happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD! tinyurl.com/3yutyd8c

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab) www.nature.com/articles/s41...

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social jci.org/articles/vie... 1/6

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...

ICYMI:

Good Sunday, all. Here is a summary of papers in #cancermetabolism and #mitochondrialbiology, packed with superexciting science and discoveries. Don't miss it, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "Love is the quality of attention we pay to things." -J. D. McClatchy

excited to share our latest work now online @natmetabolism.nature.com, led by @kyle-flickinger.bsky.social, where we unravel a mechanistic basis for the conditional essentiality of NADK, one of the many interesting hits from our previously reported CRISPR screening with HPLM rdcu.be/ekpu6

🚨 pleased to share a new preprint made possible through a fantastic collaboration with the Skala & Palecek labs! can medium composition impact the behavior of hPSC-derived cardiomyocytes? Andy & Aaron co-led efforts to tackle this question w/HPLM! tinyurl.com/ux2arjw8

congrats, @milansavani.com, Sam, et al! very cool approach and findings! www.biorxiv.org/content/10.1...

excited for a weekend of great science #ASBMB25! if you're in CHI, I encourage you to check out a session that Kevin Tharp & I organized, Sat @ 930 (W176): events.rdmobile.com/Sessions/Det... +a talk from Kyle (Sun @ 9, W178), and posters from Kim, Kyle, & Gavin (Sun @ 430, W375c)! (fixed link)

www.nature.com/articles/s42... Metabolites are not genes. repeat, please!

happy to share our forum now online @Cell_Metabolism! fun for us (Guy & myself) to collaborate with @dfazakerley.bsky.social, Joycelyn, & Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! www.cell.com/cell-metabol...

Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵

Safeguarding the future of biomedical science in the United States: www.cell.com/cell/fulltex...

Breaking news: 22 states are suing to block NIH’s cutting of indirect costs. See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v

excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!

The National Institutes of Health plans to severely cut the percentage of its grant money that can be used for overhead costs rather than research.

Excited to co-chair #ASBMB2025 with the incredible Dave Pagliarini! This year’s ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts. t.co/UwgMdxBo15

a bit of good news for our team as we close out the year and turn the page to 2025, v grateful to NIGMS for enthusiastically supporting our R35/MIRA! excited to continue on a few current threads and begin to explore others! wishing a happy new year from our lab to yours! 🥂

a fitting first post to mark the beautiful PhD thesis defense this afternoon from our lab’s very first student! Kim’s courage to join a brand-new lab and her ensuing grit, enthusiasm, and creativity were exceptional! extremely proud of all she has achieved, stay tuned for some of her cool findings!