Amy Strom
@dnamystrom.bsky.social
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Chromatin and cancer and condensates. Lab Head in Discovery Oncology at Genentech. AmyStrom.com
pinned post!
If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
about 1 year ago
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30% of our proteome is disordered, yet we still don't have reliable ways to predict functional implications of mutations in disordered regions, or drug them. Here's the latest on chromatin, condensates, and cancer from my group in Discovery Onc at Genentech
journals.biologists.com/jcs/article/...
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Decoding intrinsically disordered regions in chromatin dysfunction and cancer
Summary: This Perspective describes cancer variants that rewire chromatin regulation through intrinsically disordered regions (IDRs) and argues for comprehensive mapping of condensate-related nuclear ...
https://journals.biologists.com/jcs/article/139/12/jcs264844/371950/Decoding-intrinsically-disordered-regions-in?guestAccessKey=b3fad663-edbe-4e46-8d7a-d7b28cbc5462
17 days ago
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I'm hiring a summer intern! Pursuing a PhD and interested in industry experience? Apply at the link below by Jan 26 to spend 12 weeks onsite at South San Francisco with Genentech's Discovery Oncology department in May-July 2026 pursuing novel therapies targeting disordered protein regions.
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2026 Summer Intern - Discovery Oncology
2026 Summer Intern - Discovery Oncology Department Summary The Department of Discovery Oncology is seeking a talented and motivated summer intern to join the biology research efforts to identify and c...
https://roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/job/South-San-Francisco/XMLNAME-2026-Summer-Intern---Discovery-Oncology_202601-100471
5 months ago
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Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!
www.molbiolcell.org/doi/full/10....
Shout-out
@drjorine.bsky.social
@brangwynnelab.bsky.social
And huge thank you
@ascbiology.bsky.social
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Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell
Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...
https://www.molbiolcell.org/doi/full/10.1091/mbc.E24-01-0046?af=R
10 months ago
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Getting Strom Lab set up!
10 months ago
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First day at my new job! I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech. I'll be searching for new targets to develop cancer treatments. 2nd photo is my newest friend on campus, decoy-ote.
@genentech.bsky.social
11 months ago
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The latest in my favorite love triangle: Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics
add a skeleton here at some point
12 months ago
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Cancelling grants that were already competitively won and awarded is the waste and abuse.
www.nytimes.com/2025/07/10/u...
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The Surprising Scientists Hit by Trump’s D.E.I. Cuts
https://www.nytimes.com/2025/07/10/us/trump-science-nih-grants-dei-cuts.html
12 months ago
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I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology! I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
12 months ago
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If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
about 1 year ago
5
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28
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