Hot off the press!! 🚨📰 Check out @palpurab.bsky.social work focusing on the effect of ceramides on breast cancer cells aacrjournals.org/mcr/article/...

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

RESEARCH | S Xiao, M Wang, TG Martin, J Long et al @stanfordmedicine.bsky.social Para-tyramine-O-sulphate is a conserved postprandial metabolite that links nutrient intake to energy balance in pythons and mice🧪 www.nature.com/articles/s42...

Also, check out this excellent N&V writeup from @frezzalab.bsky.social that nicely summarizes our findings and contextualizes them with other fascinating work on succinate interactions with nucleotide synthesis from the @bensahralab.bsky.social and Hirschey Labs! www.nature.com/articles/s42...

new out in Nature www.nature.com/articles/s41...

RESEARCH | C Hepler, J Bass et al. (Northwestern University) 🧪 Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.

Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

#Autophagy and #mTOR papers from last week, very interesting stuff going on in the field, don’t miss it! 👇🏼 biomed.news/bims-auttor/...

#Mitochondria in #Health and #Disease - last 2 weeks of published research 📚: biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social Mito control of glycerolipid synthesis by a PEP shuttle www.cell.com/cell/abstrac...

Happy to share the second paper from the group this year, out in @moloncology.bsky.social Another story about the dNTPase & drug resistance factor SAMHD1 and our attempts to find ways to suppress its activity in cancer cells 👇 febs.onlinelibrary.wiley.com/doi/10.1002/... @scilifelab.se @ki.se

Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

#NatMetabPicks | In @nature.com led by @skinnider.bsky.social ( @princeton.edu ) 🧪 DeepMet is a chemical language model designed to predict the existence of previously unrecognized metabolites. www.nature.com/articles/s41...

What happens when tumor cells can't find enough nutrients? They "call" other cells. We have found a new mediator of this phenomenon: the multifunctional cytokine LIF 👇🧵

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity www.nature.com/articles/s42...

Good Sunday, all. There is a wonderful curated selection of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading The real truth, that dare not speak itself, is that no one is in control. Absolutely no one. Terence McKenna

Papers are increasingly challenging to navigate, not only because of the sheer volume of data they contain but also because of their structure. This is a delicate point of discussion that we, as a community, should address. I would love hearing your views on this. network.febs.org/posts/thinki...

Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading "Attention is the rarest and purest form of generosity."-Simone Weil

Why is obesity often associated with dysregulated, low-grade chronic inflammation? In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis www.nature.com/articles/s41...

Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: www.sablesys.com/metphys-the-...

Here’s a new compilation of papers about cancer metabolism published last month MetaboList - December 2025 Special section about diet and cancer metabolist.wordpress.com/2026/01/09/m...

Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

happy to announce that i have post-doc openings for mid-2016 to advance this science please read our work, think about the most exciting questions & approaches, & be in touch for an interview note that there are now human data in support of our model www.medrxiv.org/content/10.6...

Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳 www.nature.com/articles/s41...

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!

Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell www.cell.com/cell/fulltex...

Leveraging biochemical covariance to better understand biology

happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD! tinyurl.com/3yutyd8c

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one." -Wei Wu Wei

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "There are years that ask questions and years that answer."-Zora Neale Hurston

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/... Great work from @rjdlab.bsky.social !!

2. A new paper in @cp-molcell.bsky.social from @bensahralab.bsky.social (ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee) @luriecancer.bsky.social revealing a molecular link between succinate dehydrogenase and purine synthesis. Read the paper here: lnkd.in/eibyMezn

Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!

New in @science.org 🧬 What if an enzyme you thought you knew turned out to control metabolism in a completely new way? We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs. www.science.org/doi/10.1126/...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...

www.nature.com/articles/s41... Secretome translation shaped by lysosomes and lunapark-marked ER junctions

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41... We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.

Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views. network.febs.org/posts/thinki...

Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "Coming back to where you started is not the same as never leaving."-Terry Pratchett

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps:// www.sciencedirect.com/science/article/abs/pii/S1097276525008196 Congratulations @bensahralab.bsky.social !!