Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "There are years that ask questions and years that answer."-Zora Neale Hurston

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/... Great work from @rjdlab.bsky.social !!

2. A new paper in @cp-molcell.bsky.social from @bensahralab.bsky.social (ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee) @luriecancer.bsky.social revealing a molecular link between succinate dehydrogenase and purine synthesis. Read the paper here: lnkd.in/eibyMezn

Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!

New in @science.org 🧬 What if an enzyme you thought you knew turned out to control metabolism in a completely new way? We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs. www.science.org/doi/10.1126/...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...

www.nature.com/articles/s41... Secretome translation shaped by lysosomes and lunapark-marked ER junctions

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41... We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.

Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views. network.febs.org/posts/thinki...

Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "Coming back to where you started is not the same as never leaving."-Terry Pratchett

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps:// www.sciencedirect.com/science/article/abs/pii/S1097276525008196 Congratulations @bensahralab.bsky.social !!

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now:

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚 "Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

www.nature.com/articles/s41... Spatial metabolic gradients in the liver and small intestine

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti... Congratulations to Thomas MacVicar & team!

John M. Martinis, Michel H. Devoret & John Clarke recount the history of their milestone discovery, which today won the Nobel Prize in Physics go.nature.com/4gVswyS

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize

NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria www.biorxiv.org/content/10.1...

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses: Cancer Cell www.cell.com/cancer-cell/...

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

Better late than never. Cancer metabolism: literature from July 2025 (The MetaboList) Amino acids, lipid metabolism, diet and cancer and more... metabolist.wordpress.com/2025/09/02/m...

Good Sunday, all! After a technical glitch last week, we are back again, with TWO exciting curated selections of papers in #cancermetabolism and #mitochondrialbiology @biomednews.bsky.social. Check them here #keepreading: biomed.news/bims-camemi/... biomed.news/bims-camemi/...

Last two weeks of literature relevant for #MitochondrialDisease! 📚 @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social Please browse the collections here! 👇 biomed.news/bims-mitdis/... biomed.news/bims-mitdis/...

New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published this week @nature.com and led by stellar postdoc Drew Scott (comentored by @lyssiotislab.bsky.social and currently on job market with a K99/R00). www.nature.com/articles/s41...

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell www.cell.com/cell/fulltex...

Mitochondrial transfer is a fascinating phenomenon where cells shuttle mitos. The therapeutic potential is compelling and observational science is solid but the mechanism is a black box. Excellent Viewpoint in @naturemetabolism.bsky.social breaks down one of cell biology’s biggest emerging mysteries

Mitochondrial activity tunes nociceptor resilience to excitotoxicity: Cell www.cell.com/cell/fulltex...

Mechanical confinement governs phenotypic plasticity in melanoma www.nature.com/articles/s41...

Good Sunday all! There is another beutifully exciting selection of papers in #cancermetabolism and #mitochondrialbiology waiting for you here: biomed.news/bims-camemi/... Biomed News #keepreading "Things take the time they take. Don't worry." Mary Oliver

Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...

Vagal blockade of the brain-liver axis deters cancer-associated cachexia: Cell www.cell.com/cell/fulltex... better link now about this wonderful piece of work

Wonderful selection of papers on #MitochondrialDisease from #week31! biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social A few highlights below, many more inside! www.nature.com/articles/s42...

Good Sunday, all. This week was a blast for @cancermetabolism and @mitochondrialbiology. Don't miss the curated issue of papers, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "There was another life that I might have had, but I am having this one."-Kazuo Ishiguro

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...

Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab) www.nature.com/articles/s41...

Excited to share our work just published in @natmetabolism.nature.com examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.

Just two of thousands of such stories. substack.com/home/post/p-...

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice. www.nature.com/articles/s42...

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉 🧫 New galactose #CRISPR screen 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂 Mito defects in #Menieres www.cell.com/cell-reports...

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...