynskey
3 months ago
Climate change affects EVERYTHING. Itâs mad that the issue has become left-coded when it should be just reality-coded
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All you other swim shadies are just imitating
www.bbc.co.uk/news/article...
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Eminem sues Australian beach brand 'Swim Shady'
The rapper alleges the beachwear brand created a
https://www.bbc.co.uk/news/articles/ckgkr13lnp1o
3 months ago
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Peter Sarkies
The Green Party of England & Wales
3 months ago
The Greens donât believe providing safe refuge for endangered asylum seekers is an âout-of-controlâ policy. Nor do we believe making life more difficult for those in need is the way to unify British society. Refugees are welcome.
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Genetics Society UK
3 months ago
Today we have our fantastic Autumn Meeting on Ancient Genomes
@royalsociety.org
!
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Reading this super biography of Crick right now. It's almost as fun to read as Crick's life seems to have been!
@matthewcobb.bsky.social
highlights and explains all the good, bad, and eccentric characteristics of Crick. So many contributions at the dawn of molecular biology.
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3 months ago
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students, take note please. Your teachers also know how to use chatgpt even if we think TikTok is some kind of antelope.
4 months ago
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This is a great tool for evaluating papers using AI, developed by Oded Rechavi- I've used the demo version and it has been really useful, spot on with its comments. Highly recommended!
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4 months ago
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A super opportunity!
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4 months ago
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Bringing back an extinct hominid is a horrific suggestion; I would go further than this article and suggest that it is banned outright.
journals.plos.org/plosbiology/...
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Should scientists be allowed to bring distant human ancestors back to life?
Recently, several attempts have been made to modify modern species with ancient DNA in the name of âde-extinctionâ. This Perspective argues that independent ethical oversight needs to be put in place ...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003384
5 months ago
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Peter Sarkies
Itai Yanai
5 months ago
Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens â without yet knowing that science had forbidden it â changed science forever, and with it how we see ourselves.
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Just listened to George Church on The Life Scientific. very brilliant guy but the idea that Mammothising elephants is going to save the environment is total fiction. Itâs a cruel vanity project with no conceivable justification.
5 months ago
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oh the joy of the hassle that accompanies trying to submit an article. Password forgotten, orcid linked to a different account, metadata collection, all for it to be most likely rejected editorially. Everything takes an age on a clunky system designed in the 2000s. Basically 'Der Process.'
5 months ago
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Talk about stating the bleeding obvious
www.bbc.co.uk/news/article...
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Keir Starmer calls Reform migrant policy 'racist' and 'immoral'
The prime minister told the BBC he needed
https://www.bbc.co.uk/news/articles/cj6xdw1dg4zo
5 months ago
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I was only very dimly aware of this event before and was surprised there could be a whole podcast about it... but turns out it's really interesting! especially striking to hear some clips from the speech; Labour could really do with an orator of Kinnock's calibre right now
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5 months ago
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While the other senior figures in labour hide behind the fantasy of the 'special relationship' Sadiq gets it right.
www.bbc.co.uk/news/article...
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Sir Sadiq Khan hits back at Donald Trump's Sharia London claim
The Mayor of London responds to the US president's speech to the United Nations.
https://www.bbc.co.uk/news/articles/cre53qn8v07o
5 months ago
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Peter Sarkies
Adam Rutherford
5 months ago
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
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Trump is basically Fred Durst in a suit.
5 months ago
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If you havenât watched the Thursday Murder Club film⊠donât. Utter drivel. And wtf is Pierce Brosnanâs accent?
5 months ago
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That time of year again: where the f are my gloves?
5 months ago
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Peter Sarkies
Yaser Atlasi
5 months ago
We have an exciting, fully funded PhD studentship (UK and ROI) to investigate mechanisms of epigenetic regulation in drug resistant B-cell lymphoma. We are looking for a highly motivated, driven candidate to join our team.
eur02.safelinks.protection.outlook.com?url=https%3A...
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Targeting USP7-PRC1 axis as a novel therapeutic approach in drug resistant Diffuse Large B-Cell Lymphoma at Queenâs University Belfast on FindAPhD.com
PhD Project - Targeting USP7-PRC1 axis as a novel therapeutic approach in drug resistant Diffuse Large B-Cell Lymphoma at Queenâs University Belfast, listed on FindAPhD.com
https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.findaphd.com%2Fphds%2Fproject%2Ftargeting-usp7-prc1-axis-as-a-novel-therapeutic-approach-in-drug-resistant-diffuse-large-b-cell-lymphoma%2F%3Fp186926&data=05%7C02%7CY.Atlasi%40qub.ac.uk%7Cfa2e6e2d7c6e4daf9f7b08ddf46cf936%7Ceaab77eab4a549e3a1e8d6dd23a1f286%7C0%7C0%7C638935471045338400%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=AWnDAK3XLkApi%2FTM6wNqCe28%2FZe3kZeF%2Biht%2F9%2FQkFo%3D&reserved=0
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Thank god he didnât become chancellor of Oxford
5 months ago
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Peter Sarkies
Another Green
5 months ago
Daily Mail, the Daily Express, the Sun...every day they work to make cruelty popular, to destroy attempts to tackle climate change, to harm our society. Put them in the bin!
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@leaypi.bsky.social
is an incredibly clear thinker and this discussion, particularly of Kant and Nietzsche, made some tricky ideas understandable to me for the first time. highly recommended
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5 months ago
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@cecerelab.bsky.social
lab is doing outstanding work on C elegans sRNAs: a great opportunity for a PhD with them
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5 months ago
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Peter Sarkies
Rebecca Mosher
6 months ago
This is an amazing opportunity to join the plant sciences faculty in the Oxford Department of Biology! I am so impressed with the quality and collegiality of these colleagues. Iâm not on the committee, but Iâm happy to answer questions as I can.
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New Deftones album is very good. Some big riffs and lighter moments. Missing Sergio's inventive basslines though.
6 months ago
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