Jean Nakhle
@jeannakhle.bsky.social
📤 1166
📥 225
📝 111
Associate Editor
@natmetabolism.nature
.com He/Him/His. Views are my own.
reposted by
Jean Nakhle
Nature Metabolism
5 days ago
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The genetics of obesity: aetiology, prevention and therapy
Nature Metabolism, Published online: 24 March 2026; doi:10.1038/s42255-026-01497-wThis Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesity.
http://dlvr.it/TRpQY9
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Jean Nakhle
Nature Metabolism
7 days ago
✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about #AdiposeTissue, #EVs, #Incretins, #Immune cells, #LiverMetabolism, #MitochondrialMetabolism, #SpatialOmics, #Tumorbiology and many more topics! 🧪
http://dlvr.it/TRmC3C
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reposted by
Jean Nakhle
Nature Metabolism
10 days ago
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Advances and opportunities in measuring dietary intake: from omics to AI
Nature Metabolism, Published online: 18 March 2026; doi:10.1038/s42255-026-01494-zThis Review highlights recent technological advances in measuring dietary food intake, including artificial intelligence-based methods and approaches informed by the gut microbiome.
http://dlvr.it/TRj13F
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New Editorial in
@natmetabolism.nature.com
for World Obesity Day 📆
add a skeleton here at some point
about 1 month ago
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. 🧪 Read about
#AdiposeInnervation
,
#Amylin
,
#Cancer
,
#LiverMetabolism
,
#MitochondrialMetabolism
,
#Mycobiome
,
#Neurometabolism
,
#Redox
,
#T2D
and many more topics!
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Mann Lab
about 1 month ago
Ever wondered how the human liver looks like at single-cell, spatial protein resolution? We used single-cell Deep Visual Proteomics to map human liver zonation at the protein level - one hepatocyte at a time. Our paper is out in
@natmetabolism.nature.com
!
www.nature.com/articles/s42...
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Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture - Nature Metabolism
Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.
https://www.nature.com/articles/s42255-026-01459-2
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reposted by
Jean Nakhle
Lauren Albrecht
about 1 month ago
Excited to share our latest work out today in
@naturemetabolism.bsky.social
@ucirvine.bsky.social
www.nature.com/articles/s42...
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PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism
Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.
https://www.nature.com/articles/s42255-026-01457-4
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
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Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome
Nature Metabolism, Published online: 18 February 2026; doi:10.1038/s42255-026-01464-5Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.
http://dlvr.it/TR8ZCC
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reposted by
Jean Nakhle
Nature Metabolism
about 2 months ago
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Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion
Nature Metabolism, Published online: 05 February 2026; doi:10.1038/s42255-026-01453-8Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as obesity, caloric restriction and changes to meal timing, alter hepatic protein secretion.
http://dlvr.it/TQwJdC
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reposted by
Jean Nakhle
Ben Weger
about 2 months ago
Our study is out today 🎉 in
@natmetabolism.nature.com
. The liver doesn’t secrete proteins nonstop; it follows a daily rhythm. Meal timing controls liver protein release via glycogen metabolism, and disrupted eating blunts these rhythms. A 🧵 ...
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Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion - Nature Metabolism
Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as...
https://rebrand.ly/ddab66
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
METABOLIC MESSENGERS | Testosterone S Bhasin, F Mauvais-Jarvis
@harvardmed.bsky.social
,
@tulanemedicine.bsky.social
Testosterone’s role in cardiometabolic & musculoskeletal health 🧪
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Metabolic Messengers: testosterone - Nature Metabolism
Mauvais-Jarvis and Bhasin provide an in-depth review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from testosterone replacement therapy in humans and mechanistic research in rodent models.
http://dlvr.it/TQkkKJ
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#AMPK
,
#Cachexia
,
#ImmuneSignalling
,
#Microbiome
,
#NAD
,
#Nutrition
,
#TissueCrosstalk
and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Sri Narasimhan
2 months ago
Today at Cell: A new
#HallmarksofCancer
review by Doug Hanahan:
www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social
@cellpress.bsky.social
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Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...
https://www.cell.com/cell/fulltext/S0092-8674(25)01498-9
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reposted by
Jean Nakhle
Nature
2 months ago
Nature research paper: The transition from monocyte to tissue-resident macrophage requires DHPS
go.nature.com/4sSiFPX
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The transition from monocyte to tissue-resident macrophage requires DHPS - Nature
In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.
https://go.nature.com/4sSiFPX
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ADHD: The quest to understand and treat a pervasive and mystifying mental health condition.
@nature.com
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Nature Outlook: ADHD
The quest to understand and treat a pervasive and mystifying mental health condition.
https://www.nature.com/immersive/ADHD/index.html
2 months ago
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reposted by
Jean Nakhle
The Journal of Physiology
5 months ago
#Research
by Rémi Montané of
toulouseuniversite.bsky.social
et al. observes that brown
#adipose
tissue activity impacts systemic
#lactate
clearance in male mice 🔬 📉 📜 Read the study here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
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reposted by
Jean Nakhle
Lori Zeltser, PhD
2 months ago
Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳
www.nature.com/articles/s42...
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
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reposted by
Jean Nakhle
Nature
2 months ago
Nature research paper: A foundation model for continuous glucose monitoring data
go.nature.com/3LkpysA
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A foundation model for continuous glucose monitoring data - Nature
GluFormer, a generative foundation model, uses continuous glucose monitoring data to accurately forecast glycaemia-related health responses, particularly for long-term outcomes.
https://go.nature.com/3LkpysA
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Out now in
@natmetabolism.nature.com
🧪
@zeltserlab.bsky.social
et al. provide a mechanistic explanation of how the thermogenic and glucoregulatory functions of BAT are controlled by molecularly, anatomically, and functionally distinct neuronal populations within the stellate ganglion.
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
2 months ago
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Out now in
#NatureMetabolism
🧪 How does psychological stress influence tumor development? Chronic stress disrupts catecholamine signalling, which in turn rewires the hepatic kynurenine pathway. This shift suppresses hepatic CD8⁺ T cell activity and promotes immune evasion.
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Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance - Nature Metabolism
Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8+ T cell function and promotes liver cancer progression.
https://www.nature.com/articles/s42255-025-01430-7
3 months ago
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reposted by
Jean Nakhle
Jason Cantor
3 months ago
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work
@natmetabolism.nature.com
, led by
@thebiokimist.bsky.social
. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
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reposted by
Jean Nakhle
Nature
3 months ago
Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites
go.nature.com/4b1vrFk
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Language model-guided anticipation and discovery of mammalian metabolites - Nature
Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.
https://go.nature.com/4b1vrFk
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reposted by
Jean Nakhle
Nature Metabolism
6 months ago
EDITORIAL | Nutritional advice on social media: clicks over credibility Social media based nutritional misinformation can lead to poorly managed health conditions. Experts need to adapt and engage effectively to counteract this trend. 🧪
www.nature.com/articles/s42...
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Nutritional advice on social media: clicks over credibility - Nature Metabolism
Social media has become a go-to source for nutritional advice, and a space in which influencers compete with, and often drown out, evidence-based guidance. The scientific community should counter this viral spread of misinformation by making trustworthy information more accessible.
https://www.nature.com/articles/s42255-025-01385-9
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Out now in
@natmetabolism.nature.com
🧪 Mauvais-Jarvis and Bhasin provide a review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from humans and rodents.
doi.org/10.1038/s422...
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Client Challenge
https://doi.org/10.1038/s42255-025-01431-6
3 months ago
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Out now in
@natmetabolism.nature.com
🧪 Elevated adipocyte-derived AFABP in obesity binds to plasma transferrin which leads to iron overload in intestinal stem cells (ISCs). Disruption of iron homeostasis impairs PPARα signalling and blocks ISC differentiation after injury.
doi.org/10.1038/s422...
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Client Challenge
https://doi.org/10.1038/s42255-025-01425-4
3 months ago
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reposted by
Jean Nakhle
Barbara Marte
3 months ago
new out in Nature
www.nature.com/articles/s41...
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Nutrient requirements of organ-specific metastasis in breast cancer - Nature
How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.
https://www.nature.com/articles/s41586-025-09898-9
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🎂
add a skeleton here at some point
3 months ago
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#Cognition
,
#FoodCues
,
#Microbiome
,
#Neurometabolism
,
#Regeneration
,
#Tumor
biology and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Current Biology
4 months ago
HAPPY HOLIDAYS TO ALL OF YOU!🎄✨
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reposted by
Jean Nakhle
Nature Metabolism
4 months ago
#Throwback
🧪 CORRESPONDENCE | EMito-Metrix enables automated evaluation of mitochondrial morphology across species JP Pradère et al.
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EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism
https://bit.ly/49gLJJ3
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Watch this space 😉
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4 months ago
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7/10 🫢 “Each time we scroll past without thinking, another lie takes root.”
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4 months ago
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Out now in
@natmetabolism.nature.com
🚨 Happy to share these back-to-back studies from the labs of Ana Maria Cuervo and Pura Muñoz-Cánoves, who jointly uncover how the age-related decline of chaperone-mediated autophagy (CMA) impacts muscle health.
4 months ago
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reposted by
Jean Nakhle
LPJ Lab - Neuroimmunometabolism
4 months ago
⚠️ Just out in
@natmetabolism.nature.com
⚠️ Our latest review with
@pluchinolab.bsky.social
&
@biancasilvalab.bsky.social
explores how
#microglia
and
#neuron
#metabolism
shapes
#brain
health and cognition! 🧠 Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
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The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
https://www.nature.com/articles/s42255-025-01409-4
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reposted by
Jean Nakhle
Nature Metabolism
4 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#AI
in metabolism,
#MASLD
,
#Mitochondrial
Metabolism,
#MetabolicBiomarkers
,
#Neurometabolism
and many more topics! 🧪
www.nature.com/natmetab/vol...
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Out now in
@natmetabolism.nature.com
🚨 This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing as well as in metabolic, neuroinflammatory and neurodegenerative diseases contributes to cognitive decline.
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The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
https://www.nature.com/articles/s42255-025-01409-4
4 months ago
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reposted by
Jean Nakhle
Communications Biology
5 months ago
🏳️🌈🏳️⚧️To commemorate LGBTQIA+ in STEM day today, we reached out to
@geosantiagom.bsky.social
and
@fabriceroux7.bsky.social
to discuss their experiences in STEM, the main barriers queer researchers currently face, and more. See both Q&As below 🔽
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reposted by
Jean Nakhle
Nature Metabolism
5 months ago
On
#WorldDiabetesDay
, we highlight key findings from our latest primary research and review articles 🧵 (1/8)
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Out now in
@natmetabolism.nature.com
by
@jourdainlab.bsky.social
📢 A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://doi.org/10.1038/s42255-025-01419-2
5 months ago
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reposted by
Jean Nakhle
Alexis A. Jourdain
5 months ago
Very excited to share the published version of our
#uridine
#CRISPR
screen in
naturemetabolism.bsky.social
! 🎉 Led by Abigail Strefeler with
@pagliarini-lab.bsky.social
@zakbaker.bsky.social
and team!
#NUDT5
#DMQ
@dib-unil.bsky.social
@fbm-unil.bsky.social
🔗
www.nature.com/articles/s42...
🧵1/17
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://www.nature.com/articles/s42255-025-01419-2
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reposted by
Jean Nakhle
Orr laboratory
5 months ago
Thrilled to publish our new study on
#mitochondrial
ROS coming from complex III, revealing this key site in
#astrocytes
🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for
#dementia
#FTD
💊
rdcu.be/eOc0m
👈💪 Great commentary by H. Pan and F. Yin🤩!
tinyurl.com/4hdytw4c
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Read this Research Highlight of the SWEET trial by
@natrevendo.nature.com
:
www.nature.com/articles/s42...
add a skeleton here at some point
5 months ago
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Jean Nakhle
Nature Portfolio
5 months ago
@commsaicomp.bsky.social
has launched and seeks your submissions for publications! You can follow them and all our journals with our starter pack.
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Last chance to apply 🚨
add a skeleton here at some point
5 months ago
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reposted by
Jean Nakhle
Nature Metabolism
5 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines 🧪 Read about
#DietarySugars
,
#Drosophila
development,
#Exenatide
,
#Ketone
metabolism,
#Neurolipids
,
#NAD+
,
#RedoxPathways
, and many more topics!
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Metabolism
6 months ago
Register for this exciting Nature Conference on 'Healthy Brain Aging' and meet eminent researchers in the field as well as editors from
@natmetabolism.nature.com
& other
@natureportfolio.nature.com
journals! 🧪 🚨Abstract submission deadline Oct 17th! Registration and other details:
t.co/iiCzYAv9mH
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Out now in
@natmetabolism.nature.com
🧪 FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors. Read the full study by
@martinpicardenergy.bsky.social
here:
doi.org/10.1038/s422...
6 months ago
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reposted by
Jean Nakhle
Revati Dewal
6 months ago
In this viewpoint, 12
#Metabolism
scientists talk about how they think
#AI
will be incorporated in Metabolic Research 🧪 Read in
@natmetabolism.nature.com
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reposted by
Jean Nakhle
Magdalena Skipper
6 months ago
Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize. “Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems” 🧪
#academicSky
www.nature.com/articles/d41...
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More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys
The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.
https://www.nature.com/articles/d41586-025-03247-6
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