Jean Nakhle
@jeannakhle.bsky.social
📤 1154
📥 222
📝 109
Associate Editor
@natmetabolism.nature
.com He/Him/His. Views are my own.
reposted by
Jean Nakhle
Lori Zeltser, PhD
5 days ago
Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳
www.nature.com/articles/s42...
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
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reposted by
Jean Nakhle
Nature
7 days ago
Nature research paper: A foundation model for continuous glucose monitoring data
go.nature.com/3LkpysA
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A foundation model for continuous glucose monitoring data - Nature
GluFormer, a generative foundation model, uses continuous glucose monitoring data to accurately forecast glycaemia-related health responses, particularly for long-term outcomes.
https://go.nature.com/3LkpysA
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@natmetabolism.nature.com
🧪
@zeltserlab.bsky.social
et al. provide a mechanistic explanation of how the thermogenic and glucoregulatory functions of BAT are controlled by molecularly, anatomically, and functionally distinct neuronal populations within the stellate ganglion.
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
7 days ago
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Out now in
#NatureMetabolism
🧪 How does psychological stress influence tumor development? Chronic stress disrupts catecholamine signalling, which in turn rewires the hepatic kynurenine pathway. This shift suppresses hepatic CD8⁺ T cell activity and promotes immune evasion.
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Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance - Nature Metabolism
Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8+ T cell function and promotes liver cancer progression.
https://www.nature.com/articles/s42255-025-01430-7
7 days ago
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reposted by
Jean Nakhle
Jason Cantor
10 days ago
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work
@natmetabolism.nature.com
, led by
@thebiokimist.bsky.social
. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
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reposted by
Jean Nakhle
Nature
11 days ago
Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites
go.nature.com/4b1vrFk
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Language model-guided anticipation and discovery of mammalian metabolites - Nature
Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.
https://go.nature.com/4b1vrFk
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reposted by
Jean Nakhle
Nature Metabolism
4 months ago
EDITORIAL | Nutritional advice on social media: clicks over credibility Social media based nutritional misinformation can lead to poorly managed health conditions. Experts need to adapt and engage effectively to counteract this trend. 🧪
www.nature.com/articles/s42...
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Nutritional advice on social media: clicks over credibility - Nature Metabolism
Social media has become a go-to source for nutritional advice, and a space in which influencers compete with, and often drown out, evidence-based guidance. The scientific community should counter this viral spread of misinformation by making trustworthy information more accessible.
https://www.nature.com/articles/s42255-025-01385-9
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Out now in
@natmetabolism.nature.com
🧪 Mauvais-Jarvis and Bhasin provide a review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from humans and rodents.
doi.org/10.1038/s422...
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Client Challenge
https://doi.org/10.1038/s42255-025-01431-6
17 days ago
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@natmetabolism.nature.com
🧪 Elevated adipocyte-derived AFABP in obesity binds to plasma transferrin which leads to iron overload in intestinal stem cells (ISCs). Disruption of iron homeostasis impairs PPARα signalling and blocks ISC differentiation after injury.
doi.org/10.1038/s422...
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Client Challenge
https://doi.org/10.1038/s42255-025-01425-4
17 days ago
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reposted by
Jean Nakhle
Barbara Marte
19 days ago
new out in Nature
www.nature.com/articles/s41...
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Nutrient requirements of organ-specific metastasis in breast cancer - Nature
How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.
https://www.nature.com/articles/s41586-025-09898-9
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19 days ago
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#Cognition
,
#FoodCues
,
#Microbiome
,
#Neurometabolism
,
#Regeneration
,
#Tumor
biology and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Current Biology
about 1 month ago
HAPPY HOLIDAYS TO ALL OF YOU!🎄✨
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reposted by
Jean Nakhle
Nature Metabolism
about 1 month ago
#Throwback
🧪 CORRESPONDENCE | EMito-Metrix enables automated evaluation of mitochondrial morphology across species JP Pradère et al.
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EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism
https://bit.ly/49gLJJ3
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Watch this space 😉
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about 2 months ago
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7/10 🫢 “Each time we scroll past without thinking, another lie takes root.”
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about 2 months ago
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Out now in
@natmetabolism.nature.com
🚨 Happy to share these back-to-back studies from the labs of Ana Maria Cuervo and Pura Muñoz-Cánoves, who jointly uncover how the age-related decline of chaperone-mediated autophagy (CMA) impacts muscle health.
about 2 months ago
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reposted by
Jean Nakhle
LPJ Lab - Neuroimmunometabolism
2 months ago
⚠️ Just out in
@natmetabolism.nature.com
⚠️ Our latest review with
@pluchinolab.bsky.social
&
@biancasilvalab.bsky.social
explores how
#microglia
and
#neuron
#metabolism
shapes
#brain
health and cognition! 🧠 Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
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The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
https://www.nature.com/articles/s42255-025-01409-4
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines. Read about
#AI
in metabolism,
#MASLD
,
#Mitochondrial
Metabolism,
#MetabolicBiomarkers
,
#Neurometabolism
and many more topics! 🧪
www.nature.com/natmetab/vol...
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Out now in
@natmetabolism.nature.com
🚨 This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing as well as in metabolic, neuroinflammatory and neurodegenerative diseases contributes to cognitive decline.
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The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
https://www.nature.com/articles/s42255-025-01409-4
2 months ago
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reposted by
Jean Nakhle
Communications Biology
2 months ago
🏳️🌈🏳️⚧️To commemorate LGBTQIA+ in STEM day today, we reached out to
@geosantiagom.bsky.social
and
@fabriceroux7.bsky.social
to discuss their experiences in STEM, the main barriers queer researchers currently face, and more. See both Q&As below 🔽
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reposted by
Jean Nakhle
Nature Metabolism
2 months ago
On
#WorldDiabetesDay
, we highlight key findings from our latest primary research and review articles 🧵 (1/8)
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Out now in
@natmetabolism.nature.com
by
@jourdainlab.bsky.social
📢 A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://doi.org/10.1038/s42255-025-01419-2
2 months ago
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reposted by
Jean Nakhle
Alexis A. Jourdain
2 months ago
Very excited to share the published version of our
#uridine
#CRISPR
screen in
naturemetabolism.bsky.social
! 🎉 Led by Abigail Strefeler with
@pagliarini-lab.bsky.social
@zakbaker.bsky.social
and team!
#NUDT5
#DMQ
@dib-unil.bsky.social
@fbm-unil.bsky.social
🔗
www.nature.com/articles/s42...
🧵1/17
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://www.nature.com/articles/s42255-025-01419-2
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reposted by
Jean Nakhle
Orr laboratory
3 months ago
Thrilled to publish our new study on
#mitochondrial
ROS coming from complex III, revealing this key site in
#astrocytes
🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for
#dementia
#FTD
💊
rdcu.be/eOc0m
👈💪 Great commentary by H. Pan and F. Yin🤩!
tinyurl.com/4hdytw4c
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Read this Research Highlight of the SWEET trial by
@natrevendo.nature.com
:
www.nature.com/articles/s42...
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3 months ago
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Jean Nakhle
Nature Portfolio
3 months ago
@commsaicomp.bsky.social
has launched and seeks your submissions for publications! You can follow them and all our journals with our starter pack.
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Last chance to apply 🚨
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3 months ago
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
✨New issue✨ Check out the latest in
#Metabolism
research from across all disciplines 🧪 Read about
#DietarySugars
,
#Drosophila
development,
#Exenatide
,
#Ketone
metabolism,
#Neurolipids
,
#NAD+
,
#RedoxPathways
, and many more topics!
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Metabolism
3 months ago
Register for this exciting Nature Conference on 'Healthy Brain Aging' and meet eminent researchers in the field as well as editors from
@natmetabolism.nature.com
& other
@natureportfolio.nature.com
journals! 🧪 🚨Abstract submission deadline Oct 17th! Registration and other details:
t.co/iiCzYAv9mH
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Out now in
@natmetabolism.nature.com
🧪 FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors. Read the full study by
@martinpicardenergy.bsky.social
here:
doi.org/10.1038/s422...
3 months ago
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reposted by
Jean Nakhle
Revati Dewal
4 months ago
In this viewpoint, 12
#Metabolism
scientists talk about how they think
#AI
will be incorporated in Metabolic Research 🧪 Read in
@natmetabolism.nature.com
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reposted by
Jean Nakhle
Magdalena Skipper
4 months ago
Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize. “Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems” 🧪
#academicSky
www.nature.com/articles/d41...
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More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys
The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.
https://www.nature.com/articles/d41586-025-03247-6
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Come work with us! 🧪
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4 months ago
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Out now in
@natmetabolism.nature.com
🧪 In a multicenter, randomized, controlled trial, long-term consumption of sweeteners and sweetness enhancers improved body weight control and elicited beneficial gut microbiota changes in adults with overweight or obesity.
www.nature.com/articles/s42...
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Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study - Nature Metabolism
The SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.
https://www.nature.com/articles/s42255-025-01381-z
4 months ago
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reposted by
Jean Nakhle
Nature
4 months ago
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more.
#NobelPrize
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I’ll be attending the Metabolism & Cancer congress in La Grande-Motte next week. If you’re there, let’s chat 😊
4 months ago
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I’ll be in Daegu 🇰🇷 for the Nature Conference on Healthy Brain Aging. Come say hi if you’re around and want to chat about Nature Metabolism (or metabolism stuff in general!) 🧠🧪
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4 months ago
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reposted by
Jean Nakhle
Nature Microbiology
4 months ago
#Editorial
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky
#AcademicChatter
www.nature.com/articles/s41...
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Why editors go to conferences - Nature Microbiology
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we demystify the editorial aims of conference attendance.
https://www.nature.com/articles/s41564-025-02151-z?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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reposted by
Jean Nakhle
Merja Joensuu
4 months ago
🌟 Thrilled to share that my lab’s first publication is now out in
@natmetabolism.nature.com
. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
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reposted by
Jean Nakhle
Springer Nature
4 months ago
One of our top-rated articles on
altmetric.com
this past week was published open access in @natmetabolism.nature.com. You can read 'Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD' here:
www.nature.com/articles/s42...
#CanSky
#OncoSky
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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD - Nature Metabolism
Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).
https://www.nature.com/articles/s42255-025-01368-w
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Out now in
#NatureMetabolism
🧪 This year marks 20 years since the first GLP-1R agonist was approved. Former employees at Amylin Pharmaceuticals look back on how it all began. Led by James Trevaskis.
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4 months ago
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reposted by
Jean Nakhle
Nature Metabolism
4 months ago
✨New issue!✨ Check out the latest in
#metabolism
research from across all disciplines. Read about
#Ferroptosis
,
#MASLD
,
#DietaryBiomarkers
,
#CoA
metabolism,
#Immune
signaling,
#Tumor
biology and many more topics! 🧪
www.nature.com/natmetab/vol...
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reposted by
Jean Nakhle
Nature Portfolio
4 months ago
Genotype-phenotype data from over 450,000 people was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual, according to a paper in Nature Medicine.
go.nature.com/4pDuTKP
#medsky
🧬 🧪
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reposted by
Jean Nakhle
Nature Portfolio
4 months ago
A study in Nature Metabolism shows that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).
go.nature.com/3IaPoO9
#medsky
🧪
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Out now in
#NatureMetabolism
🧪 Preferential use of gluconeogenic pathways in the liver depends on exercise load and affects performance.
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4 months ago
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reposted by
Jean Nakhle
Nature
4 months ago
Nature research paper: Molecular subtypes of human skeletal muscle in cancer cachexia
go.nature.com/4pm7EVo
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.
https://go.nature.com/4pm7EVo
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I will be at
#EASD2025
starting tomorrow. Reach out if you are around 😊
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4 months ago
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Out now in
@natmetabolism.nature.com
Viral doesn’t always mean accurate. We unpack the dangers of online nutrition advice in this Editorial.
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5 months ago
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