Ben-Sahra Lab
@bensahralab.bsky.social
📤 624
📥 259
📝 24
Nucleotide Metabolism, Molecular Metabolism, and Signaling Pathways
https://www.bensahralab.org/
reposted by
Ben-Sahra Lab
Coloff Lab
1 day ago
Hot off the press!! 🚨📰 Check out
@palpurab.bsky.social
work focusing on the effect of ceramides on breast cancer cells
aacrjournals.org/mcr/article/...
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Ceramide-induced endoplasmic reticulum stress reveals a targetable vulnerability in endocrine therapy-resistant breast cancer
Abstract. Despite the success of endocrine therapy (ET) in treating hormone receptor-positive breast cancer, a significant proportion of patients relapse during or after treatment, making ET resistanc...
https://aacrjournals.org/mcr/article/doi/10.1158/1541-7786.MCR-25-0964/785668/Ceramide-induced-endoplasmic-reticulum-stress
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1
1
reposted by
Ben-Sahra Lab
Dan Landau
2 days ago
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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44
reposted by
Ben-Sahra Lab
Nature Metabolism
21 days ago
RESEARCH | S Xiao, M Wang, TG Martin, J Long et al
@stanfordmedicine.bsky.social
Para-tyramine-O-sulphate is a conserved postprandial metabolite that links nutrient intake to energy balance in pythons and mice🧪
www.nature.com/articles/s42...
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Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway - Nature Metabolism
Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient intake to energy balanc...
https://www.nature.com/articles/s42255-026-01485-0?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
0
6
1
reposted by
Ben-Sahra Lab
Lucas Sullivan
29 days ago
Also, check out this excellent N&V writeup from
@frezzalab.bsky.social
that nicely summarizes our findings and contextualizes them with other fascinating work on succinate interactions with nucleotide synthesis from the
@bensahralab.bsky.social
and Hirschey Labs!
www.nature.com/articles/s42...
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Succinate calls a time-out on pyrimidine biosynthesis - Nature Metabolism
Cell metabolism is a dynamic network of highly interconnected biochemical reactions. In this issue of Nature Metabolism, time-lapse analysis of the amino acid aspartate revealed an unexpected regulati...
https://www.nature.com/articles/s42255-026-01523-x
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5
4
reposted by
Ben-Sahra Lab
Barbara Marte
about 2 months ago
new out in Nature
www.nature.com/articles/s41...
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Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers - Nature
Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...
https://www.nature.com/articles/s41586-026-10344-7
0
12
7
reposted by
Ben-Sahra Lab
Nature Metabolism
about 2 months ago
RESEARCH | C Hepler, J Bass et al. (Northwestern University) 🧪 Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.
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Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome - Nature Metabolism
Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.
http://dlvr.it/TS4Dc9
0
8
1
reposted by
Ben-Sahra Lab
Lucas Sullivan
about 2 months ago
Pleased to share our recent work out today in
@natmetabolism.nature.com
. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
add a skeleton here at some point
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50
24
reposted by
Ben-Sahra Lab
Nature Metabolism
2 months ago
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Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells
Nature Metabolism, Published online: 03 April 2026; doi:10.1038/s42255-026-01491-2This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues.
http://dlvr.it/TRsLRG
0
4
1
reposted by
Ben-Sahra Lab
Korolchuk Lab
3 months ago
#Autophagy
and
#mTOR
papers from last week, very interesting stuff going on in the field, don’t miss it! 👇🏼
biomed.news/bims-auttor/...
0
8
5
reposted by
Ben-Sahra Lab
Catalina Vasilescu, PhD
3 months ago
#Mitochondria
in
#Health
and
#Disease
- last 2 weeks of published research 📚:
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social
@gavinmcstay.bsky.social
@mitoscientist.bsky.social
Mito control of glycerolipid synthesis by a PEP shuttle
www.cell.com/cell/abstrac...
0
9
9
reposted by
Ben-Sahra Lab
Sean Rudd
3 months ago
Happy to share the second paper from the group this year, out in @moloncology.bsky.social Another story about the dNTPase & drug resistance factor SAMHD1 and our attempts to find ways to suppress its activity in cancer cells 👇
febs.onlinelibrary.wiley.com/doi/10.1002/...
@scilifelab.se
@ki.se
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FEBS Press
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors ...
https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70226
0
7
3
reposted by
Ben-Sahra Lab
Cell - a Cell Press journal
3 months ago
Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
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Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.
http://dlvr.it/TRC77c
0
8
4
reposted by
Ben-Sahra Lab
Nature Metabolism
3 months ago
#NatMetabPicks
| In
@nature.com
led by
@skinnider.bsky.social
(
@princeton.edu
) 🧪 DeepMet is a chemical language model designed to predict the existence of previously unrecognized metabolites.
www.nature.com/articles/s41...
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Language model-guided anticipation and discovery of mammalian metabolites - Nature
Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.
https://www.nature.com/articles/s41586-025-09969-x
0
6
3
reposted by
Ben-Sahra Lab
Cristina Muñoz Pinedo
3 months ago
What happens when tumor cells can't find enough nutrients? They "call" other cells. We have found a new mediator of this phenomenon: the multifunctional cytokine LIF 👇🧵
2
15
2
reposted by
Ben-Sahra Lab
James Olzmann
3 months ago
Sooo happy to share our new paper in
@nature.com
“CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with
@arrudalab.bsky.social
, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...
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CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
https://www.nature.com/articles/s41586-025-10064-4
6
85
38
reposted by
Ben-Sahra Lab
Catalina Vasilescu, PhD
3 months ago
A wonderful collection of literature from
#week8
on
#Mitochondria
in
#Health
&
#Disease
! 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social
@gavinmcstay.bsky.social
@mitoscientist.bsky.social
A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...
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A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism
The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...
https://www.nature.com/articles/s42255-025-01450-3
0
11
5
reposted by
Ben-Sahra Lab
Christian Frezza
3 months ago
Good Sunday, all. There is a wonderful curated selection of papers in
#cancermetabolism
and
#mitochondrialbiology
here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
The real truth, that dare not speak itself, is that no one is in control. Absolutely no one. Terence McKenna
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20
5
reposted by
Ben-Sahra Lab
Christian Frezza
4 months ago
Papers are increasingly challenging to navigate, not only because of the sheer volume of data they contain but also because of their structure. This is a delicate point of discussion that we, as a community, should address. I would love hearing your views on this.
network.febs.org/posts/thinki...
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Thinking Like a Scientist, Part Three: Hypothesis Retrofitting
Scientific papers are more complex than ever, but are we gaining deeper understanding or losing sight of the hypothesis? In this third part of Thinking like a scientist, I reflect on data-driven scien...
https://network.febs.org/posts/thinking-like-a-scientist-part-three-hypothesis-retrofitting
4
26
10
reposted by
Ben-Sahra Lab
Christian Frezza
4 months ago
Good Sunday, mitolovers. Here is the weekly curated issue of papers in
#cancermetabolism
and
#mitochondrialbiology
, with truly remarkable papers:
lnkd.in/e7HDuVuU
@biomednews.bsky.social
#keepreading
"Attention is the rarest and purest form of generosity."-Simone Weil
1
20
12
reposted by
Ben-Sahra Lab
Zhenyu Zhong
5 months ago
Why is obesity often associated with dysregulated, low-grade chronic inflammation? In our new paper in
@science.org
we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger.
www.science.org/doi/10.1126/...
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Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...
https://www.science.org/doi/10.1126/science.adq9006
2
53
13
reposted by
Ben-Sahra Lab
Jason Cantor
5 months ago
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work
@natmetabolism.nature.com
, led by
@thebiokimist.bsky.social
. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
3
56
29
reposted by
Ben-Sahra Lab
Christian Frezza
5 months ago
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
www.nature.com/articles/s41...
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Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis - Nature Immunology
Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.
https://www.nature.com/articles/s41590-025-02390-6?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20260115&utm_content=10.1038/s41590-025-02390-6
0
8
2
reposted by
Ben-Sahra Lab
Phillip White
5 months ago
Excited to announce that registration is officially open for
#METPHYS2026
! All meeting details can be found here:
www.sablesys.com/metphys-the-...
0
15
13
reposted by
Ben-Sahra Lab
Cristina Muñoz Pinedo
5 months ago
Here’s a new compilation of papers about cancer metabolism published last month MetaboList - December 2025 Special section about diet and cancer
metabolist.wordpress.com/2026/01/09/m...
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MetaboList – December 2025
Diet and cancer Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation Tong et al, Zhen Lei Hubing Shi ∙ Xuelei Ma. Dietary restriction…
https://metabolist.wordpress.com/2026/01/09/metabolist-december-2025/
0
6
3
reposted by
Ben-Sahra Lab
Rich Possemato
5 months ago
Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include
@airdlab.bsky.social
@bensahralab.bsky.social
Javier Garcia-Bermudez, Marcus Goncalves,
@naama-kanarek.bsky.social
@bdmanning.bsky.social
Erika Pearce,
1
10
7
reposted by
Ben-Sahra Lab
Gina DeNicola
5 months ago
Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc
@kimyumi0201.bsky.social
: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵
2
17
10
reposted by
Ben-Sahra Lab
Charles Brenner, PhD
5 months ago
happy to announce that i have post-doc openings for mid-2016 to advance this science please read our work, think about the most exciting questions & approaches, & be in touch for an interview note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
add a skeleton here at some point
0
5
1
reposted by
Ben-Sahra Lab
James Olzmann
6 months ago
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and
#ferroptosis
in in vivo cancer models. Beautiful work from
@ubellackerlab.bsky.social
, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
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In vivo models bring FSP1 inhibitors to life - Nature Cell Biology
FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...
https://www.nature.com/articles/s41556-025-01849-w
0
41
11
reposted by
Ben-Sahra Lab
Lamming Lab
6 months ago
Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!
1
5
3
reposted by
Ben-Sahra Lab
Christian Frezza
6 months ago
Good Sunday, all. Don't miss this week's selection of papers in
#cancermetabolism
and
#mitochondrialbiology
as there are some true gems:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
1
24
10
reposted by
Ben-Sahra Lab
Nature Metabolism
6 months ago
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Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
Nature Metabolism, Published online: 05 December 2025; doi:10.1038/s42255-025-01410-xA machine-learning-based computational approach to probe pathway coessentiality reveals that complex II of the electron transport chain regulates de novo purine synthesis, and can be targeted to treat acute myeloid leukaemia.
https://bit.ly/44dL1cR
0
7
6
reposted by
Ben-Sahra Lab
Christian Frezza
6 months ago
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell
www.cell.com/cell/fulltex...
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A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
A fin-like structural loop in GPX4 is critical for anchoring the enzyme to cellular membranes, thereby preventing ferroptosis. A patient-associated R152H mutation destabilizes this loop, leading to fe...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901310-8
0
13
2
reposted by
Ben-Sahra Lab
Molecular Cell
6 months ago
Leveraging biochemical covariance to better understand biology
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Leveraging biochemical covariance to better understand biology
In a recent Nature article, Xiao et al. report development of a metabolite-protein covariation architecture (MPCA) database from a diversity outbred mouse cohort that facilitates the deciphering of metabolite-protein relationships in liver and brown adipose tissue (BAT). Using these correlations, the authors describe a role for LRRC58 in controlling cysteine-taurine metabolism.
http://dlvr.it/TPSsQ8
0
3
1
reposted by
Ben-Sahra Lab
Jason Cantor
7 months ago
happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD!
tinyurl.com/3yutyd8c
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Human plasma‐like medium enhances structural and metabolic maturation of human pluripotent stem cell‐derived cardiomyocytes
Human plasma-like medium (HPLM), a synthetic physiologic medium containing over 60 metabolites and small ions at concentrations reflective of adult human plasma, enhances the structural and metabolic....
https://tinyurl.com/3yutyd8c
1
6
3
reposted by
Ben-Sahra Lab
RyanLab_TCD
7 months ago
Very excited to announce that the first paper from the lab is now live
@natcomms.nature.com
#mitochondria
#immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out!
www.nature.com/articles/s41...
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An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
https://www.nature.com/articles/s41467-025-65023-4
5
38
14
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
Good Sunday!. A wonderful selection of papers in
#cancermetabolism
and
#mitochondrialbiology
is waiting for you here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one." -Wei Wu Wei
0
14
8
reposted by
Ben-Sahra Lab
Alexis A. Jourdain
7 months ago
Very excited to share the published version of our
#uridine
#CRISPR
screen in
naturemetabolism.bsky.social
! 🎉 Led by Abigail Strefeler with
@pagliarini-lab.bsky.social
@zakbaker.bsky.social
and team!
#NUDT5
#DMQ
@dib-unil.bsky.social
@fbm-unil.bsky.social
🔗
www.nature.com/articles/s42...
🧵1/17
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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
https://www.nature.com/articles/s42255-025-01419-2
3
28
14
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
Good Sunday, all. The weekly curated issue of papers in
#cancermetabolism
and
#mitochondrialbiology
is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
0
16
8
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science
www.science.org/doi/10.1126/...
Great work from
@rjdlab.bsky.social
!!
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NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
https://www.science.org/doi/10.1126/science.adx9717
0
10
4
reposted by
Ben-Sahra Lab
American Cancer Society
7 months ago
2. A new paper in
@cp-molcell.bsky.social
from
@bensahralab.bsky.social
(ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee)
@luriecancer.bsky.social
revealing a molecular link between succinate dehydrogenase and purine synthesis. Read the paper here:
lnkd.in/eibyMezn
1
3
2
reposted by
Ben-Sahra Lab
Zheng Wu
7 months ago
Super excited to share that my second project in the
@rjdlab.bsky.social
is now published in Science! Many thanks to all co-authors, especially
@ptnguyen.bsky.social
for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
add a skeleton here at some point
1
20
4
reposted by
Ben-Sahra Lab
ChemBioHub - Huber Lab
7 months ago
New in
@science.org
🧬 What if an enzyme you thought you knew turned out to control metabolism in a completely new way? We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
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A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
https://www.science.org/doi/10.1126/science.adv4257
2
21
14
reposted by
Ben-Sahra Lab
DeBerardinis Lab at UT Southwestern Medical Center
7 months ago
1/New paper from Zheng Wu, Phong Nguyen et al.
@cri-utsw.bsky.social
shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
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NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
https://www.science.org/doi/10.1126/science.adx9717
7
72
27
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
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Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
https://www.nature.com/articles/s41586-025-09718-0
0
11
7
reposted by
Ben-Sahra Lab
Ubellacker Lab
7 months ago
Excited to share our work
@nature.com
! Postdoc
@mariopalma.bsky.social
, with major contributions from
@retickerflynn.bsky.social
and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression.
#TeamFSP1
www.nature.com/articles/s41...
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Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
https://www.nature.com/articles/s41586-025-09709-1
7
30
11
reposted by
Ben-Sahra Lab
Mario Palma
7 months ago
Excited to share my postdoctoral work, out today in Nature!
www.nature.com/articles/s41...
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
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Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
https://www.nature.com/articles/s41586-025-09709-1
3
16
6
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.
network.febs.org/posts/thinki...
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Thinking like a Scientist: The Limits of Genome Editing and Omics
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
https://network.febs.org/posts/thinking-like-a-scientist-part-two-the-omics-illusion
4
16
6
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
Good Sunday, mitolovers. Here is a wonderful selection of papers in
#cancermetabolism
and
#mitochondrialbiology
:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
0
13
8
reposted by
Ben-Sahra Lab
Christian Frezza
7 months ago
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations
@bensahralab.bsky.social
!!
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Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
https://www.sciencedirect.com/science/article/abs/pii/S1097276525008196
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