One of our top-rated articles on altmetric.com this past week was published open access in @natmetabolism.nature.com. You can read 'Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD' here: www.nature.com/articles/s42... #CanSky #OncoSky

Out now in #NatureMetabolism 🧪 This year marks 20 years since the first GLP-1R agonist was approved. Former employees at Amylin Pharmaceuticals look back on how it all began. Led by James Trevaskis.

✨New issue!✨ Check out the latest in #metabolism research from across all disciplines. Read about #Ferroptosis, #MASLD, #DietaryBiomarkers, #CoA metabolism, #Immune signaling, #Tumor biology and many more topics! 🧪 www.nature.com/natmetab/vol...

Genotype-phenotype data from over 450,000 people was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual, according to a paper in Nature Medicine. go.nature.com/4pDuTKP #medsky 🧬 🧪

A study in Nature Metabolism shows that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD). go.nature.com/3IaPoO9 #medsky 🧪

Out now in #NatureMetabolism 🧪 Preferential use of gluconeogenic pathways in the liver depends on exercise load and affects performance.

Nature research paper: Molecular subtypes of human skeletal muscle in cancer cachexia go.nature.com/4pm7EVo

I will be at #EASD2025 starting tomorrow. Reach out if you are around 😊

Out now in @natmetabolism.nature.com Viral doesn’t always mean accurate. We unpack the dangers of online nutrition advice in this Editorial.

I will be at the @easdnews.bsky.social #EASD2025 meeting in Vienna in two weeks. Hit me up if you'd like to chat about everything @natmetabolism.nature.com 🤗

🔬Honored for the opportunity to contribute this viewpoint @naturemetabolism.bsky.social where we discuss on Mitochondrial transfer; its evidences, challenges and opportunities, with plenty of room for exciting research yet to come! rdcu.be/eCFRX

Honoured to contribute to this #Viewpoint on mitochondrial transfer, now out in @natmetabolism.nature.com Lots of open questions + much more to explore! @irbbarcelona.org @ageinves.bsky.social @caixaresearch.bsky.social rdcu.be/eCFRX

✨New issue!✨ Check out the latest in #metabolism research from across all disciplines. Read about #TumourMetabolism, #Lactate signalling, #WeighLoss, #Thermogenesis, #DietaryInterventions and many more topics! 🧪 www.nature.com/natmetab/vol...

New online: Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability

Find out how food structure plays a key role in digestion and health ⤵️ quadram.ac.uk/new-uk-study...

The results of a study in Nature Metabolism highlight the significance of diet in maintaining a healthy immune system and suggest that modifying dietary fat may improve cancer outcomes in obesity. #medsky 🧪

Out now in #NatureMetabolism 🧪 In this double-blind, randomised, crossover trial, a diet rich in fermentable foods was shown to improve the glucose-lowering efficacy of metformin in people with prediabetes due, at least in part, to changes in gut microbiota composition. doi.org/10.1038/s422...

Excited to share our work just published in @natmetabolism.nature.com examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice. www.nature.com/articles/s42...

COMMENT | ‪🧪 @colbyvorland.bsky.social ‬, L Golzarri-Arroyo & DB Allison (Indiana Uni) This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses. www.nature.com/articles/s42...

Out now in #NatureMetabolism 🧪 This study shows that, compared to plant-based fats, animal-based fats accelerate tumour growth and impair anti-tumour response to melanoma in obese mice. Same calories, different outcomes! From the lab of @lydialynch.bsky.social doi.org/10.1038/s422...

✨New issue!✨ 🧪 Check out the latest in #metabolism research from across all disciplines. Read about #Triglycerides in the #Brain, #CagriSema, #Exercise, #LipidMetabolism, the #Microbiome - and many more topics! www.nature.com/natmetab/vol...

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood, according to a paper in Nature Medicine. go.nature.com/3H0sA2N #medsky 🧪

My mitochondria are telling me to go to bed 😴

A super cool Perspective highlighting the intersection of metabolic hallmarks of both aging and cancer. In it, they also explore how population-related metabolic differences associated with longevity may contribute to racial disparities in cancer risk & prognosis. Give it a read!! 🤓

Tell Me Again About Neurons Now | Science

We are #hiring! Please repost! If you have a PhD, are passionate about aging research and curious about other disciplines than your own, consider joining the journal’s editorial team. springernature.wd3.myworkdayjobs.com/SpringerNatu...

A study in Nature Metabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. go.nature.com/44T8kct 🧪

🧠Check out our newest #NatureMedicine collection focused on the Global Neurodegeneration Proteomics Consortium, an international database using proteomics + clinical data to improve our understanding of neurodegenerative diseases! www.nature.com/collections/...

Metabolic psychiatry: key priorities for an emerging field | Nature Mental Health rdcu.be/eutEg

When I began studying mitochondria transfer during my master's internship in 2016, a committee member dismissed it as artificial and irrelevant to (patho)physiology. It's great to see growing evidence from recent studies proving otherwise 😊

ICYMI: New content online: Adipose tissue ageing: implications for metabolic health and lifespan

✨New issue!✨ Check out the latest in #metabolism research! Read about #Cysteine in #WeightLoss, #GutMicrobiome, #Satiety, #Incretins, #Itaconate - and many more topics! https://bit.ly/44njRQ5

With the cover of it's June issue, @natmentalhealth.nature.com reflects on the salience of support for and interaction among academic and clinical researchers and practitioners and the LGBT+ people whom they serve during particularly challenging sociopolitical times. Check out the issue:

Out now in #NatureMetabolism 📢 In the newest installment of our Metabolic Messengers series, Hevener and Correa provide a comprehensive overview of the preclinical and clinical evidence showing the metabolic role of oestradiol and its receptors in both women and men.

Presented at #ADASciSessions: In the REDEFINE 1 phase 3a trial, semaglutide at a dose of 2.4 mg with cagrilintide at a dose of 2.4 mg led to significant body-weight reduction in adults without diabetes and with overweight or obesity. Full trial results: nej.md/444aW7f

Out now in #NatureMetabolism 📢 Grouped data are very common in preclinical studies, and can artificially inflate statistical significance. In this Comment, the authors define grouped data, and provide best practices to account for them from the experimental design to the data analysis stage.

Out now in #NatureMetabolism 📢 In this randomized crossover study, human gastrointestinal digesta were collected using a unique intubation technique to compare how meals with contrasting cellular structures affect postprandial luminal metabolites, glycaemia, gut hormones and satiety sensation.

I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology: rdcu.be/erwl4 #DataVisualization #PhD #SciComm Thx for review @bethcimini.bsky.social + 2

We are hiring a new editor! If you want to join the Nature Structural & Molecular Biology team and help publish exciting research, please apply. Deadline is June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

2 days left to apply!

🧪We are recruiting 🧪Group Leader positions available

REVIEW | M van Hul, P Cani et al. (UC Louvain): This Review discusses the impact of the gut #microbiota on #cancer and on cancer therapy. 💊 🧫 FREE to read:

✨New issue! ✨ Check out the latest in metabolic #science from across all disciplines. Read about #Metabolism in the #Brain, #Liver, #GutMicrobiome, #AdiposeTissue, about #Cancers, #Metabolites, #Epigenetics - and many more topics! https://bit.ly/43uzq80

A look inside the corruption of the scientific literature - complete with a chart of payments:

As the US National Institutes of Health (NIH) cuts billions of dollars of research grants and contracts, one entity has emerged as the driving force behind these unprecedented changes — billionaire Elon Musk’s US Department of Government Efficiency (DOGE). https://go.nature.com/4k8TJit

Nature research paper: Unravelling cysteine-deficiency-associated rapid weight loss https://go.nature.com/4mpetns

Come work with us 🤗

Out now in #NatureMetabolism 📢 Nuclear SREBP2 forms nuclear condensates through its N-terminal intrinsically disordered region, which is essential for the transcriptional activation of lipogenic genes.