Jean Nakhle
@jeannakhle.bsky.social
📤 1177
📥 228
📝 111
Associate Editor
@natmetabolism.nature
.com He/Him/His. Views are my own.
reposted by
Jean Nakhle
Nature Metabolism
3 days ago
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Polyendocrine metabolic ovarian syndrome — a new name for an old problem
Nature Metabolism, Published online: 03 June 2026; doi:10.1038/s42255-026-01552-6The recent global consensus to rename polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS) accurately reframes the condition as a lifelong, multisystemic disorder rather than a localized ovarian pathology. This transition underscores the central role of metabolic dysfunction, specifically the high prevalence of insulin resistance and hyperinsulinaemia, and has important consequences for basic and clinical research.
http://dlvr.it/TSs89w
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Jean Nakhle
Nature Metabolism
9 days ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#ChromatinOrganization
,
#DietaryDogmas
,
#GlycemicPatterns
,
#Irisin
,
#FructoseSignalling
,
#LipidMetabolism
,
#RedoxRhythms
and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Barbara Marte
10 days ago
new out in Nature
www.nature.com/articles/s41...
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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
https://www.nature.com/articles/s41586-026-10584-7
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Jean Nakhle
Nature Portfolio
10 days ago
The findings of a study in Nature Metabolism suggest that irisin induction in response to exercise confers direct neuroprotective effects in an inflammation-driven neurodegenerative condition, making it an attractive therapeutic candidate for multiple sclerosis.
#medsky
🧪
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The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis - Nature Metabolism
Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral administration of irisin.
https://go.nature.com/4tZK5mj
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Jean Nakhle
Nature Metabolism
15 days ago
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Glycerol is a new ally for heat production and bone health
Nature Metabolism, Published online: 22 May 2026; doi:10.1038/s42255-026-01545-5The mechanisms controlling activation of the futile creatine cycle are unknown, calling into question its physiological relevance. In work recently published in Nature, Hussain, Krishnan, Carroll et al. identify glycerol as an allosteric activator of tissue-nonspecific alkaline phosphatase (TNAP) and demonstrate that this activates the futile creatine cycle in adipocytes and osteoblast mineralization in bone.
http://dlvr.it/TSgQ2k
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Jean Nakhle
Nature
11 days ago
Nature research paper: Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite
go.nature.com/4tJN7ef
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Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and function.
https://go.nature.com/4tJN7ef
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reposted by
Jean Nakhle
Nature Portfolio
24 days ago
Strategies for maintaining weight lost following injectable treatment or via dieting are described in two unrelated randomised controlled trials published in Nature Medicine.
go.nature.com/4tAkDUq
go.nature.com/4fgodiL
#medsky
🧪
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reposted by
Jean Nakhle
Nature Portfolio
24 days ago
Faecal
#microbiome
profiling of individuals with obesity and type 2 diabetes (T2D) before and 12 months after bariatric surgery links surgery-induced changes in microbiota composition to metabolic improvements and potentially to T2D remission, according to a paper in Nature Metabolism. 🧪
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Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission - Nature Metabolism
Faecal microbiome profiling of individuals with obesity and type 2 diabetes (T2D) before and 12 months after bariatric surgery links surgery-induced changes in microbiota composition to metabolic improvements and potentially to T2D remission.
https://go.nature.com/4uJHKwK
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reposted by
Jean Nakhle
Springer Nature
25 days ago
Strategies for maintaining weight lost following injectable treatment or via dieting are described in two unrelated randomised controlled trials published in @natmed.nature.com.
spklr.io/63325EzggV
and
spklr.io/63328Ezggk
#medsky
🩺⚕️
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Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial - Nature Medicine
As presented at the European Congress on Obesity, this randomized, placebo-controlled trial demonstrates that oral orforglipron, a nonpeptide GLP-1 receptor agonist, preserves weight loss and cardiometabolic benefits achieved with injectable GLP-1 receptor agonist therapies, making it a viable oral maintenance strategy.
http://spklr.io/63325EzggV
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reposted by
Jean Nakhle
Nature Metabolism
29 days ago
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Metformin lowers blood glucose by targeting intestinal mitochondrial complex I
Nature Metabolism, Published online: 08 May 2026; doi:10.1038/s42255-026-01532-wMetabolomic analysis of plasma from metformin-treated humans, together with mechanistic studies in mouse models, reveals that metformin selectively inhibits mitochondrial complex I in the intestinal epithelium. This mechanism unifies multiple clinical effects of metformin, including enhanced intestinal glucose use, improved postprandial glycaemic control and increased production of GDF15 and N-lactoyl-phenylalanine.
http://dlvr.it/TSS3vd
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reposted by
Jean Nakhle
Lucas Sullivan
29 days ago
Also, check out this excellent N&V writeup from
@frezzalab.bsky.social
that nicely summarizes our findings and contextualizes them with other fascinating work on succinate interactions with nucleotide synthesis from the
@bensahralab.bsky.social
and Hirschey Labs!
www.nature.com/articles/s42...
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Succinate calls a time-out on pyrimidine biosynthesis - Nature Metabolism
Cell metabolism is a dynamic network of highly interconnected biochemical reactions. In this issue of Nature Metabolism, time-lapse analysis of the amino acid aspartate revealed an unexpected regulati...
https://www.nature.com/articles/s42255-026-01523-x
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reposted by
Jean Nakhle
Lucas Sullivan
29 days ago
New out this week in
@natmetabolism.nature.com
– We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive "aspartate rebound" effect, mediated by succinate impairing pyrimidine synthesis.
www.nature.com/articles/s42...
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Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase - Nature Metabolism
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase (ATCase), leading to impaired pyrimidine biosynthesis and reduced proliferation under SDH inhibition.
https://www.nature.com/articles/s42255-026-01524-w
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reposted by
Jean Nakhle
Nature
about 1 month ago
Nature research paper: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
go.nature.com/4tR7wir
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GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice - Nature
GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse models via synergistic incretin and PPAR activity.
https://go.nature.com/4tR7wir
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Jean Nakhle
Nature Metabolism
about 1 month ago
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Good things come in twos
Nature Metabolism, Published online: 28 April 2026; doi:10.1038/s42255-026-01522-yCo-submissions bring together independent studies that offer complementary insights and strengthen one another, and they remain an integral part of how we support robust research at Nature Metabolism.
http://dlvr.it/TSGvGw
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Jean Nakhle
Nature Metabolism
about 1 month ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about the
#GeneticsOfObesity
,
#DietaryFoodIntake
,
#Python
Metabolomics,
#Irisin
,
#PancreaticCancer
,
#IsletEpigenetics
,
#Immunometabolism
and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
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Longitudinal multimorbidity trajectories shape personalized glycaemic patterns
Nature Metabolism, Published online: 16 April 2026; doi:10.1038/s42255-026-01512-0In a multi-cohort longitudinal study integrating continuous glucose monitoring and circulating proteomics, cumulative age-related disease trajectories shape daily glycaemic variability and postprandial response to standardized meals.
http://dlvr.it/TSBGF7
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
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The diversity and consistency of what and when people eat
Nature Metabolism, Published online: 23 April 2026; doi:10.1038/s42255-026-01504-0An exploratory, observational analysis involving 2.5 million food logs from over 20,000 adults across 2 weeks highlights both consistent and divergent patterns in food habits that may, in turn, influence human health.
http://dlvr.it/TSBN01
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reposted by
Jean Nakhle
Nature Metabolism
about 2 months ago
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Fructose: metabolic signal and modern hazard
Nature Metabolism, Published online: 17 April 2026; doi:10.1038/s42255-026-01506-yJohnson et al. discuss the role of dietary and endogenous fructose as a calorie source and modulator of metabolic health and disease.
http://dlvr.it/TS54kB
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Jean Nakhle
Nature Metabolism
about 2 months ago
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Overcoming dietary dogmas
Nature Metabolism, Published online: 15 April 2026; doi:10.1038/s42255-026-01526-8Early mechanistic hypotheses in nutrition research are frequently converted into durable dietary dogma. We argue that context-dependent biological effects are reduced to simple narratives of harm or benefit, with lasting consequences for research, policy and public understanding.
http://dlvr.it/TS3HK3
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Jean Nakhle
Nature
about 2 months ago
Scientists have identified a set of genetic variants that could help to explain why responses to obesity drugs vary markedly from person to person
go.nature.com/4ccK07M
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Why obesity drugs work better for some people: these genes hold clues
Study of almost 28,000 people also identifies genetic variants that raise the risk of gastrointestinal side effects from GLP-1 medications.
https://go.nature.com/4ccK07M
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
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Drowning in cysteine
Nature Metabolism, Published online: 07 April 2026; doi:10.1038/s42255-026-01511-1In this issue of Nature Metabolism, Brain, Vigil et al. show that NRF2-induced cystine uptake drives the formation of several cysteine–sugar metabolites. This process acts as a ‘sink’ for free cysteine and can lead to metabolic vulnerabilities and toxicity in NRF2-activated tumours.
http://dlvr.it/TRwLV2
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reposted by
Jean Nakhle
Jen Brain (Crainic)
2 months ago
Check out our latest work out today in
@natmetabolism.nature.com
in which we describe a new metabotype (metabolic phenotype): excess cysteine stress. We discovered novel cysteine conjugates and show how pyruvate modulates free intracellular cysteine levels. Grateful for an awesome team!!
add a skeleton here at some point
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reposted by
Jean Nakhle
Lucas Sullivan
about 2 months ago
Pleased to share our recent work out today in
@natmetabolism.nature.com
. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
add a skeleton here at some point
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
#Throwback
🧪 CORRESPONDENCE | EMito-Metrix enables automated evaluation of mitochondrial morphology across species JP Pradère et al.
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EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism
http://dlvr.it/TRrDgX
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reposted by
Jean Nakhle
Lyssiotis Lab
2 months ago
10/ Thanks Wellen Lab for the News & Views: “Metabolism modulates stress and neoplasia”. They synthesize both papers around a shared model: NADPH-producing enzymes constrain ROS and pancreatic neoplasia, while ROS→NRF2 signaling helps drive ADM.
www.nature.com/articles/s42...
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Metabolism modulates stress and neoplasia - Nature Metabolism
Two studies published in Nature Metabolism show that dysregulation of specific metabolic enzymes within the pancreas leads to increased oxidative stress, which promotes pancreatic neoplasia in the pre...
https://www.nature.com/articles/s42255-026-01500-4
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reposted by
Jean Nakhle
Lyssiotis Lab
2 months ago
9/ Co-published study from Vousden Lab identifies ALDH1L2 as acinar-enriched mitochondrial one-carbon NADPH enzyme, which also regulates ROS and ADM. ALDH1L2 loss elevates ROS, accelerates ADM/PanIN, and links to rising circulating formate as a PDAC biomarker.
www.nature.com/articles/s42...
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ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas - Nature Metabolism
In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreas...
https://www.nature.com/articles/s42255-026-01456-5
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reposted by
Jean Nakhle
Lyssiotis Lab
2 months ago
🚨New
@lyssiotislab.bsky.social
paper led by
@radykm.bsky.social
in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of Vousden Lab co-published study and News & Views link from Wellen Lab!
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
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The genetics of obesity: aetiology, prevention and therapy
Nature Metabolism, Published online: 24 March 2026; doi:10.1038/s42255-026-01497-wThis Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesity.
http://dlvr.it/TRpQY9
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about #AdiposeTissue, #EVs, #Incretins, #Immune cells, #LiverMetabolism, #MitochondrialMetabolism, #SpatialOmics, #Tumorbiology and many more topics! 🧪
http://dlvr.it/TRmC3C
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
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Advances and opportunities in measuring dietary intake: from omics to AI
Nature Metabolism, Published online: 18 March 2026; doi:10.1038/s42255-026-01494-zThis Review highlights recent technological advances in measuring dietary food intake, including artificial intelligence-based methods and approaches informed by the gut microbiome.
http://dlvr.it/TRj13F
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New Editorial in
@natmetabolism.nature.com
for World Obesity Day 📆
add a skeleton here at some point
3 months ago
0
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. 🧪 Read about
#AdiposeInnervation
,
#Amylin
,
#Cancer
,
#LiverMetabolism
,
#MitochondrialMetabolism
,
#Mycobiome
,
#Neurometabolism
,
#Redox
,
#T2D
and many more topics!
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Mann Lab
4 months ago
Ever wondered how the human liver looks like at single-cell, spatial protein resolution? We used single-cell Deep Visual Proteomics to map human liver zonation at the protein level - one hepatocyte at a time. Our paper is out in
@natmetabolism.nature.com
!
www.nature.com/articles/s42...
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Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture - Nature Metabolism
Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.
https://www.nature.com/articles/s42255-026-01459-2
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reposted by
Jean Nakhle
Lauren Albrecht
3 months ago
Excited to share our latest work out today in
@naturemetabolism.bsky.social
@ucirvine.bsky.social
www.nature.com/articles/s42...
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PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism
Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.
https://www.nature.com/articles/s42255-026-01457-4
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
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Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome
Nature Metabolism, Published online: 18 February 2026; doi:10.1038/s42255-026-01464-5Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.
http://dlvr.it/TR8ZCC
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reposted by
Jean Nakhle
Nature Metabolism
4 months ago
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Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion
Nature Metabolism, Published online: 05 February 2026; doi:10.1038/s42255-026-01453-8Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as obesity, caloric restriction and changes to meal timing, alter hepatic protein secretion.
http://dlvr.it/TQwJdC
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reposted by
Jean Nakhle
Ben Weger
4 months ago
Our study is out today 🎉 in
@natmetabolism.nature.com
. The liver doesn’t secrete proteins nonstop; it follows a daily rhythm. Meal timing controls liver protein release via glycogen metabolism, and disrupted eating blunts these rhythms. A 🧵 ...
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Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion - Nature Metabolism
Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as...
https://rebrand.ly/ddab66
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reposted by
Jean Nakhle
Nature Metabolism
4 months ago
METABOLIC MESSENGERS | Testosterone S Bhasin, F Mauvais-Jarvis
@harvardmed.bsky.social
,
@tulanemedicine.bsky.social
Testosterone’s role in cardiometabolic & musculoskeletal health 🧪
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Metabolic Messengers: testosterone - Nature Metabolism
Mauvais-Jarvis and Bhasin provide an in-depth review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from testosterone replacement therapy in humans and mechanistic research in rodent models.
http://dlvr.it/TQkkKJ
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Jean Nakhle
Nature Metabolism
4 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#AMPK
,
#Cachexia
,
#ImmuneSignalling
,
#Microbiome
,
#NAD
,
#Nutrition
,
#TissueCrosstalk
and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Sri Narasimhan
4 months ago
Today at Cell: A new
#HallmarksofCancer
review by Doug Hanahan:
www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social
@cellpress.bsky.social
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Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...
https://www.cell.com/cell/fulltext/S0092-8674(25)01498-9
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reposted by
Jean Nakhle
Nature
4 months ago
Nature research paper: The transition from monocyte to tissue-resident macrophage requires DHPS
go.nature.com/4sSiFPX
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The transition from monocyte to tissue-resident macrophage requires DHPS - Nature
In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.
https://go.nature.com/4sSiFPX
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ADHD: The quest to understand and treat a pervasive and mystifying mental health condition.
@nature.com
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Nature Outlook: ADHD
The quest to understand and treat a pervasive and mystifying mental health condition.
https://www.nature.com/immersive/ADHD/index.html
4 months ago
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reposted by
Jean Nakhle
The Journal of Physiology
7 months ago
#Research
by Rémi Montané of
toulouseuniversite.bsky.social
et al. observes that brown
#adipose
tissue activity impacts systemic
#lactate
clearance in male mice 🔬 📉 📜 Read the study here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
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reposted by
Jean Nakhle
Lori Zeltser, PhD
5 months ago
Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳
www.nature.com/articles/s42...
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
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reposted by
Jean Nakhle
Nature
5 months ago
Nature research paper: A foundation model for continuous glucose monitoring data
go.nature.com/3LkpysA
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A foundation model for continuous glucose monitoring data - Nature
GluFormer, a generative foundation model, uses continuous glucose monitoring data to accurately forecast glycaemia-related health responses, particularly for long-term outcomes.
https://go.nature.com/3LkpysA
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Out now in
@natmetabolism.nature.com
🧪
@zeltserlab.bsky.social
et al. provide a mechanistic explanation of how the thermogenic and glucoregulatory functions of BAT are controlled by molecularly, anatomically, and functionally distinct neuronal populations within the stellate ganglion.
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
5 months ago
1
1
0
Out now in
#NatureMetabolism
🧪 How does psychological stress influence tumor development? Chronic stress disrupts catecholamine signalling, which in turn rewires the hepatic kynurenine pathway. This shift suppresses hepatic CD8⁺ T cell activity and promotes immune evasion.
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Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance - Nature Metabolism
Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8+ T cell function and promotes liver cancer progression.
https://www.nature.com/articles/s42255-025-01430-7
5 months ago
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reposted by
Jean Nakhle
Jason Cantor
5 months ago
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work
@natmetabolism.nature.com
, led by
@thebiokimist.bsky.social
. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
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reposted by
Jean Nakhle
Nature
5 months ago
Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites
go.nature.com/4b1vrFk
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Language model-guided anticipation and discovery of mammalian metabolites - Nature
Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.
https://go.nature.com/4b1vrFk
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reposted by
Jean Nakhle
Nature Metabolism
8 months ago
EDITORIAL | Nutritional advice on social media: clicks over credibility Social media based nutritional misinformation can lead to poorly managed health conditions. Experts need to adapt and engage effectively to counteract this trend. 🧪
www.nature.com/articles/s42...
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Nutritional advice on social media: clicks over credibility - Nature Metabolism
Social media has become a go-to source for nutritional advice, and a space in which influencers compete with, and often drown out, evidence-based guidance. The scientific community should counter this viral spread of misinformation by making trustworthy information more accessible.
https://www.nature.com/articles/s42255-025-01385-9
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