0/ 💡💡💡Had one of those slightly weird moments reading something today. Two seemingly very different research traditions—starting from opposite directions—appear to be converging on almost the same conclusion about one of biology’s biggest questions: How do genomes generate phenotypes? 👇🧵

Possibly the best novel by one of the greatest 20thC writers. And as this podcast episode explains it is a very realistic idea of a truly free society. Perhaps Le Guin drew on her anthropology knowledge (her father was a professor of anthropology I believe)

A different kind of publication for me- a poem, published on Spillwords! Please read and comment here: spillwords.com/ammonite/

To me it is not to be celebrated that Trump respects an unelected monarch more than the UK government. It’s typical of his approach.

now just waiting for the survey that says that 50% of men think they could win in a fight against this creature. www.science.org/doi/10.1126/...

Orwell on Hitler is a real WTF moment

This is a really great article and fun to read! Strongly recommend!

I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins. Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2

Thought the idea of neo conservativism derived from Trotsky was an April fool’s joke but seems not! Intriguing.

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Happy pi (RNA) day everyone! And what better way to enjoy than to revisit the unusual features of nematode piRNAs: www.cell.com/developmenta...

Another horse has died at this year’s Cheltenham Festival. HMS Seahorse’s death follows that of Hansard, bringing the total number of horses who have died at the festival since 2000 to 80*. This is unacceptable. If this happened in any other sport, there would be a huge outcry. *Animal Aid

Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.

Most nematodes don't have piRNAs?!!

This is really interesting. Tony Blair condemned Saddam Hussein's execution publicly. Was this genuine or was he perhaps happy with it behind the scenes? If he was genuinely opposed, what would he have preferred? UN trial might not have gone the way he would have wanted.

the current Greenland thing shows that fawning to Trump like Starmer has been doing is totally pointless as well as degrading.

Check out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.

Epimutations: raw material for evolution? Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection link.springer.com/article/10.1...

Incredibly cool- a must read!

don't miss this! will be very interesting

Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein: doi.org/10.1038/s443...

Worth a read. In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm. www.cell.com/trends/genet...

On BBC News today: striking that it’s the two old establishment parties - Labour and the Conservatives - refusing to condemn the US breaking international law and doing what it wants. Feels like politics stuck in the past, while the public has clearly moved on.

Starmer and Farage both drape themselves in flags but once again it's really clear where their loyalty really is. It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime. This is not patriotism. It's subservience.

Whatever you might think of Maduro, the seizure and kidnapping of a head of state takes us to a very dark place. Vast, arbitrary, extra-legal power, which could be exercised almost anywhere, regardless of the character of the target government.

Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from @reneketting.bsky.social lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.

RIP international law.

Nibbler or Trimmer? www.bbc.co.uk/news/article...

Very exciting to see this published- opens lots of real interesting possibilities about how memory works!

Truly a great meeting with so many highlights- thanks to @embo.org and all organisers for inspiring science program!

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

I had heard of the trial of Lady Chatterley's Lover but had no idea of the details. The whole case is so strange it's amazing it took place during my parents' lifetime- today DH Lawrence would not be considered even edgy let alone obscene. Fascinating episode.

RIP Tom Stoppard. Forever with Rosencrantz and Guildenstern now.

Great seminar in @oxfordbiochemistry.bsky.social today from Laura Landweber on the awesome world of ciliate DNA elimination- so many different gene regulation/repair pathways come together to achieve this remarkable feat

baffled that Black Friday deals seem to have spread to companies selling PCR reagents.

I’m fairly sure we don’t have to go back to Farage’s schooldays to find evidence of racism.

Climate change affects EVERYTHING. It’s mad that the issue has become left-coded when it should be just reality-coded

All you other swim shadies are just imitating www.bbc.co.uk/news/article...

The Greens don’t believe providing safe refuge for endangered asylum seekers is an “out-of-control” policy. Nor do we believe making life more difficult for those in need is the way to unify British society. Refugees are welcome.

Today we have our fantastic Autumn Meeting on Ancient Genomes @royalsociety.org !

Reading this super biography of Crick right now. It's almost as fun to read as Crick's life seems to have been! @matthewcobb.bsky.social highlights and explains all the good, bad, and eccentric characteristics of Crick. So many contributions at the dawn of molecular biology.

students, take note please. Your teachers also know how to use chatgpt even if we think TikTok is some kind of antelope.

This is a great tool for evaluating papers using AI, developed by Oded Rechavi- I've used the demo version and it has been really useful, spot on with its comments. Highly recommended!

A super opportunity!

Bringing back an extinct hominid is a horrific suggestion; I would go further than this article and suggest that it is banned outright. journals.plos.org/plosbiology/...

Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.

Just listened to George Church on The Life Scientific. very brilliant guy but the idea that Mammothising elephants is going to save the environment is total fiction. It’s a cruel vanity project with no conceivable justification.

oh the joy of the hassle that accompanies trying to submit an article. Password forgotten, orcid linked to a different account, metadata collection, all for it to be most likely rejected editorially. Everything takes an age on a clunky system designed in the 2000s. Basically 'Der Process.'

Talk about stating the bleeding obvious www.bbc.co.uk/news/article...