Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading "Attention is the rarest and purest form of generosity."-Simone Weil

Why is obesity often associated with dysregulated, low-grade chronic inflammation? In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis www.nature.com/articles/s41...

Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: www.sablesys.com/metphys-the-...

Here’s a new compilation of papers about cancer metabolism published last month MetaboList - December 2025 Special section about diet and cancer metabolist.wordpress.com/2026/01/09/m...

Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

happy to announce that i have post-doc openings for mid-2016 to advance this science please read our work, think about the most exciting questions & approaches, & be in touch for an interview note that there are now human data in support of our model www.medrxiv.org/content/10.6...

Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳 www.nature.com/articles/s41...

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!

Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell www.cell.com/cell/fulltex...

🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at [email protected] for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky

Leveraging biochemical covariance to better understand biology

happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD! tinyurl.com/3yutyd8c

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one." -Wei Wu Wei

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "There are years that ask questions and years that answer."-Zora Neale Hurston

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/... Great work from @rjdlab.bsky.social !!

2. A new paper in @cp-molcell.bsky.social from @bensahralab.bsky.social (ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee) @luriecancer.bsky.social revealing a molecular link between succinate dehydrogenase and purine synthesis. Read the paper here: lnkd.in/eibyMezn

Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!

New in @science.org 🧬 What if an enzyme you thought you knew turned out to control metabolism in a completely new way? We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs. www.science.org/doi/10.1126/...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...

www.nature.com/articles/s41... Secretome translation shaped by lysosomes and lunapark-marked ER junctions

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41... We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.

Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views. network.febs.org/posts/thinki...

Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "Coming back to where you started is not the same as never leaving."-Terry Pratchett

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps:// www.sciencedirect.com/science/article/abs/pii/S1097276525008196 Congratulations @bensahralab.bsky.social !!

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now:

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚 "Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

www.nature.com/articles/s41... Spatial metabolic gradients in the liver and small intestine

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti... Congratulations to Thomas MacVicar & team!

John M. Martinis, Michel H. Devoret & John Clarke recount the history of their milestone discovery, which today won the Nobel Prize in Physics go.nature.com/4gVswyS

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize

NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria www.biorxiv.org/content/10.1...

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses: Cancer Cell www.cell.com/cancer-cell/...

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

Better late than never. Cancer metabolism: literature from July 2025 (The MetaboList) Amino acids, lipid metabolism, diet and cancer and more... metabolist.wordpress.com/2025/09/02/m...

Good Sunday, all! After a technical glitch last week, we are back again, with TWO exciting curated selections of papers in #cancermetabolism and #mitochondrialbiology @biomednews.bsky.social. Check them here #keepreading: biomed.news/bims-camemi/... biomed.news/bims-camemi/...

Last two weeks of literature relevant for #MitochondrialDisease! 📚 @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social Please browse the collections here! 👇 biomed.news/bims-mitdis/... biomed.news/bims-mitdis/...