Jean Nakhle
@jeannakhle.bsky.social
📤 1151
📥 221
📝 102
Associate Editor
@natmetabolism.nature
.com He/Him/His. Views are my own.
reposted by
Jean Nakhle
Nature Metabolism
13 days ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#Cognition
,
#FoodCues
,
#Microbiome
,
#Neurometabolism
,
#Regeneration
,
#Tumor
biology and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Current Biology
16 days ago
HAPPY HOLIDAYS TO ALL OF YOU!🎄✨
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reposted by
Jean Nakhle
Nature Metabolism
18 days ago
#Throwback
🧪 CORRESPONDENCE | EMito-Metrix enables automated evaluation of mitochondrial morphology across species JP Pradère et al.
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EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism
https://bit.ly/49gLJJ3
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Watch this space 😉
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about 1 month ago
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7/10 🫢 “Each time we scroll past without thinking, another lie takes root.”
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about 1 month ago
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Out now in
@natmetabolism.nature.com
🚨 Happy to share these back-to-back studies from the labs of Ana Maria Cuervo and Pura Muñoz-Cánoves, who jointly uncover how the age-related decline of chaperone-mediated autophagy (CMA) impacts muscle health.
about 1 month ago
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Jean Nakhle
LPJ Lab - Neuroimmunometabolism
about 1 month ago
⚠️ Just out in
@natmetabolism.nature.com
⚠️ Our latest review with
@pluchinolab.bsky.social
&
@biancasilvalab.bsky.social
explores how
#microglia
and
#neuron
#metabolism
shapes
#brain
health and cognition! 🧠 Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
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The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
https://www.nature.com/articles/s42255-025-01409-4
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#AI
in metabolism,
#MASLD
,
#Mitochondrial
Metabolism,
#MetabolicBiomarkers
,
#Neurometabolism
and many more topics! 🧪
www.nature.com/natmetab/vol...
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Out now in
@natmetabolism.nature.com
🚨 This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing as well as in metabolic, neuroinflammatory and neurodegenerative diseases contributes to cognitive decline.
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The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
https://www.nature.com/articles/s42255-025-01409-4
about 1 month ago
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reposted by
Jean Nakhle
Communications Biology
about 2 months ago
🏳️🌈🏳️⚧️To commemorate LGBTQIA+ in STEM day today, we reached out to
@geosantiagom.bsky.social
and
@fabriceroux7.bsky.social
to discuss their experiences in STEM, the main barriers queer researchers currently face, and more. See both Q&As below 🔽
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reposted by
Jean Nakhle
Nature Metabolism
about 2 months ago
On
#WorldDiabetesDay
, we highlight key findings from our latest primary research and review articles 🧵 (1/8)
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Out now in
@natmetabolism.nature.com
by
@jourdainlab.bsky.social
📢 A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://doi.org/10.1038/s42255-025-01419-2
about 2 months ago
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reposted by
Jean Nakhle
Alexis A. Jourdain
about 2 months ago
Very excited to share the published version of our
#uridine
#CRISPR
screen in
naturemetabolism.bsky.social
! 🎉 Led by Abigail Strefeler with
@pagliarini-lab.bsky.social
@zakbaker.bsky.social
and team!
#NUDT5
#DMQ
@dib-unil.bsky.social
@fbm-unil.bsky.social
🔗
www.nature.com/articles/s42...
🧵1/17
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://www.nature.com/articles/s42255-025-01419-2
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reposted by
Jean Nakhle
Orr laboratory
2 months ago
Thrilled to publish our new study on
#mitochondrial
ROS coming from complex III, revealing this key site in
#astrocytes
🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for
#dementia
#FTD
💊
rdcu.be/eOc0m
👈💪 Great commentary by H. Pan and F. Yin🤩!
tinyurl.com/4hdytw4c
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Read this Research Highlight of the SWEET trial by
@natrevendo.nature.com
:
www.nature.com/articles/s42...
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2 months ago
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reposted by
Jean Nakhle
Nature Portfolio
2 months ago
@commsaicomp.bsky.social
has launched and seeks your submissions for publications! You can follow them and all our journals with our starter pack.
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Last chance to apply 🚨
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2 months ago
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines 🧪 Read about
#DietarySugars
,
#Drosophila
development,
#Exenatide
,
#Ketone
metabolism,
#Neurolipids
,
#NAD+
,
#RedoxPathways
, and many more topics!
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
Register for this exciting Nature Conference on 'Healthy Brain Aging' and meet eminent researchers in the field as well as editors from
@natmetabolism.nature.com
& other
@natureportfolio.nature.com
journals! 🧪 🚨Abstract submission deadline Oct 17th! Registration and other details:
t.co/iiCzYAv9mH
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Out now in
@natmetabolism.nature.com
🧪 FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors. Read the full study by
@martinpicardenergy.bsky.social
here:
doi.org/10.1038/s422...
3 months ago
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reposted by
Jean Nakhle
Revati Dewal
3 months ago
In this viewpoint, 12
#Metabolism
scientists talk about how they think
#AI
will be incorporated in Metabolic Research 🧪 Read in
@natmetabolism.nature.com
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reposted by
Jean Nakhle
Magdalena Skipper
3 months ago
Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize. “Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems” 🧪
#academicSky
www.nature.com/articles/d41...
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More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys
The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.
https://www.nature.com/articles/d41586-025-03247-6
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Come work with us! 🧪
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3 months ago
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Out now in
@natmetabolism.nature.com
🧪 In a multicenter, randomized, controlled trial, long-term consumption of sweeteners and sweetness enhancers improved body weight control and elicited beneficial gut microbiota changes in adults with overweight or obesity.
www.nature.com/articles/s42...
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Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study - Nature Metabolism
The SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.
https://www.nature.com/articles/s42255-025-01381-z
3 months ago
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reposted by
Jean Nakhle
Nature
3 months ago
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more.
#NobelPrize
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I’ll be attending the Metabolism & Cancer congress in La Grande-Motte next week. If you’re there, let’s chat 😊
3 months ago
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I’ll be in Daegu 🇰🇷 for the Nature Conference on Healthy Brain Aging. Come say hi if you’re around and want to chat about Nature Metabolism (or metabolism stuff in general!) 🧠🧪
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3 months ago
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reposted by
Jean Nakhle
Nature Microbiology
3 months ago
#Editorial
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky
#AcademicChatter
www.nature.com/articles/s41...
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Why editors go to conferences - Nature Microbiology
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we demystify the editorial aims of conference attendance.
https://www.nature.com/articles/s41564-025-02151-z?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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reposted by
Jean Nakhle
Merja Joensuu
3 months ago
🌟 Thrilled to share that my lab’s first publication is now out in
@natmetabolism.nature.com
. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
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reposted by
Jean Nakhle
Springer Nature
3 months ago
One of our top-rated articles on
altmetric.com
this past week was published open access in @natmetabolism.nature.com. You can read 'Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD' here:
www.nature.com/articles/s42...
#CanSky
#OncoSky
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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD - Nature Metabolism
Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).
https://www.nature.com/articles/s42255-025-01368-w
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Out now in
#NatureMetabolism
🧪 This year marks 20 years since the first GLP-1R agonist was approved. Former employees at Amylin Pharmaceuticals look back on how it all began. Led by James Trevaskis.
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3 months ago
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
✨New issue!✨ Check out the latest in
#metabolism
research from across all disciplines. Read about
#Ferroptosis
,
#MASLD
,
#DietaryBiomarkers
,
#CoA
metabolism,
#Immune
signaling,
#Tumor
biology and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Portfolio
3 months ago
Genotype-phenotype data from over 450,000 people was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual, according to a paper in Nature Medicine.
go.nature.com/4pDuTKP
#medsky
🧬 🧪
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reposted by
Jean Nakhle
Nature Portfolio
3 months ago
A study in Nature Metabolism shows that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).
go.nature.com/3IaPoO9
#medsky
🧪
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Out now in
#NatureMetabolism
🧪 Preferential use of gluconeogenic pathways in the liver depends on exercise load and affects performance.
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3 months ago
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reposted by
Jean Nakhle
Nature
4 months ago
Nature research paper: Molecular subtypes of human skeletal muscle in cancer cachexia
go.nature.com/4pm7EVo
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.
https://go.nature.com/4pm7EVo
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I will be at
#EASD2025
starting tomorrow. Reach out if you are around 😊
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4 months ago
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Out now in
@natmetabolism.nature.com
Viral doesn’t always mean accurate. We unpack the dangers of online nutrition advice in this Editorial.
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4 months ago
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I will be at the
@easdnews.bsky.social
#EASD2025
meeting in Vienna in two weeks. Hit me up if you'd like to chat about everything
@natmetabolism.nature.com
🤗
4 months ago
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reposted by
Jean Nakhle
Quintana-Cabrera Lab
4 months ago
🔬Honored for the opportunity to contribute this viewpoint
@naturemetabolism.bsky.social
where we discuss on Mitochondrial transfer; its evidences, challenges and opportunities, with plenty of room for exciting research yet to come!
rdcu.be/eCFRX
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Mitochondrial transfer
Nature Metabolism - Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues...
https://rdcu.be/eCFRX
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reposted by
Jean Nakhle
Ana Victoria Lechuga-Vieco
4 months ago
Honoured to contribute to this
#Viewpoint
on mitochondrial transfer, now out in
@natmetabolism.nature.com
Lots of open questions + much more to explore!
@irbbarcelona.org
@ageinves.bsky.social
@caixaresearch.bsky.social
rdcu.be/eCFRX
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Mitochondrial transfer
Nature Metabolism - Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues...
https://rdcu.be/eCFRX
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reposted by
Jean Nakhle
Nature Metabolism
5 months ago
✨New issue!✨ Check out the latest in
#metabolism
research from across all disciplines. Read about
#TumourMetabolism
,
#Lactate
signalling,
#WeighLoss
,
#Thermogenesis
,
#DietaryInterventions
and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Structural & Molecular Biology
5 months ago
New online: Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability
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Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability
Nature Structural & Molecular Biology, Published online: 12 August 2025; doi:10.1038/s41594-025-01614-5Wang et al. show that pregnane X receptor (PXR), a well-known DNA-binding nuclear receptor, has mRNA stabilization functions when in the cytoplasm, thus unveiling a noncanonical perspective to understand and target PXR as an RNA-binding protein.
https://go.nature.com/3UTPrQW
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reposted by
Jean Nakhle
Quadram Institute
5 months ago
Find out how food structure plays a key role in digestion and health ⤵️
quadram.ac.uk/new-uk-study...
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reposted by
Jean Nakhle
Nature Portfolio
5 months ago
The results of a study in Nature Metabolism highlight the significance of diet in maintaining a healthy immune system and suggest that modifying dietary fat may improve cancer outcomes in obesity.
#medsky
🧪
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The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
https://go.nature.com/41rcQwC
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Out now in
#NatureMetabolism
🧪 In this double-blind, randomised, crossover trial, a diet rich in fermentable foods was shown to improve the glucose-lowering efficacy of metformin in people with prediabetes due, at least in part, to changes in gut microbiota composition.
doi.org/10.1038/s422...
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Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes - Nature Metabolism
In this double-blind, randomised, crossover trial, a diet rich in fermentable foods was shown to improve the glucose-lowering efficacy of metformin due, at least in part, to changes in gut microbiota ...
https://doi.org/10.1038/s42255-025-01336-4
5 months ago
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reposted by
Jean Nakhle
Jennifer Gill, MD, PhD
5 months ago
Excited to share our work just published in
@natmetabolism.nature.com
examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.
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reposted by
Jean Nakhle
DeBerardinis Lab at UT Southwestern Medical Center
5 months ago
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
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Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
https://www.nature.com/articles/s42255-025-01338-2?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250729&utm_content=10.1038/s42255-025-01338-2
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reposted by
Jean Nakhle
Nature Metabolism
5 months ago
COMMENT | 🧪
@colbyvorland.bsky.social
, L Golzarri-Arroyo & DB Allison (Indiana Uni) This comment discusses how clustering and nesting (C&N) arise in
#preclinical
studies, as well as valid designs and analyses.
www.nature.com/articles/s42...
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A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism
Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. He...
https://www.nature.com/articles/s42255-025-01323-9?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
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