Ben-Sahra Lab
@bensahralab.bsky.social
📤 612
📥 254
📝 22
Nucleotide Metabolism, Molecular Metabolism, and Signaling Pathways
https://www.bensahralab.org/
reposted by
Ben-Sahra Lab
Charles Brenner, PhD
12 days ago
happy to announce that i have post-doc openings for mid-2016 to advance this science please read our work, think about the most exciting questions & approaches, & be in touch for an interview note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
add a skeleton here at some point
0
4
1
reposted by
Ben-Sahra Lab
James Olzmann
25 days ago
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and
#ferroptosis
in in vivo cancer models. Beautiful work from
@ubellackerlab.bsky.social
, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
loading . . .
In vivo models bring FSP1 inhibitors to life - Nature Cell Biology
FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...
https://www.nature.com/articles/s41556-025-01849-w
0
40
11
reposted by
Ben-Sahra Lab
Lamming Lab
26 days ago
Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!
1
5
3
reposted by
Ben-Sahra Lab
Christian Frezza
about 1 month ago
Good Sunday, all. Don't miss this week's selection of papers in
#cancermetabolism
and
#mitochondrialbiology
as there are some true gems:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
1
24
10
reposted by
Ben-Sahra Lab
Nature Metabolism
about 1 month ago
loading . . .
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
Nature Metabolism, Published online: 05 December 2025; doi:10.1038/s42255-025-01410-xA machine-learning-based computational approach to probe pathway coessentiality reveals that complex II of the electron transport chain regulates de novo purine synthesis, and can be targeted to treat acute myeloid leukaemia.
https://bit.ly/44dL1cR
0
7
6
reposted by
Ben-Sahra Lab
Christian Frezza
about 1 month ago
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell
www.cell.com/cell/fulltex...
loading . . .
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
A fin-like structural loop in GPX4 is critical for anchoring the enzyme to cellular membranes, thereby preventing ferroptosis. A patient-associated R152H mutation destabilizes this loop, leading to fe...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901310-8
0
13
2
reposted by
Ben-Sahra Lab
Frances Yap
about 1 month ago
🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at
[email protected]
for details.
sites.northwestern.edu/yaplab/
. Pls repost
#Microsky
loading . . .
Homepage | Yap Laboratory
https://sites.northwestern.edu/yaplab/
0
13
21
reposted by
Ben-Sahra Lab
Molecular Cell
about 1 month ago
Leveraging biochemical covariance to better understand biology
loading . . .
Leveraging biochemical covariance to better understand biology
In a recent Nature article, Xiao et al. report development of a metabolite-protein covariation architecture (MPCA) database from a diversity outbred mouse cohort that facilitates the deciphering of metabolite-protein relationships in liver and brown adipose tissue (BAT). Using these correlations, the authors describe a role for LRRC58 in controlling cysteine-taurine metabolism.
http://dlvr.it/TPSsQ8
0
3
1
reposted by
Ben-Sahra Lab
Jason Cantor
about 2 months ago
happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD!
tinyurl.com/3yutyd8c
loading . . .
Human plasma‐like medium enhances structural and metabolic maturation of human pluripotent stem cell‐derived cardiomyocytes
Human plasma-like medium (HPLM), a synthetic physiologic medium containing over 60 metabolites and small ions at concentrations reflective of adult human plasma, enhances the structural and metabolic....
https://tinyurl.com/3yutyd8c
1
6
3
reposted by
Ben-Sahra Lab
RyanLab_TCD
about 2 months ago
Very excited to announce that the first paper from the lab is now live
@natcomms.nature.com
#mitochondria
#immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out!
www.nature.com/articles/s41...
loading . . .
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
https://www.nature.com/articles/s41467-025-65023-4
5
36
14
reposted by
Ben-Sahra Lab
Christian Frezza
about 2 months ago
Good Sunday!. A wonderful selection of papers in
#cancermetabolism
and
#mitochondrialbiology
is waiting for you here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one." -Wei Wu Wei
0
14
8
reposted by
Ben-Sahra Lab
Alexis A. Jourdain
about 2 months ago
Very excited to share the published version of our
#uridine
#CRISPR
screen in
naturemetabolism.bsky.social
! 🎉 Led by Abigail Strefeler with
@pagliarini-lab.bsky.social
@zakbaker.bsky.social
and team!
#NUDT5
#DMQ
@dib-unil.bsky.social
@fbm-unil.bsky.social
🔗
www.nature.com/articles/s42...
🧵1/17
loading . . .
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://www.nature.com/articles/s42255-025-01419-2
3
28
14
reposted by
Ben-Sahra Lab
Christian Frezza
about 2 months ago
Good Sunday, all. The weekly curated issue of papers in
#cancermetabolism
and
#mitochondrialbiology
is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
0
16
8
reposted by
Ben-Sahra Lab
Christian Frezza
2 months ago
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science
www.science.org/doi/10.1126/...
Great work from
@rjdlab.bsky.social
!!
loading . . .
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
https://www.science.org/doi/10.1126/science.adx9717
0
10
4
reposted by
Ben-Sahra Lab
American Cancer Society
2 months ago
2. A new paper in
@cp-molcell.bsky.social
from
@bensahralab.bsky.social
(ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee)
@luriecancer.bsky.social
revealing a molecular link between succinate dehydrogenase and purine synthesis. Read the paper here:
lnkd.in/eibyMezn
1
3
2
reposted by
Ben-Sahra Lab
Zheng Wu
2 months ago
Super excited to share that my second project in the
@rjdlab.bsky.social
is now published in Science! Many thanks to all co-authors, especially
@ptnguyen.bsky.social
for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
add a skeleton here at some point
1
20
4
reposted by
Ben-Sahra Lab
ChemBioHub - Huber Lab
2 months ago
New in
@science.org
🧬 What if an enzyme you thought you knew turned out to control metabolism in a completely new way? We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
loading . . .
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
https://www.science.org/doi/10.1126/science.adv4257
2
21
14
reposted by
Ben-Sahra Lab
DeBerardinis Lab at UT Southwestern Medical Center
2 months ago
1/New paper from Zheng Wu, Phong Nguyen et al.
@cri-utsw.bsky.social
shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
loading . . .
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
https://www.science.org/doi/10.1126/science.adx9717
7
70
27
reposted by
Ben-Sahra Lab
Christian Frezza
2 months ago
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
loading . . .
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
https://www.nature.com/articles/s41586-025-09718-0
0
11
7
reposted by
Ben-Sahra Lab
Ubellacker Lab
2 months ago
Excited to share our work
@nature.com
! Postdoc
@mariopalma.bsky.social
, with major contributions from
@retickerflynn.bsky.social
and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression.
#TeamFSP1
www.nature.com/articles/s41...
loading . . .
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
https://www.nature.com/articles/s41586-025-09709-1
7
30
11
reposted by
Ben-Sahra Lab
Mario Palma
2 months ago
Excited to share my postdoctoral work, out today in Nature!
www.nature.com/articles/s41...
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
loading . . .
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
https://www.nature.com/articles/s41586-025-09709-1
3
16
6
reposted by
Ben-Sahra Lab
Christian Frezza
2 months ago
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.
network.febs.org/posts/thinki...
loading . . .
Thinking like a Scientist: The Limits of Genome Editing and Omics
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
https://network.febs.org/posts/thinking-like-a-scientist-part-two-the-omics-illusion
4
16
6
reposted by
Ben-Sahra Lab
Christian Frezza
2 months ago
Good Sunday, mitolovers. Here is a wonderful selection of papers in
#cancermetabolism
and
#mitochondrialbiology
:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
0
13
8
reposted by
Ben-Sahra Lab
Christian Frezza
2 months ago
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations
@bensahralab.bsky.social
!!
loading . . .
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
https://www.sciencedirect.com/science/article/abs/pii/S1097276525008196
1
14
7
reposted by
Ben-Sahra Lab
Mike Lange
2 months ago
Excited to share my postdoc work
@olzmannlab.bsky.social
! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
loading . . .
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
https://www.nature.com/articles/s41556-025-01790-y
5
70
21
reposted by
Ben-Sahra Lab
James Olzmann
2 months ago
Excited to share our study out in
@natcellbio.nature.com
! Led by
@mikelangelipid.bsky.social
, we identify the first
#LipidDroplet
lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated
#ferroptosis
.
www.nature.com/articles/s41...
loading . . .
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
https://www.nature.com/articles/s41556-025-01790-y
6
120
39
reposted by
Ben-Sahra Lab
Molecular Cell
2 months ago
Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now:
loading . . .
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
Nengroo et al. show that succinate dehydrogenase (SDH) maintains purine synthesis. SDH inhibition elevates succinate, inducing SHMT2 succinylation that suppresses mitochondrial one-carbon flow and formate supply, thereby constraining purine assembly. Cancer cells compensate via purine salvage, and dual inhibition of SDH and salvage yields significant antiproliferative effects and suppresses tumor growth.
http://dlvr.it/TNxBtc
0
5
2
Excited to share our latest work out today in
@cp-molcell.bsky.social
, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo!
www.sciencedirect.com/science/arti...
!
loading . . .
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
https://www.sciencedirect.com/science/article/pii/S1097276525008196?dgcid=author
2 months ago
1
61
18
reposted by
Ben-Sahra Lab
Rushika M. Perera
3 months ago
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and
@robzonculab.bsky.social
Keynote speakers incl. Eileen White,
@idikic.bsky.social
and Sharon Tooze- Registration is open: link⬇️
www.grc.org/autophagy-in...
loading . . .
2026 Autophagy in Stress, Development and Disease Conference GRC
The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.
https://www.grc.org/autophagy-in-stress-development-and-disease-conference/2026/
0
16
12
reposted by
Ben-Sahra Lab
Christian Frezza
3 months ago
Good Sunday, mitolovers! 🌟 Exciting news in the world of
#cancermetabolism
and
#mitochondrialbiology
! 🧬 Check out the papers from last week here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading📚
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
0
24
9
reposted by
Ben-Sahra Lab
Christian Frezza
3 months ago
www.nature.com/articles/s41...
Spatial metabolic gradients in the liver and small intestine
loading . . .
Spatial metabolic gradients in the liver and small intestine - Nature
Mapping of spatial metabolic gradients in the mouse liver and intestine identifies fructose-induced focal derangements in liver metabolism.
https://www.nature.com/articles/s41586-025-09616-5
0
12
3
reposted by
Ben-Sahra Lab
Lucas Sullivan
3 months ago
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC,
@asbmbjournals.bsky.social
! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here:
www.sciencedirect.com/science/arti...
add a skeleton here at some point
1
35
18
reposted by
Ben-Sahra Lab
Christian Frezza
3 months ago
www.nature.com/articles/s42...
loading . . .
NAD+ precursor supplementation in human ageing: clinical evidence and challenges - Nature Metabolism
This Review summarizes existing data, as well as crucial knowledge gaps, emerging from clinical trials involving NAD+ precursor supplementation in humans.
https://www.nature.com/articles/s42255-025-01387-7
0
5
4
reposted by
Ben-Sahra Lab
Christian Frezza
3 months ago
www.sciencedirect.com/science/arti...
Congratulations to Thomas MacVicar & team!
loading . . .
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…
https://www.sciencedirect.com/science/article/pii/S1097276525007038
0
14
3
reposted by
Ben-Sahra Lab
Nature
3 months ago
John M. Martinis, Michel H. Devoret & John Clarke recount the history of their milestone discovery, which today won the Nobel Prize in Physics
go.nature.com/4gVswyS
loading . . .
Quantum Josephson junction circuits and the dawn of artificial atoms - Nature Physics
In 1985, experiments revealed the quantum behaviour of a macroscopic degree of freedom: the phase difference across a Josephson junction. The authors recount the history of this milestone for the development of superconducting quantum circuits.
https://go.nature.com/4gVswyS
0
31
13
reposted by
Ben-Sahra Lab
Nature
3 months ago
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more.
#NobelPrize
1
224
108
reposted by
Ben-Sahra Lab
Anupam Patgiri
3 months ago
NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria
www.biorxiv.org/content/10.1...
loading . . .
NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria
Nicotinamide adenine dinucleotide plays a central role in energy metabolism, and its decline is linked to various degenerative diseases. While NAD+ restoration holds therapeutic promise, its long term...
https://www.biorxiv.org/content/10.1101/2025.10.02.678456v1
0
4
1
reposted by
Ben-Sahra Lab
Christian Frezza
3 months ago
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses: Cancer Cell
www.cell.com/cancer-cell/...
loading . . .
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
Ren et al. demonstrate pseudo-synaptic connections between sensory neurons and pancreatic ductal adenocarcinoma (PDAC) cells. These pseudo-synapses exhibit enrichment of NMDA receptor subunit GRIN2D/G...
https://www.cell.com/cancer-cell/fulltext/S1535-6108%2825%2900395-2
0
7
1
reposted by
Ben-Sahra Lab
Muir Lab
4 months ago
Super excited to share our new preprint from
@cssheehan.bsky.social
on how the tumor microenvironment causes drug resistance in pancreatic cancer:
www.biorxiv.org/content/10.1...
loading . . .
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
https://www.biorxiv.org/content/10.1101/2025.09.04.673818v1
1
32
9
reposted by
Ben-Sahra Lab
Cristina Muñoz Pinedo
4 months ago
Better late than never. Cancer metabolism: literature from July 2025 (The MetaboList) Amino acids, lipid metabolism, diet and cancer and more...
metabolist.wordpress.com/2025/09/02/m...
loading . . .
MetaboList – July 2025
Glucose metabolism Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells Yabo Zhou, Chaoying Zhang, Lina He, Youli Kang, Dianheng W…
https://metabolist.wordpress.com/2025/09/02/metabolist-july-2025/
0
4
1
reposted by
Ben-Sahra Lab
Christian Frezza
4 months ago
Good Sunday, all! After a technical glitch last week, we are back again, with TWO exciting curated selections of papers in
#cancermetabolism
and
#mitochondrialbiology
@biomednews.bsky.social
. Check them here
#keepreading
:
biomed.news/bims-camemi/...
biomed.news/bims-camemi/...
0
17
8
reposted by
Ben-Sahra Lab
Catalina Vasilescu, PhD
5 months ago
Last two weeks of literature relevant for
#MitochondrialDisease
! 📚
@biomednews.bsky.social
@gavinmcstay.bsky.social
@mitoscientist.bsky.social
@mitoscientists.bsky.social
Please browse the collections here! 👇
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
0
15
9
reposted by
Ben-Sahra Lab
Dan Wahl
4 months ago
New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published this week
@nature.com
and led by stellar postdoc Drew Scott (comentored by
@lyssiotislab.bsky.social
and currently on job market with a K99/R00).
www.nature.com/articles/s41...
loading . . .
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
https://www.nature.com/articles/s41586-025-09460-7
3
42
13
reposted by
Ben-Sahra Lab
4 months ago
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell
www.cell.com/cell/fulltex...
loading . . .
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation
Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...
https://www.cell.com/cell/fulltext/S0092-8674(25)00916-X
0
3
1
reposted by
Ben-Sahra Lab
Alexey Amunts
4 months ago
Mitochondrial transfer is a fascinating phenomenon where cells shuttle mitos. The therapeutic potential is compelling and observational science is solid but the mechanism is a black box. Excellent Viewpoint in
@naturemetabolism.bsky.social
breaks down one of cell biology’s biggest emerging mysteries
2
33
12
reposted by
Ben-Sahra Lab
Christian Frezza
4 months ago
Mitochondrial activity tunes nociceptor resilience to excitotoxicity: Cell
www.cell.com/cell/fulltex...
loading . . .
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport cha...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900914-6
0
6
3
reposted by
Ben-Sahra Lab
Christian Frezza
4 months ago
Mechanical confinement governs phenotypic plasticity in melanoma
www.nature.com/articles/s41...
loading . . .
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
https://www.nature.com/articles/s41586-025-09445-6
0
6
2
reposted by
Ben-Sahra Lab
Christian Frezza
5 months ago
Good Sunday all! There is another beutifully exciting selection of papers in
#cancermetabolism
and
#mitochondrialbiology
waiting for you here:
biomed.news/bims-camemi/...
Biomed News
#keepreading
"Things take the time they take. Don't worry." Mary Oliver
0
20
6
reposted by
Ben-Sahra Lab
Gina DeNicola
5 months ago
Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here:
moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...
loading . . .
Tenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cancer Center CareersTenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cance...
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
https://moffitt-cancer-center-careers.hctsportals.com/jobs/1883440-tenure-earning-assistant-member-metabolism-and-physiology-faculty
0
7
6
reposted by
Ben-Sahra Lab
Christian Frezza
5 months ago
Vagal blockade of the brain-liver axis deters cancer-associated cachexia: Cell
www.cell.com/cell/fulltex...
better link now about this wonderful piece of work
loading . . .
Vagal blockade of the brain-liver axis deters cancer-associated cachexia
Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia. Blocking the right cervical vagus nerve with various invasive or non-invasive approaches alleviates cachexia, d...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900805-0
0
6
3
Load more
feeds!
log in