Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates

I am on paternity leave but I need to talk about this work by the @andersshansen.bsky.social lab that was published @natsmb.nature.com. The authors provide absolute quantification of chromatin loops across the genome. www.nature.com/articles/s41... Putting actual numbers in E-P, P-P and all loops!

A group of great developers we know has made this entertaining and engaging game: store.steampowered.com/app/2437390/... It's now on playtest, so if you like challenging and fun playshooter games, give it a go!

Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...

Happy to share our collaborative project with Stephane Marcand, on the protective role of Rap1 at telomeres. It turned out that our favorite protein, MRX, has the ability to measure telomere length, and activate response pathways when telomeres become too short. www.nature.com/articles/s41...

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

So how do mRNAs get localised at specific areas of the cell if there are no unifying sequence or structural patterns? Work from the labs of @simonbullock11.bsky.social @carter-lab.bsky.social @natsmb.nature.com provides insightful answers to this longstanding question. www.nature.com/articles/s41...

www.nature.com/articles/s41... An insighful study, leveraging MINFLUX to study chromatin dynamics by the @andersshansen.bsky.social lab @natsmb.nature.com . I am left wondering what if how we model chromatin with polymer simualtions needs rethinking, but surely many interesting findings here.

back to back with related study from Jan-Michael Peters' group PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes www.cell.com/molecular-ce...

📖 The final version of our paper is out in press Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption authors.elsevier.com/a/1m%7EU03vV... or www.cell.com/molecular-ce...

Quantitative biology community: QBMM is back! Line up is just stellar and many abstract selected talks. Apply! 👇

✉️ Research Briefing by @mamartirenom.bsky.social and I on our recent study, where we employ a new method, METALoci, to explore the 3D regulatory landscape of sex determination. 👏Thanks to @mcgambetta.bsky.social & @dimitristypas.bsky.social for their insights. 👉 Full manuscript: rdcu.be/e5sm2

The @natsmb.nature.com March issue is out! Though always interested in proteostasis, in 2026 we have published and will continue to do so relevant content. Our editorial www.nature.com/articles/s41... recaps why the processes and mechanisms of proteostasis continue to interest us.

A well-worth-your-time Comment by Dr. Edith Heard, of @crick.ac.uk, and Dr. Gitte Neubauer, one of the founders of Cellzome, now at GSK, is out @natsmb.nature.com. They provide valuable insight into what makes a successful partnership between academia and industry. www.nature.com/articles/s41...

Tempted to add Metal gifs; that's how cool METALoci sounds! In their recent article @natsmb.nature.com, @dariloops.bsky.social @mamartirenom.bsky.social @jrotwitguez.bsky.social @imotagom.bsky.social and colleagues shed light on sex-determining 3D regulatory hubs. www.nature.com/articles/s41...

March kickstarted @natsmb.nature.com focus on Proteostasis. Throughout the year we will be publishing state-of-the-art Reviews and Perspectives. What a better way to start than excellent Review by Michael Rapé and colleagues on the mitochondrial stress response. www.nature.com/articles/s41...

Late to the party, but I wanted to highlight a recent @natsmb.nature.com paper by the Hajkova and Vaquerizas labs, which notably advances our understanding of how chromatin organisations regulates gametogenesis. Very enjoyable and insightful work! www.nature.com/articles/s41...

An insightful piece worth reading and pondering about by @pedrobeltrao.bsky.social on our pages @natsmb.nature.com on AlphaGenome, www.nature.com/articles/s41...

These scientists and medical experts are taking to social media to counter climate denialism, vaccine scepticism and wellness pseudoscience go.nature.com/4rUFb9C

New online: Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription

A striking mechanism in how histone supply is regulated out @natsmb.nature.com which is definitely worth reading, www.nature.com/articles/s41...

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️

I'd be remiss not to highlight this study www.nature.com/articles/s41... from the lab of @kevincorbett.bsky.social now out @natsmb.nature.com Always striking to see how inventive bacteria are and what an unorthodox ubiquitylation-like mechanism this may be (probably oxyester dependent).

Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.

Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...

The @natsmb.nature.com Returning Home series is now complete, www.nature.com/nsmb/article... with the final piece by Hugo Sepulveda on his return to Chile published. It has been a joy to work on this series and, if our readers appreciate these pieces, I hope that it may continue or evolve!

We @natsmb.nature.com aim to provide a stage for our readers. That includes voicing their experiences and perspectives. We hope this makes us a more attuned and representative outlet for our communities. We launched new content to do so and explain why in our editorial www.nature.com/articles/s41...

here is the correct link: ista.ac.at/en/job/tenur...

Come work with us! 🧪

New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus

Our series on scientists Returning Home after working abroad continues here @natsmb.nature.com Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...

New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer

The September @natsmb.nature.com issue is out! www.nature.com/articles/s41... We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.

New Online! Learning about break-induced replication from bacteriophages

A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @natsmb.nature.com www.nature.com/articles/s41...

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: [email protected]

This insightful manuscript implicating STAG3 in mitotic, rather than the known meiotic, control of chromatin architecture came out a couple of days ago. Glad to see it in our pages @natsmb.nature.com and I am looking forward to see what the community will think www.nature.com/articles/s41...

Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin. STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation. www.nature.com/articles/s41...

@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read. www.nature.com/articles/s41...

📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...

Another installment of the 'Returning home" series at NSMB. This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw

Out @natsmb.nature.com a great Q&A with @fmattiroli.bsky.social. I really enjoyed reading it and I am very happy that Francesca had the time to work with us. www.nature.com/articles/s41...

Did not have time to post about this before vacation. Such a joy to have this chat with @davidlabmsk.bsky.social and Nobel Laureate Charles Rice on Yael's amazing work, capitalising on chromatin biology to understand hepatitis. www.nature.com/articles/s41...

Working with collaborators at the Crick Institute and the University of Utah, CSHL's President and CEO Bruce Stillman explores how pre-replicative complexes (pre-RCs)—even earlier than ORCs—assemble to initiate DNA replication in all plants, animals, and fungi.

Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @natsmb.nature.com will publish 5 pieces on those that returned. The first one discusses Dr. Gomes Dias' return to Brazil. Touching and inspiring. www.nature.com/articles/s41...

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

Out @natsmb.nature.com a Review on origin licensing with probably the most comprehensive (and coolest!) movies on how pre-RC assembly works. Decades of structural and biochemical work are beautifully illustrated. Kudos to Janet Iwasa, John Diffley and Bruce Stillman. www.nature.com/articles/s41...

@natsmb.nature.com recently published a very interesting pair of insightful studies on the role of H2A.Z during oocyte maturation by the labs of Wei Xie, Yu Zhang, and Yunlong Xiang, nature.com/articles/s41..., and the lab of Azusa Inoue, www.nature.com/articles/s41....