Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳 www.nature.com/articles/s42...

Nature research paper: A foundation model for continuous glucose monitoring data go.nature.com/3LkpysA

Out now in @natmetabolism.nature.com 🧪 @zeltserlab.bsky.social et al. provide a mechanistic explanation of how the thermogenic and glucoregulatory functions of BAT are controlled by molecularly, anatomically, and functionally distinct neuronal populations within the stellate ganglion.

Out now in #NatureMetabolism 🧪 How does psychological stress influence tumor development? Chronic stress disrupts catecholamine signalling, which in turn rewires the hepatic kynurenine pathway. This shift suppresses hepatic CD8⁺ T cell activity and promotes immune evasion.

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites go.nature.com/4b1vrFk

EDITORIAL | Nutritional advice on social media: clicks over credibility Social media based nutritional misinformation can lead to poorly managed health conditions. Experts need to adapt and engage effectively to counteract this trend. 🧪 www.nature.com/articles/s42...

Out now in @natmetabolism.nature.com 🧪 Mauvais-Jarvis and Bhasin provide a review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from humans and rodents. doi.org/10.1038/s422...

Out now in @natmetabolism.nature.com 🧪 Elevated adipocyte-derived AFABP in obesity binds to plasma transferrin which leads to iron overload in intestinal stem cells (ISCs). Disruption of iron homeostasis impairs PPARα signalling and blocks ISC differentiation after injury. doi.org/10.1038/s422...

new out in Nature www.nature.com/articles/s41...

🎂

✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about #Cognition, #FoodCues, #Microbiome, #Neurometabolism, #Regeneration, #Tumor biology and many more topics! 🧪 www.nature.com/natmetab/vol...

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

#Throwback 🧪 CORRESPONDENCE | EMito-Metrix enables automated evaluation of mitochondrial morphology across species JP Pradère et al.

Watch this space 😉

7/10 🫢 “Each time we scroll past without thinking, another lie takes root.”

Out now in @natmetabolism.nature.com 🚨 Happy to share these back-to-back studies from the labs of Ana Maria Cuervo and Pura Muñoz-Cánoves, who jointly uncover how the age-related decline of chaperone-mediated autophagy (CMA) impacts muscle health.

⚠️ Just out in @natmetabolism.nature.com ⚠️ Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠 Our Evridiki Asimakidou did a wonderful job leading this! 👏 www.nature.com/articles/s42...

✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about #AI in metabolism, #MASLD, #Mitochondrial Metabolism, #MetabolicBiomarkers, #Neurometabolism and many more topics! 🧪 www.nature.com/natmetab/vol...

Out now in @natmetabolism.nature.com 🚨 This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing as well as in metabolic, neuroinflammatory and neurodegenerative diseases contributes to cognitive decline.

🏳️‍🌈🏳️‍⚧️To commemorate LGBTQIA+ in STEM day today, we reached out to @geosantiagom.bsky.social and @fabriceroux7.bsky.social to discuss their experiences in STEM, the main barriers queer researchers currently face, and more. See both Q&As below 🔽

On #WorldDiabetesDay, we highlight key findings from our latest primary research and review articles 🧵 (1/8)

Out now in @natmetabolism.nature.com by @jourdainlab.bsky.social 📢 A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

Thrilled to publish our new study on #mitochondrial ROS coming from complex III, revealing this key site in #astrocytes 🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for #dementia #FTD 💊 rdcu.be/eOc0m 👈💪 Great commentary by H. Pan and F. Yin🤩! tinyurl.com/4hdytw4c

Read this Research Highlight of the SWEET trial by @natrevendo.nature.com : www.nature.com/articles/s42...

@commsaicomp.bsky.social has launched and seeks your submissions for publications! You can follow them and all our journals with our starter pack.

Last chance to apply 🚨

✨New issue✨ Check out the latest in #Metabolism research from across all disciplines 🧪 Read about #DietarySugars, #Drosophila development, #Exenatide, #Ketone metabolism, #Neurolipids, #NAD+, #RedoxPathways, and many more topics! www.nature.com/natmetab/vol...

Register for this exciting Nature Conference on 'Healthy Brain Aging' and meet eminent researchers in the field as well as editors from @natmetabolism.nature.com & other @natureportfolio.nature.com journals! 🧪 🚨Abstract submission deadline Oct 17th! Registration and other details: t.co/iiCzYAv9mH

Out now in @natmetabolism.nature.com 🧪 FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors. Read the full study by @martinpicardenergy.bsky.social here: doi.org/10.1038/s422...

In this viewpoint, 12 #Metabolism scientists talk about how they think #AI will be incorporated in Metabolic Research 🧪 Read in @natmetabolism.nature.com

Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize. “Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems” 🧪 #academicSky www.nature.com/articles/d41...

Come work with us! 🧪

Out now in @natmetabolism.nature.com 🧪 In a multicenter, randomized, controlled trial, long-term consumption of sweeteners and sweetness enhancers improved body weight control and elicited beneficial gut microbiota changes in adults with overweight or obesity. www.nature.com/articles/s42...

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize

I’ll be attending the Metabolism & Cancer congress in La Grande-Motte next week. If you’re there, let’s chat 😊

I’ll be in Daegu 🇰🇷 for the Nature Conference on Healthy Brain Aging. Come say hi if you’re around and want to chat about Nature Metabolism (or metabolism stuff in general!) 🧠🧪

#Editorial If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need. #MicroSky #AcademicChatter www.nature.com/articles/s41...

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

One of our top-rated articles on altmetric.com this past week was published open access in @natmetabolism.nature.com. You can read 'Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD' here: www.nature.com/articles/s42... #CanSky #OncoSky

Out now in #NatureMetabolism 🧪 This year marks 20 years since the first GLP-1R agonist was approved. Former employees at Amylin Pharmaceuticals look back on how it all began. Led by James Trevaskis.

✨New issue!✨ Check out the latest in #metabolism research from across all disciplines. Read about #Ferroptosis, #MASLD, #DietaryBiomarkers, #CoA metabolism, #Immune signaling, #Tumor biology and many more topics! 🧪 www.nature.com/natmetab/vol...

Genotype-phenotype data from over 450,000 people was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual, according to a paper in Nature Medicine. go.nature.com/4pDuTKP #medsky 🧬 🧪

A study in Nature Metabolism shows that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD). go.nature.com/3IaPoO9 #medsky 🧪

Out now in #NatureMetabolism 🧪 Preferential use of gluconeogenic pathways in the liver depends on exercise load and affects performance.

Nature research paper: Molecular subtypes of human skeletal muscle in cancer cachexia go.nature.com/4pm7EVo

I will be at #EASD2025 starting tomorrow. Reach out if you are around 😊

Out now in @natmetabolism.nature.com Viral doesn’t always mean accurate. We unpack the dangers of online nutrition advice in this Editorial.