Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️

I'd be remiss not to highlight this study www.nature.com/articles/s41... from the lab of @kevincorbett.bsky.social now out @natsmb.nature.com Always striking to see how inventive bacteria are and what an unorthodox ubiquitylation-like mechanism this may be (probably oxyester dependent).

Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.

Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...

The @natsmb.nature.com Returning Home series is now complete, www.nature.com/nsmb/article... with the final piece by Hugo Sepulveda on his return to Chile published. It has been a joy to work on this series and, if our readers appreciate these pieces, I hope that it may continue or evolve!

We @natsmb.nature.com aim to provide a stage for our readers. That includes voicing their experiences and perspectives. We hope this makes us a more attuned and representative outlet for our communities. We launched new content to do so and explain why in our editorial www.nature.com/articles/s41...

here is the correct link: ista.ac.at/en/job/tenur...

Come work with us! 🧪

New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus

Our series on scientists Returning Home after working abroad continues here @natsmb.nature.com Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...

New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer

The September @natsmb.nature.com issue is out! www.nature.com/articles/s41... We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.

New Online! Learning about break-induced replication from bacteriophages

A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @natsmb.nature.com www.nature.com/articles/s41...

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: [email protected]

This insightful manuscript implicating STAG3 in mitotic, rather than the known meiotic, control of chromatin architecture came out a couple of days ago. Glad to see it in our pages @natsmb.nature.com and I am looking forward to see what the community will think www.nature.com/articles/s41...

Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin. STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation. www.nature.com/articles/s41...

@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read. www.nature.com/articles/s41...

📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...

Another installment of the 'Returning home" series at NSMB. This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw

Out @natsmb.nature.com a great Q&A with @fmattiroli.bsky.social. I really enjoyed reading it and I am very happy that Francesca had the time to work with us. www.nature.com/articles/s41...

Did not have time to post about this before vacation. Such a joy to have this chat with @davidlabmsk.bsky.social and Nobel Laureate Charles Rice on Yael's amazing work, capitalising on chromatin biology to understand hepatitis. www.nature.com/articles/s41...

Working with collaborators at the Crick Institute and the University of Utah, CSHL's President and CEO Bruce Stillman explores how pre-replicative complexes (pre-RCs)—even earlier than ORCs—assemble to initiate DNA replication in all plants, animals, and fungi.

Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @natsmb.nature.com will publish 5 pieces on those that returned. The first one discusses Dr. Gomes Dias' return to Brazil. Touching and inspiring. www.nature.com/articles/s41...

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

Out @natsmb.nature.com a Review on origin licensing with probably the most comprehensive (and coolest!) movies on how pre-RC assembly works. Decades of structural and biochemical work are beautifully illustrated. Kudos to Janet Iwasa, John Diffley and Bruce Stillman. www.nature.com/articles/s41...

@natsmb.nature.com recently published a very interesting pair of insightful studies on the role of H2A.Z during oocyte maturation by the labs of Wei Xie, Yu Zhang, and Yunlong Xiang, nature.com/articles/s41..., and the lab of Azusa Inoue, www.nature.com/articles/s41....

This editorial details why we think it's a good idea to standarise reporting of microscopy data and what we are doing towards that. I also feel that it is both important and a step towards helping the community. www.nature.com/articles/s41...

This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u A short thread follows 1/n

If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments www.biorxiv.org/content/10.1...

Go fund a brain gain The gutting of US research funding represents a once-in-a-generation opportunity for Europe to boost world-class research deprioritized by the Trump administration go.nature.com/4jGhU6V

Come and work with our new colleague on very cool project!

So excited to share that we @natsmb.nature.com are hiring a new editor! If you are interested about working with an intelligent, compassionate and funny team helping scientists publish great research, please consider applying. Deadline June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Dr. Basto recaps and discusses in this N&Vs www.nature.com/articles/s41... two very interesting TRIM37-mTOCs papers recently out @natsmb.nature.com, by the labs of Prof. Holland www.nature.com/articles/s41... and Prof. Oegema and Desai www.nature.com/articles/s41...

Branched ubiquitin chains are both very interesting and somewhat lagging behind in how well we understand them. Insightful work by ‪@samuelmaiwald.bsky.social from the lab of Brenda Schulman now out @[email protected] delineating a key player, TRIP12. www.nature.com/articles/s41...

@natsmb.nature.com has launched new content this month, namely Q&As. This interview with Dr. Joseph @jerelleaj.bsky.social‬ www.nature.com/articles/s41... highlights what's great about these pieces. Get to learn about the scientist and their interesting work (consensates/computational biol)!

For the DNA polymerase θ afficionados: www.nature.com/articles/s41... This N&Vs by Sylvie Doublié nicely contextualises the progress imparted by this NSMB paper www.nature.com/articles/s41... by ‪@landerlab.bsky.social and this NatComms paper www.nature.com/articles/s41... by the Chen/Pomerantz labs

On 9 May 2025, we launched the Artificial Intelligence Methodology in Structural Biology Collection between: Communications Biology, Nature Communications, Nature Structural & Molecular Biology, and Scientific Reports. www.nature.com/collections/... We are looking forward to your submissions!

NSMB is also part of the DNA repair and human disease collection, with Communications Biology, Nature Chemical Biology, Nature Communications, and Scientific Reports. www.nature.com/collections/... NSMB has been a welcoming venue for insightful genome stability studies, hoping to continue to do so.

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

Out today and I feel that I have to explicitly mention this very interesting story by the lab @maltegersch.bsky.social, developing specific inhibitors for the key mitophagy regulator USP30, based on a potential unifying and exploitable facet of USPs. www.nature.com/articles/s41...

I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...

Many interesting articles recently out @natsmb.nature.com. Here two that piqued my interest: www.nature.com/articles/s41..., another example of insightful work on the mechanisms of early development, www.nature.com/articles/s41..., another example of genomics technique development with XCI insight

Cup? Platter? Stained glass? Our imaginations were inspired (even during uncertain times!) by these beautiful molecular complexes: the Erlin and prohibitin complexes implicated in quality control at the ER and mitochondria, respectively. Check them out here: www.biorxiv.org/content/10.1...

Finally for today, a collaborative effort led by the lab of @zeqiraj.bsky.social discovers molecular glues for BRISC, a deubiquitylating enzyme regulating inflammatory signalling. A delightful read here: www.nature.com/articles/s41... and the authors original thread here: bsky.app/profile/zeqi...

Another insightful piece recently out @natsmb.nature.com delineating how Shigella utilises its effector IpaH1.4 to counteract host RNF213-induced LPS ubiquitylation. Very interesting work by the lab of @felixrandow.bsky.social. If you want to, have a go at it: www.nature.com/articles/s41...

We @natsmb.nature.com recently published an insightful manuscript on ubiquitin-independent proteasomal degradation via the NUB1-FAT10 axis by the lab of Andreas Martin. A very interesting read found here: www.nature.com/articles/s41...

I am bit late to write about this perspective but I thought I would be remiss not to mention it. In this manuscript, the authors contextualise the importance of accurately intepreting dual-reporter results and propose minimal guidelines to ensure such accuracy.